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| Genetic Polymorphisms of Drug-Metabolizing Enzymes Involved in 6-Mercaptopurine-Induced Myelosuppression in Thai Pediatric Acute Lymphoblastic Leukemia Patients. Journal of pediatric genetics 2021 Mar 10 (1): 29-34. Khaeso Kanyarat, Nakkam Nontaya, Komwilaisak Patcharee, Wongmast Piyathida, Chainansamit Su-On, Dornsena Areerat, Kanjanawart Sirimas, Vannaprasaht Suda, Tassaneeyakul Wichitt |
| Hepatic sinusoidal obstruction syndrome and short-term application of 6-thioguanine in pediatric acute lymphoblastic leukemia. Leukemia 2021 Mar . Stanulla Martin, Schaeffeler Elke, Möricke Anja, Buchmann Swantje, Zimmermann Martin, Igel Svitlana, Schmiegelow Kjeld, Flotho Christian, Hartmann Hans, Illsinger Sabine, Sauerbrey Axel, Junk Stefanie V, Schütte Peter, Hinze Laura, Lauten Melchior, Modlich Simon, Kolb Reinhard, Rossig Claudia, Schwabe Georg, Gnekow Astrid K, Fleischhack Gudrun, Schlegel Paul Gerhard, Schünemann Holger J, Kratz Christian P, Cario Gunnar, Schrappe Martin, Schwab Matthi |
| TPMT polymorphisms and minimal residual disease after 6-mercaptopurine post-remission consolidation therapy of childhood acute lymphoblastic leukaemia. Pediatric hematology and oncology 2020 Nov 1-12. Dreisig Karin, Brünner Emilie Damgaard, Marquart Hanne V, Helt Louise Rold, Nersting Jacob, Frandsen Thomas Leth, Jonsson Olafur Gisli, Taskinen Mervi, Vaitkeviciene Goda, Lund Bendik, Abrahamsson Jonas, Lepik Kristi, Schmiegelow Kje |
| Homozygote CRIM1 variant is associated with thiopurine-induced neutropenia in leukemic patients with both wildtype NUDT15 and TPMT. Journal of translational medicine 2020 Jul 18 (1): 265. Park Yoomi, Kim Hyery, Seo Heewon, Choi Jung Yoon, Ma Youngeun, Yun Sunmin, Min Byung-Joo, Seo Myung-Eui, Yoo Keon Hee, Kang Hyoung Jin, Im Ho Joon, Kim Ju H |
| Association of NUDT15*3 and FPGS 2572C>T Variants with the Risk of Early Hematologic Toxicity During 6-MP and Low-Dose Methotrexate-Based Maintenance Therapy in Indian Patients with Acute Lymphoblastic Leukemia. Genes 2020 May 11 (6): . Kodidela Sunitha, Dorababu Patchava, Thakkar Dimpal N, Dubashi Biswajit, Sundaram Rajan, Muralidharan Niveditha, Nidanapu Ravi Prasad, Aribandi Anil, Pradhan Suresh Chandra, Uppugunduri Chakradhara Rao Satyanaraya |
| Childhood acute lymphoblastic leukemia mercaptopurine intolerance is associated with NUDT15 variants. Pediatric research 2020 Mar . Wang Der-Shiun, Yu Chih-Hsiang, Lin Chien-Yu, Chang Ya-Hsuan, Lin Kai-Hsin, Lin Dong-Tsamn, Jou Shiann-Tarng, Lu Meng-Yao, Chang Hsiu-Hao, Lin Shu-Wha, Chen Hsuan-Yu, Yang Yung- |
| [Genetic basis of subsequent malignant neoplasms]. [Rinsho ketsueki] The Japanese journal of clinical hematology 2020 61 (9): 1174-1178. Yoshida Masanori, Kato Motohi |
| Ancestry and TPMT-VNTR Polymorphism: Relationship with Hematological Toxicity in Uruguayan Patients with Acute Lymphoblastic Leukemia. Frontiers in pharmacology 2020 11 594262. Burgueño-Rodríguez Gabriela, Méndez Yessika, Olano Natalia, Dabezies Agustín, Bertoni Bernardo, Souto Jorge, Castillo Luis, da Luz Julio, Soler Ana Mar |
| PACSIN2 rs2413739 influence on thiopurine pharmacokinetics: validation studies in pediatric patients. The pharmacogenomics journal 2019 Dec . Franca Raffaella, Stocco Gabriele, Favretto Diego, Giurici Nagua, Del Rizzo Irene, Locatelli Franco, Vinti Luciana, Biondi Andrea, Colombini Antonella, Fagioli Franca, Barisone Elena, Pelin Marco, Martellossi Stefano, Ventura Alessandro, Decorti Giuliana, Rabusin Mar |
| Prevalence of TPMT, ITPA and NUDT 15 genetic polymorphisms and their relation to 6MP toxicity in north Indian children with acute lymphoblastic leukemia. Cancer chemotherapy and pharmacology 2019 Feb 83 (2): 341-348. Khera Sanjeev, Trehan Amita, Bhatia Prateek, Singh Minu, Bansal Deepak, Varma Neel |
| Star Allele-Based Haplotyping versus Gene-Wise Variant Burden Scoring for Predicting 6-Mercaptopurine Intolerance in Pediatric Acute Lymphoblastic Leukemia Patients. Frontiers in pharmacology 2019 10 654. Park Yoomi, Kim Hyery, Choi Jung Yoon, Yun Sunmin, Min Byung-Joo, Seo Myung-Eui, Im Ho Joon, Kang Hyoung Jin, Kim Ju H |
| Optimal predictor for 6-mercaptopurine intolerance in Chinese children with acute lymphoblastic leukemia: NUDT15, TPMT, or ITPA genetic variants? BMC cancer 2018 May 18 (1): 516. Zhou Hong, Li Lei, Yang Peng, Yang Lin, Zheng Jin E, Zhou Ying, Han Yo |
| SLCO1B1 Polymorphisms are Associated With Drug Intolerance in Childhood Leukemia Maintenance Therapy. Journal of pediatric hematology/oncology 2018 Apr . Eldem ?rem, Yavuz Duygu, Cumao?ullari Özge, ?leri Talia, Ünal ?nce Elif, Ertem Mehmet, Do?anay Erdo?an Beyza, Bindak Recep, Özda? Hilal, ?atiro?lu-Tufan N Lale, Uysal L Zümr |
| Role of TPMT and ITPA variants in mercaptopurine disposition. Cancer chemotherapy and pharmacology 2018 Feb . Gerbek Tina, Ebbesen Maria, Nersting Jacob, Frandsen Thomas L, Appell Malin Lindqvist, Schmiegelow Kje |
| Genetic Polymorphism of Thiopurine S-methyltransferase in Children with Acute Lymphoblastic Leukemia in Jordan Asian Pacific journal of cancer prevention : APJCP 2018 Jan 19 (1): 199-205. Alsous Mervat, Yousef Al-Motassem, Abdel Jalil Mariam, Zawiah Mohammed, Yacoub Shorouq, Momani Deema, Gharabli Alia, Omar Suha, Rihani Raw |
| Influence of NUDT15 variants on hematological pictures of patients with inflammatory bowel disease treated with thiopurines. World journal of gastroenterology 2018 Jan 24 (4): 511-518. Kojima Yuichiro, Hirotsu Yosuke, Omata Wataru, Sugimori Makoto, Takaoka Shinya, Ashizawa Hiroshi, Nakagomi Keiko, Yoshimura Dai, Hosoda Kenji, Suzuki Yoji, Mochizuki Hitoshi, Omata Mas |
| Frequency of thiopurine S-methyltransferase gene variations in Turkish children with acute leukemia. The Turkish journal of pediatrics 2018 60 (2): 147-152. Akin Dilara Fatma, Aslar-Öner Deniz, Kürekçi Emin, Akar Nej |
| Novel variants in NUDT15 and thiopurine intolerance in children with acute lymphoblastic leukemia from diverse ancestry. Blood 2017 Jun . Moriyama Takaya, Yang Yung-Li, Nishii Rina, Ariffin Hany, Liu Chengcheng, Lin Ting-Nien, Yang Wenjian, Lin Dong-Tsamn, Yu Chih-Hsiang, Kham Shirley, Pui Ching-Hon, Evans William E, Jeha Sima, Relling Mary V, Yeoh Allen Eng-Juh, Yang Jun |
| Thiopurine S-methyltransferase polymorphisms in acute lymphoblastic leukemia, inflammatory bowel disease and autoimmune disorders: influence on treatment response. Pharmacogenomics and personalized medicine 2017 10 143-156. Abaji Rachid, Krajinovic Ma |
| A Simple Method for TPMT and ITPA Genotyping Using Multiplex HRMA for Patients Treated with Thiopurine Drugs. Molecular diagnosis & therapy 2016 Oct 20 (5): 493-9. Skrzypczak-Zielinska Marzena, Borun Pawel, Bartkowiak-Kaczmarek Anna, Zakerska-Banaszak Oliwia, Walczak Michal, Dobrowolska Agnieszka, Kurzawski Mateusz, Waszak Malgorzata, Lipinski Daniel, Plawski Andrzej, Slomski Rysza |
Polymorphic variation in TPMT is the principal determinant of TPMT phenotype: A meta-analysis of three genome-wide association studies.
Clinical pharmacology and therapeutics 2016 Oct . Tamm Riin, Mägi Reedik, Tremmel Roman, Winter Stefan, Mihailov Evelin, Smid Alenka, Möricke Anja, Klein Kathrin, Schrappe Martin, Stanulla Martin, Houlston Richard, Weinshilboum Richard, Mlinari? Raš?an Irena, Metspalu Andres, Milani Lili, Schwab Matthias, Schaeffeler El |
| Genomewide Approach Validates Thiopurine Methyltransferase Activity Is a Monogenic Pharmacogenomic Trait.
Clinical pharmacology and therapeutics 2016 Aug . Liu Chengcheng, Yang Wenjian, Pei Deqing, Cheng Cheng, Smith Colton, Landier Wendy, Hageman Lindsey, Chen Yanjun, Yang Jun J, Crews Kristine R, Kornegay Nancy, Karol Seth E, Wong F Lennie, Jeha Sima, Sandlund John T, Ribeiro Raul R, Rubnitz Jeffrey E, Metzger Monika L, Pui Ching-Hon, Evans William E, Bhatia Smita, Relling Mary |
| NUDT15 and TPMT genetic polymorphisms are related to 6-mercaptopurine intolerance in children treated for acute lymphoblastic leukemia at the Children's Cancer Center of Lebanon. Pediatric blood & cancer 2016 Aug . Zgheib Nathalie K, Akika Reem, Mahfouz Rami, Aridi Carol Al, Ghanem Khaled M, Saab Raya, Abboud Miguel R, Tarek Nidale, El Solh Hassan, Muwakkit Samar |
| Risk factors for symptomatic osteonecrosis in childhood ALL: A retrospective study of a Slovenian pediatric ALL population between 1970 and 2004. Experimental and therapeutic medicine 2016 Aug 12 (2): 840-846. Karas-Kuželi?ki Nataša, Mencej-Bedra? Simona, Jazbec Janez, Marc Janja, Mlinari?-Raš?an Ire |
| Association Between Combined Presence of Hepatitis C Virus and Polymorphisms in Different Genes With Toxicities of Methotrexate and 6-Mercaptopurine in Children With Acute Lymphoblastic Leukemia. Pediatric blood & cancer 2016 May . Abdelaziz Doaa H, Elhosseiny Noha M, Khaleel Sahar A, Sabry Nirmeen A, Attia Ahmed S, El-Sayed Manal |
| Involvement of MTHFR and TPMT genes in susceptibility to childhood acute lymphoblastic leukemia (ALL) in Mexicans. Drug metabolism and personalized therapy 2016 Feb . Gutiérrez-Álvarez Ossyneidee, Lares-Asseff Ismael, Galaviz-Hernández Carlos, Reyes-Espinoza Elio-Aarón, Almanza-Reyes Horacio, Sosa-Macías Martha, Hernández Isaías Chairez, Salas-Pacheco José-Manuel, Bailón-Soto Claudia |
| NUDT15 polymorphisms alter thiopurine metabolism and hematopoietic toxicity. Nature genetics 2016 Feb . Moriyama Takaya, Nishii Rina, Perez-Andreu Virginia, Yang Wenjian, Klussmann Federico Antillon, Zhao Xujie, Lin Ting-Nien, Hoshitsuki Keito, Nersting Jacob, Kihira Kentaro, Hofmann Ute, Komada Yoshihiro, Kato Motohiro, McCorkle Robert, Li Lie, Koh Katsuyoshi, Najera Cesar Rolando, Kham Shirley Kow-Yin, Isobe Tomoya, Chen Zhiwei, Chiew Edwynn Kean-Hui, Bhojwani Deepa, Jeffries Cynthia, Lu Yan, Schwab Matthias, Inaba Hiroto, Pui Ching-Hon, Relling Mary V, Manabe Atsushi, Hori Hiroki, Schmiegelow Kjeld, Yeoh Allen E J, Evans William E, Yang Jun |
| Analysis of Thiopurine S-Methyltransferase Deficient Alleles in Acute Lymphoblastic Leukemia Patients in Mexican Patients. Archives of medical research 2016 11 47 (8): 615-622. Jiménez-Morales Silvia, Ramírez-Florencio Mireya, Mejía-Aranguré Juan Manuel, Núñez-Enríquez Juan Carlos, Bekker-Mendez Carolina, Torres-Escalante José Luis, Flores-Lujano Janet, Jiménez-Hernández Elva, Del Carmen Rodríguez-Zepeda María, Leal Yelda A, González-Montalvo Pablo Miguel, Pantoja-Guillen Francisco, Peñaloza-Gonzalez José Gabriel, Gutiérrez-Juárez Erick Israel, Núñez-Villegas Nora Nancy, Pérez-Saldivar Maria Luisa, Guerra-Castillo Francisco Xavier, Flores-Villegas Luz Victoria, Ramos-Cervantes María Teresa, Fragoso José Manuel, García-Escalante María Guadalupe, Del Carmen Pinto-Escalante Doris, Ramírez-Bello Julián, Hidalgo-Miranda Alfre |
| PACSIN2 polymorphism is associated with thiopurine-induced hematological toxicity in children with acute lymphoblastic leukaemia undergoing maintenance therapy. Scientific reports 2016 6 30244. Smid Alenka, Karas-Kuzelicki Natasa, Jazbec Janez, Mlinaric-Rascan Ire |
| Influence of variants in folate metabolism genes on 6-mercaptopurine induced toxicity during treatment for childhood acute lymphocytic leukemia. Journal of B.U.ON. : official journal of the Balkan Union of Oncology 0 24 (5): 2075-2083. Milosevic Goran, Kotur Nikola, Lazic Jelena, Krstovski Nada, Stankovic Biljana, Zukic Branka, Janic Dragana, Jurisic Vladimir, Pavlovic Sonja, Dokmanovic Lidi |
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- Page last updated:Jan 20, 2022
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