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| Genetic Susceptibility Determines ß-Cell Function and Fasting Glycemia Trajectories Throughout Childhood: A 12-Year Cohort Study (EarlyBird 76). Diabetes care 2020 Jan . Carayol Jerome, Hosking Joanne, Pinkney Jonathan, Marquis Julien, Charpagne Aline, Metairon Sylviane, Jeffery Alison, Hager Jörg, Martin Francois-Pier |
Genome-wide association study of metabolic syndrome in Korean populations.
PloS one 2020 15 (1): e0227357. Oh Seung-Won, Lee Jong-Eun, Shin Eunsoon, Kwon Hyuktae, Choe Eun Kyung, Choi Su-Yeon, Rhee Hwanseok, Choi Seung |
| Contribution of genetic, biochemical and environmental factors on insulin resistance and obesity in Mexican young adults. Obesity research & clinical practice 2019 Nov . Flores-Viveros Karla Lucero, Aguilar-Galarza Beatriz Adriana, Ordóñez-Sánchez María Luisa, Anaya-Loyola Miriam Aracely, Moreno-Celis Ulisses, Vázquez-Cárdenas Paola, García-Gasca Tere |
| Insulin Resistance Exacerbates Genetic Predisposition to Nonalcoholic Fatty Liver Disease in Individuals Without Diabetes. Hepatology communications 2019 Jul 3 (7): 894-907. Barata Llilda, Feitosa Mary F, Bielak Lawrence F, Halligan Brian, Baldridge Abigail S, Guo Xiuqing, Yerges-Armstrong Laura M, Smith Albert V, Yao Jie, Palmer Nicholette D, VanWagner Lisa B, Carr J Jeffrey, Chen Yii-Der I, Allison Matthew, Budoff Matthew J, Handelman Samuel K, Kardia Sharon L R, Mosley Thomas H, Ryan Kathleen, Harris Tamara B, Launer Lenore J, Gudnason Vilmundur, Rotter Jerome I, Fornage Myriam, Rasmussen-Torvik Laura J, Borecki Ingrid B, O'Connell Jeffrey R, Peyser Patricia A, Speliotes Elizabeth K, Province Michael |
| No clinical utility of common polymorphisms in IGF1, IRS1, GCKR, PPARG, GCK1 and KCTD1 genes previously associated with insulin resistance in overweight children from Romania and Moldova. Journal of pediatric endocrinology & metabolism : JPEM 2019 Jan 32 (1): 33-39. Chirita-Emandi Adela, Munteanu Diana, Andreescu Nicoleta, Tutac Paul, Paul Corina, Velea Iulian Puiu, Pusztai Agneta Maria, Hlistun Victoria, Boiciuc Chiril, Sacara Victoria, Vudu Lorina, Usurelu Natalia, Puiu Mar |
| Metabolic Features of Nonalcoholic Fatty Liver (NAFL) in Obese Adolescents: Findings From a Multiethnic Cohort. Hepatology (Baltimore, Md.) 2018 Apr . Tricò Domenico, Caprio Sonia, Umano Giuseppina Rosaria, Pierpont Bridget, Nouws Jessica, Galderisi Alfonso, Kim Grace, Mata Mariana M, Santoro Nico |
| The rs626283 Variant in the MBOAT7 Gene is Associated with Insulin Resistance and Fatty Liver in Caucasian Obese Youth. The American journal of gastroenterology 2018 Feb . Umano Giuseppina R, Caprio Sonia, Di Sessa Anna, Chalasani Naga, Dykas Daniel J, Pierpont Bridget, Bale Allen E, Santoro Nico |
| Genetic determinants of hepatic steatosis and serum cytokeratin-18 fragment levels in Taiwanese children. Liver international : official journal of the International Association for the Study of the Liver 2018 Jan . Lin Yu-Cheng, Chang Pi-Feng, Chang Mei-Hwei, Ni Yen-Hsu |
| Genotype effects of glucokinase regulator on lipid profiles and glycemic status are modified by circulating calcium levels: results from the Korean Genome and Epidemiology Study. Nutrition research (New York, N.Y.) 2018 12 60 96-105. Kim Oh Yoen, Kwak So-Young, Lim Hyunjung, Shin Min-Jeo |
| Effect of genetic variants and traits related to glucose metabolism and their interaction with obesity on breast and colorectal cancer risk among postmenopausal women. BMC cancer 2017 Apr 17 (1): 290. Jung Su Yon, Sobel Eric M, Papp Jeanette C, Zhang Zuo-Fe |
| The ADAMTS9 gene is associated with cognitive aging in the elderly in a Taiwanese population. PloS one 2017 12 (2): e0172440. Lin Eugene, Tsai Shih-Jen, Kuo Po-Hsiu, Liu Yu-Li, Yang Albert C, Kao Chung-Feng, Yang Cheng-Hu |
| Obesity and associated lifestyles modify the effect of glucose metabolism-related genetic variants on impaired glucose homeostasis among postmenopausal women. Genetic epidemiology 2016 Jul . Jung Su Yon, Sobel Eric M, Papp Jeanette C, Crandall Carolyn J, Fu Alan N, Zhang Zuo-Fe |
| Interaction of Insulin Resistance and Related Genetic Variants With Triglyceride-Associated Genetic Variants. Circulation. Cardiovascular genetics 2016 Feb . Klimentidis Yann C, Arora Am |
| A Genome-Wide mQTL Analysis in Human Adipose Tissue Identifies Genetic Variants Associated with DNA Methylation, Gene Expression and Metabolic Traits. PloS one 2016 11 (6): e0157776. Volkov Petr, Olsson Anders H, Gillberg Linn, Jørgensen Sine W, Brøns Charlotte, Eriksson Karl-Fredrik, Groop Leif, Jansson Per-Anders, Nilsson Emma, Rönn Tina, Vaag Allan, Ling Charlot |
| Pleiotropic effects of lipid genes on plasma glucose, HbA1c, and HOMA-IR levels. Diabetes 2014 Sep 63 (9): 3149-58. Li Naishi, van der Sijde Marijke R, , Bakker Stephan J L, Dullaart Robin P F, van der Harst Pim, Gansevoort Ron T, Elbers Clara C, Wijmenga Cisca, Snieder Harold, Hofker Marten H, Fu Jingyu |
| Impact of type 2 diabetes susceptibility variants on quantitative glycemic traits reveals mechanistic heterogeneity. Diabetes 2013 Dec . Dimas AS, Lagou V, Barker A, Knowles JW, Mägi R, Hivert MF, Benazzo A, Rybin D, Jackson AU, Stringham HM, Song C, Fischer-Rosinsky A, Boesgaard TW, Grarup N, Abbasi FA, Assimes TL, Hao K, Yang X, Lecoeur C, Barroso I, Bonnycastle LL, Böttcher Y, Bumpstead S, Chines PS, Erdos MR, Graessler J, Kovacs P, Morken MA, Narisu N, Payne F, Stancakova A, Swift AJ, Tönjes A, Bornstein SR, Cauchi S, Froguel P, Meyre D, Schwarz PE, Häring HU, Smith U, Boehnke M, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, Quertemous T, Lind L, Hansen T, Pedersen O, Walker M, Pfeiffer AF, Spranger J, Stumvoll M, Meigs JB, Wareham NJ, Kuusisto J, Laakso M, Langenberg C, Dupuis J, Watanabe RM, Florez JC, Ingelsson E, McCarthy MI, Prokopenko I |
| Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men. Diabetes 2013 Oct 62 (10): 3618-26. Mahendran Yuvaraj, Vangipurapu Jagadish, Cederberg Henna, Stancáková Alena, Pihlajamäki Jussi, Soininen Pasi, Kangas Antti J, Paananen Jussi, Civelek Mete, Saleem Niyas K, Pajukanta Päivi, Lusis Aldons J, Bonnycastle Lori L, Morken Mario A, Collins Francis S, Mohlke Karen L, Boehnke Michael, Ala-Korpela Mika, Kuusisto Johanna, Laakso Mark |
| GCKR variants increase triglycerides while protecting from insulin resistance in Chinese children. PloS one 2013 8 (1): 1. Shen Y, Wu L, Xi B, Liu X, Zhao X, Cheng H, Hou D, Wang X, Mi J |
| Association of glucokinase regulatory protein polymorphism with type 2 diabetes and fasting plasma glucose: a meta-analysis. Molecular biology reports 2013 Jan . Li H, Xu R, Peng X, Wang Y, Wang T |
| The association between hepatic fat content and liver injury in obese children and adolescents: effects of ethnicity, insulin resistance, and common gene variants. Diabetes care 2012 Dec . Santoro N, Feldstein AE, Enoksson E, Pierpont B, Kursawe R, Kim G, Caprio S |
| Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.
Human molecular genetics 2012 Jul . Chen G, Bentley A, Adeyemo A, Shriner D, Zhou J, Doumatey A, Huang H, Ramos E, Erdos M, Gerry N, Herbert A, Christman M, Rotimi C |
| Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. Diabetes 2012 Jul 61 (7): 1895-902. Stancáková Alena, Civelek Mete, Saleem Niyas K, Soininen Pasi, Kangas Antti J, Cederberg Henna, Paananen Jussi, Pihlajamäki Jussi, Bonnycastle Lori L, Morken Mario A, Boehnke Michael, Pajukanta Päivi, Lusis Aldons J, Collins Francis S, Kuusisto Johanna, Ala-Korpela Mika, Laakso Mark |
| Triglyceride response to an intensive lifestyle intervention is enhanced in carriers of the GCKR Pro446Leu polymorphism. The Journal of clinical endocrinology and metabolism 2011 Jul 96 (7): E1142-7. Pollin Toni I, Jablonski Kathleen A, McAteer Jarred B, Saxena Richa, Kathiresan Sekar, Kahn Steven E, Goldberg Ronald B, Altshuler David, Florez Jose C, |
| Glucokinase regulatory protein genetic variant interacts with omega-3 PUFA to influence insulin resistance and inflammation in metabolic syndrome. PloS one 2011 6 (6): e20555. Perez-Martinez Pablo, Delgado-Lista Javier, Garcia-Rios Antonio, Mc Monagle Jolene, Gulseth Hanne L, Ordovas Jose M, Shaw Danielle I, Karlström Brita, Kiec-Wilk Beata, Blaak Ellen E, Helal Olfa, Malczewska-Malec Ma?gorzata, Defoort Catherine, Risérus Ulf, Saris Wim H M, Lovegrove Julie A, Drevon Christian A, Roche Helen M, Lopez-Miranda Jo |
| Glucose-raising genetic variants in MADD and ADCY5 impair conversion of proinsulin to insulin. PloS one 2011 6 (8): e23639. Wagner Robert, Dudziak Katarzyna, Herzberg-Schäfer Silke A, Machicao Fausto, Stefan Norbert, Staiger Harald, Häring Hans-Ulrich, Fritsche Andre |
| The GCKR rs780094 polymorphism is associated with susceptibility of type 2 diabetes, reduced fasting plasma glucose levels, increased triglycerides levels and lower HOMA-IR in Japanese population. Journal of human genetics 2010 Sep 55 (9): 600-4. Onuma Hiroshi, Tabara Yasuharu, Kawamoto Ryuichi, Shimizu Ikki, Kawamura Ryoichi, Takata Yasunori, Nishida Wataru, Ohashi Jun, Miki Tetsuro, Kohara Katsuhiko, Makino Hideichi, Osawa Haruhi |
| New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.
Nature genetics 2010 Feb 42 (2): 2. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, Elliott P, Rybin D, Thorleifsson G, Steinthorsdottir V, Henneman P, Grallert H, Dehghan A, Hottenga JJ, Franklin CS, Navarro P, Song K, Goel A, Perry JR, Egan JM, Lajunen T, Grarup N, Sparsø T, Doney A, Voight BF, Stringham HM, Li M, Kanoni S, Shrader P, Cavalcanti-Proença C, Kumari M, Qi L, Timpson NJ, Gieger C, Zabena C, Rocheleau G, Ingelsson E, An P, O'Connell J, Luan J, Elliott A, McCarroll SA, Payne F, Roccasecca RM, Pattou F, Sethupathy P, Ardlie K, Ariyurek Y, Balkau B, Barter P, Beilby JP, Ben-Shlomo Y, Benediktsson R, Bennett AJ, Bergmann S, Bochud M, Boerwinkle E, Bonnefond A, Bonnycastle LL, Borch-Johnsen K, Böttcher Y, Brunner E, Bumpstead SJ, Charpentier G, Chen YD, Chines P, Clarke R, Coin LJ, Cooper MN, Cornelis M, Crawford G, Crisponi L, Day IN, de Geus EJ, Delplanque J, Dina C, Erdos MR, Fedson AC, Fischer-Rosinsky A, Forouhi NG, Fox CS, Frants R, Franzosi MG, Galan P, Goodarzi MO, Graessler J, Groves CJ, Grundy S, Gwilliam R, Gyllensten U, Hadjadj S, Hallmans G, Hammond N, Han X, Hartikainen AL, Hassanali N, Hayward C, Heath SC, Hercberg S, Herder C, Hicks AA, Hillman DR, Hingorani AD, Hofman A, Hui J, Hung J, Isomaa B, Johnson PR, Jørgensen T, Jula A, Kaakinen M, Kaprio J, Kesaniemi YA, Kivimaki M, Knight B, Koskinen S, Kovacs P, Kyvik KO, Lathrop GM, Lawlor DA, Le Bacquer O, Lecoeur C, Li Y, Lyssenko V, Mahley R, Mangino M, Manning AK, Martínez-Larrad MT, McAteer JB, McCulloch LJ, McPherson R, Meisinger C, Melzer D, Meyre D, Mitchell BD, Morken MA, Mukherjee S, Naitza S, Narisu N, Neville MJ, Oostra BA, Orrù M, Pakyz R, Palmer CN, Paolisso G, Pattaro C, Pearson D, Peden JF, Pedersen NL, Perola M, Pfeiffer AF, Pichler I, Polasek O, Posthuma D, Potter SC, Pouta A, Province MA, Psaty BM, Rathmann W, Rayner NW, Rice K, Ripatti S, Rivadeneira F, Roden M, Rolandsson O, Sandbaek A, Sandhu M, Sanna S, Sayer AA, Scheet P, Scott LJ, Seedorf U, Sharp SJ, Shields B, Sigurethsson G, Sijbrands EJ, Silveira A, Simpson L, Singleton A, Smith NL, Sovio U, Swift A, Syddall H, Syvänen AC, Tanaka T, Thorand B, Tichet J, Tönjes A, Tuomi T, Uitterlinden AG, van Dijk KW, van Hoek M, Varma D, Visvikis-Siest S, Vitart V, Vogelzangs N, Waeber G, Wagner PJ, Walley A, Walters GB, Ward KL, Watkins H, Weedon MN, Wild SH, Willemsen G, Witteman JC, Yarnell JW, Zeggini E, Zelenika D, Zethelius B, Zhai G, Zhao JH, Zillikens MC, Borecki IB, Loos RJ, Meneton P, Magnusson PK, Nathan DM, Williams GH, Hattersley AT, Silander K, Salomaa V, Smith GD, Bornstein SR, Schwarz P, Spranger J, Karpe F, Shuldiner AR, Cooper C, Dedoussis GV, Serrano-Ríos M, Morris AD, Lind L, Palmer LJ, Hu FB, Franks PW, Ebrahim S, Marmot M, Kao WH, Pankow JS, Sampson MJ, Kuusisto J, Laakso M, Hansen T, Pedersen O, Pramstaller PP, Wichmann HE, Illig T, Rudan I, Wright AF, Stumvoll M, Campbell H, Wilson JF, Bergman RN, Buchanan TA, Collins FS, Mohlke KL, Tuomilehto J, Valle TT, Altshuler D, Rotter JI, Siscovick DS, Penninx BW, Boomsma DI, Deloukas P, Spector TD, Frayling TM, Ferrucci L, Kong A, Thorsteinsdottir U, Stefansson K, van Duijn CM, Aulchenko YS, Cao A, Scuteri A, Schlessinger D, Uda M, Ruokonen A, Jarvelin MR, Waterworth DM, Vollenweider P, Peltonen L, Mooser V, Abecasis GR, Wareham NJ, Sladek R, Froguel P, Watanabe RM, Meigs JB, Groop L, Boehnke M, McCarthy MI, Florez JC, Barroso I |
| Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms. Human molecular genetics 2010 Jan 19 (2): 387-95. van der Harst Pim, Bakker Stephan J L, de Boer Rudolf A, Wolffenbuttel Bruce H R, Johnson Toby, Caulfield Mark J, Navis Gerj |
| Association of rs780094 in GCKR with metabolic traits and incident diabetes and cardiovascular disease: the ARIC Study. PloS one 2010 5 (7): e11690. Bi Mark, Kao Wen Hong Linda, Boerwinkle Eric, Hoogeveen Ron C, Rasmussen-Torvik Laura J, Astor Brad C, North Kari E, Coresh Josef, Köttgen An |
| The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population. Diabetes 2008 Jun . Vaxillaire M, Cavalcanti-Proença C, Dechaume A, Tichet J, Marre M, Balkau B, Froguel P |
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- Page last updated:May 26, 2022
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