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| Hepatic patatin-like phospholipase domain-containing 3 levels are increased in I148M risk allele carriers and correlate with NAFLD in humans. Hepatology communications 2022 Jul . Ericson Elke, Bergenholm Linnéa, Andréasson Anne-Christine, Dix Carly I, Knöchel Jane, Hansson Sara F, Lee Richard, Schumi Jennifer, Antonsson Madeleine, Fjellström Ola, Nasr Patrik, Liljeblad Mathias, Carlsson Björn, Kechagias Stergios, Lindén Daniel, Ekstedt Matti |
| Metabolic and Genetic Risk Factors Are the Strongest Predictors of Severity of Alcohol-Related Liver Fibrosis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2020 Dec . Israelsen Mads, Juel Helene Bæk, Detlefsen Sönke, Madsen Bjørn Stæhr, Rasmussen Ditlev Nytoft, Larsen Trine R, Kjærgaard Maria, Fernandes Jensen Mary Jo, Stender Stefan, Hansen Torben, Krag Aleksander, Thiele Maja, |
Genome-wide and Mendelian randomisation studies of liver MRI yield insights into the pathogenesis of steatohepatitis.
Journal of hepatology 2020 Aug 73 (2): 241-251. Parisinos Constantinos A, Wilman Henry R, Thomas E Louise, Kelly Matt, Nicholls Rowan C, McGonigle John, Neubauer Stefan, Hingorani Aroon D, Patel Riyaz S, Hemingway Harry, Bell Jimmy D, Banerjee Rajarshi, Yaghootkar Hani |
| PNPLA3 rs738409 associates with alcoholic liver cirrhosis but not with serum levels of IL6, IL10, IL8 or CCL2 in the Russian population. Annals of hepatology 2020 Aug . Peregud Danil I, Baronets Valeria Yu, Lobacheva Anna S, Ivanov Alexandr S, Garmash Irina V, Kobalava Zhanna D, Pirozhkov Sergey V, Terebilina Natalia |
| Attenuated effect of PNPLA3 on hepatic fibrosis by HSD17B13 in Japanese patients with non-alcoholic fatty liver disease. Liver international : official journal of the International Association for the Study of the Liver 2020 Apr . Seko Yuya, Yamaguchi Kanji, Tochiki Nozomi, Yano Kota, Takahashi Aya, Okishio Shinya, Kataoka Seita, Okuda Keiichiroh, Umemura Atsushi, Moriguchi Michihisa, Tanaka Saiyu, Mori Kojiroh, Okanoue Takeshi, Itoh Yoshi |
| The ATG16L1 gene variant rs2241880 (p.T300A) is associated with susceptibility to HCC in patients with cirrhosis. Liver international : official journal of the International Association for the Study of the Liver 2019 Sep . Reuken Philipp A, Lutz Philipp, Casper Markus, Al-Herwi Eihab, Stengel Sven, Spengler Ulrich, Stallmach Andreas, Lammert Frank, Nischalke Hans Dieter, Bruns To |
| Biomarker and Genomic Risk Factors for Liver Function Test Abnormality in Hazardous Drinkers.
Alcoholism, clinical and experimental research 2019 Mar 43 (3): 473-482. Whitfield John B, Zhu Gu, Madden Pamela A F, Montgomery Grant W, Heath Andrew C, Martin Nicholas |
| Genetic determinants of steatosis and fibrosis progression in paediatric non-alcoholic fatty liver disease. Liver international : official journal of the International Association for the Study of the Liver 2019 Mar 39 (3): 540-556. Hudert Christian A, Selinski Silvia, Rudolph Birgit, Bläker Hendrik, Loddenkemper Christoph, Thielhorn Ria, Berndt Nikolaus, Golka Klaus, Cadenas Cristina, Reinders Jörg, Henning Stephan, Bufler Philip, Jansen Peter L M, Holzhütter Hermann-Georg, Meierhofer David, Hengstler Jan G, Wiegand Susan |
| PNPLA3 rs139051 is associated with phospholipid metabolite profile and hepatic inflammation in nonalcoholic fatty liver disease. World journal of clinical cases 2018 Sep 6 (10): 355-364. Luo Ji-Jun, Cao Hai-Xia, Yang Rui-Xu, Zhang Rui-Nan, Pan Q |
| Identification of pleiotropic genetic variants affecting osteoporosis risk in a Korean elderly cohort. Journal of bone and mineral metabolism 2017 Dec . Hong Eun Pyo, Rhee Ka Hyun, Kim Dong Hyun, Park Ji W |
| Association of single nucleotide polymorphism at PNPLA3 with fatty liver, steatohepatitis, and cirrhosis of liver. Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology 2017 Sep 36 (5): 366-372. Alam Shahinul, Islam Mohammad Shaiful, Islam Saiful, Mustafa Golam, Saleh Ahmed Abu, Ahmad Noorudd |
| Liver and Cardiovascular Damage in Patients With Lean Nonalcoholic Fatty Liver Disease, and Association With Visceral Obesity. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2017 May . Fracanzani Anna Ludovica, Petta Salvatore, Lombardi Rosa, Pisano Giuseppina, Russello Maurizio, Consonni Dario, Di Marco Vito, Cammà Calogero, Mensi Laura, Dongiovanni Paola, Valenti Luca, Craxì Antonio, Fargion Silv |
| Low Birthweight Increases the Likelihood of Severe Steatosis in Pediatric Non-Alcoholic Fatty Liver Disease. The American journal of gastroenterology 2017 May . Bugianesi Elisabetta, Bizzarri Carla, Rosso Chiara, Mosca Antonella, Panera Nadia, Veraldi Silvio, Dotta Andrea, Giannone Germana, Raponi Massimiliano, Cappa Marco, Alisi Anna, Nobili Valer |
| Hepatic nucleotide binding oligomerization domain-like receptors pyrin domain-containing 3 inflammasomes are associated with the histologic severity of non-alcoholic fatty liver disease. Hepatology research : the official journal of the Japan Society of Hepatology 2017 Feb . Mitsuyoshi Hironori, Yasui Kohichiroh, Hara Tasuku, Taketani Hiroyoshi, Ishiba Hiroshi, Okajima Akira, Seko Yuya, Umemura Atsushi, Nishikawa Taichiro, Yamaguchi Kanji, Moriguchi Michihisa, Minami Masahito, Itoh Yoshi |
| Characteristics of non-obese non-alcoholic fatty liver disease: Effect of genetic and environmental factors. Hepatology research : the official journal of the Japan Society of Hepatology 2016 Jan . Honda Yasushi, Yoneda Masato, Kessoku Takaomi, Ogawa Yuji, Tomeno Wataru, Imajo Kento, Mawatari Hironori, Fujita Koji, Hyogo Hideyuki, Ueno Takato, Chayama Kazuaki, Saito Satoru, Nakajima Atsushi, Hotta Kiku |
| PNPLA3 148M Carriers with Inflammatory Bowel Diseases Have Higher Susceptibility to Hepatic Steatosis and Higher Liver Enzymes. Inflammatory bowel diseases 2015 Sep . Mancina Rosellina Margherita, Spagnuolo Rocco, Milano Marta, Brogneri Simona, Morrone Attilio, Cosco Cristina, Lazzaro Veronica, Russo Cristina, Ferro Yvelise, Pingitore Piero, Pujia Arturo, Montalcini Tiziana, Doldo Patrizia, Garieri Pietro, Piodi Luca, Caprioli Flavio, Valenti Luca, Romeo Stefa |
| Genetic variation in transmembrane 6 superfamily member 2 and the risk of nonalcoholic fatty liver disease and histological disease severity. Hepatology (Baltimore, Md.) 2015 Feb 61 (2): 515-25. Sookoian Silvia, Castaño Gustavo O, Scian Romina, Mallardi Pablo, Fernández Gianotti Tomas, Burgueño Adriana L, San Martino Julio, Pirola Carlos |
| The impact of PNPLA3 (rs738409 C>G) polymorphisms on liver histology and long-term clinical outcome in chronic hepatitis B patients. Liver international : official journal of the International Association for the Study of the Liver 2015 Feb 35 (2): 438-47. Brouwer Willem P, van der Meer Adriaan J, Boonstra Andre, Pas Suzan D, de Knegt Robert J, de Man Rob A, Hansen Bettina E, ten Kate Fiebo J W, Janssen Harry L |
| Novel association between a nonsynonymous variant (R270H) of the G-protein-coupled receptor 120 and liver injury in children and adolescents with obesity. Journal of pediatric gastroenterology and nutrition 2014 Oct 59 (4): 472-5. Marzuillo Pierluigi, Grandone Anna, Conte Mariasole, Capuano Francesco, Cirillo Grazia, Di Sessa Anna, Umano Giuseppina R, Romano Roberta, Perrone Laura, del Giudice Emanuele Miragl |
| Glucokinase regulatory protein gene polymorphism affects liver fibrosis in non-alcoholic fatty liver disease. PloS one 2014 9 (2): e87523. Petta Salvatore, Miele Luca, Bugianesi Elisabetta, Cammà Calogero, Rosso Chiara, Boccia Stefania, Cabibi Daniela, Di Marco Vito, Grimaudo Stefania, Grieco Antonio, Pipitone Rosaria Maria, Marchesini Giulio, Craxì Anton |
| A gene variant of PNPLA3, but not of APOC3, is associated with histological parameters of NAFLD in an obese population. Obesity (Silver Spring, Md.) 2013 Oct 21 (10): 2138-45. Verrijken A, Beckers S, Francque S, Hilden H, Caron S, Zegers D, Ruppert M, Hubens G, Van Marck E, Michielsen P, Staels B, Taskinen M-R, Van Hul W, Van Gaal |
| Adipocyte size is associated with NAFLD independent of obesity, fat distribution, and PNPLA3 genotype. Obesity (Silver Spring, Md.) 2013 Jun 21 (6): 1174-9. Petäjä Elina M, Sevastianova Ksenia, Hakkarainen Antti, Orho-Melander Marju, Lundbom Nina, Yki-Järvinen Hanne |
| Adipose tissue is inflamed in NAFLD due to obesity but not in NAFLD due to genetic variation in PNPLA3. Diabetologia 2013 Apr 56 (4): 886-92. Lallukka S, Sevastianova K, Perttilä J, Hakkarainen A, Orho-Melander M, Lundbom N, Olkkonen V M, Yki-Järvinen |
| PNPLA3 gene-by-visceral adipose tissue volume interaction and the pathogenesis of fatty liver disease: the NHLBI family heart study. International journal of obesity (2005) 2013 Mar 37 (3): 432-8. Graff M, North K E, Franceschini N, Reiner A P, Feitosa M, Carr J J, Gordon-Larsen P, Wojczynski M K, Borecki I |
| Genetic variation at NCAN locus is associated with inflammation and fibrosis in non-alcoholic fatty liver disease in morbid obesity. Human heredity 2013 75 (1): 34-43. Gorden Alexis, Yang Rongze, Yerges-Armstrong Laura M, Ryan Kathleen A, Speliotes Elizabeth, Borecki Ingrid B, Harris Tamara B, Chu Xin, Wood G Craig, Still Christopher D, Shuldiner Alan R, Gerhard Glenn S, |
| Genetic polymorphism in cyclooxygenase-2 promoter affects hepatic inflammation and fibrosis in patients with chronic hepatitis C. Journal of viral hepatitis 2012 Sep 19 (9): 9. Miyashita M, Ito T, Sakaki M, Kajiwara A, Nozawa H, Hiroishi K, Kobayashi M, Kumada H, Imawari M |
| The association of genetic variants with hepatic steatosis in patients with genotype 1 chronic hepatitis C infection. Digestive diseases and sciences 2012 Aug 57 (8): 2213-21. Clark Paul J, Thompson Alexander J, Zhu Qianqian, Vock David M, Zhu Mingfu, Patel Keyur, Harrison Stephen A, Naggie Susanna, Ge Dongliang, Tillmann Hans L, Urban Thomas J, Shianna Kevin, Fellay Jacques, Goodman Zachary, Noviello Stephanie, Pedicone Lisa D, Afdhal Nezam, Sulkowski Mark, Albrecht Janice K, Goldstein David B, McHutchison John G, Muir Andrew |
| IL28B and PNPLA3 polymorphisms affect histological liver damage in patients with non-alcoholic fatty liver disease. Journal of hepatology 2012 Feb . Petta S, Grimaudo S, Cammà C, Cabibi D, Di Marco V, Licata G, Pipitone RM, Craxì A |
| Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.
PloS one 2012 7 (6): e38322. Kawaguchi Takahisa, Sumida Yoshio, Umemura Atsushi, Matsuo Keitaro, Takahashi Meiko, Takamura Toshinari, Yasui Kohichiroh, Saibara Toshiji, Hashimoto Etsuko, Kawanaka Miwa, Watanabe Sumio, Kawata Sumio, Imai Yasuharu, Kokubo Miki, Shima Toshihide, Park Hyohun, Tanaka Hideo, Tajima Kazuo, Yamada Ryo, Matsuda Fumihiko, , Japan Study Group of Nonalcoholic Fatty Liver Diseas |
| Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
Nature genetics 2011 Nov 43 (11): 1131-8. Chambers John C, Zhang Weihua, Sehmi Joban, Li Xinzhong, Wass Mark N, Van der Harst Pim, Holm Hilma, Sanna Serena, Kavousi Maryam, Baumeister Sebastian E, Coin Lachlan J, Deng Guohong, Gieger Christian, Heard-Costa Nancy L, Hottenga Jouke-Jan, Kühnel Brigitte, Kumar Vinod, Lagou Vasiliki, Liang Liming, Luan Jian'an, Vidal Pedro Marques, Mateo Leach Irene, O'Reilly Paul F, Peden John F, Rahmioglu Nilufer, Soininen Pasi, Speliotes Elizabeth K, Yuan Xin, Thorleifsson Gudmar, Alizadeh Behrooz Z, Atwood Larry D, Borecki Ingrid B, Brown Morris J, Charoen Pimphen, Cucca Francesco, Das Debashish, de Geus Eco J C, Dixon Anna L, Döring Angela, Ehret Georg, Eyjolfsson Gudmundur I, Farrall Martin, Forouhi Nita G, Friedrich Nele, Goessling Wolfram, Gudbjartsson Daniel F, Harris Tamara B, Hartikainen Anna-Liisa, Heath Simon, Hirschfield Gideon M, Hofman Albert, Homuth Georg, Hyppönen Elina, Janssen Harry L A, Johnson Toby, Kangas Antti J, Kema Ido P, Kühn Jens P, Lai Sandra, Lathrop Mark, Lerch Markus M, Li Yun, Liang T Jake, Lin Jing-Ping, Loos Ruth J F, Martin Nicholas G, Moffatt Miriam F, Montgomery Grant W, Munroe Patricia B, Musunuru Kiran, Nakamura Yusuke, O'Donnell Christopher J, Olafsson Isleifur, Penninx Brenda W, Pouta Anneli, Prins Bram P, Prokopenko Inga, Puls Ralf, Ruokonen Aimo, Savolainen Markku J, Schlessinger David, Schouten Jeoffrey N L, Seedorf Udo, Sen-Chowdhry Srijita, Siminovitch Katherine A, Smit Johannes H, Spector Timothy D, Tan Wenting, Teslovich Tanya M, Tukiainen Taru, Uitterlinden Andre G, Van der Klauw Melanie M, Vasan Ramachandran S, Wallace Chris, Wallaschofski Henri, Wichmann H-Erich, Willemsen Gonneke, Würtz Peter, Xu Chun, Yerges-Armstrong Laura M, , , , , , , , Abecasis Goncalo R, Ahmadi Kourosh R, Boomsma Dorret I, Caulfield Mark, Cookson William O, van Duijn Cornelia M, Froguel Philippe, Matsuda Koichi, McCarthy Mark I, Meisinger Christa, Mooser Vincent, Pietiläinen Kirsi H, Schumann Gunter, Snieder Harold, Sternberg Michael J E, Stolk Ronald P, Thomas Howard C, Thorsteinsdottir Unnur, Uda Manuela, Waeber Gérard, Wareham Nicholas J, Waterworth Dawn M, Watkins Hugh, Whitfield John B, Witteman Jacqueline C M, Wolffenbuttel Bruce H R, Fox Caroline S, Ala-Korpela Mika, Stefansson Kari, Vollenweider Peter, Völzke Henry, Schadt Eric E, Scott James, Järvelin Marjo-Riitta, Elliott Paul, Kooner Jaspal |
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- Page last updated:Aug 10, 2022
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