HuGE Literature Finder
Records 1-54
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Germline DNA Sequencing Reveals Novel Mutations Predictive of Overall Survival in a Cohort of Pancreatic Cancer Patients.
Clinical cancer research : an official journal of the American Association for Cancer Research 2019 Dec . Goldstein Jennifer B, Zhao Li, Wang Xuemei, Ghelman Yael, Overman Michael J, Javle Milind, Shroff Rachna T, Varadhachary Gauri R, Wolf Robert A, McAllister Florencia, Futreal P Andrew, Fogelman David |
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Addition of triple negativity of breast cancer as an indicator for germline mutations in predisposing genes increases sensitivity of clinical selection criteria.
BMC cancer 2018 Sep 18 (1): 926. Hoyer Juliane, Vasileiou Georgia, Uebe Steffen, Wunderle Marius, Kraus Cornelia, Fasching Peter A, Thiel Christian T, Hartmann Arndt, Beckmann Matthias W, Lux Michael P, Reis And |
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Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer.
Genetics in medicine : official journal of the American College of Medical Genetics 2018 Jul . Yurgelun Matthew B, Chittenden Anu B, Morales-Oyarvide Vicente, Rubinson Douglas A, Dunne Richard F, Kozak Margaret M, Qian Zhi Rong, Welch Marisa W, Brais Lauren K, Da Silva Annacarolina, Bui Justin L, Yuan Chen, Li Tingting, Li Wanwan, Masuda Atsuhiro, Gu Mancang, Bullock Andrea J, Chang Daniel T, Clancy Thomas E, Linehan David C, Findeis-Hosey Jennifer J, Doyle Leona A, Thorner Aaron R, Ducar Matthew D, Wollison Bruce M, Khalaf Natalia, Perez Kimberly, Syngal Sapna, Aguirre Andrew J, Hahn William C, Meyerson Matthew L, Fuchs Charles S, Ogino Shuji, Hornick Jason L, Hezel Aram F, Koong Albert C, Nowak Jonathan A, Wolpin Brian |
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Association of genetic variants in ATR-CHEK1 and ATM-CHEK2 pathway genes with risk of colorectal cancer in a Chinese population.
Oncotarget 2018 Jun 9 (42): 26616-26624. Wang Shijia, Zhang Yue, Chen Min, Wang Yong, Feng Yifei, Xu Ziwei, Zhang Dongsheng, Sun Yueming, Fu Z |
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Network Meta-Analysis on the Effects of DNA Damage Response-Related Gene Mutations on Overall Survival of Breast Cancer Based on TCGA Database.
Journal of cellular biochemistry 2017 May . Liu Chang, Chang Hong, Li Xiao-Han, Qi Ya-Fei, Wang Jin-Ou, Zhang Ying, Yang Xiang-Ho |
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Clinical Significance of DNA Damage Response Factors and Chromosomal Instability in Primary Lung Adenocarcinoma.
Anticancer research 2017 04 37 (4): 1729-1735. Okamoto Tatsuro, Kohno Mikihiro, Ito Kensaku, Takada Kazuki, Katsura Masakazu, Morodomi Yosuke, Toyokawa Gouji, Shoji Fumihiro, Maehara Yoshihi |
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Current perspectives on CHEK2 mutations in breast cancer.
Breast cancer (Dove Medical Press) 2017 9 331-335. Apostolou Panagiotis, Papasotiriou Ioann |
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Association of CHEK2 polymorphisms with the efficacy of platinum-based chemotherapy for advanced non-small-cell lung cancer in Chinese never-smoking women.
Journal of thoracic disease 2016 Sep 8 (9): 2519-2529. Xu Wen, Liu Di, Yang Yang, Ding Xi, Sun Yifeng, Zhang Baohong, Xu Jinfu, Su |
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A Comparison between CHEK2*1100delC/I157T Mutation Carrier and Noncarrier Breast Cancer Patients: A Clinicopathological Analysis.
Oncology 2016 Mar 90 (4): . Huszno Joanna, Budryk Magdalena, Ko?osza Zofia, T?cza Karolina, Pamu?a Pi?at Jolanta, Nowara El?bieta, Grzybowska E |
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Novel Nonsense Variants c.58C>T (p.Q20X) and c.256G>T (p.E85X) in the CHEK2 Gene Identified dentified in Breast Cancer Patients from Balochistan.
Asian Pacific journal of cancer prevention : APJCP 2016 17 (3): 1089-92. Baloch Abdul Hameed, Khosa Ahmad Nawaz, Bangulzai Nasrullah, Shuja Jamila, Naseeb Hafiz Khush, Jan Mohammad, Marghazani Illahi Bakhsh, Kakar Masood-Ul-Haq, Baloch Dost Mohammad, Cheema Abdul Majeed, Ahmad Jam |
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Novel Nonsense Variants c.58C>T (p.Q20X) and c.256G>T (p.E85X) in the CHEK2 Gene Identified in Breast Cancer Patients from Balochistan.
Asian Pacific journal of cancer prevention : APJCP 2016 17 (7): 3623-6. Baloch Abdul Hameed, Khosa Ahmad Nawaz, Bangulzai Nasrullah, Shuja Jamila, Naseeb Hafiz Khush, Jan Mohammad, Marghazani Illahi Bakhsh, Kakar MasoodulHaq, Baloch Dost Mohammad, Cheema Abdul Majeed, Ahmad Jam |
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A novel recurrent CHEK2 Y390C mutation identified in high-risk Chinese breast cancer patients impairs its activity and is associated with increased breast cancer risk.
Oncogene 2015 Jan . Wang N, Ding H, Liu C, Li X, Wei L, Yu J, Liu M, Ying M, Gao W, Jiang H, Wang |
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Association of Germline CHEK2 Gene Variants with Risk and Prognosis of Non-Hodgkin Lymphoma.
PloS one 2015 10 (10): e0140819. Havranek Ondrej, Kleiblova Petra, Hojny Jan, Lhota Filip, Soucek Pavel, Trneny Marek, Kleibl Zden |
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Low prevalence of CHEK2 gene mutations in multiethnic cohorts of breast cancer patients in Malaysia.
PloS one 2015 10 (1): e0117104. Mohamad Suriati, Isa Nurismah Md, Muhammad Rohaizak, Emran Nor Aina, Kitan Nor Mayah, Kang Peter, Kang In Nee, Taib Nur Aishah Mohd, Teo Soo Hwang, Akmal Sharifah No |
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Prevalence of Germline Mutations in Genes Engaged in DNA Damage Repair by Homologous Recombination in Patients with Triple-Negative and Hereditary Non-Triple-Negative Breast Cancers.
PloS one 2015 10 (6): e0130393. Domagala Pawel, Jakubowska Anna, Jaworska-Bieniek Katarzyna, Kaczmarek Katarzyna, Durda Katarzyna, Kurlapska Agnieszka, Cybulski Cezary, Lubinski J |
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The CHEK2 1100delC allelic variant is not present in familial and sporadic breast cancer cases from Moroccan population.
SpringerPlus 2015 4 38. Marouf Chaymaa, Hajji Omar, Diakité Brehima, Tazzite Amal, Jouhadi Hassan, Benider Abdellatif, Nadifi Sella |
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Identification of two poorly prognosed ovarian carcinoma subtypes associated with CHEK2 germ-line mutation and non-CHEK2 somatic mutation gene signatures.
Cell cycle (Georgetown, Tex.) 2014 13 (14): 2262-80. Ow Ghim Siong, Ivshina Anna V, Fuentes Gloria, Kuznetsov Vladimir |
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Rare key functional domain missense substitutions in MRE11A, RAD50, and NBN contribute to breast cancer susceptibility: results from a Breast Cancer Family Registry case-control mutation-screening study.
Breast cancer research : BCR 2014 16 (3): R58. Damiola Francesca, Pertesi Maroulio, Oliver Javier, Le Calvez-Kelm Florence, Voegele Catherine, Young Erin L, Robinot Nivonirina, Forey Nathalie, Durand Geoffroy, Vallée Maxime P, Tao Kayoko, Roane Terrell C, Williams Gareth J, Hopper John L, Southey Melissa C, Andrulis Irene L, John Esther M, Goldgar David E, Lesueur Fabienne, Tavtigian Sean |
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Haplotype analysis of eight genes of the monoubiquitinated FANCD2-DNA damage-repair pathway in breast cancer patients.
Cancer epidemiology 2013 Jun 37 (3): 311-7. Tang Li-Li, Chen Fei-Yu, Wang Hao, Hu Xue-Li, Dai Xu, Mao Jie, Shen Zheng-Tang, Wu Yu-Hui, Wang Shou-Man, Hai Jian, Yan Guo-Jiao, Li Hui, Huang Ju |
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The effect of CHEK2 variant I157T on cancer susceptibility: evidence from a meta-analysis.
DNA and cell biology 2013 Jun 32 (6): 329-35. Han Fei-fei, Guo Chang-long, Liu Li-ho |
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The risk of gastric cancer in carriers of CHEK2 mutations.
Familial cancer 2013 Jan . Teodorczyk U, Cybulski C, Woko?orczyk D, Jakubowska A, Starzy?ska T, Lawniczak M, Domaga?a P, Ferenc K, Marlicz K, Banaszkiewicz Z, Wi?niowski R, Narod SA, Lubi?ski J |
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Comprehensive analysis of BRCA1, BRCA2 and TP53 germline mutation and tumor characterization: a portrait of early-onset breast cancer in Brazil.
PloS one 2013 8 (3): e57581. Carraro Dirce Maria, Koike Folgueira Maria Aparecida Azevedo, Garcia Lisboa Bianca Cristina, Ribeiro Olivieri Eloisa Helena, Vitorino Krepischi Ana Cristina, de Carvalho Alex Fiorini, de Carvalho Mota Louise Danielle, Puga Renato David, do Socorro Maciel Maria, Michelli Rodrigo Augusto Depieri, de Lyra Eduardo Carneiro, Grosso Stana Helena Giorgi, Soares Fernando Augusto, Achatz Maria Isabel Alves de Souza Waddington, Brentani Helena, Moreira-Filho Carlos Alberto, Brentani Maria Mit |
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Constitutional CHEK2 mutations are infrequent in early-onset and familial breast/ovarian cancer patients from Pakistan.
BMC cancer 2013 13 312. Rashid Muhammad U, Muhammad Noor, Faisal Saima, Amin Asim, Hamann U |
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CHEK2 1100DELC germline mutation: a frequency study in hereditary breast and colon cancer Brazilian families.
Arquivos de gastroenterologia 2012 Dec 49 (4): 273-8. Abud Jamile, Prolla João Carlos, |
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An inherited NBN mutation is associated with poor prognosis prostate cancer.
British journal of cancer 2012 Nov . Cybulski C, Woko?orczyk D, Klu?niak W, Jakubowska A, Górski B, Gronwald J, Huzarski T, Kashyap A, Byrski T, D?bniak T, Go??b A, Gliniewicz B, Sikorski A, Swita?a J, Borkowski T, Borkowski A, Antczak A, Wojnar L, Przyby?a J, Sosnowski M, Ma?kiewicz B, Zdrojowy R, Sikorska-Radek P, Matych J, Wilkosz J, Ró?a?ski W, Ki? J, Bar K, Bryniarski P, Paradysz A, Jersak K, Niemirowicz J, S?upski P, Jarzemski P, Skrzypczyk M, Dobruch J, Domaga?a P, Narod SA, Lubi?ski J |
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CHEK2 1100delC, IVS2+1G>A and I157T mutations are not present in colorectal cancer cases from Turkish population.
Cancer epidemiology 2012 Oct 36 (5): 453-7. Bayram Süleyman, Topakta? Mehmet, Akk?z Hikmet, Bekar Aynur, Akgöllü Ers |
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Variants in activators and downstream targets of ATM, radiation exposure, and contralateral breast cancer risk in the WECARE study.
Human mutation 2012 Jan 33 (1): 158-64. Brooks Jennifer D, Teraoka Sharon N, Reiner Anne S, Satagopan Jaya M, Bernstein Leslie, Thomas Duncan C, Capanu Marinela, Stovall Marilyn, Smith Susan A, Wei Shan, Shore Roy E, Boice John D, Lynch Charles F, Mellemkjaer Lene, Malone Kathleen E, Liang Xiaolin, , Haile Robert W, Concannon Patrick, Bernstein Jonine |
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CHEK2 gene alterations independently increase the risk of death from breast cancer in Bulgarian patients.
Neoplasma 2012 59 (6): 622-30. Angelova S G, Krasteva M E, Gospodinova Z I, Georgieva E |
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Variant allele of CHEK2 is associated with a decreased risk of esophageal cancer lymph node metastasis in a Chinese population.
Molecular biology reports 2011 Dec . Gu H, Qiu W, Wan Y, Ding G, Tang W, Liu C, Shi Y, Chen Y, Chen S |
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Alterations of CHEK2 forkhead-associated domain increase the risk of Hodgkin lymphoma.
Neoplasma 2011 58 (5): 392-5. Havranek O, Spacek M, Hubacek P, Mocikova H, Markova J, Trneny M, Kleibl |
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Variation in the checkpoint kinase 2 gene is associated with type 2 diabetes in multiple populations.
Acta diabetologica 2010 Dec 47 Suppl 1 199-207. North Kari E, Franceschini Nora, Avery Christy L, Baird Lisa, Graff Mariaelisa, Leppert Mark, Chung Jay H, Zhang Jinghui, Hanis Craig, Boerwinkle Eric, Volcik Kelly A, Grove Megan L, Mosley Thomas H, Gu Charles, Heiss Gerardo, Pankow James S, Couper David J, Ballantyne Christie M, Linda Kao W H, Weder Alan B, Cooper Richard S, Ehret Georg B, O'Connor Ashley A, Chakravarti Aravinda, Hunt Steven |
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A variant in the CHEK2 promoter at a methylation site relieves transcriptional repression and confers reduced risk of lung cancer.
Carcinogenesis 2010 Jul 31 (7): 1251-8. Zhang Shuyu, Lu Juan, Zhao Xueying, Wu Wenting, Wang Huibo, Lu Jun, Wu Qihan, Chen Xin, Fan Weiwei, Chen Hongyan, Wang Feng, Hu Zhibin, Jin Li, Wei Qingyi, Shen Hongbing, Huang Wei, Lu Da |
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Single-nucleotide polymorphisms in the p53 pathway genes modify cancer risk in BRCA1 and BRCA2 carriers of Jewish-Ashkenazi descent.
Molecular carcinogenesis 2010 Jun 49 (6): 545-55. Yarden Ronit I, Friedman Eitan, Metsuyanim Sally, Olender Tzvia, Ben-Asher Edna, Papa Moshe |
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Absence of the CHEK2*1100delC mutation in non-BRCA1/2 families with multiple cancer types in a high-risk clinic population of Caucasian ancestry.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2009 May 27 (15_suppl): 11040. Gorin M A, Iniesta M D, Douglas J A, Milliron K J, Merajver S |
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The association of cell cycle checkpoint 2 variants and kidney function: findings of the Family Blood Pressure Program and the Atherosclerosis Risk In Communities study.
American journal of hypertension 2009 May 22 (5): 552-8. Franceschini Nora, North Kari E, Arnett Donna, Pankow James S, Chung Jay H, Baird Lisa, Leppert Mark F, Eckfeldt John H, Boerwinkle Eric, Gu C Charles, Lewis Cora E, Myers Richard H, Turner Stephen T, Weder Alan, Kao W H Linda, Mosley Thomas H, Chakravarti Aravinda, Kramer Holly, Zhang Jinghui, Hunt Steven |
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The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population.
European journal of cancer (Oxford, England : 1990) 2009 Mar 45 (4): 618-24. Kleibl Zdenek, Havranek Ondrej, Hlavata Ivona, Novotny Jan, Sevcik Jan, Pohlreich Petr, Soucek Pav |
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Identification and characterization of novel SNPs in CHEK2 in Ashkenazi Jewish men with prostate cancer.
Cancer letters 2008 Oct 270 (1): 173-80. Tischkowitz Marc D, Yilmaz Ahmet, Chen Long Q, Karyadi Danielle M, Novak David, Kirchhoff Tomas, Hamel Nancy, Tavtigian Sean V, Kolb Suzanne, Bismar Tarek A, Aloyz Raquel, Nelson Peter S, Hood Lee, Narod Steven A, White Kirsten A, Ostrander Elaine A, Isaacs William B, Offit Kenneth, Cooney Kathleen A, Stanford Janet L, Foulkes William |
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Constitutional CHEK2 mutations are associated with a decreased risk of lung and laryngeal cancers.
Carcinogenesis 2008 Apr 29 (4): 762-5. Cybulski Cezary, Masojc Bartlomiej, Oszutowska Dorota, Jaworowska Ewa, Grodzki Tomasz, Waloszczyk Piotr, Serwatowski Piotr, Pankowski Juliusz, Huzarski Tomasz, Byrski Tomasz, Górski Bohdan, Jakubowska Anna, Debniak Tadeusz, Wokolorczyk Dominika, Gronwald Jacek, Tarnowska Czeslawa, Serrano-Fernández Pablo, Lubinski Jan, Narod Steven |
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Single-nucleotide polymorphisms of DNA damage response genes are associated with overall survival in patients with pancreatic cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2008 Apr 14 (7): 2042-8. Okazaki Taro, Jiao Li, Chang Ping, Evans Douglas B, Abbruzzese James L, Li Dongh |
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Risk for contralateral breast cancer among carriers of the CHEK2*1100delC mutation in the WECARE Study.
British journal of cancer 2008 Feb 98 (4): 728-33. Mellemkjaer L, Dahl C, Olsen J H, Bertelsen L, Guldberg P, Christensen J, Børresen-Dale A-L, Stovall M, Langholz B, Bernstein L, Lynch C F, Malone K E, Haile R W, Andersson M, Thomas D C, Concannon P, Capanu M, Boice J D, , Bernstein J |
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CHEK2 mutations affecting kinase activity together with mutations in TP53 indicate a functional pathway associated with resistance to epirubicin in primary breast cancer.
PloS one 2008 3 (8): e3062. Chrisanthar Ranjan, Knappskog Stian, Løkkevik Erik, Anker Gun, Østenstad Bjørn, Lundgren Steinar, Berge Elisabet O, Risberg Terje, Mjaaland Ingvil, Maehle Lovise, Engebretsen Lars Fredrik, Lillehaug Johan Richard, Lønning Per Eyste |
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Identification of a novel CHEK2 variant and assessment of its contribution to the risk of breast cancer in French Canadian women.
BMC cancer 2008 8 (1): 239. Novak David J, Chen Long Qi, Ghadirian Parviz, Hamel Nancy, Zhang Phil, Rossiny Vanessa, Cardinal Guy, Robidoux André, Tonin Patricia N, Rousseau Francois, Narod Steven A, Foulkes William |
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Inherited predisposition of lung cancer: a hierarchical modeling approach to DNA repair and cell cycle control pathways.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2007 Dec 16 (12): 2736-44. Hung Rayjean J, Baragatti Meili, Thomas Duncan, McKay James, Szeszenia-Dabrowska Neonila, Zaridze David, Lissowska Jolanta, Rudnai Peter, Fabianova Eleonora, Mates Dana, Foretova Lenka, Janout Vladimir, Bencko Vladimir, Chabrier Amelie, Moullan Norman, Canzian Federico, Hall Janet, Boffetta Paolo, Brennan Pa |
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Uncommon CHEK2 mis-sense variant and reduced risk of tobacco-related cancers: case control study.
Human molecular genetics 2007 Aug 16 (15): 1794-801. Brennan Paul, McKay James, Moore Lee, Zaridze David, Mukeria Anush, Szeszenia-Dabrowska Neonilia, Lissowska Jolanta, Rudnai Peter, Fabianova Eleonora, Mates Dana, Bencko Vladimir, Foretova Lenka, Janout Vladimir, Chow Wong-Ho, Rothman Nathanial, Chabrier Amelie, Gaborieau Valerie, Odefrey Fabrice, Southey Melissa, Hashibe Mia, Hall Janet, Boffetta Paolo, Peto Julian, Peto Richard, Hung Rayjean |
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The association of sequence variants in DNA repair and cell cycle genes with cancers of the upper aerodigestive tract.
Carcinogenesis 2007 Mar 28 (3): 665-71. Hall Janet, Hashibe Mia, Boffetta Paolo, Gaborieau Valerie, Moullan Norman, Chabrier Amelie, Zaridze David, Shangina Oxana, Szeszenia-Dabrowska Neonila, Mates Dana, Janout Vladimir, Fabiánová Eleonóra, Holcatova Ivana, Hung Rayjean J, McKay James, Canzian Federico, Brennan Pa |
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Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study.
Breast cancer research : BCR 2007 9 (2): R26. Broeks Annegien, Braaf Linde M, Huseinovic Angelina, Nooijen Anke, Urbanus Jos, Hogervorst Frans B L, Schmidt Marjanka K, Klijn Jan G M, Russell Nicola S, Van Leeuwen Flora E, Van 't Veer Laura |
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Variants in the ATM-BRCA2-CHEK2 axis predispose to chronic lymphocytic leukemia.
Blood 2006 Jul 108 (2): 638-44. Rudd Matthew F, Sellick Gabrielle S, Webb Emily L, Catovsky Daniel, Houlston Richard |
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CHEK2*1100delC is not an important high-risk gene in families with hereditary prostate cancer in southern Sweden.
Scandinavian journal of urology and nephrology 2006 40 (1): 23-5. Wagenius M, Borg A, Johansson L, Giwercman A, Bratt |
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TP53-binding protein variants and breast cancer risk: a case-control study.
Breast cancer research : BCR 2005 7 (4): R502-5. Frank Bernd, Hemminki Kari, Bermejo Justo Lorenzo, Klaes Rüdiger, Bugert Peter, Wappenschmidt Barbara, Schmutzler Rita K, Burwinkel Barba |
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CHEK2 is a multiorgan cancer susceptibility gene.
American journal of human genetics 2004 Dec 75 (6): 1131-5. Cybulski C, Górski B, Huzarski T, Masoj? B, Mierzejewski M, Debniak T, Teodorczyk U, Byrski T, Gronwald J, Matyjasik J, Zlowocka E, Lenner M, Grabowska E, Nej K, Castaneda J, Medrek K, Szyma?ska A, Szyma?ska J, Kurzawski G, Suchy J, Oszurek O, Witek A, Narod S A, Lubi?ski |
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CHEK2 variant I157T may be associated with increased breast cancer risk.
International journal of cancer. Journal international du cancer 2004 Sep 111 (4): 543-7. Kilpivaara Outi, Vahteristo Pia, Falck Jacob, Syrjäkoski Kirsi, Eerola Hannaleena, Easton Douglas, Bartkova Jirina, Lukas Jiri, Heikkilä Päivi, Aittomäki Kristiina, Holli Kaija, Blomqvist Carl, Kallioniemi Olli-Pekka, Bartek Jiri, Nevanlinna He |
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ATM polymorphisms as risk factors for prostate cancer development.
British journal of cancer 2004 Aug 91 (4): 783-7. Angèle S, Falconer A, Edwards S M, Dörk T, Bremer M, Moullan N, Chapot B, Muir K, Houlston R, Norman A R, Bullock S, Hope Q, Meitz J, Dearnaley D, Dowe A, Southgate C, Ardern-Jones A, Easton D F, Eeles R A, Hall |
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The CHEK2(*)1100delC mutation has no major contribution in oesophageal carcinogenesis.
British journal of cancer 2004 Feb 90 (4): 888-91. Koppert L B, Schutte M, Abbou M, Tilanus H W, Dinjens W N |
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Common polymorphisms in checkpoint kinase 2 are not associated with breast cancer risk.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2003 Aug 12 (8): 809-12. Kuschel B, Auranen A, Gregory C S, Day N E, Easton D F, Ponder B A J, Dunning A M, Pharoah Paul D |
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- Page last updated:Feb 20, 2020
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