HuGE Literature Finder
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Records 1-100
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[Combined detection of KRAS, NRAS, BRAF and PIK3CA mutations in the plasma and tumor tissues of colorectal cancer patients].
Zhonghua bing li xue za zhi = Chinese journal of pathology 2019 May 48 (5): 373-377. Liu X N, Tian Z, Wei X F, Wang Q, Zhang J X, Jin M S, Duan X |
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Clinicopathological and molecular differences in colorectal cancer according to location.
The International journal of biological markers 2019 Mar 1724600818807164. Hsu Yu-Lun, Lin Chun-Chi, Jiang Jeng-Kai, Lin Hung-Hsin, Lan Yuan-Tzu, Wang Huann-Sheng, Yang Shung-Haur, Chen Wei-Shone, Lin Tzu-Chen, Lin Jen-Kou, Lin Pei-Ching, Chang Shih-Chi |
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Comparative sequence analysis of patient-matched primary colorectal cancer, metastatic, and recurrent metastatic tumors after adjuvant FOLFOX chemotherapy.
BMC cancer 2019 Mar 19 (1): 255. Harada Kazuaki, Okamoto Wataru, Mimaki Sachiyo, Kawamoto Yasuyuki, Bando Hideaki, Yamashita Riu, Yuki Satoshi, Yoshino Takayuki, Komatsu Yoshito, Ohtsu Atsushi, Sakamoto Naoya, Tsuchihara Katsu |
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Positive association of PIK3CA mutation with KRAS mutation but not BRAF mutation in colorectal cancer suggests co-selection is gene specific but not pathway specific.
Journal of clinical pathology 2019 03 72 (3): 263-264. Susanti Susanti, Fadhil Wakkas, Murtaza Shamayal, Hassall James C, Ebili Henry O, Oniscu Anca, Ilyas Mohamm |
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Analysis of KRAS, NRAS, BRAF, and PIK3CA mutations could predict metastases in colorectal cancer: A preliminary study.
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2018 Aug . Wojas-Krawczyk Kamila, Kalinka-Warzocha Ewa, Reszka Katarzyna, Nico? Marcin, Szumi?o Justyna, Ma?dziuk S?awomir, Szczepaniak Katarzyna, Kupnicka Dorota, Lewandowski Remigiusz, Milanowski Janusz, Krawczyk Paw |
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The gene mutational discrepancies between primary and paired metastatic colorectal carcinoma detected by next-generation sequencing.
Journal of cancer research and clinical oncology 2018 Aug . Zou Shuang-Mei, Li Wei-Hua, Wang Wen-Miao, Li Wen-Bin, Shi Su-Sheng, Ying Jian-Ming, Lyu Ni |
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Circulating tumor DNA detectable in early- and late-stage colorectal cancer patients.
Bioscience reports 2018 Jun . Yang Ying-Chi, Wang Dong, Jin Lan, Yao Hong-Wei, Zhang Jing-Hui, Wang Jin, Zhao Xiao-Mu, Shen Chun-Ying, Chen Wei, Wang Xue-Liang, Shi Rong, Chen Si-Yi, Zhang Zhong-T |
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First-Line Cetuximab Monotherapy in KRAS/NRAS/BRAF Mutation-Negative Colorectal Cancer Patients.
Clinical drug investigation 2018 Jun 38 (6): 553-562. Moiseyenko Vladimir M, Moiseyenko Fedor V, Yanus Grigoriy A, Kuligina Ekatherina Sh, Sokolenko Anna P, Bizin Ilya V, Kudriavtsev Alexey A, Aleksakhina Svetlana N, Volkov Nikita M, Chubenko Vyacheslav A, Kozyreva Kseniya S, Kramchaninov Mikhail M, Zhuravlev Alexandr S, Shelekhova Kseniya V, Pashkov Denis V, Ivantsov Alexandr O, Venina Aigul R, Sokolova Tatyana N, Preobrazhenskaya Elena V, Mitiushkina Natalia V, Togo Alexandr V, Iyevleva Aglaya G, Imyanitov Evgeny |
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Phase II Trial of Biweekly Cetuximab and Irinotecan as Third-Line Therapy for Pretreated KRAS Exon 2 Wild-Type Colorectal Cancer.
Cancer science 2018 Jun . Osumi Hiroki, Shinozaki Eiji, Mashima Tetsuo, Wakatsuki Takeru, Suenaga Mitsukuni, Ichimura Takashi, Ogura Mariko, Ota Yumiko, Nakayama Izuma, Takahari Daisuke, Chin Keisho, Miki Yoshio, Yamaguchi Kens |
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Molecular Landscape of ERBB2/ERBB3 Mutated Colorectal Cancer.
Journal of the National Cancer Institute 2018 Apr . Loree Jonathan M, Bailey Ann M, Johnson Amber M, Yu Yao, Wu Wenhui, Bristow Christopher A, Davis Jennifer S, Shaw Kenna R, Broaddus Russell, Banks Kimberly C, Lanman Richard B, Meric-Bernstam Funda, Overman Michael J, Kopetz Scott, Raghav Kanw |
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Mutation status and prognostic values of KRAS, NRAS, BRAF and PIK3CA in 353 Chinese colorectal cancer patients.
Scientific reports 2018 Apr 8 (1): 6076. Guo Fang, Gong Hai, Zhao Huanhuan, Chen Jing, Zhang Yiming, Zhang Lihua, Shi Xin, Zhang Aifeng, Jin Hui, Zhang Jianqiong, He You |
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Performance validation of an amplicon-based targeted next-generation sequencing assay and mutation profiling of 648 Chinese colorectal cancer patients.
Virchows Archiv : an international journal of pathology 2018 Apr . Wang Yajian, Liu Haijing, Hou Yingyong, Zhou Xiaoyan, Liang Li, Zhang Zhihong, Shi Huaiyin, Xu Sanpeng, Hu Peizhen, Zheng Zuyu, Liu Rui, Tang Tingdong, Ye Feng, Liang Zhiyong, Bu Ho |
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The Molecular Landscape of Synchronous Colorectal Cancer Reveals Genetic Heterogeneity.
Carcinogenesis 2018 Mar . Wang Xiangfeng, Fang Hu, Cheng Yong, Li Lin, Sun Xiaohui, Fu Tao, Huang Peide, Zhang Anping, Feng Zhimin, Li Chunxue, Huang Xuanlin, Li Guangyan, Du Peina, Yang Huanming, Fang Xiaodong, Li Fan, Gao Qiang, Liu Baoh |
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World journal of gastroenterology 2018 Feb 24 (5): 631-640. Li A-Jian, Li Hua-Guang, Tang Er-Jiang, Wu Wei, Chen Ying, Jiang Hui-Hong, Lin Mou-Bin, Yin |
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Frequency of Somatic TP53 Mutations in Combination with Known Pathogenic Mutations in Colon Adenocarcinoma, Non-Small Cell Lung Carcinoma, and Gliomas as Identified by Next-Generation Sequencing.
Neoplasia (New York, N.Y.) 2018 Feb 20 (3): 256-262. Shajani-Yi Zahra, de Abreu Francine B, Peterson Jason D, Tsongalis Gregory |
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Associations between primary tumor RAS, BRAF and PIK3CA mutation status and metastatic site in patients with chemo-resistant metastatic colorectal cancer.
Acta oncologica (Stockholm, Sweden) 2018 Jan 1-6. Christensen Troels Dreier, Palshof Jesper Andreas, Larsen Finn Ole, Poulsen Tim Svenstrup, Høgdall Estrid, Pfeiffer Per, Jensen Benny Vittrup, Yilmaz Mette Karen, Nielsen Dor |
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Clinical Sequencing Defines the Genomic Landscape of Metastatic Colorectal Cancer.
Cancer cell 2018 Jan 33 (1): 125-136.e3. Yaeger Rona, Chatila Walid K, Lipsyc Marla D, Hechtman Jaclyn F, Cercek Andrea, Sanchez-Vega Francisco, Jayakumaran Gowtham, Middha Sumit, Zehir Ahmet, Donoghue Mark T A, You Daoqi, Viale Agnes, Kemeny Nancy, Segal Neil H, Stadler Zsofia K, Varghese Anna M, Kundra Ritika, Gao Jianjiong, Syed Aijazuddin, Hyman David M, Vakiani Efsevia, Rosen Neal, Taylor Barry S, Ladanyi Marc, Berger Michael F, Solit David B, Shia Jinru, Saltz Leonard, Schultz Nikola |
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Mutations of key driver genes in colorectal cancer progression and metastasis.
Cancer metastasis reviews 2018 Jan . Huang Dongdong, Sun Wenjie, Zhou Yuwei, Li Peiwei, Chen Fang, Chen Hanwen, Xia Dajing, Xu Enping, Lai Maode, Wu Yihua, Zhang Hong |
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Clinical Impact and Prognostic Role of KRAS/BRAF/PIK3CA Mutations in Stage I Colorectal Cancer.
Disease markers 2018 2018 2959801. Reggiani Bonetti Luca, Barresi Valeria, Maiorana Antonino, Manfredini Samantha, Caprera Cecilia, Bettelli Stefan |
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Molecular profiling and genome-wide analysis based on somatic copy number alterations in advanced colorectal cancers.
Molecular carcinogenesis 2017 Dec . Sugai Tamotsu, Takahashi Yayoi, Eizuka Makoto, Sugimoto Ryo, Fujita Yasuko, Habano Wataru, Otsuka Kouki, Sasaki Akira, Yamamoto Eiichiro, Matsumoto Takayuki, Suzuki Hiro |
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Primary tumor location predicts poor clinical outcome with cetuximab in RAS wild-type metastatic colorectal cancer.
BMC gastroenterology 2017 Nov 17 (1): 121. Kim Dalyong, Kim Sun Young, Lee Ji Sung, Hong Yong Sang, Kim Jeong Eun, Kim Kyu-Pyo, Kim Jihun, Jang Se Jin, Yoon Young-Kwang, Kim Tae W |
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Molecular Profiling of Patients With Advanced Colorectal Cancer: Princess Margaret Cancer Centre Experience.
Clinical colorectal cancer 2017 Oct . Chiu Joanne W, Krzyzanowska Monika K, Serra Stefano, Knox Jennifer J, Dhani Neesha C, Mackay Helen, Hedley David, Moore Malcolm, Liu Geoffrey, Burkes Ronald L, Brezden-Masley Christine, Roehrl Michael H, Craddock Kenneth J, Tsao Ming-Sound, Zhang Tong, Yu Celeste, Kamel-Reid Suzanne, Siu Lillian L, Bedard Philippe L, Chen Eric |
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EGFR pathway subgroups in Chilean colorectal cancer patients, detected by mutational and expression profiles, associated to different clinicopathological features.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Sep 39 (9): 1010428317724517. Alvarez Karin, Orellana Paulina, Villarroel Cynthia, Contreras Luis, Kawachi Hiroshi, Kobayashi Maki, Wielandt Ana Maria, De la Fuente Marjorie, Triviño Juan Carlos, Kronberg Udo, Carvallo Pilar, López-Köstner Francis |
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Measurement of Telomere Length in Colorectal Cancers for Improved Molecular Diagnosis.
International journal of molecular sciences 2017 Aug 18 (9): . Balc'h Eric Le, Grandin Nathalie, Demattei Marie-Véronique, Guyétant Serge, Tallet Anne, Pagès Jean-Christophe, Ouaissi Mehdi, Lecomte Thierry, Charbonneau Mich |
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Investigation of correlation between mutational status in key EGFR signaling genes and prognosis of stage II colorectal cancer.
Future oncology (London, England) 2017 Jul . Li Li, Ni Bei-Bei, Zhong Qing-Hua, Liu Yan-Hui, Zhang Ming-Hui, Zhang Ke-Ping, Chen Dai-Ci, Wang L |
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Oncogene mutation profile predicts tumor regression and survival in locally advanced rectal cancer patients treated with preoperative chemoradiotherapy and radical surgery.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul 39 (7): 1010428317709638. Peng Jianhong, Lin Junzhong, Qiu Miaozhen, Zhao Yujie, Deng Yuxiang, Shao Jianyong, Ding Peirong, Zhang Huizhong, Wan Desen, Lu Zhenhai, Pan Zhizho |
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Analysis of mutant allele fractions in driver genes in colorectal cancer - biological and clinical insights.
Molecular oncology 2017 Jun . Dienstmann Rodrigo, Elez Elena, Argiles Guillem, Matos Ignacio, Sanz-Garcia Enrique, Ortiz Carolina, Macarulla Teresa, Capdevila Jaume, Alsina Maria, Sauri Tamara, Verdaguer Helena, Vilaro Marta, Ruiz-Pace Fiorella, Viaplana Cristina, Garcia Ariadna, Landolfi Stefania, Palmer Hector G, Nuciforo Paolo, Rodon Jordi, Vivancos Ana, Tabernero Jos |
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Genomic Profiling of Small-Bowel Adenocarcinoma.
JAMA oncology 2017 Jun . Schrock Alexa B, Devoe Craig E, McWilliams Robert, Sun James, Aparicio Thomas, Stephens Philip J, Ross Jeffrey S, Wilson Richard, Miller Vincent A, Ali Siraj M, Overman Michael |
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Local recurrences at the anastomotic area are clonally related to the primary tumor in sporadic colorectal carcinoma.
Oncotarget 2017 Jun 8 (26): 42487-42494. Vakiani Efsevia, Shah Ronak H, Berger Michael F, Makohon-Moore Alvin P, Reiter Johannes G, Ostrovnaya Irina, Attiyeh Marc A, Cercek Andrea, Shia Jinru, Iacobuzio-Donahue Christine A, Solit David B, Weiser Martin |
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Targeted sequencing-based analyses of candidate gene variants in ulcerative colitis-associated colorectal neoplasia.
British journal of cancer 2017 Jun 117 (1): 136-143. Chakrabarty Sanjiban, Varghese Vinay Koshy, Sahu Pranoy, Jayaram Pradyumna, Shivakumar Bhadravathi M, Pai Cannanore Ganesh, Satyamoorthy Kapaet |
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Association between mutations of critical pathway genes and survival outcomes according to the tumor location in colorectal cancer.
Cancer 2017 May . Lee Dae-Won, Han Sae-Won, Cha Yongjun, Bae Jeong Mo, Kim Hwang-Phill, Lyu Jaemyun, Han Hyojun, Kim Hyoki, Jang Hoon, Bang Duhee, Huh Iksoo, Park Taesung, Won Jae-Kyung, Jeong Seung-Yong, Park Kyu Joo, Kang Gyeong Hoon, Kim Tae-Y |
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Risk factors for brain metastases in patients with metastatic colorectal cancer.
Acta oncologica (Stockholm, Sweden) 2017 May 56 (5): 639-645. Christensen Troels Dreier, Palshof Jesper Andreas, Larsen Finn Ole, Høgdall Estrid, Poulsen Tim Svenstrup, Pfeiffer Per, Jensen Benny Vittrup, Yilmaz Mette Karen, Christensen Ib Jarle, Nielsen Dor |
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FBXW7 missense mutation: a novel negative prognostic factor in metastatic colorectal adenocarcinoma.
Oncotarget 2017 Apr . Korphaisarn Krittiya, Karlyle Morris Van, Overman Michael J, Fogelman David R, Kee Bryan K, Pratap Singh Raghav Kanwal, Manuel Shanequa, Shureiqi Imad, Wolff Robert A, Eng Cathy, Menter David, Hamilton Stanley R, Kopetz Scott, Dasari Arvi |
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Mitochondrial DNA alteration in primary and metastatic colorectal cancer: Different frequency and association with selected clinicopathological and molecular markers.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Mar 39 (3): 1010428317692246. Kleist Britta, Meurer Thuja, Poetsch Micae |
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EGFR gene copy number predicts response to anti-EGFR treatment in RAS wild type and RAS/BRAF/PIK3CA wild type metastatic colorectal cancer.
International journal of cancer 2017 Feb 140 (4): 922-929. Ålgars Annika, Sundström Jari, Lintunen Minnamaija, Jokilehto Terhi, Kytölä Soili, Kaare Milja, Vainionpää Reetta, Orpana Arto, Österlund Pia, Ristimäki Ari, Carpen Olli, Ristamäki Rai |
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Molecular profiling of metastatic colorectal tumors using next-generation sequencing: A single-institution experience.
Oncotarget 2017 Feb . Gong Jun, Cho May, Sy Marvin, Salgia Ravi, Fakih Marw |
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Prevalence and coexistence of KRAS, BRAF, PIK3CA, NRAS, TP53, and APC mutations in Indian colorectal cancer patients: Next-generation sequencing-based cohort study.
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Feb 39 (2): 1010428317692265. Jauhri Mayank, Bhatnagar Akanksha, Gupta Satish, Bp Manasa, Minhas Sachin, Shokeen Yogender, Aggarwal Shy |
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Retrospective study of RAS/PIK3CA/BRAF tumor mutations as predictors of response to first-line chemotherapy with bevacizumab in metastatic colorectal cancer patients.
BMC cancer 2017 01 17 (1): 38. Nakayama Izuma, Shinozaki Eiji, Matsushima Tomohiro, Wakatsuki Takeru, Ogura Mariko, Ichimura Takashi, Ozaka Masato, Takahari Daisuke, Suenaga Mitsukuni, Chin Keisho, Mizunuma Nobuyuki, Yamaguchi Kens |
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[A Case of Metastatic Colon Cancer Dramatically Affected by Anti-EGFR Antibody Therapy].
Gan to kagaku ryoho. Cancer & chemotherapy 2016 Nov 43 (12): 1800-1802. Yagi Ryoma, Shimada Yoshifumi, Miura Kohei, Tajima Yosuke, Okamura Takuma, Nakano Masato, Ichikawa Hiroshi, Nagahashi Masayuki, Sakata Jun, Kobayashi Takashi, Kameyama Hitoshi, Wakai Toshifumi, Nogami Hitoshi, Maruyama Satoshi, Takii Yasuma |
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Mutation location on the RAS oncogene effects pathologic features and survival after resection of colorectal liver metastases.
Cancer 2016 Oct . Frankel Timothy L, Vakiani Efsevia, Nathan Hari, DeMatteo Ronald P, Kingham T Peter, Allen Peter J, Jarnagin William R, Kemeny Nancy E, Solit David B, D'Angelica Michael |
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Prognostic impact of KRAS, NRAS, BRAF, and PIK3CA mutations in primary colorectal carcinomas: a population-based study.
Journal of translational medicine 2016 Oct 14 (1): 292. Palomba Grazia, Doneddu Valentina, Cossu Antonio, Paliogiannis Panagiotis, Manca Antonella, Casula Milena, Colombino Maria, Lanzillo Annamaria, Defraia Efisio, Pazzola Antonio, Sanna Giovanni, Putzu Carlo, Ortu Salvatore, Scartozzi Mario, Ionta Maria Teresa, Baldino Giovanni, Sarobba Giuseppina, Capelli Francesca, Sedda Tito, Virdis Luciano, Barca Michela, Gramignano Giulia, Budroni Mario, Tanda Francesco, Palmieri Giusep |
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Spatio-temporal mutation profiles of case-matched colorectal carcinomas and their metastases reveal unique de novo mutations in metachronous lung metastases by targeted next generation sequencing.
Molecular cancer 2016 Oct 15 (1): 63. Kovaleva Valentina, Geissler Anna-Lena, Lutz Lisa, Fritsch Ralph, Makowiec Frank, Wiesemann Sebastian, Hopt Ulrich T, Passlick Bernward, Werner Martin, Lassmann Sil |
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Comparison of the molecular profile of brain metastases from colorectal cancer and corresponding primary tumors.
Future oncology (London, England) 2016 Aug . Aprile Giuseppe, Casagrande Mariaelena, De Maglio Giovanna, Fontanella Caterina, Rihawi Karim, Bonotto Marta, Pisa Federica E, Tuniz Francesco, Pizzolitto Stefano, Fasola Gianpie |
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Prognostic and predictive biomarkers in metastatic colorectal cancer anti-EGFR therapy.
World journal of gastroenterology 2016 Aug 22 (30): 6944-54. Lo Nigro Cristiana, Ricci Vincenzo, Vivenza Daniela, Granetto Cristina, Fabozzi Teresa, Miraglio Emanuela, Merlano Marco |
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Tumor LINE-1 methylation level and colorectal cancer location in relation to patient survival.
Oncotarget 2016 Aug 7 (34): 55098-55109. Mima Kosuke, Nowak Jonathan A, Qian Zhi Rong, Cao Yin, Song Mingyang, Masugi Yohei, Shi Yan, da Silva Annacarolina, Gu Mancang, Li Wanwan, Hamada Tsuyoshi, Zhang Xuehong, Wu Kana, Meyerhardt Jeffrey A, Baba Hideo, Giovannucci Edward L, Chan Andrew T, Fuchs Charles S, Ogino Shuji, Nishihara Rei |
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Challenging a dogma: co-mutations exist in MAPK pathway genes in colorectal cancer.
Virchows Archiv : an international journal of pathology 2016 Jul . Grellety Thomas, Gros Audrey, Pedeutour Florence, Merlio Jean-Philippe, Duranton-Tanneur Valerie, Italiano Antoine, Soubeyran Isabel |
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Comparison of KRAS mutation status between primary tumor and metastasis in Chinese colorectal cancer patients.
Medical oncology (Northwood, London, England) 2016 Jul 33 (7): 71. Li Zhe-Zhen, Bai Long, Wang Feng, Zhang Zi-Chen, Wang Fang, Zeng Zhao-Lei, Zeng Jun-Bo, Zhang Dong-Sheng, Wang Feng-Hua, Wang Zhi-Qiang, Li Yu-Hong, Shao Jian-Yong, Xu Rui-H |
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CpG island methylator phenotype is associated with the efficacy of sequential oxaliplatin- and irinotecan-based chemotherapy and EGFR-related gene mutation in Japanese patients with metastatic colorectal cancer.
International journal of clinical oncology 2016 Jul . Zhang Xiaofei, Shimodaira Hideki, Soeda Hiroshi, Komine Keigo, Takahashi Hidekazu, Ouchi Kota, Inoue Masahiro, Takahashi Masanobu, Takahashi Shin, Ishioka Chikas |
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Paired Primary and Metastatic Tumor Analysis of Somatic Mutations in Synchronous and Metachronous Colorectal Cancer.
Cancer research and treatment : official journal of Korean Cancer Association 2016 Jul . Kim Kyu-Pyo, Kim Jeong-Eun, Hong Yong Sang, Ahn Sung-Min, Chun Sung Min, Hong Seung-Mo, Jang Se Jin, Yu Chang Sik, Kim Jin Cheon, Kim Tae W |
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Prognostic role of tumor PIK3CAmutation in colorectal cancer: a systematic review and meta-analysis.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2016 Jul . Mei Z, Duan C, Li C, Cui L, Ogino |
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[New molecular classification of colorectal cancer, pancreatic cancer and stomach cancer: Towards "à la carte" treatment?]
Bulletin du cancer 2016 Jun . Dreyer Chantal, Afchain Pauline, Trouilloud Isabelle, André Thier |
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Frequent PIK3CA Mutations in Colorectal and Endometrial Tumors with 2 or More Somatic Mutations in Mismatch Repair Genes.
Gastroenterology 2016 Jun . Cohen Stacey A, Turner Emily H, Beightol Mallory B, Jacobson Angela, Gooley Ted A, Salipante Stephen J, Haraldsdottir Sigurdis, Smith Christina, Scroggins Sheena, Tait Jonathan F, Grady William M, Lin Edward H, Cohn David E, Goodfellow Paul J, Arnold Mark W, de la Chapelle Albert, Pearlman Rachel, Hampel Heather, Pritchard Colin |
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Mutations of KRAS, NRAS, BRAF, EGFR, and PIK3CA genes in urachal carcinoma - occurence and prognostic significance.
Oncotarget 2016 Jun . Módos Orsolya, Reis Henning, Niedworok Christian, Rübben Herbert, Szendröi Attila, Szász Marcell A, Tímár József, Baghy Kornélia, Kovalszky Ilona, Golabek Tomasz, Chlosta Piotr, Okon Krzysztof, Peyronnet Benoit, Mathieu Romain, Shariat Shahrokh F, Hollósi Péter, Nyirády Péter, Szarvas Tib |
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Mutational analysis of anal cancers demonstrates frequent PIK3CA mutations associated with poor outcome after salvage abdominoperineal resection.
British journal of cancer 2016 May . Cacheux Wulfran, Rouleau Etienne, Briaux Adrien, Tsantoulis Petros, Mariani Pascale, Richard-Molard Marion, Buecher Bruno, Dangles-Marie Virginie, Richon Sophie, Lazartigues Julien, Jeannot Emmanuelle, Farkhondeh Fereshteh, Sastre-Garau Xavier, de La Rochefordière Anne, Labib Alain, Falcou Marie-Christine, Stevens Denise, Roth Arnaud, Roman-Roman Sergio, Mitry Emmanuel, Bièche Ivan, Lièvre Astr |
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Recurrent, truncating Sox9 mutations are associated with sox9 overexpression, KRAS mutation, and TP53 wild type status in colorectal carcinoma.
Oncotarget 2016 May . Javier Breanna M, Yaeger Rona, Wang Lu, Sanchez-Vega Francisco, Zehir Ahmet, Middha Sumit, Sadowska Justyna, Vakiani Efsevia, Shia Jinru, Klimstra David, Ladanyi Marc, Iacobuzio-Donahue Christine A, Hechtman Jaclyn |
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Tumour CD274 (PD-L1) expression and T cells in colorectal cancer.
Gut 2016 May . Masugi Yohei, Nishihara Reiko, Yang Juhong, Mima Kosuke, da Silva Annacarolina, Shi Yan, Inamura Kentaro, Cao Yin, Song Mingyang, Nowak Jonathan A, Liao Xiaoyun, Nosho Katsuhiko, Chan Andrew T, Giannakis Marios, Bass Adam J, Hodi F Stephen, Freeman Gordon J, Rodig Scott, Fuchs Charles S, Qian Zhi Rong, Ogino Shu |
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Mutation profiling in chinese patients with metastatic colorectal cancer and its correlation with clinicopathological features and anti-EGFR treatment response.
Oncotarget 2016 Apr . Li Zhe-Zhen, Wang Feng, Zhang Zi-Chen, Wang Fang, Zhao Qi, Zhang Dong-Sheng, Wang Feng-Hua, Wang Zhi-Qiang, Luo Hui-Yan, He Ming-Ming, Wang De-Shen, Jin Ying, Ren Chao, Qiu Miao-Zhen, Ren Jian, Pan Zhi-Zhong, Li Yu-Hong, Shao Jiao-Yong, Xu Rui-H |
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Mutations of KRAS/NRAS/BRAF predict cetuximab resistance in metastatic colorectal cancer patients.
Oncotarget 2016 Apr 7 (16): 22257-70. Hsu Hung-Chih, Thiam Tan Kien, Lu Yen-Jung, Yeh Chien Yuh, Tsai Wen-Sy, You Jeng Fu, Hung Hsin Yuan, Tsai Chi-Neu, Hsu An, Chen Hua-Chien, Chen Shu-Jen, Yang Tsai-She |
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Prediagnosis Plasma Adiponectin in Relation to Colorectal Cancer Risk According to KRAS Mutation Status.
Journal of the National Cancer Institute 2016 Apr 108 (4): . Inamura Kentaro, Song Mingyang, Jung Seungyoun, Nishihara Reiko, Yamauchi Mai, Lochhead Paul, Qian Zhi Rong, Kim Sun A, Mima Kosuke, Sukawa Yasutaka, Masuda Atsuhiro, Imamura Yu, Zhang Xuehong, Pollak Michael N, Mantzoros Christos S, Harris Curtis C, Giovannucci Edward, Fuchs Charles S, Cho Eunyoung, Chan Andrew T, Wu Kana, Ogino Shu |
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A Randomized, Phase II Trial of Cetuximab With or Without PX-866, an Irreversible Oral Phosphatidylinositol 3-Kinase Inhibitor, in Patients With Metastatic Colorectal Carcinoma.
Clinical colorectal cancer 2016 Mar . Bowles Daniel W, Kochenderfer Mark, Cohn Allen, Sideris Lucas, Nguyen Nghia, Cline-Burkhardt Vivian, Schnadig Ian, Choi Minsig, Nabell Lisle, Chaudhry Arvind, Ruxer Robert, Ucar Antonio, Hausman Diana, Walker Luke, Spira Alexander, Jimeno Anton |
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MicroRNA <i>MIR21</i> (miR-21) and PTGS2 expression in colorectal cancer and patient survival.
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 Mar . Mima Kosuke, Nishihara Reiko, Yang Juhong, Dou Ruoxu, Masugi Yohei, Shi Yan, da Silva Annacarolina, Cao Yin, Song Mingyang, Nowak Jonathan, Gu Mancang, Li Wanwan, Morikawa Teppei, Zhang Xuehong, Wu Kana, Baba Hideo, Giovannucci Edward L, Meyerhardt Jeffrey A, Chan Andrew T, Fuchs Charles S, Qian Zhi Rong, Ogino Shu |
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RAS mutation is a prognostic biomarker in colorectal cancer patients with metastasectomy.
International journal of cancer 2016 Mar . Osumi Hiroki, Shinozaki Eiji, Suenaga Mitsukuni, Matsusaka Satoshi, Konishi Tsuyoshi, Akiyoshi Takashi, Fujimoto Yoshiya, Nagayama Satoshi, Fukunaga Yosuke, Ueno Masashi, Mise Yoshihiro, Ishizawa Takeaki, Inoue Yosuke, Takahashi Yu, Saiura Akio, Uehara Hirohumi, Mun Mingyon, Okumura Sakae, Mizunuma Nobuyuki, Miki Yoshio, Yamaguchi Toshiha |
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The Prognostic Influence of BRAF Mutation and other Molecular, Clinical and Laboratory Parameters in Stage IV Colorectal Cancer.
Pathology oncology research : POR 2016 Mar . Karadima Maria L, Saetta Angelica A, Chatziandreou Ilenia, Lazaris Andreas C, Patsouris Efstratios, Tsavaris Nikola |
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BRAF, PIK3CA, and HER2 Oncogenic Alterations According to KRAS Mutation Status in Advanced Colorectal Cancers with Distant Metastasis.
PloS one 2016 11 (3): e0151865. Nam Soo Kyung, Yun Sumi, Koh Jiwon, Kwak Yoonjin, Seo An Na, Park Kyoung Un, Kim Duck-Woo, Kang Sung-Bum, Kim Woo Ho, Lee Hye Seu |
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Clinical significance of frequent somatic mutations detected by high-throughput targeted sequencing in archived colorectal cancer samples.
Journal of translational medicine 2016 14 (1): 118. Dallol Ashraf, Buhmeida Abdelbaset, Al-Ahwal Mahmoud Shaheen, Al-Maghrabi Jaudah, Bajouh Osama, Al-Khayyat Shadi, Alam Rania, Abusanad Atlal, Turki Rola, Elaimi Aisha, Alhadrami Hani A, Abuzenadah Mohammed, Banni Huda, Al-Qahtani Mohammed H, Abuzenadah Adel |
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Genomic profiling of stage II and III colon cancers reveals APC mutations to be associated with survival in stage III colon cancer patients.
Oncotarget 2016 11 7 (45): 73876-73887. van den Broek Evert, Krijgsman Oscar, Sie Daoud, Tijssen Marianne, Mongera Sandra, van de Wiel Mark A, Belt Eric J Th, den Uil Sjoerd H, Bril Herman, Stockmann Hein B A C, Ylstra Bauke, Carvalho Beatriz, Meijer Gerrit A, Fijneman Remond J |
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Molecular differences in the microsatellite stable phenotype between left-sided and right-sided colorectal cancer.
International journal of cancer 2016 12 139 (11): 2493-501. Takahashi Yayoi, Sugai Tamotsu, Habano Wataru, Ishida Kazuyuki, Eizuka Makoto, Otsuka Koki, Sasaki Akira, Takayuki Matsumoto , Morikawa Takanori, Unno Michiaki, Suzuki Hiro |
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Prognostic impact of mutation profiling in patients with stage II and III colon cancer.
Scientific reports 2016 6 24310. Shen Yinchen, Han Xiaohong, Wang Jianfei, Wang Shuai, Yang Hongying, Lu Shih-Hsin, Shi Yuank |
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Value of KRAS, BRAF, and PIK3CA Mutations and Survival Benefit from Systemic Chemotherapy in Colorectal Peritoneal Carcinomatosis.
Asian Pacific journal of cancer prevention : APJCP 2016 17 (2): 539-43. Sasaki Yusuke, Hamaguchi Tetsuya, Yamada Yasuhide, Takahashi Naoki, Shoji Hirokazu, Honma Yoshitaka, Iwasa Satoru, Okita Natsuko, Takashima Atsuo, Kato Ken, Nagai Yushi, Taniguchi Hirokazu, Boku Narikazu, Ushijima Toshikazu, Shimada Yasuhi |
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KRAS mutation in lung metastases from colorectal cancer: prognostic implications.
Cancer medicine 2015 Dec . Ghidini Michele, Personeni Nicola, Bozzarelli Silvia, Baretti Marina, Basso Gianluca, Bianchi Paolo, Tronconi Maria Chiara, Pressiani Tiziana, Grizzi Fabio, Giordano Laura, Malesci Alberto, Alloisio Marco, Laghi Luigi, Santoro Armando, Rimassa Loren |
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PIK3CA Mutation, Aspirin Use after Diagnosis and Survival of Colorectal Cancer. A Systematic Review and Meta-analysis of Epidemiological Studies.
Clinical oncology (Royal College of Radiologists (Great Britain)) 2015 Dec . Paleari L, Puntoni M, Clavarezza M, DeCensi M, Cuzick J, DeCensi |
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A set of defined oncogenic mutation alleles seems to better predict the response to cetuximab in CRC patient-derived xenograft than KRAS 12/13 mutations.
Oncotarget 2015 Oct . Chen Dawei, Huang Xuesong, Cai Jie, Guo Sheng, Qian Wubin, Wery Jean-Pierre, Li Qi-Xia |
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Mutation Spectra of Common Cancer-Associated Genes in Different Phenotypes of Colorectal Carcinoma Without Distant Metastasis.
Annals of surgical oncology 2015 Oct . Chang Shih-Ching, Lin Pei-Ching, Lin Jen-Kou, Lin Chien-Hsing, Yang Shung-Haur, Liang Wen-Yi, Chen Wei-Shone, Jiang Jeng-K |
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Mutational profiling of colorectal cancers with microsatellite instability.
Oncotarget 2015 Oct . Lin Elaine I, Tseng Li-Hui, Gocke Christopher D, Reil Stacy, Le Dung T, Azad Nilofer S, Eshleman James |
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Prognostic utility of molecular factors by age at diagnosis of colorectal cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 Oct . McCleary Nadine J, Sato Kaori, Nishihara Reiko, Inamura Kentaro, Morikawa Teppei, Zhang Xuehong, Wu Kana, Yamauchi Mai, Kim Sun A, Sukawa Yasutaka, Mima Kosuke, Qian Zhi Rong, Fuchs Charles S, Ogino Shuji, Meyerhardt Jeffrey |
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Prospective blinded study of somatic mutation detection in cell-free DNA utilizing a targeted 54-gene next generation sequencing panel in metastatic solid tumor patients.
Oncotarget 2015 Oct . Kim Seung Tae, Lee Won-Suk, Lanman Richard B, Mortimer Stefanie, Zill Oliver A, Kim Kyoung-Mee, Jang Kee Taek, Kim Seok-Hyung, Park Se Hoon, Park Joon Oh, Park Young Suk, Lim Ho Yeong, Eltoukhy Helmy, Kang Won Ki, Lee Woo Yong, Kim Hee-Cheol, Park Keunchil, Lee Jeeyun, Talasaz AmirA |
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Prognostic Value of BRAF, PI3K, PTEN, EGFR Copy Number, Amphiregulin and Epiregulin Status in Patients with KRAS Codon 12 Wild-Type Metastatic Colorectal Cancer Receiving First-Line Chemotherapy with Anti-EGFR Therapy.
Molecular diagnosis & therapy 2015 Sep . Llovet Patricia, Sastre Javier, Ortega Julián Sanz, Bando Inmaculada, Ferrer Milagros, García-Alfonso Pilar, Donnay Olga, Carrato Alfredo, Jiménez Ana, Aranda Enrique, León Ana, Grávalos Cristina, Cámara Juan Carlos, Feliú Jaime, Sanchíz Bárbara, Caldés Trinidad, Díaz-Rubio Eduar |
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Wild-type APC predicts poor prognosis in microsatellite-stable proximal colon cancer.
British journal of cancer 2015 Sep 113 (6): 979-88. Jorissen Robert N, Christie Michael, Mouradov Dmitri, Sakthianandeswaren Anuratha, Li Shan, Love Christopher, Xu Zheng-Zhou, Molloy Peter L, Jones Ian T, McLaughlin Stephen, Ward Robyn L, Hawkins Nicholas J, Ruszkiewicz Andrew R, Moore James, Burgess Antony W, Busam Dana, Zhao Qi, Strausberg Robert L, Lipton Lara, Desai Jayesh, Gibbs Peter, Sieber Oliver |
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Analysis of circulating DNA and protein biomarkers to predict the clinical activity of regorafenib and assess prognosis in patients with metastatic colorectal cancer: a retrospective, exploratory analysis of the CORRECT trial.
The Lancet. Oncology 2015 Aug 16 (8): 937-48. Tabernero Josep, Lenz Heinz-Josef, Siena Salvatore, Sobrero Alberto, Falcone Alfredo, Ychou Marc, Humblet Yves, Bouché Olivier, Mineur Laurent, Barone Carlo, Adenis Antoine, Yoshino Takayuki, Goldberg Richard M, Sargent Daniel J, Wagner Andrea, Laurent Dirk, Teufel Michael, Jeffers Michael, Grothey Axel, Van Cutsem Er |
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Correlation between DPYD gene variation and KRAS wild type status in colorectal cancer.
Journal of clinical pathology 2015 Aug . Kleist Britta, Kempa Marcel, Meurer Thuja, Poetsch Micae |
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Heterogeneity of KRAS, NRAS, BRAF and PIK3CA mutations in metastatic colorectal cancer and potential effects on therapy in the CAPRI GOIM trial.
Annals of oncology : official journal of the European Society for Medical Oncology / ESMO 2015 Aug 26 (8): 1710-4. Normanno N, Rachiglio A M, Lambiase M, Martinelli E, Fenizia F, Esposito C, Roma C, Troiani T, Rizzi D, Tatangelo F, Botti G, Maiello E, Colucci G, Ciardiello F, |
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Genetic mutations in human rectal cancers detected by targeted sequencing.
Journal of human genetics 2015 Jul . Bai Jun, Gao Jinglong, Mao Zhijun, Wang Jianhua, Li Jianhui, Li Wensheng, Lei Yu, Li Shuaishuai, Wu Zhuo, Tang Chuanning, Jones Lindsey, Ye Hua, Lou Feng, Liu Zhiyuan, Dong Zhishou, Guo Baishuai, Huang Xue F, Chen Si-Yi, Zhang En |
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Identification of high-risk Dukes B colorectal cancer by microRNA expression profiling: a preliminary study.
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2015 Jul 17 (7): 578-88. Aslam M I, Venkatesh J, Jameson J S, West K, Pringle J H, Singh |
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PIK3CA Somatic Mutation Status in Relation to Patient and Tumor Factors in Racial/Ethnic Minorities with Colorectal Cancer.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2015 Jul 24 (7): 1046-51. Phipps Amanda I, Ahnen Dennis J, Cheng Iona, Newcomb Polly A, Win Aung Ko, Burnett Terril |
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Elucidating the prognostic significance of KRAS, NRAS, BRAF and PIK3CA mutations in Chinese patients with metastatic colorectal cancer.
Asia-Pacific journal of clinical oncology 2015 Jun 11 (2): 160-9. Ma Brigette B, Mo Frankie, Tong Joanna H, Wong Ashley, Wong S C Cesar, Ho Wing M, Wu Cherry, Lam Polly W Y, Chan K F, Chan Timothy S K, Tsui Wilson M S, Tsang Alex K H, Fung Mandy N S, Chan Anthony T C, To Ka F |
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Mutations in the RAS and PI3K pathways are associated with metastatic location in colorectal cancers.
Journal of surgical oncology 2015 Jun 111 (7): 905-10. Lan Yuan-Tzu, Jen-Kou Lin, Lin Chien-Hsing, Yang Shung-Haur, Lin Chun-Chi, Wang Huann-Sheng, Chen Wei-Shone, Lin Tzu-Chen, Jiang Jeng-Kai, Chang Shih-Chi |
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Polymorphic GT dinucleotide repeat in the PIK3CA gene and risk of colorectal cancer.
Cancer biomarkers : section A of Disease markers 2015 Jun 15 (4): 397-403. Parsafar Soha, Hematti Simin, Ghorbani Fateme, Safari Forousan, Tavassoli Manooche |
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Emergence of Multiple EGFR Extracellular Mutations during Cetuximab Treatment in Colorectal Cancer.
Clinical cancer research : an official journal of the American Association for Cancer Research 2015 May 21 (9): 2157-66. Arena Sabrina, Bellosillo Beatriz, Siravegna Giulia, Martínez Alejandro, Cañadas Israel, Lazzari Luca, Ferruz Noelia, Russo Mariangela, Misale Sandra, González Iria, Iglesias Mar, Gavilan Elena, Corti Giorgio, Hobor Sebastijan, Crisafulli Giovanni, Salido Marta, Sánchez Juan, Dalmases Alba, Bellmunt Joaquim, De Fabritiis Gianni, Rovira Ana, Di Nicolantonio Federica, Albanell Joan, Bardelli Alberto, Montagut Cla |
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Novel molecular insights from routine genotyping of colorectal carcinomas.
Human pathology 2015 Apr 46 (4): 507-13. Stachler Matthew D, Rinehart Elizabeth, Lindeman Neal, Odze Robert, Srivastava Amita |
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RAS mutations affect pattern of metastatic spread and increase propensity for brain metastasis in colorectal cancer.
Cancer 2015 Apr 121 (8): 1195-203. Yaeger Rona, Cowell Elizabeth, Chou Joanne F, Gewirtz Alexandra N, Borsu Laetitia, Vakiani Efsevia, Solit David B, Rosen Neal, Capanu Marinela, Ladanyi Marc, Kemeny Nan |
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[Molecular analysis of sporadic colon cancer].
Revista médica de Chile 2015 Mar 143 (3): 310-9. Hurtado Claudia, Wielandt Ana María, Zárate Alejandro J, Kronberg Udo, Castro Magdalena, Yamagiwa Ken, Ito Takashi, Eishi Yoshinobu, Contreras Luis, López-Köstner Francis |
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PIK3CA mutations predict recurrence in localized microsatellite stable colon cancer.
Cancer medicine 2015 Mar 4 (3): 371-82. Manceau Gilles, Marisa Laetitia, Boige Valérie, Duval Alex, Gaub Marie-Pierre, Milano Gérard, Selves Janick, Olschwang Sylviane, Jooste Valérie, le Legrain Michè, Lecorre Delphine, Guenot Dominique, Etienne-Grimaldi Marie-Christine, Kirzin Sylvain, Martin Laurent, Lepage Come, Bouvier Anne-Marie, Laurent-Puig Pier |
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Prognostic role of KRAS, NRAS, BRAF and PIK3CA mutations in advanced colorectal cancer.
Future oncology (London, England) 2015 Feb 11 (4): 629-40. Foltran Luisa, De Maglio Giovanna, Pella Nicoletta, Ermacora Paola, Aprile Giuseppe, Masiero Elena, Giovannoni Mariella, Iaiza Emiliana, Cardellino Giovanni Gerardo, Lutrino Stefania Eufemia, Mazzer Micol, Giangreco Manuela, Pisa Federica Edith, Pizzolitto Stefano, Fasola Gianpie |
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Identification of novel mutations by exome sequencing in African American colorectal cancer patients.
Cancer 2015 Jan 121 (1): 34-42. Ashktorab Hassan, Daremipouran Mohammad, Devaney Joe, Varma Sudhir, Rahi Hamed, Lee Edward, Shokrani Babak, Schwartz Russell, Nickerson Michael L, Brim Hass |
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A functional variant at miR-520a binding site in PIK3CA alters susceptibility to colorectal cancer in a Chinese Han population.
BioMed research international 2015 2015 373252. Ding Lifang, Jiang Zao, Chen Qiaoyun, Qin Rong, Fang Yue, Li H |
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A pathway-centric survey of somatic mutations in Chinese patients with colorectal carcinomas.
PloS one 2015 10 (1): e0116753. Ling Chao, Wang Lin, Wang Zheng, Xu Luming, Sun Lifang, Yang Hui, Li Wei-Dong, Wang K |
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A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA mutations in Japanese patients with metastatic colorectal cancer.
BMC cancer 2015 15 258. Kawazoe Akihito, Shitara Kohei, Fukuoka Shota, Kuboki Yasutoshi, Bando Hideaki, Okamoto Wataru, Kojima Takashi, Fuse Nozomu, Yamanaka Takeharu, Doi Toshihiko, Ohtsu Atsushi, Yoshino Takayu |
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Exploratory biomarker analysis for treatment response in KRAS wild type metastatic colorectal cancer patients who received cetuximab plus irinotecan.
BMC cancer 2015 15 (1): 747. Kim Seung Tae, Ahn Tae Jin, Lee Eunjin, Do In-Gu, Lee Su Jin, Park Se Hoon, Park Joon Oh, Park Young Suk, Lim Ho Yeong, Kang Won Ki, Kim Suk Hyeong, Lee Jeeyun, Kim Hee Che |
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High Prevalence and Clinical Relevance of Genes Affected by Chromosomal Breaks in Colorectal Cancer.
PloS one 2015 10 (9): e0138141. van den Broek Evert, Dijkstra Maurits J J, Krijgsman Oscar, Sie Daoud, Haan Josien C, Traets Joleen J H, van de Wiel Mark A, Nagtegaal Iris D, Punt Cornelis J A, Carvalho Beatriz, Ylstra Bauke, Abeln Sanne, Meijer Gerrit A, Fijneman Remond J |
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Roles of genetic variants in the PI3K/PTEN pathways in susceptibility to colorectal carcinoma and clinical outcomes treated with FOLFOX regimen.
International journal of clinical and experimental pathology 2015 8 (10): 13314-22. Lin Lin, Zhang Zhaoxu, Zhang Wen, Wang Lin, Wang Jinw |
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