Archive
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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Archived Hot Topics of the Day By Date
Being precise with anticoagulation to reduce adverse drug reactions: are we there yet?
Benjamin Cross et al. Pharmacogenomics J 2024 3 (2) 7
(Posted: Mar 12, 2024 0PM)
Targeted next-generation sequencing of genes involved in Warfarin Pharmacodynamics and pharmacokinetics pathways using the Saudi Warfarin Pharmacogenetic study (SWAP)
M Al Ammari et al, The PGX journal, February 6, 2023
(Posted: Feb 07, 2023 6AM)
Nine-gene pharmacogenomics profile service: The Mayo Clinic experience.
Matey Eric T et al. The pharmacogenomics journal 2021 10 (1) 69-74
(Posted: Oct 22, 2022 0PM)
Implementation of pharmacogenomic clinical decision support for health systems: a cost-utility analysis
S Jiang et al, The PGX journal, April 1, 2022
(Posted: Apr 02, 2022 8AM)
Nine-gene pharmacogenomics profile service: The Mayo Clinic experience
ET Matey et al, The PGX Journal, October 19, 2021
(Posted: Oct 20, 2021 1PM)
Systematic review of the evidence on the cost-effectiveness of pharmacogenomics-guided treatment for cardiovascular diseases
Ye Zhu, et al. Genetics in Medicine, October 8, 2019
(Posted: Oct 10, 2019 8AM)
Pharmacogenomic genotypes define genetic ancestry in patients and enable population-specific genomic implementation
W Hernandez et al, The Pharmacogenomics Journal. September 10, 2019
(Posted: Sep 11, 2019 9AM)
Algorithm for predicting low maintenance doses of warfarin using age and polymorphisms in genes CYP2C9 and VKORC1 in Brazilian subjects.
de Oliveira Magalhães Mourão Aline et al. The pharmacogenomics journal 2019 Aug
(Posted: Aug 12, 2019 8AM)
Precision dosing of warfarin: open questions and strategies
X Li et al, Pharmacogenomics J, February 12, 2019
(Posted: Feb 14, 2019 8AM)
Genotype-guided Warfarin Dosing in Patients with Mechanical Valves: a Randomized Controlled Trial.
Xu Zhe et al. The Annals of thoracic surgery 2018 Sep
(Posted: Sep 12, 2018 9AM)
Genotype-guided versus traditional clinical dosing of warfarin in patients of Asian ancestry: a randomized controlled trial.
Syn Nicholas L et al. BMC medicine 2018 Jul 16(1) 104
(Posted: Jul 11, 2018 9AM)
Genotype-guided warfarin therapy: current status.
Tavares Letícia C et al. Pharmacogenomics 2018 Apr
(Posted: May 02, 2018 9AM)
Pharmacogenomics Guided-Personalization of Warfarin and Tamoxifen.
Wigle Theodore J et al. Journal of personalized medicine 2017 Dec (4)
(Posted: Jan 02, 2018 11AM)
Precision Medicine: Making Warfarin Safer
NIH Director's blog, Oct 3, 2017
(Posted: Oct 03, 2017 11AM)
Pharmacogenomic Testing and Warfarin
JD Emery et al, JAMA Sep 26, 2017
(Posted: Sep 27, 2017 0PM)
Effect of Genotype-Guided Warfarin Dosing on Clinical Events and Anticoagulation Control Among Patients Undergoing Hip or Knee Arthroplasty
BF Gage et al, JAMA 26, Sep 2017
(Posted: Sep 27, 2017 0PM)
Pharmacogenetic dosing of warfarin in the Han-Chinese population: a randomized trial.
Wen Ming-Shien et al. Pharmacogenomics 2017 Feb 18(3) 245-253
(Posted: Jul 26, 2017 9AM)
Genotype-guided dosing of warfarin through modeling and simulation.
Deng Jiexin et al. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 2017 May
(Posted: May 17, 2017 9AM)
STRATEGIES FOR EQUITABLE PHARMACOGENOMIC-GUIDED WARFARIN DOSING AMONG EUROPEAN AND AFRICAN AMERICAN INDIVIDUALS IN A CLINICAL POPULATION.
Wiley Laura K et al. Pacific Symposium on Biocomputing. Pacific Symposium on Biocomputing 2016 22545-556
(Posted: Mar 22, 2017 10AM)
Clinical pharmacogenetics implementation consortium (cpic) guideline for pharmacogenetics-guided warfarin dosing: 2017 update.
Johnson Julie A et al. Clinical pharmacology and therapeutics 2017 Feb
(Posted: Feb 22, 2017 11AM)
The Impact of Genetic and Non-Genetic Factors on Warfarin Dose Prediction in MENA Region: A Systematic Review.
Bader Loulia Akram et al. PloS one 2016 11(12) e0168732
(Posted: Dec 21, 2016 10AM)
Iterative Development and Evaluation of a Pharmacogenomic-Guided Clinical Decision Support System for Warfarin Dosing.
Melton Brittany L et al. Applied clinical informatics 2016 Nov 7(4) 1088-1106
(Posted: Nov 30, 2016 11AM)
Prediction of Warfarin Dose in Pediatric Patients: An Evaluation of the Predictive Performance of Several Models.
Marek Elizabeth et al. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 21(3) 224-32
(Posted: Aug 03, 2016 9AM)
Implementing algorithm-guided warfarin dosing in an ethnically diverse patient population using electronic health records and pre-emptive CYP2C9 and VKORC1 genetic testing.
Obeng Aniwaa Owusu et al. Clinical pharmacology and therapeutics 2016 Jul
(Posted: Jul 13, 2016 9AM)
Verification of five pharmacogenomics-based warfarin administration models.
Lin Meiqin et al. Indian journal of pharmacology 48(3) 258-63
(Posted: Jun 15, 2016 10AM)
Cost-effectiveness of pharmacogenetic-guided dosing of warfarin in the United Kingdom and Sweden.
Verhoef T I et al. The pharmacogenomics journal 2016 Jun
(Posted: Jun 15, 2016 10AM)
Anticoagulants: What Is New and What is the Standard?
Lesko Lawrence et al. Clinical pharmacology and therapeutics 2016 May
(Posted: Jun 08, 2016 2PM)
Warfarin Pharmacogenetics Reevaluated: Subgroup Analysis Reveals a Likely Underestimation of the Maximum Pharmacogenetic Benefit by Clinical Trials.
Stack Gary et al. American journal of clinical pathology 2016 May (5) 671-86
(Posted: Jun 08, 2016 2PM)
A Bayesian Estimation Framework for Pharmacogenomics Driven Warfarin Dosing: A Comparative Study.
Öztaner Serdar Murat et al. IEEE journal of biomedical and health informatics 2015 Sep 19(5) 1724-33
(Posted: Mar 30, 2016 9AM)
Alcohol misuse, genetics, and major bleeding among warfarin therapy patients in a community setting.
Roth Joshua A et al. Pharmacoepidemiology and drug safety 2015 Jun 24(6) 619-27
(Posted: Feb 24, 2016 10AM)
Pharmacogenetics-based warfarin dosing algorithm decreases time to stable anticoagulation and the risk of major hemorrhage: an updated meta-analysis of randomized controlled trials.
Wang Zhi-Quan et al. Journal of cardiovascular pharmacology 2015 Apr 65(4) 364-70
(Posted: Feb 03, 2016 3PM)
Pharmacogenetics-Based versus Conventional Dosing of Warfarin: A Meta-Analysis of Randomized Controlled Trials.
Shi Changcheng et al. PloS one 2015 10(12) e0144511
(Posted: Dec 29, 2015 10AM)
Genetic risk for atrial fibrillation could motivate patient adherence to warfarin therapy: a cost effectiveness analysis.
Shiffman Dov et al. BMC cardiovascular disorders 2015 15(1) 104
(Posted: Oct 06, 2015 5PM)
Cost-effectiveness analysis of pharmacogenetic-guided warfarin dosing in Thailand.
Chong Huey Yi et al. Thromb. Res. 2014 Dec 134(6) 1278-84
(Posted: Aug 11, 2015 4PM)
Universal versus genotype-guided use of direct oral anticoagulants in atrial fibrillation patients: a decision analysis.
You Joyce Hs et al. Pharmacogenomics 2015 Jul 31. 1-12
(Posted: Aug 04, 2015 2PM)
International warfarin genotype-guided dosing algorithms in the Turkish population and their preventive effects on major and life-threatening hemorrhagic events.
Karaca Sefayet et al. Pharmacogenomics 2015 Jul 28. 1-10
(Posted: Jul 29, 2015 11AM)
Clinical Practice Recommendations on Genetic Testing of CYP2C9 and VKORC1 Variants in Warfarin Therapy.
Shaw Kaitlyn et al. Ther Drug Monit 2015 Aug 37(4) 428-36
(Posted: Jul 22, 2015 0PM)
Medicare National Coverage Determinations
Baltimore (MD):Centers for Medicare & Medicaid Services (US) 2009
(Posted: Jul 01, 2015 2PM)
Development of a pharmacogenetic-based warfarin dosing algorithm and its performance in Brazilian patients: highlighting the importance of population-specific calibration.
Santos Paulo Caleb Junior Lima et al. Pharmacogenomics 2015 Jun 8. 1-12
(Posted: Jun 10, 2015 4PM)
Genotype-guided Drug Prescribing: A Systematic Review and Meta-analysis of Randomized Control Trials.
Goulding Rebecca et al. Br J Clin Pharmacol 2014 Jul 24.
(Posted: Mar 11, 2015 9AM)
The COAG and EU-PACT trials: what is the clinical benefit of pharmacogenetic-guided coumarin dosing during therapy initiation?
Baranova E V et al. Curr. Mol. Med. 2014 (7) 841-8
(Posted: Mar 11, 2015 9AM)
Warfarin pharmacogenomics: recommendations with available patented clinical technologies.
Borkowski Andrew A et al. Recent Pat Biotechnol 2014 (2) 110-5
(Posted: Mar 11, 2015 9AM)
Warfarin pharmacogenetics.
Johnson Julie A et al. Trends Cardiovasc. Med. 2015 Jan (1) 33-41
(Posted: Mar 11, 2015 9AM)
Novel single nucleotide polymorphism in CYP2C9 is associated with changes in warfarin clearance and CYP2C9 expression levels in African Americans.
Hernandez Wenndy et al. Transl Res 2014 Nov 22.
(Posted: Mar 11, 2015 9AM)
Genotype and risk of major bleeding during warfarin treatment.
Kawai Vivian K et al. Pharmacogenomics 2014 Dec (16) 1973-83
(Posted: Mar 11, 2015 9AM)
Genotype-guided coumarin dosing: where are we now and where do we need to go next?
Baranova Ekaterina V et al. Expert Opin Drug Metab Toxicol 2015 Jan 16. 1-14
(Posted: Mar 11, 2015 9AM)
CYP2C19*17 affects R-warfarin plasma clearance and warfarin INR/dose ratio in patients on stable warfarin maintenance therapy.
Chang Ming et al. Eur. J. Clin. Pharmacol. 2015 Feb 6.
(Posted: Mar 11, 2015 9AM)
Economic Analysis of Thrombo inCode, a Clinical-Genetic Function for Assessing the Risk of Venous Thromboembolism.
Rubio-Terrés C et al. Appl Health Econ Health Policy 2015 Feb 5.
(Posted: Mar 11, 2015 9AM)
PGWD: integrating personal genome for warfarin dosing.
Pan Yidan et al. Interdiscip Sci 2015 Feb 6.
(Posted: Mar 11, 2015 9AM)
Oral anticoagulation: a critique of recent advances and controversies.
Pirmohamed Munir et al. Trends Pharmacol. Sci. 2015 Mar (3) 153-163
(Posted: Mar 11, 2015 9AM)
Impact of CYP2C9 and VKORC1 genetic polymorphisms upon warfarin dose requirements in Egyptian patients with acute coronary syndrome.
Ghozlan Manal F et al. Blood Coagul. Fibrinolysis 2015 Feb 19.
(Posted: Mar 11, 2015 9AM)
Dosing Guideline for warfarin and CYP2C9, VKORC1
Clinical Pharmacogenomics Implementation Consortium 2014
(Posted: Mar 11, 2015 9AM)
Genetics and the clinical response to warfarin and edoxaban: findings from the randomised, double-blind ENGAGE AF-TIMI 48 trial
Jessica Mega et al. Lancet, March 10, 2015
(Posted: Mar 11, 2015 9AM)
Warfarin: What is it and Why is it used?
MedlinePlus, National Library of Medicine
(Posted: Mar 11, 2015 9AM)
Warfarin syndrome
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Warfarin sensitivity
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Warfarin resistance
From NCATS Genetic and Rare Diseases Information Center
(Posted: Jan 01, 2011 0AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
- Page last updated:Mar 27, 2024
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