Making cough count in tuberculosis care
AJ Zimmer et al, Comm Medicine, July 6, 2022
Acoustic epidemiology is an emerging field that uses technology to detect cough sounds and analyze cough patterns to improve health outcomes among people with respiratory conditions linked to cough. This field is increasingly exploring the potential of artificial intelligence (AI) for more advanced applications, such as analyzing cough sounds as a biomarker for disease screening. While much of the data are preliminary, objective cough assessment could potentially transform disease control programs, including TB, and support individual patient management.
Using Pharmacogenetics to Enhance Tuberculosis (TB) Treatment
M Moore et al, CDC Blog Post, February 22, 2022
A new CDC project provides an unprecedented opportunity to develop a tailored approach, by leveraging existing information collected in the international phase 3 clinical trial, to identify specific dosage recommendations of TB drugs for populations, which can improve TB treatment across all patient groups. Researchers will utilize precision public health techniques to assess treatment outcomes for TB treatment regimens, which may lead to improvements in the prevention and treatment of TB disease.
Precision Public Health in Action: New CDC Pilot Projects Integrating Human Genomics into Public Health Surveillance and Applied Research
M Clyne et al, CDC Blog Post, February 14, 2022
Six CDC projects were selected for funding in 2022 and 2023. They cover a wide range of topics, including: Assessing the impact of genetics in the control of two infectious diseases (Tuberculosis and Ebola), enhancing the reporting of gene/genome sequencing in newborn screening programs, examining the role of medications and genetics in the National Birth Defects Prevention Study (NBDPS), establishing population-based, ethnicity-specific allele frequencies for pharmacogenomic traits of public health importance using the National Health and Nutrition Examination Survey (NHANES), and enhancing the evaluation of genetic risk prediction models for inhibitor development among people with hemophilia in different populations.
Using Genomic Epidemiology to Advance Public Health Action
CDC Preventive Medicine Grand Rounds, February 22, 2022
Rapid advances in genomic technologies, such as genomic sequencing, are transforming how we respond to public health threats. Scientists use genomic sequencing to identify and prevent a wide variety of pathogens, including those that cause foodborne illness, tuberculosis, and COVID-19. Combining genomics and epidemiology—coined “genomic epidemiology”—provides a powerful tool for surveillance, outbreak detection, as well as response, and indicates a future where the human genome can direct public health action.