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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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143 hot topic(s) found with the query "Stroke "

Alternate approach to stroke phenotyping identifies a genetic risk locus for small vessel stroke
J Von Berg et al, EJHG, February 11, 2020 (Posted: Feb-12-2020 8AM)

The Stroke Family
The FH Foundation, January 6, 2020 (Posted: Jan-07-2020 8AM)

When some people are first diagnosed with FH, they have a hard time believing that they must be on medication to ensure protection of their arteries. There are folks coming to FH groups in disbelief, asking “if I don’t take my statins, or some other therapy, will I really get a heart attack? Will I be young when these things might happen to me?”

Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study
MC Georgakis et al, MedRXIV, December 30, 2019 (Posted: Dec-30-2019 9AM)

This study supports causal effects of T2D and hyperglycemia on large artery and small vessel stroke. We show differential effects of genetically determined insulin resistance and ß-cell dysfunction on large artery and small vessel stroke that might have implications for anti-diabetic treatments targeting these mechanisms.

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke.
Abraham Gad et al. Nature communications 2019 Dec (1) 5819 (Posted: Dec-23-2019 3PM)

Using a meta-scoring approach, we develop a metaGRS for ischaemic stroke (IS). The metaGRS hazard ratio for IS (1.26, 95% CI 1.22–1.31 per metaGRS standard deviation) doubles that of a previous GRS, identifying a subset of individuals at monogenic levels of risk: the top 0.25% of metaGRS have three-fold risk of IS.

Discovery of 318 novel loci for type-2 diabetes and related micro- and macrovascular outcomes among 1.4 million participants in a multi-ethnic meta-analysis.
M Vujkovic et al, BIoRXIV preprints, November 2019 (Posted: Nov-30-2019 10AM)

We investigated the genetic etiology of T2D-related vascular outcomes in the MVP and observed statistical SNP-T2D interactions at 13 variants, including 3 for coronary heart disease, 1 for PAD, 2 for stroke, 4 for retinopathy, 2 for CKD, and 1 for neuropathy.

Causal relationships between obesity and the leading causes of death in women and men.
Censin Jenny C et al. PLoS genetics 2019 Oct (10) e1008405 (Posted: Nov-16-2019 7AM)

Using mendelian randomization, obesity traits were found to be causally involved in the majority of the leading causes of death, and some obesity traits affect disease risk differently in men and women. This has potential implications for public health strategies and indicates that sex-specific preventative measures may be needed.

Opening the Black Box of Artificial Intelligence for Clinical Decision Support: A Study Predicting Stroke Outcome
E Zihni et al, MedRXIV, November 4, 2019 (Posted: Nov-04-2019 8AM)

We present in this work the first explainability comparison of two modern ML methods, tree boosting and multilayer perceptrons, to traditional logistic regression methods using a stroke outcome prediction paradigm. Here, we used clinical features to predict a dichotomized 90 days post-stroke.

Heart Disease and Stroke Map Widget
CDC, 2019 Brand (Posted: Oct-01-2019 8AM)

Genetic underpinnings of recovery after stroke: an opportunity for gene discovery, risk stratification, and precision medicine.
Acosta Julián N et al. Genome medicine 2019 Sep (1) 58 (Posted: Sep-18-2019 9AM)

Men and Stroke
CDC, 2019 Brand (Posted: Aug-28-2019 8AM)

Recovering From a Stroke Can Be a Long Road, But Don’t Give Up
CDC Information, 2019 Brand (Posted: Aug-28-2019 7AM)

Clark ate healthy and was in good physical condition before the stroke, but he also had high blood pressure and high cholesterol, which may have been a part of his family history; his grandmother passed away from a stroke.

Risk of Ischemic Stroke and Peripheral Arterial Disease in Heterozygous Familial Hypercholesterolemia: A Meta-Analysis.
Akioyamen Leo E et al. Angiology 2019 Sep 70(8) 726-736 (Posted: Aug-21-2019 8AM)

Heterozygous familial hypercholesterolemia (HeFH) is a common genetic disorder predisposing affected individuals to lifelong low-density lipoprotein cholesterol (LDL-C) elevation and coronary heart disease. However, whether HeFH increases the risk of peripheral arterial disease (PAD) and ischemic stroke is undetermined.

Association of APOL1 Risk Alleles with Cardiovascular Disease in African Americans in the Million Veteran Program.
Bick Alexander G et al. Circulation 2019 Jul (Posted: Jul-30-2019 8AM)

13% of African-Americans carry two copies of the APOL1 risk alleles, which are associated with increased risk of chronic kidney disease. The study We sought to test the association of APOL1 G1/G2 alleles with coronary artery disease (CAD), peripheral artery disease (PAD), and stroke among African American individuals in the Million Veteran Program (MVP).

Automating Ischemic Stroke Subtype Classification Using Machine Learning and Natural Language Processing.
Garg Ravi et al. Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 2019 Jul 28(7) 2045-2051 (Posted: Jul-24-2019 10AM)

Elevated Lipoprotein(a) and Risk of Ischemic Stroke
A Langsted et al, JACC, July 2019 (Posted: Jul-03-2019 9AM)

Genomic risk score offers predictive performance comparable to clinical risk factors for ischaemic stroke
G Abraham et al, BioXRIV preprints, July 3, 2019 (Posted: Jul-03-2019 8AM)

Recent genome-wide association studies in stroke have enabled the generation of genomic risk scores (GRS) but the predictive power of these GRS has been modest in comparison to established stroke risk factors. Using the UK biobank data, a new polygenic risk score for ischemic stroke was published. Predictive performance of the score is at least comparable to established clinical risk factors.

Predictive analytics and machine learning in stroke and neurovascular medicine.
Saber Hamidreza et al. Neurological research 2019 Apr 1-10 (Posted: May-20-2019 8AM)

Stroke genetics: discovery, biology, and clinical applications.
Dichgans Martin et al. The Lancet. Neurology 2019 Apr (Posted: Apr-17-2019 9AM)

Machine Learning-Based Model for Prediction of Outcomes in Acute Stroke.
Heo JoonNyung et al. Stroke 2019 Mar STROKEAHA118024293 (Posted: Mar-27-2019 8AM)

Blood Biomarkers for Stroke Diagnosis and Management.
Kamtchum-Tatuene Joseph et al. Neuromolecular medicine 2019 Mar (Posted: Mar-06-2019 9AM)

Gene in Infamous Experiment on Embryos Points to New Stroke Treatment
K Weintraub, Scientific American, February 20, 2019 (Posted: Feb-22-2019 9AM)

Association Between ABCB1 Polymorphisms and Outcomes of Clopidogrel Treatment in Patients With Minor Stroke or Transient Ischemic Attack- Secondary Analysis of a Randomized Clinical Trial
Y Pan et al, JAMA Neurology, February 11, 2019 (Posted: Feb-13-2019 8AM)

Matched Sibling Donor Hematopoietic Stem Cell Transplantation to Prevent Stroke in Children With Sickle Cell Anemia.
Kwiatkowski Janet L et al. JAMA 2019 Jan (3) 251-252 (Posted: Jan-24-2019 8AM)

Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants
LCA Rutten-Jacobs et al, BMJ, October 24, 2018 (Posted: Oct-25-2018 9AM)

A stroke gene panel for whole-exome sequencing
A Ilinca et al, EJHG, October 24, 2018 (Posted: Oct-24-2018 3PM)

Screening for Atrial Fibrillation With Electrocardiography: Evidence Report and Systematic Review for the US Preventive Services Task Force.
Jonas Daniel E et al. JAMA 2018 Aug (5) 485-498 (Posted: Aug-09-2018 9AM)

Screening for Atrial Fibrillation With Electrocardiography: US Preventive Services Task Force Recommendation Statement.
et al. JAMA 2018 Aug (5) 478-484 (Posted: Aug-09-2018 9AM)

Association Between Midlife Risk Factors and Late-Onset Epilepsy: Results From the Atherosclerosis Risk in Communities Study.
Johnson Emily L et al. JAMA neurology 2018 Jul (Posted: Aug-02-2018 8AM)

Genetic, laboratory and clinical risk factors in the development of overt ischemic stroke in children with sickle cell disease.
Belisário André Rolim et al. Hematology, transfusion and cell therapy 40(2) 166-181 (Posted: Aug-01-2018 10AM)

The Subtype Specificity of Genetic Loci Associated with Stroke in 16,664 cases and 32,792 controls
M Traylor et al, BioRxIV, July 20, 2018 (Posted: Jul-24-2018 8AM)

Validation of a Proteomic Biomarker Panel to Diagnose Minor-Stroke and Transient Ischaemic Attack: Phase 2 of SpecTRA, a Large Scale Translational Study.
Penn Andrew M et al. Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals 2018 Jul 1-45 (Posted: Jul-18-2018 9AM)

Large-Scale Phenome-Wide Association Study of PCSK9 Variants Demonstrates Protection Against Ischemic Stroke.
Rao Abhiram S et al. Circulation. Genomic and precision medicine 2018 Jul (7) e002162 (Posted: Jul-16-2018 2PM)

New layers in research, treatment of sickle cell trait and stroke
American Heart Association News, June 19, 2018 (Posted: Jun-19-2018 11AM)

A “Prime Example” of How Stroke Can Happen to Anyone
Brand (Posted: May-08-2018 0PM)

Challenges and Opportunities in Stroke Genetics.
Malik Rainer et al. Cardiovascular research 2018 Mar (Posted: May-01-2018 3PM)

Genetics and Family History Can Increase Risk for Stroke
Brand (Posted: May-01-2018 2PM)

National Stroke Awareness Month 2018: Stroke Can Happen to Anyone at Any Time
Focus on increasing awareness among adults ages 35 to 64 of stroke risk factors, signs, and symptoms Brand (Posted: May-01-2018 2PM)

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
R Malik et al, Nat Genet, Mar 12, 2018 (Posted: Mar-12-2018 2PM)

Genetic ancestry test beats self-reports in predicting bleeding stroke risk
American Heart Association Abstract, Jan 24, 2018 (Posted: Jan-25-2018 9AM)

Association of CETP Gene Variants With Risk for Vascular and Nonvascular Diseases Among Chinese Adults.
Millwood Iona Y et al. JAMA cardiology 2017 Nov (Posted: Nov-20-2017 2PM)

Advancing stroke genomic research in the age of Trans-Omics big data science: Emerging priorities and opportunities.
Owolabi Mayowa et al. Journal of the neurological sciences 2017 Nov 18-28 (Posted: Nov-15-2017 9AM)

Large-scale phenome-wide association study of PCSK9 loss-of-function variants demonstrates protection against ischemic stroke
AC Rao et al, BioRXiv preprints, Oct 2017 (Posted: Oct-29-2017 10AM)

The Involvement of miRNA in Carotid-Related Stroke.
Maitrias Pierre et al. Arteriosclerosis, thrombosis, and vascular biology 2017 Sep (9) 1608-1617 (Posted: Oct-19-2017 2PM)

Genetic signatures in ischemic stroke: Focus on aspirin resistance.
Munshi Anjana et al. CNS & neurological disorders drug targets 2017 Oct (Posted: Oct-19-2017 2PM)

Association of a Family History of Atrial Fibrillation With Incidence and Outcomes of Atrial Fibrillation: A Population-Based Family Cohort Study.
Chang Shang-Hung et al. JAMA cardiology 2017 Aug (8) 863-870 (Posted: Sep-24-2017 6AM)

Preventing Stroke Deaths
CDC Vital Signs, Sep 6, 2017 Brand (Posted: Sep-06-2017 2PM)

Biomarkers of stroke recovery: Consensus-based core recommendations from the Stroke Recovery and Rehabilitation Roundtable.
Boyd Lara A et al. International journal of stroke : official journal of the International Stroke Society 2017 Jul 12(5) 480-493 (Posted: Jul-19-2017 8AM)

Aspirin to Prevent a First Heart Attack or Stroke
NHLBI, 2017 Brand (Posted: Jul-13-2017 1PM)

Conditions that increase the risk of stroke include genetic diseases such as Sickle cell disease
Brand (Posted: May-09-2017 1PM)

20th Workshop of the International Stroke Genetics Consortium, November 3-4, 2016, Milan, Italy: 2016.036 ISGC research priorities.
Woo Daniel et al. Neurology. Genetics 2017 Mar (1 Suppl 1) S12-S18 (Posted: May-01-2017 10AM)

Genome-based cholesterol drug boosts heart health Treatment reduces the risk of heart attack and stroke, but might not live up to outsized expectations.
H Ledford, Nature News, March 18 2017 (Posted: Mar-20-2017 4PM)

PCOS and Diabetes, Heart Disease, Stroke...
Brand (Posted: Feb-10-2017 2PM)

Factors associated with young adults' knowledge regarding family history of Stroke.
Lima Maria Jose Melo Ramos et al. Revista latino-americana de enfermagem 2016 Nov 24e2814 (Posted: Nov-30-2016 11AM)

World Stroke Day: We Can Prevent Stroke
Brand (Posted: Oct-24-2016 2PM)

Pediatric Sickle Cell Disease - Past Successes and Future Challenges.
Meier Emily Riehm et al. Pediatric research 2016 Oct (Posted: Oct-20-2016 3PM)

Can the cardiovascular family history reported by our patients be trusted? The Norwegian Stroke in the Young Study.
Øygarden H et al. European journal of neurology 2016 Jan 23(1) 154-9 (Posted: Sep-07-2016 10AM)

Thousands of genes responsible for inherited risk for MI, stroke identified in specific tissues
Franzen O et al, Cardiology Today, August 2016 (Posted: Aug-29-2016 8AM)

Precision Medicine for Ischemic Stroke.
Rostanski Sara K et al. JAMA neurology 2016 Jul (7) 773-4 (Posted: Jul-25-2016 9PM)

Mind Your Risks and Act FAST to Prevent and Treat Strokes
CDC Public Health Grand Rounds, May 2016 Brand (Posted: May-10-2016 10AM)

Understanding Stroke Risk in Women
Brand (Posted: May-10-2016 8AM)

Genetic susceptibility to cerebrovascular disease.
Della-Morte David et al. Current opinion in lipidology 2016 Apr (2) 187-95 (Posted: May-02-2016 9AM)

Genetics as a molecular window into recovery, its treatment, and stress responses after stroke.
Juth Vanessa et al. Journal of investigative medicine : the official publication of the American Federation for Clinical Research 2016 Apr (Posted: May-02-2016 9AM)

Stop Stroke at Any Age
Brand (Posted: May-02-2016 9AM)

Genetic influences on the risk of stroke
Genomics Education UK, April 18, 2016 (Posted: Apr-18-2016 3PM)

What is Tay-Sachs Disease?
Information from the National Institute for Neurological Disorders and Stroke Brand (Posted: Dec-29-2015 8PM)

A diagnostic approach for cerebral palsy in the genomic era.
Lee Ryan W et al. Neuromolecular medicine 2014 Dec (4) 821-44 (Posted: Dec-10-2015 5PM)

Stroke is the fifth leading cause of death in the United States and is a major cause of adult disability
Brand (Posted: Oct-26-2015 4PM)

Heritability of young- and old-onset ischaemic stroke.
Bluher A et al. European journal of neurology : the official journal of the European Federation of Neurological Societies 2015 Nov (11) 1488-91 (Posted: Oct-26-2015 0PM)

Genome-wide association study on progression of carotid artery intima media thickness over 10 years in a Chinese cohort.
Xie Gaoqiang et al. Atherosclerosis 2015 Nov (1) 30-7 (Posted: Oct-26-2015 0PM)

Differences in Common Genetic Predisposition to Ischemic Stroke by Age and Sex.
Traylor Matthew et al. Stroke; a journal of cerebral circulation 2015 Oct (Posted: Oct-26-2015 0PM)

Universal versus genotype-guided use of direct oral anticoagulants in atrial fibrillation patients: a decision analysis.
You Joyce Hs et al. Pharmacogenomics 2015 Jul 31. 1-12 (Posted: Aug-04-2015 2PM)

Comparison of Atrial Fibrillation Guidelines.
Overvad Thure Filskov et al. J Gen Intern Med 2015 May 5. (Posted: Jun-21-2015 7PM)

Clinical Benefit of American College of Chest Physicians Versus European Society of Cardiology Guidelines for Stroke Prophylaxis in Atrial Fibrillation.
Andrade Ambar A et al. J Gen Intern Med 2015 May 7. (Posted: Jun-21-2015 7PM)

Stroke prevention in atrial fibrillation: a systematic review.
Lip Gregory Y H et al. JAMA 2015 May 19. (19) 1950-62 (Posted: Jun-21-2015 7PM)

Implementing Guidelines: The Cost and Clinical Impact of Anticoagulants in the UK Atrial Fibrillation Population.
Shields Gemma E et al. Appl Health Econ Health Policy 2015 Jun 16. (Posted: Jun-21-2015 7PM)

Stroke with atrial fibrillation or atrial flutter: a descriptive population-based study from the Brest stroke registry.
Jannou Virginie et al. BMC Geriatr 2015 (1) 63 (Posted: Jun-21-2015 7PM)

Stroke genomics in people of African ancestry: charting new paths.
Akinyemi R O et al. Cardiovasc J Afr 2015 Mar-Apr (2 Suppl 1) S39-49 (Posted: May-26-2015 1PM)

Familial risk for common diseases in primary care: the Family Healthware Impact Trial.
O'Neill Suzanne M et al. Am J Prev Med 2009 Jun (6) 506-14 (Posted: May-14-2015 11AM)

Family history and perceptions about risk and prevention for chronic diseases in primary care: a report from the family healthware impact trial.
Acheson Louise S et al. Genet. Med. 2010 Apr (4) 212-8 (Posted: May-14-2015 11AM)

Effect of preventive messages tailored to family history on health behaviors: the Family Healthware Impact Trial.
Ruffin Mack T et al. Ann Fam Med 2011 Jan-Feb (1) 3-11 (Posted: May-14-2015 11AM)

Health beliefs among individuals at increased familial risk for type 2 diabetes: implications for prevention.
Dorman Janice S et al. Diabetes Res. Clin. Pract. 2012 May (2) 156-62 (Posted: May-14-2015 11AM)

Check out genetic conditions and tests associated with stroke
from the NIH Genetic Testing Registry Brand (Posted: May-06-2015 4PM)

CYP2C8 rs17110453 and EPHX2 rs751141 two-locus interaction increases susceptibility to ischemic stroke.
Yi Xingyang et al. Gene 2015 Jul 1. (1) 85-9 (Posted: May-05-2015 10AM)

Association between the FGB gene polymorphism and ischemic stroke: a meta-analysis.
Zhang X F et al. Genet. Mol. Res. 2015 (1) 1741-7 (Posted: May-05-2015 10AM)

Tobacco smoking strongly modifies the association of prothrombin G20210A with undetermined stroke: Consecutive survivors and population-based controls.
Krajcoviechova A et al. Atherosclerosis 2015 Apr 11. (2) 446-452 (Posted: May-05-2015 10AM)

The Association between Carbohydrate-Rich Foods and Risk of Cardiovascular Disease Is Not Modified by Genetic Susceptibility to Dyslipidemia as Determined by 80 Validated Variants.
Sonestedt Emily et al. PLoS ONE 2015 (4) e0126104 (Posted: May-05-2015 10AM)

Genetic factors in cerebral small vessel disease and their impact on stroke and dementia.
Haffner Christof et al. J. Cereb. Blood Flow Metab. 2015 Apr 22. (Posted: May-05-2015 10AM)

No Additional Prognostic Value of Genetic Information in the Prediction of Vascular Events after Cerebral Ischemia of Arterial Origin: The PROMISe Study.
Achterberg Sefanja et al. PLoS ONE 2015 (4) e0119203 (Posted: May-05-2015 10AM)

Tackling shared genetic underpinnings of migraine and ischemic stroke.
Debette Stéphanie et al. Neurology 2015 May 1. (Posted: May-05-2015 10AM)

Shared genetic basis for migraine and ischemic stroke: A genome-wide analysis of common variants.
Malik Rainer et al. Neurology 2015 May 1. (Posted: May-05-2015 10AM)

Stroke in sickle cell anemia patients: a need for multidisciplinary approaches.
Menaa Farid et al. Atherosclerosis 2013 Aug (2) 496-503 (Posted: May-01-2015 11AM)

Costs of pediatric stroke care in the United States: a systematic and contemporary review.
Ellis Charles et al. Expert Rev Pharmacoecon Outcomes Res 2014 Oct (5) 643-50 (Posted: May-01-2015 11AM)

Strokes in children: a systematic review.
Gumer Lindsey Barst et al. Pediatr Emerg Care 2014 Sep (9) 660-4 (Posted: May-01-2015 11AM)

Proteomic and biomarker studies and neurological complications of pediatric sickle cell disease.
Lance Eboni I et al. Proteomics Clin Appl 2014 Dec (11-12) 813-27 (Posted: May-01-2015 11AM)

Methylenetetrahydrofolate reductase gene A1298C polymorphism in pediatric stroke--case-control and family-based study.
Balcerzyk Anna et al. J Stroke Cerebrovasc Dis 2015 Jan (1) 61-5 (Posted: May-01-2015 11AM)

Systematic review: hereditary thrombophilia associated to pediatric strokes and cerebral palsy.
Torres Vinicius M et al. J Pediatr (Rio J) 2015 Jan-Feb (1) 22-9 (Posted: May-01-2015 11AM)

Paediatric stroke: pressing issues and promising directions.
Kirton Adam et al. Lancet Neurol 2015 Jan (1) 92-102 (Posted: May-01-2015 11AM)

What causes stroke in children?
From the American Stroke Association (Posted: May-01-2015 10AM)

Genome-wide association studies of late-onset cardiovascular disease.
Smith J Gustav et al. J. Mol. Cell. Cardiol. 2015 Apr 11. (Posted: May-01-2015 9AM)

Systematic review: hereditary thrombophilia associated to pediatric strokes and cerebral palsy.
Torres Vinicius M et al. J Pediatr (Rio J) 2015 Jan-Feb (1) 22-9 (Posted: Mar-25-2015 10AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.