Archive
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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Archived Hot Topics of the Day By Date
Mediating Factors in the Association of Maternal Educational Level With Pregnancy Outcomes: A Mendelian Randomization Study.
Tormod Rogne et al. JAMA Netw Open 2024 1 (1) e2351166
(Posted: Jan 12, 2024 6AM)
Lung cancer in patients who have never smoked - an emerging disease.
Jaclyn LoPiccolo et al. Nat Rev Clin Oncol 2024 1
(Posted: Jan 11, 2024 7AM)
Comprehensive evaluation of smoking exposures and their interactions on DNA methylation
TT Hoang et al, EBiomedicine, January 9, 2024
(Posted: Jan 10, 2024 8AM)
Neighborhood Deprivation Measures and DNA Methylation Clocks-Understanding the Real Needs of Each Person.
Benjamin D Horne et al. JAMA Netw Open 2023 11 (11) e2344688
(Posted: Dec 02, 2023 9AM)
Rare coding variants in CHRNB2 reduce the likelihood of smoking.
Veera M Rajagopal et al. Nat Genet 2023 6
(Posted: Jun 13, 2023 9AM)
Potential utility of risk stratification for multicancer screening with liquid biopsy tests
ES Kim et al, NPJ Precision Oncology, April 22, 2023
(Posted: Apr 23, 2023 0PM)
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk.
Nick Shrine et al. Nature genetics 2023 3 (3) 410-422
(Posted: Mar 15, 2023 6PM)
The necessity of incorporating non-genetic risk factors into polygenic risk score models
S van Dam et al, Sci Reports, February 20, 2023
(Posted: Feb 20, 2023 8AM)
How rare mutations contribute to complex traits
LM Evans et al, Nature, February 8, 2023
(Posted: Feb 09, 2023 6AM)
Largest-ever analysis finds genetic links to smoking and drinking
M Naddaf, Nature Genetics, December 8, 2022
(Posted: Dec 08, 2022 1PM)
Multi-omics signatures of the human early life exposome
L Maitre et al, Nature Comm, November 21, 2022
(Posted: Nov 21, 2022 8AM)
Gene-environment interactions in Alzheimer disease: the emerging role of epigenetics.
Migliore Lucia et al. Nature reviews. Neurology 2022 9 (11) 643-660
(Posted: Nov 06, 2022 1PM)
From the Genome to the Exposome: Mapping Causal Associations Between Environmental Factors and Population Health
D Rasooly et al, CDC Blog Post, September 6, 2022
(Posted: Sep 06, 2022 0PM)
Rare genetic variants explain missing heritability in smoking.
Jang Seon-Kyeong et al. Nature human behaviour 2022 8
(Posted: Aug 08, 2022 7AM)
The oral microbiome and lung cancer risk: An analysis of 3 prospective cohort studies
E Vogtman et al, JNCI, August 5, 2022
(Posted: Aug 06, 2022 6AM)
Cross-ancestry genome-wide meta-analysis of 61,047 cases and 947,237 controls identifies new susceptibility loci contributing to lung cancer
J Byun et al, Nature Genetics, August 1, 2022
(Posted: Aug 01, 2022 11AM)
Mendelian randomization analysis for attention deficit/hyperactivity disorder: studying a broad range of exposures and outcomes.
Soler Artigas María et al. International journal of epidemiology 2022 6
(Posted: Jun 18, 2022 10AM)
Largest study of whole genome sequencing data reveals new clues to causes of cancer
Genomics England, April 21, 2022
(Posted: Apr 23, 2022 9AM)
Grandmaternal smoking during pregnancy is associated with differential DNA methylation in peripheral blood of their grandchildren
SM Watkins et al, EJHG, March 28, 2022
(Posted: Mar 29, 2022 7AM)
Culturally adapting internet- and mobile-based health promotion interventions might not be worth the effort: a systematic review and meta-analysis
S Balci et al, NPJ Digital Medicine, March 23, 2022
(Posted: Mar 24, 2022 8AM)
Gene-lifestyle interactions in the genomics of human complex traits
V Laville et al, EJHG, March 22, 2022
(Posted: Mar 23, 2022 8AM)
Get Inspired to Quit With the Tips From Former Smokers Campaign
CDC, March 2022
(Posted: Mar 02, 2022 8AM)
Novel insights into the consequences of obesity: a phenotype-wide Mendelian randomization study
C He et al, EJHG January 1, 2022
(Posted: Jan 03, 2022 2PM)
Interaction of Cigarette Smoking and Polygenic Risk Score on Reduced Lung Function
W Kim et al, JAMA Network Open, December 20, 2021
(Posted: Dec 21, 2021 10AM)
Compelling Interaction of Cigarette Smoking and Polygenetic Risk Emerges for Lung Function and COPD
DB Hancock et al, JAMA Network Open, December 20, 2021
(Posted: Dec 21, 2021 10AM)
Attenuation of antibody titres during 3-6 months after the second dose of the BNT162b2 vaccine depends on sex, with age and smoking as risk factors for lower antibody titres at 6 months
Y Nomura et al, MEDRXIV, November 17, 2021
(Posted: Nov 17, 2021 10AM)
Special focus issue on epigenomics and health disparities: foreword.
Argentieri M Austin et al. Epigenomics 2021 10
(Posted: Oct 15, 2021 10AM)
Four Things You Should Know About Arthritis
CDC, October 2021
(Posted: Oct 10, 2021 7AM)
Determinants of SARS-CoV-2 entry and replication in airway mucosal tissue and susceptibility in smokers
T Nakanayma et al, Cell Reports Medicine, September 27,2021
(Posted: Sep 28, 2021 2PM)
Genomic and evolutionary classification of lung cancer in never smokers
T Zhang et al, Nature Genetics, September 6, 2021
(Posted: Sep 07, 2021 6AM)
Genetically Predicted Cigarette Smoking in Relation to Risk of Polycystic Ovary Syndrome.
Tao Yingli et al. Clinical epidemiology 2021 13527-532
(Posted: Jul 13, 2021 8AM)
Mapping the human genetic architecture of COVID-19
COVID-19 Host Genetics Initiative, Nature, July 8, 2021
(Posted: Jul 08, 2021 0PM)
Health Equity for People with Disabilities
CDC, July 2021
(Posted: Jul 08, 2021 8AM)
Towards personalized treatment of smoking-related lung cancers
G Middleton, Nature, June 18, 2021
(Posted: Jun 20, 2021 7AM)
Identifying risk factors for COVID-19 severity and mortality in the UK Biobank
I Madalkatel et al, MEDRXIV, May 11, 2021
(Posted: May 12, 2021 8AM)
Central obesity, smoking habit and hypertension are associated with a blunted serological response to COVID-19 mRNA vaccine
M Watanabe et al, MERXIV, April 15, 2021
(Posted: Apr 16, 2021 7AM)
Association of genetic liability to smoking initiation with e-cigarette use in young adults: A cohort study.
Khouja Jasmine N et al. PLoS medicine 2021 3 (3) e1003555
(Posted: Mar 21, 2021 7AM)
Genetics of Smoking and Risk of Atherosclerotic Cardiovascular Diseases
A Mendelian Randomization Study
MG Levin et al, JAMA Network Open, January 19, 2021
(Posted: Jan 20, 2021 7AM)
Risk Factors for Hospitalization, Mechanical Ventilation, or Death Among 10 131 US Veterans With SARS-CoV-2 Infection
GN Ioannou et al, JAMA Network Open, September 23, 2020
(Posted: Sep 23, 2020 1PM)
Efficacy of Smartphone Applications for Smoking Cessation
A Randomized Clinical Trial
JB Bricker et al, JAMA Internal Medicine, September 21, 2020
(Posted: Sep 22, 2020 10AM)
Deep Learning Using Chest Radiographs to Identify High-Risk Smokers for Lung Cancer Screening Computed Tomography: Development and Validation of a Prediction Model.
Lu Michael T et al. Annals of internal medicine 2020 Sep
(Posted: Sep 03, 2020 7AM)
Smoking, alcohol consumption, and cancer: A mendelian randomisation study in UK Biobank and international genetic consortia participants.
Larsson Susanna C et al. PLoS medicine 2020 Jul (7) e1003178
(Posted: Jul 29, 2020 8AM)
Blood DNA methylation signatures to detect dementia prior to overt clinical symptoms
PD Fransquet et al, Blood Based Biomarkers, July 2020
(Posted: Jul 22, 2020 8AM)
Cardiometabolic traits, sepsis and severe covid-19 with respiratory failure: a Mendelian randomization investigation
PJ Mark et al, MEDRXIV, June 20, 2020
(Posted: Jun 22, 2020 8AM)
A grim scorekeeper of biological aging
JS Stevens, Sci Trans Med, May 28, 2020
(Posted: May 29, 2020 7AM)
Smoking Cessation—Progress, Barriers, and New Opportunities- The Surgeon General’s Report on Smoking Cessation
JM Adams, JAMA, May 20, 2020
(Posted: May 21, 2020 9AM)
Opportunistic deep learning of retinal photographs: the window to the body revisited
SM Waldstein, Lancet Digital Health, May 14, 2020
(Posted: May 15, 2020 3PM)
Genetic evidence for protective effects of smoking and drinking behavior on Parkinson's disease: A Mendelian Randomization study
CD Baleon et al, MEDRXIV, April 24, 2020
(Posted: Apr 24, 2020 8AM)
Whole‐Genome Approach Discovers Novel Genetic and Nongenetic Variance Components Modulated by Lifestyle for Cardiovascular Health
X Zhou et al, JAHA, April 2020
(Posted: Apr 23, 2020 8AM)
Incidence, clinical characteristics and prognostic factor of patients with COVID-19: a systematic review and meta-analysis
X Zhao et al, MEDRXIV, March 20, 2020
(Posted: Mar 22, 2020 11AM)
A randomized controlled trial of a smoking cessation smartphone application with a carbon monoxide checker
K Masaki et al, NPJ Digital Medicine, March 12, 2020
(Posted: Mar 12, 2020 10AM)
Smoking, DNA Methylation, and Lung Function: a Mendelian Randomization Analysis to Investigate Causal Pathways.
Jamieson Emily et al. American journal of human genetics 2020 Feb
(Posted: Feb 28, 2020 8AM)
Aspirin for Prevention of Cardiovascular Disease
AT Peters et al, JAMA Patient Page, February 18, 2020
(Posted: Feb 23, 2020 0PM)
Smoking Cessation: A Report of the Surgeon General
CDC, February 2020
(Posted: Feb 13, 2020 8AM)
Tobacco smoking and somatic mutations in human bronchial epithelium.
Yoshida Kenichi et al. Nature 2020 Jan
(Posted: Jan 31, 2020 9AM)
Smoke signals in the DNA of normal lung cells
Nature News, January 30, 2020
(Posted: Jan 31, 2020 9AM)
Quit Smoking for Better Health
CDC, January 2020
(Posted: Jan 27, 2020 6AM)
An exploration of smokeless tobacco product nucleic acids: a combined metagenome and metatranscriptome analysis.
Tyx R E et al. Applied microbiology and biotechnology 2020 Jan 104(2) 751-763
(Posted: Jan 22, 2020 9AM)
Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health.
Yang Qian et al. International journal of epidemiology 2019 Dec
(Posted: Dec 22, 2019 6PM)
Screening for Abdominal Aortic Aneurysm-A Call to Arms?
Mell Matthew et al. JAMA network open 2019 Dec (12) e1917168
(Posted: Dec 12, 2019 9AM)
Smokefree Through Generations
CDC, 2019
(Posted: Nov 21, 2019 11AM)
Alzheimer's Disease-Genes Do Not Equal Destiny
CDC Podcast, October 22, 2019
(Posted: Oct 23, 2019 8AM)
Pancreatic Cancer: Patient Page
JAMA, October 2019
(Posted: Oct 13, 2019 1PM)
Appraising the causal relevance of DNA methylation for risk of lung cancer.
Battram Thomas et al. International journal of epidemiology 2019 Sep
(Posted: Sep 26, 2019 8AM)
Cognitive and Affective Responses to Mass-media Based Genetic Risk Information in a Socio-demographically Diverse Sample of Smokers.
Waters Erika A et al. Journal of health communication 2019 Sep 1-11
(Posted: Sep 18, 2019 9AM)
Ambulatory Smoking Habits Investigation based on Physiology and Context (ASSIST) using wearable sensors and mobile phones: protocol for an observational study.
Zhai Donghui et al. BMJ open 2019 Sep 9(9) e028284
(Posted: Sep 18, 2019 9AM)
E-Cigarettes: Talk to Youth About the Risks
CDC Information, 2019
(Posted: Aug 21, 2019 8AM)
Identifying Smoking Environments From Images of Daily Life With Deep Learning
MM Engelhard et al, JAMA Network Open, August 2, 2019
(Posted: Aug 03, 2019 0PM)
New study offers "good news" for those with genetic risk for Alzheimer's
CBS News, July 15, 2019
(Posted: Jul 17, 2019 8AM)
A healthy lifestyle may offset genetic risk for Alzheimers
Associated Press, July 14, 2019 (via StatNews)
(Posted: Jul 16, 2019 8AM)
Experimental Acute Exposure to Thirdhand Smoke and Changes in the Human Nasal Epithelial Transcriptome
A Randomized Clinical Trial
GL Pozuelos et al, JAMA Network Open, June 28, 2019
(Posted: Jul 01, 2019 9AM)
Gene Variant Associated With Menthol Cigarette Smoking in Some African Americans
J Abbasi, JAMA, June 5, 2019
(Posted: Jun 05, 2019 0PM)
WhatsApp embedded in routine service delivery for smoking cessation: effects on abstinence rates in a randomized controlled study.
Durmaz Seyfi et al. BMC public health 2019 Apr 19(1) 387
(Posted: May 29, 2019 9AM)
Biomedical risk assessment as an aid for smoking cessation.
Clair Carole et al. The Cochrane database of systematic reviews 2019 Mar 3CD004705
(Posted: Apr 03, 2019 9AM)
Former Smokers and Their Families Speak Out
CDC, April 2019
(Posted: Apr 01, 2019 10AM)
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
Bentley Amy R et al. Nature genetics 2019 Apr (4) 636-648
(Posted: Apr 01, 2019 10AM)
GWAS of smoking behaviour in 165,436 Japanese people reveals seven new loci and shared genetic architecture
N Matoba et al, Nature Human Behavior, March 25, 2019
(Posted: Mar 26, 2019 9AM)
A specific amino acid motif of HLA-DRB1 mediates risk and interacts with smoking history in Parkinsons disease
JA Hollenbach et al, PNAS, March 25, 2019
(Posted: Mar 26, 2019 8AM)
How genes affect tobacco and alcohol use
Data from 1.2 million people reveal how tobacco and alcohol use may be linked to your genes and to various
Eureka Alert, February 21, 2019
(Posted: Feb 21, 2019 9AM)
Tobacco Use By Youth Is Rising- E-cigarettes are the main reason
CDC Vital Signs, February 2019
(Posted: Feb 13, 2019 9AM)
Smoking Cessation Pharmacotherapy Based on Genetically-Informed Biomarkers: What is the Evidence?
Panagiotou Orestis A et al. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco 2019 Jan
(Posted: Jan 30, 2019 9AM)
Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
M Liu et al, Nature Genetics, January 14, 2019
(Posted: Jan 14, 2019 11AM)
Place-Based Inequity in Smoking Prevalence in the Largest Cities in the United States
EC Leas et al, JAMA Internal Medicine, January 2019
(Posted: Jan 14, 2019 8AM)
Its Never Too Early to Quit Smoking
CDC, January 2019
(Posted: Jan 09, 2019 0PM)
Use of polygenic risk scores of nicotine metabolism in predicting smoking behaviors.
Chen Li-Shiun et al. Pharmacogenomics 2018 Nov
(Posted: Nov 19, 2018 9AM)
Most Current Smokers Desire Genetic Susceptibility Testing and Genetically-Efficacious Medication
A Chiu et al, J Neuroimmune Pharma, October 29, 2018
(Posted: Oct 30, 2018 0PM)
Predicting smoking abstinence with biological and self-report measures of adherence to varenicline: Impact on pharmacogenetic trial outcomes.
Peng Annie R et al. Drug and alcohol dependence 2018 Jun 19072-81
(Posted: Jul 11, 2018 9AM)
From genes to treatments: a systematic review of the pharmacogenetics in smoking cessation.
Salloum Naji C et al. Pharmacogenomics 2018 Jun
(Posted: Jun 20, 2018 9AM)
Polygenic Risk Score for Coronary Heart Disease Modifies the Elevated Risk by Cigarette Smoking for Disease Incidence.
Hindy George et al. Circulation. Genomic and precision medicine 2018 Jan 11(1) e001856
(Posted: Jun 11, 2018 11AM)
Tobacco Product Use Among Middle and High School Students - United States, 2011-2017.
Wang Teresa W et al. MMWR. Morbidity and mortality weekly report 2018 Jun (22) 629-633
(Posted: Jun 08, 2018 8AM)
Protect Your Heart from Tobacco
(Posted: Jun 01, 2018 1PM)
Genomic and Bioinformatics Approaches for Analysis of Genes Associated With Cancer Risks Following Exposure to Tobacco Smoking.
Al-Obaide Mohammed A I et al. Frontiers in public health 2018 84
(Posted: Apr 23, 2018 1PM)
Dear John, Theres no point in waiting any longer. Lets call it quits
S Bowen et al, CDC Blog, Mar 7, 2018
(Posted: Mar 07, 2018 7PM)
Factors influencing the impact of pharmacogenomic prescribing on adherence to nicotine replacement therapy: A qualitative study of participants from a randomized controlled trial.
Wright Alison J et al. Translational behavioral medicine 2018 Jan (1) 18-28
(Posted: Feb 02, 2018 10AM)
Current Cigarette Smoking Among Adults - United States, 2016.
Jamal Ahmed et al. MMWR. Morbidity and mortality weekly report 2018 Jan (2) 53-59
(Posted: Feb 01, 2018 9AM)
Toward the implementation of genomic applications for smoking cessation and smoking-related diseases.
Ramsey Alex T et al. Translational behavioral medicine 2018 Jan (1) 7-17
(Posted: Feb 01, 2018 8AM)
Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure.
Choi Jung Ran et al. Annals of occupational and environmental medicine 2016 13
(Posted: Jan 23, 2018 10AM)
Preparing the Way: Exploiting Genomic Medicine to Stop Smoking.
Bierut Laura J et al. Trends in molecular medicine 2018 Jan
(Posted: Jan 23, 2018 9AM)
From sperm to offspring: Assessing the heritable genetic consequences of paternal smoking and potential public health impacts.
Beal Marc A et al. Mutation research 2017 Jul 26-50
(Posted: Nov 15, 2017 8AM)
Quitting Can Make You a Winner
(Posted: Nov 15, 2017 8AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
- Page last updated:Apr 19, 2024
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