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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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52 hot topic(s) found with the query "Skin cancer"

Superior skin cancer classification by the combination of human and artificial intelligence.
Hekler Achim et al. European journal of cancer (Oxford, England : 1990) 2019 Sep 114-121 (Posted: Sep-15-2019 8AM)

Using 11,444 dermoscopic images, which were divided into five diagnostic categories, novel deep learning techniques were used to train a single network. Then, both 112 dermatologists of 13 German university hospitals and the trained neural convolutional network independently classified a set of 300 biopsy-verified skin lesions into those five classes.


Assessment of Deep Learning Using Nonimaging Information and Sequential Medical Records to Develop a Prediction Model for Nonmelanoma Skin Cancer.
Wang Hsiao-Han et al. JAMA dermatology 2019 Sep (Posted: Sep-05-2019 8AM)


Exploring various polygenic risk scores for skin cancer in the phenomes of the Michigan genomics initiative and the UK Biobank with a visual catalog: PRSWeb.
Fritsche Lars G et al. PLoS genetics 2019 Jun 15(6) e1008202 (Posted: Jun-19-2019 9AM)


What Role Does Genetics Play in Skin Cancer Risk? Protecting yourself from UV rays still matters most of all. But your genes can also have an impact.
M Schroder, US News, April 18, 2019 (Posted: Apr-20-2019 8AM)


Machine Learning in Medicine.
Rajkomar Alvin et al. The New England journal of medicine 2019 Apr (14) 1347-1358 (Posted: Apr-04-2019 10AM)


Use of gene expression profile testing as a prognostic tool in early-stage cutaneous melanoma - compelling but not ready for primetime.
Christensen Luisa et al. Melanoma research 2018 Sep (Posted: Sep-19-2018 9AM)


Immunotherapy for Melanoma Metastatic to the Brain.
Turajlic Samra et al. The New England journal of medicine 2018 Aug (8) 789-790 (Posted: Aug-23-2018 8AM)


Immunotherapy Drugs Slow Skin Cancer That Has Spread to the Brain
D Grady, NY Times, August 22, 2018 (Posted: Aug-23-2018 8AM)


Skin Cancer Prevention Progress Report
CDC, 2018 Brand (Posted: Jul-06-2018 10AM)


Sun Safe Selfie
Nearly 5 million people are treated for skin cancer each year in the United States. Skin cancer can be serious, expensive, and sometimes even deadly Brand (Posted: May-01-2018 0PM)


Genetic test reporting of CDKN2A provides informational and motivational benefits for managing melanoma risk.
Aspinwall Lisa G et al. Translational behavioral medicine 2018 Jan (1) 29-43 (Posted: Feb-06-2018 1PM)


Summer Sun Safety: Protect Yourself from UV Radiation
Brand (Posted: Jun-29-2017 1PM)


Does personalised melanoma genomic risk information trigger conversations about skin cancer prevention and skin examination with family, friends and health professionals?
Smit A K et al. The British journal of dermatology 2017 Jun (Posted: Jun-21-2017 8AM)


Translation and adaptation of skin cancer genomic risk education materials for implementation in primary care.
Rodríguez Vivian M et al. Journal of community genetics 2016 Dec (Posted: Dec-14-2016 0PM)


A pilot randomised controlled trial of the feasibility, acceptability and impact of giving information on personalised genomic risk of melanoma to the public.
Smit Amelia K et al. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2016 Oct (Posted: Oct-12-2016 11AM)


Skin Cancer—The Importance of Prevention
E Linos et al, JAMA Internal Medicine, July 26,2016 (Posted: Jul-26-2016 3PM)


Screening for Skin Cancer- US Preventive Services Task Force Recommendation Statement
USPSTF, JAMA, July 26, 2016 (Posted: Jul-26-2016 3PM)


What Are the Risk Factors for Skin Cancer?
Brand (Posted: Jul-06-2016 11AM)


Hereditary melanoma: Update on syndromes and management: Genetics of familial atypical multiple mole melanoma syndrome.
Soura Efthymia et al. Journal of the American Academy of Dermatology 2016 Mar (3) 395-407 (Posted: May-23-2016 6AM)


Familial skin cancer syndromes: Increased melanoma risk.
Ransohoff Katherine J et al. Journal of the American Academy of Dermatology 2016 Mar (3) 423-34 (Posted: May-23-2016 6AM)


'Sunscreen' gene may help protect against skin cancer
Ecancer news, May 19, 2016 (Posted: May-23-2016 6AM)


Prediction of Melanoma Risk in a Southern European Population Based on a Weighted Genetic Risk Score.
Kypreou Katerina P et al. The Journal of investigative dermatology 2016 Mar 136(3) 690-5 (Posted: Mar-30-2016 9AM)


Melanoma Epidemiology and Prevention.
Berwick Marianne et al. Cancer treatment and research 2016 17-49 (Posted: Mar-07-2016 1PM)


Genomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma
X Bonilla e al, Nature Genetics, March 7, 2016 (Posted: Mar-07-2016 1PM)


Liquid biopsy utility for the surveillance of cutaneous malignant melanoma patients.
Huang Sharon K et al. Molecular oncology 2016 Mar (3) 450-63 (Posted: Mar-04-2016 0PM)


Genomic Classification of Cutaneous Melanoma.
Cell 2015 Jun (7) 1681-96 (Posted: Jan-04-2016 10AM)


CDC Grand Rounds: Prevention and Control of Skin Cancer
MMWR, December 3, 2015 (Posted: Dec-04-2015 11AM)


Future perspectives in melanoma research: meeting report from the "Melanoma Bridge": Napoli, December 3rd-6th 2014.
Ascierto Paolo A et al. Journal of translational medicine 2015 (1) 374 (Posted: Dec-03-2015 8PM)


Update in genetic susceptibility in melanoma.
Potrony Miriam et al. Annals of translational medicine 2015 Sep (15) 210 (Posted: Dec-03-2015 8PM)


Improving outcomes in patients with melanoma: strategies to ensure an early diagnosis.
Voss Rachel K et al. Patient related outcome measures 229-242 (Posted: Dec-03-2015 8PM)


Telomere length and the risk of cutaneous melanoma and non-melanoma skin cancer: a review of the literature and meta-analysis.
Caini Saverio et al. J. Dermatol. Sci. 2015 Aug 22. (Posted: Sep-20-2015 0PM)


Genomic correlates of response to CTLA4 blockade in metastatic melanoma.
Van Allen Eliezer M et al. Science 2015 Sep 10. (Posted: Sep-13-2015 1PM)


Update on melanoma epigenetics.
de Unamuno Blanca et al. Curr Opin Oncol 2015 Sep (5) 420-6 (Posted: Aug-20-2015 10AM)


Tumor evolution. High burden and pervasive positive selection of somatic mutations in normal human skin.
Martincorena Iñigo et al. Science 2015 May 22. (6237) 880-6 (Posted: May-26-2015 10AM)


Cancer. Preprocancer.
Brash Douglas E et al. Science 2015 May 22. (6237) 867-8 (Posted: May-26-2015 10AM)


It's Melanoma and Skin Cancer Awareness Month
From the American Association for Cancer Research (Posted: May-18-2015 9AM)


Genome-Wide DNA Methylation Analysis in Melanoma Reveals the Importance of CpG Methylation in MITF Regulation.
Lauss Martin et al. J. Invest. Dermatol. 2015 Feb 23. (Posted: Apr-10-2015 1PM)


Targeted Therapies in Melanoma.
Moschos Stergios J et al. Surg. Oncol. Clin. N. Am. 2015 Apr (2) 347-358 (Posted: Apr-10-2015 1PM)


Pleiotropic and Sex-Specific Effects of Cancer GWAS SNPs on Melanoma Risk in the Population Architecture Using Genomics and Epidemiology (PAGE) Study.
Kocarnik Jonathan M et al. PLoS ONE 2015 (3) e0120491 (Posted: Apr-10-2015 1PM)


Molecular characterization of melanoma cases in denmark suspected of genetic predisposition.
Wadt Karin A W et al. PLoS ONE 2015 (3) e0122662 (Posted: Apr-10-2015 1PM)


Inherited genetic variants associated with occurrence of multiple primary melanoma.
Gibbs David C et al. Cancer Epidemiol. Biomarkers Prev. 2015 Apr 2. (Posted: Apr-10-2015 1PM)


Genetics of Skin Cancer (PDQ®)
from the National Cancer Institute (Posted: Mar-17-2015 10AM)


Milestones in skin carcinogenesis: the biology of multistage carcinogenesis.
Balmain Allan et al. J. Invest. Dermatol. 2014 (e1) E2-7 (Posted: Mar-17-2015 10AM)


Genetic basis for clinical response to CTLA-4 blockade in melanoma.
Snyder Alexandra et al. N. Engl. J. Med. 2014 Dec 4. (23) 2189-99 (Posted: Mar-17-2015 10AM)


Cancer systems biology of TCGA SKCM: efficient detection of genomic drivers in melanoma.
Guan Jian et al. Sci Rep 2015 7857 (Posted: Mar-17-2015 10AM)


Genetic variants in Hippo pathway genes YAP1, TEAD1 and TEAD4 are associated with melanoma-specific survival.
Yuan Hua et al. Int. J. Cancer 2015 Jan 13. (Posted: Mar-17-2015 10AM)


The melanoma revolution: from UV carcinogenesis to a new era in therapeutics.
Lo Jennifer A et al. Science 2014 Nov 21. (6212) 945-9 (Posted: Mar-08-2015 9AM)


CDC Information: Skin Cancer Prevention
Traveling for spring break? Don't forget to pack, protect yourself from the sun, and go! Brand (Posted: Feb-25-2015 0PM)


Prevention and Control of Skin Cancer
CDC Public Health Grand Rounds Brand (Posted: Feb-25-2015 0PM)


CDC Information: Skin Cancer Awareness
Brand (Posted: Feb-25-2015 0PM)


Genetics of Skin Cancer (PDQ®)–Health Professional Version
Brand (Posted: Jan-11-2014 11AM)

Executive Summary This executive summary reviews the topics covered in this PDQ summary on the genetics of skin cancer, with hyperlinks to detailed sections below that describe the evidence on each topic. ? Inheritance and Risk More than 100 types of tumors are clinically apparent on the skin; many are known to have familial and/or inherited components, either in isolation or as part of a syndrome with other features. Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), which are known collectively as nonmelanoma skin cancer, are two of the most common malignancies in the United States and are often caused by sun exposure, although several hereditary syndromes and genes are also associated with an increased risk of developing these cancers. Melanoma is less common than nonmelanoma skin cancer, but 5% to 10% of all melanomas arise in multiple-case families and may be inherited in an autosomal dominant fashion. ? Associated Genes and Syndromes Several genes and hereditary syndromes are associated with the development of skin cancer. Basal cell nevus syndrome (BCNS, caused by pathogenic variants in PTCH1 and PTCH2) is associated with an increased risk of BCC, while syndromes such as xeroderma pigmentosum (XP), oculocutaneous albinism, epidermolysis bullosa, and Fanconi anemia are associated with an increased risk of SCC. The major tumor suppressor gene associated with melanoma is CDKN2A; pathogenic variants in CDKN2A have been estimated to account for 35% to 40% of all familial melanomas. Pathogenic variants in many other genes, including CDK4, CDK6, BAP1, and BRCA2, have also been found to be associated with melanoma. Genome-wide searches are showing promise in identifying common, low-penetrance susceptibility alleles for many complex diseases, including melanoma, but the clinical utility of these findings remains uncertain. ? Clinical Management Risk-reducing strategies for individuals with an increased hereditary predisposition to skin cancer are similar to recommendations for the general population, and include sun avoidance, use of sunscreen, use of sun-protective clothing, and avoidance of tanning beds. Chemopreventive agents such as isotretinoin and acitretin have been studied for the treatment of BCCs in patients with BCNS and XP and are associated with a significant decrease in the number of tumors per year. Vismodegib has also shown promise in reducing the per-patient annual rate of new BCCs requiring surgery among patients with BCNS. Isotretinoin has also been shown to reduce SCC incidence among patients with XP. Treatment of hereditary skin cancers is similar to the treatment of sporadic skin cancers. One study in an XP population found therapeutic use of 5-fluorouracil to be efficacious, particularly in the treatment of extensive lesions. In addition to its role as a therapeutic and potential chemopreventive agent, vismodegib is also being studied for potential palliative effects for keratocystic odontogenic tumors in patients with BCNS. ? Psychosocial and Behavioral Issues Most of the psychosocial literature about hereditary skin cancers has focused on patients with familial melanoma. In individuals at risk of familial melanoma, psychosocial factors influence decisions about genetic testing for inherited cancer risk and risk-management strategies. Interest in genetic testing for pathogenic variants in CDKN2A is generally high. Perceived benefits among individuals with a strong family history of melanoma include information about the risk of melanoma for themselves and their children and increased motivation for sun-protective behavior. A number of studies have examined risk-reducing and early-detection behaviors in individuals with a family history of melanoma. Overall, these studies indicate inconsistent adoption and maintenance of these behaviors. Intervention studies have targeted knowledge about melanoma, sun protection, and screening behaviors in family members of melanoma patients, with mixed results. Research is ongoing to better understand and address psychosocial and behavioral issues in high-risk families. Cancer


Skin cancer, non melanoma, childhood
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan-01-2011 0AM)



Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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