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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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37 hot topic(s) found with the query "Sickle cell disease"

SCDC Fact Sheets
CDC, 2020 Brand (Posted: Nov-18-2020 10AM)

CDC has developed free sickle cell disease fact sheets for several audiences, including patients and their families; partners and public health professionals; and healthcare providers.

Did You Know Sickle Cell Has Many Faces?
CDC, September 2020 Brand (Posted: Sep-16-2020 6AM)

Did you know that sickle cell disease (SCD) affects millions of people throughout the world? View “Sickle Cell Has Many Faces” Videos-Watch people with SCD of diverse backgrounds share that SCD can affect anyone, no matter what you look like or where your family comes from.

Portable sickle disease test could aid early detection in children
NHLBI, July 2020 Brand (Posted: Aug-12-2020 6AM)

A fast, low-cost portable test for sickle cell disease (SCD) that was developed could help detect the condition in children living in areas with low resources and get them early treatment that could save lives. About 20 million people globally have SCD, including 100,000 in the United States.

Cure Sickle Cell Initiative
NIH, 2019 Brand (Posted: Nov-21-2019 7AM)

The Cure Sickle Cell Initiative is a NHLBI-led collaborative research effort that will accelerate the development of genetic therapies to cure sickle cell disease. The Initiative will identify and support the most promising genetic therapies so they can be safely used in clinical research within five to 10 years.

Fulfilling the Promise - Ensuring the Success of Newborn Screening throughout Life
CDC, November 2019 Brand (Posted: Nov-13-2019 8AM)

Each year, more than 13,000 newborn babies are identified with conditions such as cystic fibrosis, sickle cell disease, congenital heart defects, and hearing loss through a public health program called newborn screening. Without specialized care and treatment, these babies would face long-term disability, or even death.

Gene-Editing Advance Puts More Gene-Based Cures Within Reach
F Collins, NIH Director Blog, November 5, 2019 Brand (Posted: Nov-06-2019 8AM)

There’s been tremendous excitement about the potential of CRISPR and related gene-editing technologies for treating or even curing sickle cell disease (SCD), muscular dystrophy, HIV, and a wide range of other devastating conditions. Now comes word of another remarkable advance—called “prime editing”—that may bring us even closer to reaching that goal.

Caregivers and Sickle Cell Disease
CDC, September 2019 Brand (Posted: Sep-17-2019 7AM)

Caring for a loved one with sickle cell disease? You are not alone!The challenges of caring for a loved one with a chronic disease, like sickle cell disease (SCD), can be isolating and overwhelming. Learn the effect Sickle cell disease has on family members & caregivers.

Strengthening Public Health Laboratories: Newborn Screening and Genetics – Hemoglobinopathies Project
CDC, 2019 Brand (Posted: Sep-14-2019 9AM)

In 2013, the Association of Public Health Laboratories’ and the CDC began working together on the Newborn Screening and Genetics – Hemoglobinopathies Project to help prevent and lower complications related to hemoglobinopathies, such as sickle cell disease and thalassemia.

NHLBI's 2019 Annual Sickle Cell Disease Research Meeting
NHLBI, August 26-28, 2019 Brand (Posted: Aug-21-2019 8AM)

Disease of the Week: Sickle Cell Disease
CDC<,June 2019 Brand (Posted: Jun-19-2019 1PM)

Capacity Building for Sickle Cell Disease Surveillance
CDC Funding Announcement, May 2019 Brand (Posted: May-27-2019 5PM)

Holistic Health and Sickle Cell Disease: A Focus on Mental and Behavioral Health
Office of Minority Health, webinar, February 28, 2019 Brand (Posted: Feb-22-2019 9AM)

Sickle cell disease (SCD) community is hopeful that genome editing will rechart course of the disease
J Mjoseth, NHGRI, January 2019 Brand (Posted: Jan-04-2019 9AM)

A Collaborative Patient-Focused Approach to Cure Sickle Cell Disease
G Gibbons, HHS Blog, September 13, 2018 Brand (Posted: Sep-14-2018 9AM)

NIH launches initiative to accelerate genetic therapies to cure sickle cell disease
NIH, September 13, 2018 Brand (Posted: Sep-13-2018 3PM)

Sickle Cell Disease: Taking Charge of Your Health and Health Care
Brand (Posted: Jun-19-2018 9AM)

Sickle Cell Disease
CDC Videos Brand (Posted: Jun-18-2018 0PM)

CDC’s Sickle Cell Disease Surveillance History
Brand (Posted: Apr-05-2018 2PM)

Sickle Cell Disease: What You Should Know
CDC podcast, 2017 Brand (Posted: Oct-01-2017 9AM)

Living Well with Sickle Cell Disease
Brand (Posted: Aug-22-2017 0PM)

Sickle Cell Disease in the Emergency Department: Confronting Barriers to Care
Brand (Posted: Jun-23-2017 11AM)

Sickle Cell Disease
Brand (Posted: Jun-20-2017 8PM)

Conditions that increase the risk of stroke include genetic diseases such as Sickle cell disease
Brand (Posted: May-09-2017 1PM)

Key Findings: CDC’s Sickle Cell Data Collection Program Data Useful in Describing Patterns of Emergency Department Visits by Californians with Sickle Cell Disease (SCD)
Brand (Posted: Feb-07-2017 9AM)

Improving the Lives of People with Sickle Cell Disease
CDC Public Health Grand Rounds, November 15, 1-2 pm Brand (Posted: Nov-08-2016 11AM)

Public Health Research, Epidemiology, and Surveillance for Hemoglobinopathies (PHRESH)
Brand (Posted: Sep-13-2016 10AM)

Sickle Cell Data Collection (SCDC) Program
Brand (Posted: Sep-13-2016 10AM)

Sickle Cell Awareness
Brand (Posted: Sep-13-2016 10AM)

Key Findings: Sickle Cell Disease in California and Georgia: New Death Rate Estimates
Brand (Posted: Mar-27-2016 5PM)

5 Tips to Help Prevent Infections in Patients with Sickle Cell Disease
Brand (Posted: Nov-09-2015 9AM)

Sickle Cell Trait Toolkit and Fact Sheets
Brand (Posted: Sep-03-2015 3PM)

New Resources in Sickle Cell Trait Toolkit
Brand (Posted: Sep-03-2015 3PM)

CDC tips for supporting students with sickle cell disease [969.44 KB]
Brand (Posted: Feb-25-2015 0PM)

Sickle cell disease
Brand (Posted: Feb-25-2015 0PM)

New study findings: Incidence of sickle cell trait in the US
Brand (Posted: Feb-25-2015 0PM)

CDC Information: Sickle cell disease complications include stroke
Brand (Posted: Feb-25-2015 0PM)

Sickle Cell Disease
From NHLBI health topic site Brand (Posted: Jan-01-2014 0AM)

What Is The term sickle cell disease (SCD) describes a group of inherited red blood cell disorders. People with SCD have abnormal hemoglobin, called hemoglobin S or sickle hemoglobin, in their red blood cells. Hemoglobin is a protein in red blood cells that carries oxygen throughout the body. ?Inherited? means that the disease is passed by genes from parents to their children. SCD is not contagious. A person cannot catch it, like a cold or infection, from someone else. People who have SCD inherit two abnormal hemoglobin genes, one from each parent. In all forms of SCD, at least one of the two abnormal genes causes a person?s body to make hemoglobin S. When a person has two hemoglobin S genes, Hemoglobin SS, the disease is called sickle cell anemia. This is the most common and often most severe kind of SCD. Hemoglobin SC disease and hemoglobin Sâ thalassemia (thal-uh-SEE-me-uh) are two other common forms of SCD. Some Forms of Sickle Cell Disease ?Hemoglobin SS ?Hemoglobin SC ?Hemoglobin Sâ0 thalassemia ?Hemoglobin Sâ+ thalassemia ?Hemoglobin SD ?Hemoglobin SE Overview Cells in tissues need a steady supply of oxygen to work well. Normally, hemoglobin in red blood cells takes up oxygen in the lungs and carries it to all the tissues of the body. Red blood cells that contain normal hemoglobin are disc shaped (like a doughnut without a hole). This shape allows the cells to be flexible so that they can move through large and small blood vessels to deliver oxygen. Sickle hemoglobin is not like normal hemoglobin. It can form stiff rods within the red cell, changing it into a crescent, or sickle shape. Sickle-shaped cells are not flexible and can stick to vessel walls, causing a blockage that slows or stops the flow of blood. When this happens, oxygen can?t reach nearby tissues. Normal Red Cells and Sickle Red Cells An image that shows the difference between a normal red blood cell verses a sickle cell with abnormal (sickle) hemoglobin Figure A shows normal red blood cells flowing freely in a blood vessel. The inset image shows a cross-section of a normal red blood cell with normal hemoglobin. Figure B shows abnormal, sickled red blood cells blocking blood flow in a blood vessel. The inset image shows a cross-section of a sickle cell with abnormal (sickle) hemoglobin forming abnormal stiff rods. The lack of tissue oxygen can cause attacks of sudden, severe pain, called pain crises. These pain attacks can occur without warning, and a person often needs to go to the hospital for effective treatment. Most children with SCD are pain free between painful crises, but adolescents and adults may also suffer with chronic ongoing pain. The red cell sickling and poor oxygen delivery can also cause organ damage. Over a lifetime, SCD can harm a person?s spleen, brain, eyes, lungs, liver, heart, kidneys, penis, joints, bones, or skin. Sickle cells can?t change shape easily, so they tend to burst apart or hemolyze. Normal red blood cells live about 90 to 120 days, but sickle cells last only 10 to 20 days. The body is always making new red blood cells to replace the old cells; however, in SCD the body may have trouble keeping up with how fast the cells are being destroyed. Because of this, the number of red blood cells is usually lower than normal. This condition, called anemia, can make a person have less energy. Outlook Sickle cell disease is a life-long illness. The severity of the disease varies widely from person to person. In high-income countries like the United States, the life expectancy of a person with SCD is now about 40?60 years. In 1973, the average lifespan of a person with SCD in the United States was only 14 years. Advances in the diagnosis and care of SCD have made this improvement possible. At the present time, hematopoietic stem cell transplantation (HSCT) is the only cure for SCD. Unfortunately, most people with SCD are either too old for a transplant or don?t have a relative who is a good enough genetic match for them to act as a donor. A well-matched donor is needed to have the best chance for a successful transplant. There are effective treatments that can reduce symptoms and prolong life. Early diagnosis and regular medical care to prevent complications also contribute to improved well-being. Other Names ?HbS disease ?Hemoglobin S disease ?Hemoglobin SS disease ?Sickle cell disease (a broad term that includes sickle cell anemia) ?Sickle cell disorders (a broad group of conditions that includes sickle cell anemia) ?Sickling disorder due to hemoglobin S

Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.