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Last Posted: Apr 11, 2024
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Newborn Screening for Severe Combined Immunodeficiency: Lessons Learned from Screening and Follow-Up of the Preterm Newborn Population
A Gaviglio et al, IJNS, December 2023

From the abstract: " Newborn screening (NBS) for Severe Combined Immunodeficiency (SCID) by measurement of T-cell receptor excision circles (TRECs) successfully identifies newborns with SCID and severe T-cell lymphopenia, as intended. At the same time, NBS programs face the challenge of false positive results, with a disproportionately high number in the premature newborn population. This study evaluates TREC values and SCID screening outcomes in premature newborns and elucidates evidence-based SCID screening practices that reduce unnecessary follow-up activities in this population."

Screening newborns for deadly immune disorder saves lives
NIH, July 2023

Newborn screening for severe combined immunodeficiency (SCID) led to prompt treatment before life-threatening infections occurred, boosting survival of children with the disorder. The findings could encourage more widespread screening of newborns around the world for this disease.

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