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Last Posted: Dec 07, 2023
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Modernizing Federal Oversight of Laboratory-Developed Tests - Toward Safety, Validity, and Utility.
Udit Singhal et al. N Engl J Med 2023 11 (19) 1735-1737

From the paper: "Advances in precision medicine have fueled an evolution in the availability of laboratory-developed tests (LDTs). Defined as in vitro diagnostic tests that are “designed, manufactured, and used in a single laboratory,” LDTs were initially conceived as simple tests offered to limited, local groups of patients.1 But LDTs have grown in complexity, and some hospital and commercial laboratories now accept specimens from around the world. "

Polygenic risk scores for disease risk prediction in Africa: current challenges and future directions
S Fatumo et al, Genome Medicine, October 30, 2023

From the abstract: " Polygenic risk scores (PRS), which combine multiple contributing variants to predict disease risk, have the potential to influence the implementation for precision medicine. However, the majority of existing PRS were developed from European data with limited transferability to African populations. We (1) discuss the factors contributing to the poor transferability of PRS in African populations, (2) showcase the novel Africa genomic datasets for PRS development, (3) explore the potential clinical utility of PRS in African populations, and (4) provide insight into the future of PRS in Africa."

Precision medicine of obesity as an integral part of type 2 diabetes management – past, present, and future
L Szczerbinski et al. The Lancet Diabetes Endocr, October 4, 2023

From the abstract: " In this Review, we discuss advances in the genetics of obesity from the past decade—with emphasis on developments from the past 5 years—with a focus on metabolic consequences, and their potential implications for precision management of the disease. We also provide an overview of the potential role of genetics in guiding weight loss strategies. Finally, we propose a vision for the future of precision obesity management."

Precision medicine for cardiometabolic disease: a framework for clinical translation
PW Franks et al, The Lancet Diabetes Endoc, October 4, 2023

From the abstract: "To contextualise precision medicine in both research and clinical settings, and to encourage the successful translation of discovery science into clinical practice, in this Series paper we outline a model (the EPPOS model) that builds on contemporary evidence-based approaches; includes precision medicine that improves disease-related predictions by stratifying a cohort into subgroups of similar characteristics, or using participants' characteristics to model treatment outcomes directly; "

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Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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