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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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24 hot topic(s) found with the query "Occupational exposure"

Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies.
Patel Chirag J et al. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2017 Sep (9) 1370-1380 (Posted: Dec-11-2017 9AM)


The role of gene-environment interplay in occupational and environmental diseases: current concepts and knowledge gaps.
Kwo Elizabeth et al. Current opinion in pulmonary medicine 2017 Mar (2) 173-176 (Posted: May-12-2017 8AM)


Melanoma Epidemiology and Prevention.
Berwick Marianne et al. Cancer treatment and research 2016 17-49 (Posted: Mar-07-2016 1PM)


Phenotypes, Risk Factors, and Mechanisms of Adult-Onset Asthma.
Ilmarinen Pinja et al. Mediators of inflammation 2015 514868 (Posted: Dec-09-2015 7PM)


Genetic variability in ABCB1, occupational pesticide exposure, and Parkinson's disease.
Narayan Shilpa et al. Environmental research 2015 Nov (Pt A) 98-106 (Posted: Nov-24-2015 9AM)


Key Genetic and Epigenetic Mechanisms in Chemical Carcinogenesis.
Ravegnini Gloria et al. Toxicological sciences : an official journal of the Society of Toxicology 2015 Nov (1) 2-13 (Posted: Nov-24-2015 9AM)


Considerations for Using Genetic and Epigenetic Information in Occupational Health Risk Assessment and Standard Setting.
Schulte P A et al. Journal of occupational and environmental hygiene 2015 Nov (sup1) S69-S81 (Posted: Nov-24-2015 9AM)


Live animal markets in Minnesota: a potential source for emergence of novel influenza A viruses and interspecies transmission.
Choi Mary J et al. Clin. Infect. Dis. 2015 Jul 29. (Posted: Aug-07-2015 10AM)


This little piggy went to market-but perhaps should have stayed home.
Webby Richard et al. Clin. Infect. Dis. 2015 Jul 29. (Posted: Aug-07-2015 10AM)


Commentary on the contributions and future role of occupational exposure science in a vision and strategy for the discipline of exposure science.
Harper Martin et al. J Expo Sci Environ Epidemiol 2015 Feb 11. (Posted: May-20-2015 2PM)


Subclinical carotid atherosclerosis and early vascular aging from long-term low-dose ionizing radiation exposure: a genetic, telomere, and vascular ultrasound study in cardiac catheterization laboratory staff.
Andreassi Maria Grazia et al. JACC Cardiovasc Interv 2015 Apr 20. (4) 616-27 (Posted: May-01-2015 9AM)


NOS1: a susceptibility gene for reduced level of FEV1 in the setting of pesticide exposure.
de Jong K et al. Am. J. Respir. Crit. Care Med. 2014 Nov 15. (10) 1188-90 (Posted: Mar-15-2015 1PM)


Increased N7-methyldeoxyguanosine DNA adducts after occupational exposure to pesticides and influence of genetic polymorphisms of paraoxonase-1 and glutathione S-transferase M1 and T1.
Gómez-Martín Antonio et al. Environ. Mol. Mutagen. 2014 Nov 26. (Posted: Mar-15-2015 1PM)


Metabolic polymorphisms and biomarkers of effect in the biomonitoring of occupational exposure to low-levels of benzene: state of the art.
De Palma G et al. Toxicol. Lett. 2014 Dec 1. (2) 194-204 (Posted: Mar-15-2015 1PM)


Genetic variations in protocadherin 15 and their interactions with noise exposure associated with noise-induced hearing loss in Chinese population.
Zhang Xuhui et al. Environ. Res. 2014 Nov 247-52 (Posted: Mar-15-2015 1PM)


Influence of genetic polymorphisms of styrene-metabolizing enzymes on the levels of urinary biomarkers of styrene exposure.
Carbonari Damiano et al. Toxicol. Lett. 2015 Mar 4. (2) 156-62 (Posted: Mar-15-2015 1PM)


Effect of occupational exposures on lung cancer susceptibility: a study of gene-environment interaction analysis.
Malhotra Jyoti et al. Cancer Epidemiol. Biomarkers Prev. 2015 Mar (3) 570-9 (Posted: Mar-15-2015 1PM)


Increased levels of chromosomal aberrations and DNA damage in a group of workers exposed to formaldehyde.
Costa Solange et al. Mutagenesis 2015 Feb 22. (Posted: Mar-15-2015 1PM)


Exposure and genetics increase risk of beryllium sensitisation and chronic beryllium disease in the nuclear weapons industry.
Van Dyke Michael V et al. Occup Environ Med 2011 Nov (11) 842-8 (Posted: Mar-06-2015 9AM)


Risk of chronic beryllium disease by HLA-DPB1 E69 genotype and beryllium exposure in nuclear workers.
Van Dyke Mike V et al. Am. J. Respir. Crit. Care Med. 2011 Jun 15. (12) 1680-8 (Posted: Mar-06-2015 9AM)


Beryllium and other metal-induced lung disease.
Mayer Annyce et al. Curr Opin Pulm Med 2015 Mar (2) 178-84 (Posted: Mar-06-2015 9AM)


Genetic susceptibility to beryllium: a case-referent study of men and women of working age with sarcoidosis or other chronic lung disease.
Cherry Nicola et al. Occup Environ Med 2015 Jan (1) 21-7 (Posted: Mar-06-2015 9AM)


An official American Thoracic Society statement: diagnosis and management of beryllium sensitivity and chronic beryllium disease.
Balmes John R et al. Am. J. Respir. Crit. Care Med. 2014 Nov 15. (10) e34-59 (Posted: Mar-06-2015 9AM)


Genetic Susceptibility and Brain Tumors
Brand (Posted: Jan-11-2014 11AM)

Polymorphisms in genes might modify the effects of exogenous and endogenous carcinogens in brain tumor development. DCEG investigators have evaluated the glutathione-S-transferase and cytochrome P-450 families of genes, both of which encode enzymes involved in the metabolism of solvents and other substrates. Occupational exposure to lead might cause meningioma, and a polymorphism in a gene for an enzyme that influences blood levels of lead [delta-aminolevulinic acid dehydratase, (ALAD)] was positively associated with the risk of meningioma. The association between glioma risk and history of allergies is being explored by examining the relation between glioma risk and polymorphisms in cytokine genes, and polymorphisms in a large panel of genes related to innate immunity also are under study. A recent paper from this study concerning apoptosis and cell cycle control genes identified caspase 8 as a possible susceptibility gene. Analyses concerning polymorphisms in oxidative stress genes, DNA repair genes, and insulin-like growth factor genes are in progress. No single epidemiological study of brain tumors has adequate statistical power to evaluate most gene-environment or gene-gene interactions. An international consortium of brain tumor epidemiological studies (BTEC) was organized so that brain tumor risks associated with genetic susceptibility and specific exposures can be evaluated in the combined studies.



Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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