Archive
Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
Sign up MyPHGKB to receive the daily hot topic email alert.
Archived Hot Topics of the Day By Date
Distilling causality between physical activity traits and obesity via Mendelian randomization.
Zhe Wang et al. Commun Med (Lond) 2023 11 (1) 173
(Posted: Dec 02, 2023 8AM)
Association Between a First-Degree Family History and Self-Reported Personal History of Obesity, Diabetes, and Heart and Blood Conditions: Results From the All of Us Research Program.
Danielle Rasooly et al. J Am Heart Assoc 2023 11 e030779
(Posted: Nov 13, 2023 8PM)
Expanding the genetic landscape of obesity.
Jian Yang et al. Cell Genom 2023 9 (9) 100400
(Posted: Nov 10, 2023 7AM)
Rare Variants of Obesity-Associated Genes in Young Adults with Abdominal Obesity
A Bairkdar et al, JPM, October 16, 2023
(Posted: Oct 17, 2023 9AM)
Precision medicine of obesity as an integral part of type 2 diabetes management – past, present, and future
L Szczerbinski et al. The Lancet Diabetes Endocr, October 4, 2023
(Posted: Oct 06, 2023 8AM)
Epigenetics of Early-Life Socioeconomic Stressors and the Impact on Childhood Body Mass Index—Potential Mechanism and Biomarker?
UP Gujral et al, JAMA Pediatrics, September 5, 2023
(Posted: Sep 05, 2023 1PM)
CKD Risk Factors
CDC, June 2023
(Posted: Jul 01, 2023 4PM)
Antagonizing the Leptin Receptor in Obesity.
Clifford J Rosen et al. N Engl J Med 2023 6 (24) 2291-2293
(Posted: Jun 15, 2023 8AM)
Genetics, genomics, and diet interactions in obesity in the Latin American environment.
Patricia Guevara-Ramírez et al. Frontiers in nutrition 2022 12 1063286
(Posted: Mar 02, 2023 10AM)
Beyond genetic screening-functionality-based precision medicine in monogenic obesity.
Antje Körner et al. The lancet. Diabetes & endocrinology 2023 2 (3) 143-144
(Posted: Feb 28, 2023 7AM)
Effect of long-term caloric restriction on DNA methylation measures of biological aging in healthy adults from the CALERIE trial
R Waziry et al, Nature Aging, February 9, 2023
(Posted: Feb 13, 2023 10AM)
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity
S Yojoshi et al, MEDRXIV, January 31, 2023
(Posted: Feb 01, 2023 6AM)
How our microbiome is shaped by family, friends and even neighbours.
Callaway Ewen et al. Nature 2023 1
(Posted: Jan 21, 2023 6AM)
Acute respiratory distress syndrome after SARS-CoV-2 infection on young adult population: International observational federated study based on electronic health records through the 4CE consortium
B Moal et al, PLOS ONE, Jan 4, 2023
(Posted: Jan 05, 2023 5AM)
Genomics and phenomics of body mass index reveals a complex disease network.
Huang Jie et al. Nature communications 2022 12 (1) 7973
(Posted: Jan 02, 2023 0PM)
Assessment of Body Mass Index, Polygenic Risk Score, and Development of Colorectal Cancer.
Chen Xuechen et al. JAMA network open 2022 12 (12) e2248447
(Posted: Dec 23, 2022 6PM)
DNA Methylation Implicated in Human Obesity and Diabetes
ME Tucker, Medscape, November 2022
(Posted: Nov 14, 2022 6AM)
Fitbit step counts clarify the association between activity and chronic disease risk
Nature Medicine, October 11, 2022
(Posted: Oct 12, 2022 8AM)
Multi-omic phenotyping reveals host-microbe responses to bariatric surgery, glycaemic control and obesity
NC Penny et al, Comm Medicine, October 7, 2022
(Posted: Oct 08, 2022 7AM)
Clinical and Genetic Risk Factors for Acute Incident Venous Thromboembolism in Ambulatory Patients With COVID-19
J Xie et al, JAMA Internal Medicine, August 18, 2022
(Posted: Aug 18, 2022 1PM)
Predicting chronic morbidity in childhood cancer survivors.
Vrooman Lynda M et al. Nature medicine 2022 8
(Posted: Aug 09, 2022 7AM)
Genetic risk score enhances the risk prediction of severe obesity in adult survivors of childhood cancer.
Sapkota Yadav et al. Nature medicine 2022 7
(Posted: Jul 26, 2022 7AM)
Risk Factors for COVID-19 Mortality in Pediatric Populations: A Scoping Review
J Theophillia et al, Research Square, June 10, 2022
(Posted: Jun 13, 2022 7AM)
Proteome-wide Mendelian randomization implicates nephronectin as an actionable mediator of the effect of obesity on COVID-19 severity
S Yojishi et al, MEDRXIV, June 8, 2022
(Posted: Jun 09, 2022 6AM)
Integration of rare expression outlier-associated variants improves polygenic risk prediction
C Smail et al, AJHG, May 18, 2022
(Posted: May 19, 2022 10AM)
Hospitalizations of Children Aged 5–11 Years with Laboratory-Confirmed COVID-19 — COVID-NET, 14 States, March 2020–February 2022
DS Shi et al, MMWR, April 19, 2022
(Posted: Apr 20, 2022 9AM)
Chronic Kidney Disease Basics
CDC, March 2022
(Posted: Mar 15, 2022 7AM)
Applying implementation science to improve care for familial hypercholesterolemia.
Jones Laney K et al. Current opinion in endocrinology, diabetes, and obesity 2021 11 (2) 141-151
(Posted: Mar 14, 2022 7AM)
Genome-wide analysis provides genetic evidence that ACE2 influences COVID-19 risk and yields risk scores associated with severe disease
JE Horowitz et al, Nature Genetics, March 4, 2022
(Posted: Mar 04, 2022 7AM)
Clinical Characterization of Copy Number Variants Associated With Neurodevelopmental Disorders in a Large-scale Multiancestry Biobank.
Birnbaum Rebecca et al. JAMA psychiatry 2022 1 (3) 250-259
(Posted: Mar 03, 2022 8AM)
Microbiome and metabolome features of the cardiometabolic disease spectrum
S Fromentin et al, Nature Medicine, February 17, 2022
(Posted: Feb 18, 2022 8AM)
Novel insights into the consequences of obesity: a phenotype-wide Mendelian randomization study
C He et al, EJHG January 1, 2022
(Posted: Jan 03, 2022 2PM)
Characteristics and Clinical Outcomes of Children and Adolescents Aged <18 Years Hospitalized with COVID-19 — Six Hospitals, United States, July–August 2021
V Wanga et al, MMWR, December 31, 2021
(Posted: Dec 31, 2021 7AM)
Obesity-Associated GNAS Mutations and the Melanocortin Pathway.
Mendes de Oliveira Edson et al. The New England journal of medicine 2021 10
(Posted: Oct 07, 2021 6AM)
The genetics of obesity: from discovery to biology
RJF Loos et al, Nat Rev Genetics, September 23, 2021
(Posted: Sep 24, 2021 6AM)
Impact of paternal education on epigenetic ageing in adolescence and mid-adulthood: a multi-cohort study in the USA and Mexico.
Joyce Brian T et al. International journal of epidemiology 2021 9
(Posted: Sep 19, 2021 10AM)
Antibody responses to BNT162b2 mRNA vaccine: infection-naive individuals with abdominal obesity warrant attention
AE Malavazoz et al, MEDRXIV, September 14, 2021
(Posted: Sep 15, 2021 8AM)
Obesity genes open new avenues of research - A large-scale genetic sequencing study reveals a potential new therapeutic target in obesity.
K O'Leary, Nature Medicine, July 29, 2021
(Posted: Jul 31, 2021 9AM)
Obesity, Ethnicity, and Covid-19 Mortality: A population-based cohort study of 12.6 Million Adults in England
T Yates et al, MEDRXIV, July 23, 2021
(Posted: Jul 24, 2021 8AM)
Fecal microbial transplantation and fiber supplementation in patients with severe obesity and metabolic syndrome: a randomized double-blind, placebo-controlled phase 2 trial
V Munacu et al, Nature Medicine, July 5, 2021
(Posted: Jul 06, 2021 8AM)
Finding genes that control body weight
GSH Yeo et al, Science, July 2, 2021
(Posted: Jul 02, 2021 7AM)
Sequencing of 640,000 exomes identifies GPR75 variants associated with protection from obesity
S Akbari et al, Science, July 2, 2021
(Posted: Jul 02, 2021 7AM)
Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review.
et al. JAMA surgery 2021 7
(Posted: Jul 01, 2021 7AM)
Mendelian randomization suggests a bidirectional, causal relationship between physical inactivity and obesity
GD Carrasquilla, BIORXIV, June 19, 2021
(Posted: Jun 19, 2021 7AM)
The effect of obesity-related traits on COVID-19 severe respiratory symptoms is mediated by socioeconomic status: a multivariable Mendelian randomization study
BC Mendoza et al, MEDRXIV, June 12, 2021
(Posted: Jun 13, 2021 7AM)
Causality Inference of Obesity and Cancer Risk by Mendelian Randomization Analysis: Are We There yet?
S Yao et al, JNCI, May 21, 2021
(Posted: May 23, 2021 8AM)
Central obesity, smoking habit and hypertension are associated with a blunted serological response to COVID-19 mRNA vaccine
M Watanabe et al, MERXIV, April 15, 2021
(Posted: Apr 16, 2021 7AM)
Risk factors for illness severity among pregnant women with confirmed SARS-CoV-2 infection - Surveillance for Emerging Threats to Mothers and Babies Network, 20 state, local, and territorial health departments, March 29, 2020 -January 8, 2021
RR Galang et al, MEDRXIV, March 1, 2021
(Posted: Mar 02, 2021 8AM)
Revealing the role of the human blood plasma proteome in obesity using genetic drivers.
Zaghlool Shaza B et al. Nature communications 2021 2 (1) 1279
(Posted: Feb 26, 2021 8AM)
Genetic associations with temporal shifts in obesity and severe obesity during the obesity epidemic in Norway: A longitudinal population-based cohort (the HUNT Study).
Brandkvist Maria et al. PLoS medicine 2020 Dec (12) e1003452
(Posted: Dec 16, 2020 8AM)
The Promise of Lifestyle Interventions in Individuals With Genetically Higher Risk for Obesity.
Hivert Marie-France et al. JAMA pediatrics 2020 Dec e205180
(Posted: Dec 15, 2020 8AM)
Obesity Genes and Weight Loss During Lifestyle Intervention in Children With Obesity.
Heitkamp Melanie et al. JAMA pediatrics 2020 Dec e205142
(Posted: Dec 15, 2020 8AM)
Obesity as a predictor for adverse outcomes among COVID-19 patients: A meta-analysis
P Das et al, MEDRXIV, November 30, 2020
(Posted: Nov 30, 2020 2PM)
Rising incidence of early-onset colorectal cancer - a call to action.
Akimoto Naohiko et al. Nature reviews. Clinical oncology 2020 Nov
(Posted: Nov 24, 2020 8AM)
Causal Inference for Genetic Obesity, Cardiometabolic Profile and COVID-19 Susceptibility: A Mendelian Randomization Study
N Aung et al, Front in Genetics, November 11, 2020
(Posted: Nov 12, 2020 8AM)
Impact of body composition on COVID-19 susceptibility and severity: a two-sample multivariable Mendelian randomization study
D Freuer et al, MEDRXIV, October 24,2020
(Posted: Oct 25, 2020 10AM)
Characteristics Associated With Racial/Ethnic Disparities in COVID-19 Outcomes in an Academic Health Care System
T Gu et al, JAMA Network Open, October 21, 2020
(Posted: Oct 22, 2020 11AM)
How obesity could create problems for a COVID vaccine- Researchers fear that vaccines might not be as effective in people who are obese, a population already highly vulnerable to COVID-19.
H Ledford, Nature News, October 20, 2020
(Posted: Oct 20, 2020 1PM)
Risk Factors for Hospitalization, Mechanical Ventilation, or Death Among 10 131 US Veterans With SARS-CoV-2 Infection
GN Ioannou et al, JAMA Network Open, September 23, 2020
(Posted: Sep 23, 2020 1PM)
Why obesity worsens COVID-19
M Wadman, Science, September 11, 2020
(Posted: Sep 11, 2020 8AM)
Regardless of Age, Obesity and Hypertension Increase Risks With COVID-19
MH Katz, JAMA Internal Medicine, September 9, 2020
(Posted: Sep 09, 2020 3PM)
Obesity and Hypertension in the Time of COVID-19
G Rodgers et al, JAMA September 9, 2020
(Posted: Sep 09, 2020 3PM)
From genetics to bariatric surgery and soda taxes: Using all the tools to curb the rising tide of obesity
A Misra et al, PLOS Medicine, July 31, 2020
(Posted: Aug 05, 2020 8AM)
Obesity, clinical, and genetic predictors for glycemic progression in Chinese patients with type 2 diabetes: A cohort study using the Hong Kong Diabetes Register and Hong Kong Diabetes Biobank
G Jiang et al, PLOS Medicine, July 28, 2020
(Posted: Jul 29, 2020 8AM)
Factors Associated With Death in Critically Ill Patients With Coronavirus Disease 2019 in the US
S Gupta et al, JAMA Internal Medicine, July 15,2020
(Posted: Jul 16, 2020 6AM)
Cardiometabolic traits, sepsis and severe covid-19 with respiratory failure: a Mendelian randomization investigation
PJ Mark et al, MEDRXIV, June 20, 2020
(Posted: Jun 22, 2020 8AM)
Inflammasome genetics and complex diseases: a comprehensive review
FP Fernandes et al, EJHG June 5, 2020
(Posted: Jun 06, 2020 6AM)
Nearly All Patients Hospitalized With Covid-19 Had Chronic Health Issues, Study Finds- Only 6 percent of patients at one New York area health system had no chronic conditions. Hypertension, obesity and diabetes were common.
RC Rabin, NY Times, April 23, 2020
(Posted: Apr 24, 2020 8AM)
Contribution of macronutrients to obesity: implications for precision nutrition
Nat Rev Endrocrinology, March 31, 2020
(Posted: Apr 04, 2020 9AM)
Obesity Treatment Among Adolescents- A Review of Current Evidence and Future Directions
JMI Cardel et al, AMA Pediatrics, March 26, 2020
(Posted: Mar 29, 2020 8AM)
New research directions on disparities in obesity and type 2 diabetes.
Thornton Pamela L et al. Annals of the New York Academy of Sciences 2020 Feb 1461(1) 5-24
(Posted: Feb 26, 2020 9AM)
Evidence from big data in obesity research: international case studies.
Wilkins Emma et al. International journal of obesity (2005) 2020 Jan
(Posted: Feb 05, 2020 8AM)
Is Early-Life Antibiotic Exposure Associated With Obesity in Children?
Azad Meghan B et al. JAMA network open 2020 Jan (1) e1919694
(Posted: Jan 26, 2020 7AM)
A healthy childhood environment helps to combat inherited susceptibility to obesity
A Huels et al, BioRXIV, January 14, 2020
(Posted: Jan 16, 2020 8AM)
Polygenic Risk, Fitness, and Obesity in the Coronary Artery Risk Development in Young Adults (CARDIA) Study
VL Murthy et al, JAMA Cardiology, January 8, 2020
(Posted: Jan 09, 2020 8AM)
The current obesity “epidemic”: segregation of familial genetic risk in NHANES cohort supports a major role for large genetic effects
AB Jenkins et al. BIORXIV, November 2019
(Posted: Nov 18, 2019 9AM)
Causal relationships between obesity and the leading causes of death in women and men.
Censin Jenny C et al. PLoS genetics 2019 Oct (10) e1008405
(Posted: Nov 16, 2019 7AM)
Hype or hope?
Nature Rev Microbiology, November 12, 2019
(Posted: Nov 14, 2019 8AM)
Pancreatic Cancer: Patient Page
JAMA, October 2019
(Posted: Oct 13, 2019 1PM)
Wearable technology and lifestyle management: the fight against obesity and diabetes
The Lancet Digital Health, Vol 1, Iss 6, Pe 243, October 1, 2019
(Posted: Oct 11, 2019 0PM)
A Patient’s Guide to Endometrial Cancer-This cancer is on the rise. But early detection saves lives.
MO Shroeder, US News, October 4, 2019
(Posted: Oct 05, 2019 9AM)
Adult Obesity Prevalence Maps
CDC, September 12, 2019
(Posted: Sep 13, 2019 9AM)
Genetic risk of obesity as a modifier of associations between neighbourhood environment and body mass index: an observational study of 335,046 UK Biobank participants
KE Mason et al, MedRXIV, August 2019
(Posted: Sep 04, 2019 5AM)
Artificial intelligence for medicine needs a Turing test. Obesity would be a good one
M Joyner, StatNews, August 28, 2019
(Posted: Aug 28, 2019 7AM)
Leveraging Omics Profiling to Advance the Treatment of Pediatric Obesity.
Koch Sarah et al. JAMA pediatrics 2019 Aug
(Posted: Aug 27, 2019 7AM)
Circulating microbiota-derived metabolites: a "liquid biopsy?
Aragonès Gemma et al. International journal of obesity (2005) 2019 Aug
(Posted: Aug 19, 2019 8AM)
The workout that excels at countering obesity genes
Nature, August 2, 2019
(Posted: Aug 08, 2019 8AM)
Lessons Learned from the POUNDS Lost Study: Genetic, Metabolic, and Behavioral Factors Affecting Changes in Body Weight, Body Composition, and Cardiometabolic Risk
Bray GA et al, Current Obesity Reports, August 2019
(Posted: Aug 03, 2019 0PM)
Performing different kinds of physical exercise differentially attenuates the genetic effects on obesity measures: Evidence from 18,424 Taiwan Biobank participants.
Lin Wan-Yu et al. PLoS genetics 2019 Aug (8) e1008277
(Posted: Aug 02, 2019 8AM)
Development and validation of a prediction model for fat mass in children and adolescents: meta-analysis using individual participant data.
Hudda Mohammed T et al. BMJ (Clinical research ed.) 2019 07 l4293
(Posted: Jul 29, 2019 8AM)
Fecal Transplants May Hold Promise in Treating Obesity
Pagel AS, Medscape, July 23, 2019
(Posted: Jul 25, 2019 11AM)
Should obesity be recognised as a disease?
JPH Wilding et al, BMJ, July 17, 2019
(Posted: Jul 22, 2019 8AM)
Genome-Wide Polygenic Score Quantifies Inherited Susceptibility to Obesity
Mass General Hospital, July 3, 2019
(Posted: Jul 10, 2019 9AM)
Destigmatising obesity by understanding the impact of genes
M Brandkvist, BMJ Opinion, July 3, 2019
(Posted: Jul 08, 2019 8AM)
Quantifying the impact of genes on body mass index during the obesity epidemic: longitudinal findings from the HUNT Study.
Brandkvist Maria et al. BMJ (Clinical research ed.) 2019 Jul l4067
(Posted: Jul 07, 2019 0PM)
A Scientific Overview of Smartphone Applications and Electronic Devices for Weight Management in Adults
SL Holzmann et al, MDPI, June 7, 2019
(Posted: Jun 13, 2019 2PM)
The association between maternal body mass index and child obesity: A systematic review and meta-analysis.
Heslehurst Nicola et al. PLoS medicine 2019 Jun (6) e1002817
(Posted: Jun 12, 2019 7AM)
Weight management telehealth intervention for overweight and obese rural cardiac rehabilitation participants: A randomised trial.
Barnason Susan et al. Journal of clinical nursing 2019 May 28(9-10) 1808-1818
(Posted: May 29, 2019 9AM)
Lifestyle Interventions for Weight Control Modified by Genetic Variation: A Review of the Evidence.
Tan Pui Yee et al. Public health genomics 2019 May 1-17
(Posted: May 27, 2019 5PM)
Predicting nationwide obesity from food sales using machine learning.
Dunstan Jocelyn et al. Health informatics journal 2019 May 1460458219845959
(Posted: May 22, 2019 8AM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
- Page last updated:Mar 27, 2024
- Content source: