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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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87 hot topic(s) found with the query "Malaria "

Genome-wide association studies of severe P. falciparum malaria susceptibility: progress, pitfalls and prospects.
Damena Delesa et al. BMC medical genomics 2019 Aug (1) 120 (Posted: Aug-17-2019 9AM)

Precision identification of high-risk phenotypes and progression pathways in severe malaria without requiring longitudinal data
Johnston IG, et. al. npj Digital Medicine 2, Article number: 63 (2019) (Posted: Jul-12-2019 8AM)

The study applies tools from machine learning and model-based inference to harness large-scale data and dissect the heterogeneity in patterns of clinical features associated with severe malaria in 2904 Gambian children admitted to hospital with malaria. The analysis reveals features predicting the severity of individual patient outcomes, and the dynamic pathways of progression.

First proven malaria vaccine rolled out in Africa — but doubts linger- The RTS,S vaccine is up to 40% effective at preventing malaria in young children.
A Maxmen, Nature News, April 25, 2019 (Posted: Apr-26-2019 10AM)

A cytochrome P450 allele confers pyrethroid resistance on a major African malaria vector, reducing insecticide-treated bednet efficacy.
Weedall Gareth D et al. Science translational medicine 2019 Mar (484) (Posted: Mar-22-2019 10AM)

Scientists Release Controversial Genetically Modified Mosquitoes In High-Security Lab
R Stein, NPR, February 20, 2019 (Posted: Feb-20-2019 9AM)

Combating malaria by modifying mosquitoes could save thousands of lives. It’s also risky.
HT Greely, Washington Post, February 7, 2019 (Posted: Feb-07-2019 11AM)

New insights into malaria susceptibility from the genomes of 17,000 individuals from Africa, Asia, and Oceania
G Band et al, BIORXIV, February 4, 2019 (Posted: Feb-05-2019 2PM)

Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa.
Tshilolo Léon et al. The New England journal of medicine 2019 Jan (2) 121-131 (Posted: Jan-10-2019 9AM)

Here's the Plan to End Malaria With Crispr-Edited Mosquitoes
M Molteni, WIRED, September 24, 2018 (Posted: Sep-25-2018 9AM)

Scientists use gene drive to eradicate lab mosquitoes for the first time
I Swetlitz, Stat News, September 24, 2018 (Posted: Sep-25-2018 9AM)

Giving Malaria a Deadline- With a new genetic tool, scientists move a step closer to eradicating mosquitoes and the deadly diseases they carry.
N Wade, September 24, 2018 (Posted: Sep-25-2018 9AM)

Genetic approach towards a vaccine against malaria.
Garrido-Cardenas Jose Antonio et al. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 2018 Jun (Posted: Aug-03-2018 0PM)

Transcriptomic Studies of Malaria: a Paradigm for Investigation of Systemic Host-Pathogen Interactions.
Lee Hyun Jae et al. Microbiology and molecular biology reviews : MMBR 2018 Jun (2) (Posted: May-04-2018 0PM)

Scientists Reveals Genes for the Most Deadly Human Malaria Parasite
Frontline Genomics, May 4, 2018 (Posted: May-04-2018 11AM)

How One Child’s Sickle Cell Mutation Helped Protect the World From Malaria
C Zimmer, NY Times, Mar 8, 2018 (Posted: Mar-08-2018 5PM)

Whole metagenome sequencing reveals links between mosquito microbiota and insecticide resistance in malaria vectors.
Dada Nsa et al. Scientific reports 2018 Feb (1) 2084 (Posted: Feb-06-2018 3PM)

Multidrug resistant malaria spread under the radar for years in Cambodia- Study suggests that ongoing genomic surveillance is vital to inform malaria control strategies
Sanger Institute, Feb 1, 2018 (Posted: Feb-02-2018 11AM)

Novel genetic polymorphisms associated with severe malaria and under selective pressure in North-eastern Tanzania.
Ravenhall Matt et al. PLoS genetics 2018 Jan (1) e1007172 (Posted: Jan-31-2018 1PM)

Lethal malaria parasite’s weaknesses revealed - Genomic insights could inform discovery of more durable drugs.
Nature, Jan 16, 2018 (Posted: Jan-18-2018 9AM)

Systematic review of the clinical manifestations of glucose-6-phosphate dehydrogenase deficiency in the Greater Mekong Subregion: implications for malaria elimination and beyond.
Ong Ken Ing Cherng et al. BMJ global health 2017 (3) e000415 (Posted: Jan-05-2018 7AM)

Prevalence, genetic variants and clinical implications of G-6-PD deficiency in Burkina Faso: a systematic review.
Ouattara Abdoul Karim et al. BMC medical genetics 2017 11 (1) 139 (Posted: Jan-05-2018 7AM)

Five new malaria targets that could lead to an effective vaccine news, Oct 23, 2017 (Posted: Oct-24-2017 10AM)

The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito.
Hammond Andrew M et al. PLoS genetics 2017 Oct (10) e1007039 (Posted: Oct-10-2017 10AM)

New genetic technique could help identify potential drug targets for malaria
Eureka Alert, June 15, 2017 (Posted: Jun-15-2017 2PM)

Next-Generation Malaria Methods
Brand (Posted: May-02-2017 5PM)

Dissecting malaria biology and epidemiology using population genetics and genomics.
Auburn Sarah et al. International journal for parasitology 2017 Feb (2-3) 77-85 (Posted: Apr-13-2017 10AM)

Malaria Genomics in the Era of Eradication.
Neafsey Daniel E et al. Cold Spring Harbor perspectives in medicine 2017 Apr (Posted: Apr-13-2017 10AM)

AMD Project: Detecting Changing Parasites
Using AMD methods to develop tools to detect changes in parasites that cause malaria (Posted: Apr-13-2017 10AM)

Time for Genome Editing: Next-Generation Attenuated Malaria Parasites.
Singer Mirko et al. Trends in parasitology 2017 Mar (3) 202-213 (Posted: Mar-14-2017 10AM)

Tools for attenuation of gene expression in malaria parasites.
Shaw Philip J et al. International journal for parasitology 2017 Jan (Posted: Mar-14-2017 10AM)

In a remote West African village, a revolutionary genetic experiment is on its way — if residents agree to it
I Swetlitz, StatNews, March 2017 (Posted: Mar-14-2017 10AM)

To Fight Malaria, Scientists Try Genetic Engineering To Wipe Out Mosquitoes
R Stein, NPR, December 2016 (Posted: Dec-22-2016 8AM)

Two Genetic Markers that Predict Malaria Treatment Failure Found
NIAID, November 3, 2016 Brand (Posted: Nov-04-2016 9AM)

Recent advances in malaria genomics and epigenomics.
Kirchner Sebastian et al. Genome medicine 2016 Sep (1) 92 (Posted: Oct-26-2016 7PM)

Molecular basis of human cerebral malaria development.
Wah Saw Thu et al. Tropical medicine and health 2016 33 (Posted: Oct-26-2016 7PM)

Immunomic approaches for antigen discovery of human parasites.
Kassegne Kokouvi et al. Expert review of proteomics 2016 Oct (Posted: Oct-26-2016 7PM)

Advanced Molecular Detection of Malarone Resistance.
Talundzic Eldin et al. Antimicrobial agents and chemotherapy 2016 Jun (6) 3821-3 (Posted: Oct-26-2016 7PM)

The Genetic Basis of Host Preference and Resting Behavior in the Major African Malaria Vector, Anopheles arabiensis.
Main Bradley J et al. PLoS genetics 2016 Sep (9) e1006303 (Posted: Sep-19-2016 2PM)

Recent advances in malaria genomics and epigenomics
S Kirchner et al, Genome Medicine, September 7, 2016 (Posted: Sep-07-2016 3PM)

Newborn screening and prophylactic interventions for sickle cell disease in 47 countries in sub-Saharan Africa: a cost-effectiveness analysis.
Kuznik Andreas et al. BMC health services research 2016 16(1) 304 (Posted: Aug-03-2016 9AM)

Genome-scale comparison of expanded gene families in Plasmodium ovale wallikeri and Plasmodium ovale curtisi with Plasmodium malariae and with other Plasmodium species.
Ansari Hifzur Rahman et al. International journal for parasitology 2016 Jul (Posted: Jul-18-2016 9PM)

The mRNA-bound proteome of the human malaria parasite Plasmodium falciparum
EM Bunnick et al, Genome Biology, July 5, 2016 (Posted: Jul-06-2016 9AM)

Genomic analysis of local variation and recent evolution in Plasmodium vivax
RD Pearson et al, Nature Genetics, June 27, 2016 (Posted: Jun-27-2016 1PM)

Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax
DN Hupalo et al, Nature Genetics, June 27, 2016 (Posted: Jun-27-2016 0PM)

World Malaria Day: April 25
Brand (Posted: Apr-25-2016 1PM)

Researchers Design Malaria-Resistant Mosquitoes
T Hampton, JAMA, February 2, 2016 (Posted: Feb-03-2016 8AM)

The influence of host genetics on erythrocytes and malaria infection: is there therapeutic potential?
Lelliott Patrick M et al. Malaria journal 2015 289 (Posted: Feb-03-2016 8AM)

Prospects and recommendations for risk mapping to improve strategies for effective malaria vector control interventions in Latin America.
Alimi Temitope O et al. Malaria journal 2015 (1) 519 (Posted: Feb-03-2016 8AM)

New report signals country progress in the path to malaria elimination
WHO, December 9, 2015 (Posted: Dec-09-2015 7AM)

Mosquitoes engineered to pass down genes that would wipe out their species
E Callaway, Nature News, December 7, 2015 (Posted: Dec-07-2015 7PM)

Gene Drive Research Takes Aim at Malaria
Francis Collins, NIH Director, December 1, 2015 Brand (Posted: Dec-01-2015 0PM)

Engineering Mosquitoes’ Genes to Resist Malaria
N Wade, New York Times, November 23, 2015 (Posted: Nov-30-2015 8AM)

'Gene drive' mosquitoes engineered to fight malaria Mutant mozzies could rapidly spread through wild populations.
H Ledford, Nature News, November 23, 2015 (Posted: Nov-24-2015 9AM)

Population genomic structure and adaptation in the zoonotic malaria parasite Plasmodium knowlesi.
Assefa Samuel et al. Proceedings of the National Academy of Sciences of the United States of America 2015 Oct (42) 13027-32 (Posted: Nov-24-2015 7AM)

Molecular tools for studying the major malaria vector Anopheles funestus: improving the utility of the genome using a comparative poly(A) and Ribo-Zero RNAseq analysis.
Weedall Gareth D et al. BMC genomics 2015 (1) 931 (Posted: Nov-24-2015 7AM)

Mutant mosquitoes 'resist malaria'
M Roberts, BBC News, November 24, 2015 (Posted: Nov-24-2015 7AM)

Applying chemical genetic tools to the study of phospho-signalling pathways in malaria parasites.
Mitcheson Deborah F et al. Biochimica et biophysica acta 2015 Oct (10 Pt B) 1650-6 (Posted: Nov-05-2015 11AM)

Using AMD methods to develop tools for the detection and management of insecticide resistance in mosquitoes that transmit malaria
Brand (Posted: Nov-05-2015 11AM)

The genes behind malaria resistance may reveal an intriguing evolutionary history
R Feltman, Washington Post, September 30, 2015 (Posted: Oct-05-2015 9AM)

A novel locus of resistance to severe malaria in a region of ancient balancing selection
Malaria Genomic Epidemiology Consortium, Nature, September 30, 2015 (Posted: Oct-05-2015 9AM)

Malaria Policy Advisory Committee to the WHO: conclusions and recommendations of seventh biannual meeting (March 2015).
Malar. J. 2015 295 (Posted: Sep-23-2015 2PM)

Parasitic Disease and Malaria Strategic Priorities: 2015—2020
Brand (Posted: Sep-23-2015 2PM)

Evaluation of the diagnostic accuracy of CareStart G6PD deficiency Rapid Diagnostic Test (RDT) in a malaria endemic area in Ghana, Africa.
Adu-Gyasi Dennis et al. PLoS ONE 2015 (4) e0125796 (Posted: Sep-23-2015 0PM)

G6PD gene variants and its association with malaria in a Sri Lankan population.
Dewasurendra Rajika L et al. Malar. J. 2015 93 (Posted: Sep-23-2015 0PM)

G6PD deficiency in male individuals infected by Plasmodium vivax malaria in the Brazilian Amazon: a cost study.
Peixoto Henry M et al. Malar. J. 2015 126 (Posted: Sep-23-2015 0PM)

G6PD Deficiency and Hemoglobinopathies: Molecular Epidemiological Characteristics and Healthy Effects on Malaria Endemic Bioko Island, Equatorial Guinea.
Lin Min et al. PLoS ONE 2015 (4) e0123991 (Posted: Sep-23-2015 0PM)

Hemoglobin E and Glucose-6-Phosphate Dehydrogenase Deficiency and Plasmodium falciparum Malaria in the Chittagong Hill Districts of Bangladesh.
Shannon Kerry L et al. Am. J. Trop. Med. Hyg. 2015 Aug 5. (2) 281-6 (Posted: Sep-23-2015 0PM)

Tolerability and safety of weekly primaquine against relapse of Plasmodium vivax in Cambodians with glucose-6-phosphate dehydrogenase deficiency.
Kheng Sim et al. BMC Med 2015 203 (Posted: Sep-23-2015 0PM)

Glucose-6-Phosphate Dehydrogenase Deficiency and Haemoglobin Drop after Sulphadoxine-Pyrimethamine Use for Intermittent Preventive Treatment of Malaria during Pregnancy in Ghana - A Cohort Study.
Owusu Ruth et al. PLoS ONE 2015 (9) e0136828 (Posted: Sep-23-2015 0PM)

Glucose-6-phosphate dehydrogenase deficiency and the risk of malaria and other diseases in children in Kenya: a case-control and a cohort study
S Uyoga et al. Lancet, September, 2015 (Posted: Sep-23-2015 0PM)

The utility of genomic data for Plasmodium vivax population surveillance.
Daniels Rachel Fath et al. Pathog Glob Health 2015 Apr 18. (Posted: Apr-24-2015 3PM)

Plasmodium knowlesi Genome Sequences from Clinical Isolates Reveal Extensive Genomic Dimorphism.
Pinheiro Miguel M et al. PLoS ONE 2015 (4) e0121303 (Posted: Apr-24-2015 3PM)

USP38, FREM3, SDC1, DDC and LOC727982 gene polymorphisms and differential susceptibility to severe malaria in Tanzania.
Manjurano Alphaxard et al. J. Infect. Dis. 2015 Mar 24. (Posted: Apr-24-2015 3PM)

Towards genome-wide experimental genetics in the in vivo malaria model parasite Plasmodium berghei.
Matz Joachim M et al. Pathog Glob Health 2015 Mar (2) 46-60 (Posted: Apr-24-2015 3PM)

The genetic control of immunity to Plasmodium infection.
Grant Audrey V et al. BMC Immunol. 2015 14 (Posted: Apr-24-2015 3PM)

Paths to a malaria vaccine illuminated by parasite genomics.
Conway David J et al. Trends Genet. 2015 Feb (2) 97-107 (Posted: Apr-24-2015 3PM)

The case for a rational genome-based vaccine against malaria.
Proietti Carla et al. Front Microbiol 2014 741 (Posted: Apr-24-2015 3PM)

Antimalarial drug resistance in Africa: key lessons for the future.
Takala-Harrison Shannon et al. Ann. N. Y. Acad. Sci. 2015 Apr (1) 62-7 (Posted: Apr-24-2015 3PM)

World Malaria Day
(Posted: Apr-24-2015 3PM)

ß-globin genes: mutation hot-spots in the global thalassemia belt.
Kumar Rakesh et al. Hemoglobin 2015 (1) 1-8 (Posted: Apr-07-2015 0PM)

CDC Information: Partners Turn the Tide Against Malaria
Brand (Posted: Feb-25-2015 0PM)

More than 200 million cases of malaria occur worldwide every year
Brand (Posted: Feb-25-2015 0PM)

AMD Projects: Next-Generation Malaria Methods
Brand (Posted: Feb-25-2015 0PM)

Protective effects of sickle cell trait against malaria-associated mortality and morbidity
Brand (Posted: Feb-25-2015 0PM)

Brand (Posted: Jan-11-2014 11AM)

Malaria is a mosquito-borne disease that can cause infected people to become very sick with high fever, chills, and flu-like illness. It can also cause death. Substantial progress has been made globally to control and eliminate malaria, but it continues to be a significant public health problem with roughly 3.2 billion people worldwide at risk for the disease.

Schistosomiasis (Bilharzia)
Brand (Posted: Jan-11-2014 11AM)

Schistosomiasis, also known as bilharzia, is a neglected tropical disease caused by parasitic worms. It is second only to malaria as the most devastating parasitic disease. The parasites that cause schistosomiasis live in certain types of freshwater snails. The infectious form of the parasite emerge from the snail and then contaminate the water. People become infected when their skin comes into contact with the contaminated freshwater. Most human infections are caused by Schistosoma mansoni, S. haematobium, or S. japonicum.

From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan-01-2011 0AM)

Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.