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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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Archived Hot Topics of the Day By Date
Notes from the Field: The National Wastewater Surveillance System's Centers of Excellence Contributions to Public Health Action During the Respiratory Virus Season - Four U.S. Jurisdictions, 2022-23.
Diana Valencia et al. MMWR Morb Mortal Wkly Rep 2023 11 (48) 1309-1312
(Posted: Dec 01, 2023 7AM)
Evolutionary implications of SARS-CoV-2 vaccination for the future design of vaccination strategies.
Igor M Rouzine et al. Commun Med (Lond) 2023 6 (1) 86
(Posted: Jun 24, 2023 10AM)
Safety and immunogenicity of a phase 1/2 randomized clinical trial of a quadrivalent, mRNA-based seasonal influenza vaccine (mRNA-1010) in healthy adults: interim analysis.
Ivan T Lee et al. Nat Commun 2023 6 (1) 3631
(Posted: Jun 20, 2023 7AM)
BA.1 Bivalent COVID-19 Vaccine Use and Stroke in England.
Nick Andrews et al. JAMA 2023 6
(Posted: Jun 19, 2023 1PM)
Why the world needs more transparency on the origins of novel pathogens
M Venter, Nature, May 30, 2023
(Posted: May 30, 2023 6AM)
COVID's future: mini-waves rather than seasonal surges Three years after the start of the pandemic, SARS-CoV-2 shows no signs of settling into a seasonal pattern of spread, like influenza has.
E Callaway, Nature, May 1, 2023
(Posted: May 01, 2023 10AM)
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19.
Daniela Matuozzo et al. Genome medicine 2023 4 (1) 22
(Posted: Apr 09, 2023 7AM)
Joint COVID-19 and influenza-like illness forecasts in the United States using internet search information.
Simin Ma et al. Communications medicine 2023 3 (1) 39
(Posted: Mar 29, 2023 8AM)
An mRNA Influenza Vaccine - Could It Deliver?
Kathleen M Neuzil et al. The New England journal of medicine 2023 3 (12) 1139-1141
(Posted: Mar 23, 2023 6AM)
How to stop the bird flu outbreak becoming a pandemic
SM Sidik, Nature, March 1, 2023
(Posted: Mar 02, 2023 9AM)
Girl who died of bird flu did not have widely-circulating variant
S Mallapaty, Nature, February 28, 2023
(Posted: Feb 28, 2023 6AM)
Early risk-assessment of pathogen genomic variants emergence
Z Susswein et al, MEDRXIV, January 27, 2023
(Posted: Jan 28, 2023 11AM)
Should COVID vaccines be yearly? Proposal divides US scientists
M Kozlov, Nature, January 27, 2023
(Posted: Jan 27, 2023 9AM)
Massive health-record review links viral illnesses to brain disease
M Koslov, Nature, January 23, 2023
(Posted: Jan 24, 2023 8AM)
An immune dysfunction score for stratification of patients with acute infection based on whole-blood gene expression.
Cano-Gamez Eddie et al. Science translational medicine 2022 11 (669) eabq4433
(Posted: Nov 14, 2022 6AM)
Rare predicted loss-of-function variants of type I IFN immunity genes are associated with critical COVID-19
D Matuozo et al, MEDRXIV, October 25, 2022
(Posted: Oct 26, 2022 1PM)
Prediction of upcoming global infection burden of influenza seasons after relaxation of public health and social measures during the COVID-19 pandemic: a modelling study.
Ali Sheikh Taslim et al. The Lancet. Global health 2022 10 (11) e1612-e1622
(Posted: Oct 15, 2022 7AM)
Wastewater surveillance of human influenza, metapneumovirus, parainfluenza, respiratory syncytial virus (RSV), rhinovirus, and seasonal coronaviruses during the COVID-19 pandemic
A Boehm et al, MEDRXIV, September 23, 2022
(Posted: Sep 24, 2022 7AM)
Immune memory to SARS-CoV-2 Omicron BA.1 breakthrough infections: To change the vaccine or not?
van Zelm Menno C et al. Science immunology 2022 6 (74) eabq5901
(Posted: Aug 27, 2022 7AM)
Immune memory to SARS-CoV-2 Omicron BA.1 breakthrough infections: To change the vaccine or not?
MC van Zelm, Sci Immunology, June 2, 2022
(Posted: Jun 03, 2022 0PM)
Epidemiological Interactions of Influenza and SARS-CoV-2 within a University Population During Omicron B.1.1.529 Outbreak
R Malampy et al, MEDRXIV, May 27, 2022
(Posted: May 28, 2022 11AM)
Variant-specific symptoms of COVID-19 among 1,542,510 people in England
M Whitaker et al, MEDRXIV, May 23, 2022
(Posted: May 24, 2022 7AM)
The clinical progress of mRNA vaccines and immunotherapies
AJ Barbier et al, Nature Biotechnology, May 9, 2022
(Posted: May 09, 2022 11AM)
Are COVID surges becoming more predictable? New Omicron variants offer a hint
E Callaway, Nature, May 6, 2022
(Posted: May 06, 2022 1PM)
COVID-19 Vaccination—Becoming Part of the New Normal
P Marks et al, JAMA, May 2, 2022
(Posted: May 02, 2022 11AM)
Why do people die from COVID-19?
Bastard Paul et al. Science (New York, N.Y.) 2022 2 (6583) 829-830
(Posted: Mar 01, 2022 7AM)
Multiplexed CRISPR-based microfluidic platform for clinical testing of respiratory viruses and identification of SARS-CoV-2 variants
NL Welch et al, Nature Medicine, February 7, 2022
(Posted: Feb 07, 2022 0PM)
A Machine Learning Approach to Differentiate Between COVID-19 and Influenza Infection Using Synthetic Infection and Immune Response Data
SF Sardroodi et al, MEDRXIV, January 29, 2022
(Posted: Jan 29, 2022 10AM)
What is Genomic Surveillance?
CDC, January 25, 2022
(Posted: Jan 24, 2022 2PM)
Beyond Omicron: what’s next for COVID’s viral evolution
E Callaway, Nature, December 7, 2021
(Posted: Dec 08, 2021 8AM)
Genetic ancestry effects on the response to viral infection are pervasive but cell type specific
HE Randolph et al, Science, November 25, 2021
(Posted: Nov 26, 2021 10AM)
COVID-19 first and delta waves in relation to ACEI, ARB, Influenza vaccination, and comorbidity in a North Metropolitan Barcelona Health Consortium
MJ Gonzales et al, MEDRXIV, November 19, 2021
(Posted: Nov 21, 2021 10AM)
COVID-19 vaccines for children
JS Gerber et al, Science, November 19, 2021
(Posted: Nov 19, 2021 6AM)
COVID-19 first and delta waves in relation to ACEI, ARB, Influenza vaccination, and comorbidity in a North Metropolitan Barcelona Health Consortium
MJ Gonzales et al, MEDRXIV, November 17, 2021
(Posted: Nov 18, 2021 5AM)
Safety and immunogenicity of concomitant administration of COVID-19 vaccines (ChAdOx1 or BNT162b2) with seasonal influenza vaccines in adults in the UK (ComFluCOV): a multicentre, randomised, controlled, phase 4 trial
R Lazarus et al, The Lancet, November 11, 2021
(Posted: Nov 13, 2021 6AM)
The Future of SARS-CoV-2 Vaccination - Lessons from Influenza.
Monto Arnold S et al. The New England journal of medicine 2021 11 (20) 1825-1827
(Posted: Nov 11, 2021 0PM)
COVID super-immunity: one of the pandemic’s great puzzles
E Callaway, Nature, October 14, 2021
(Posted: Oct 16, 2021 7AM)
Assessment of the Feasibility of Using Noninvasive Wearable Biometric Monitoring Sensors to Detect Influenza and the Common Cold Before Symptom Onset
E Grzesiak et al, JAMA Network Open, September 29, 2021
(Posted: Sep 30, 2021 7AM)
Incidence, co-occurrence, and evolution of long-COVID features: A 6-month retrospective cohort study of 273,618 survivors of COVID-19
M Taquet et al, PLOS Medicine, September 28, 2021
(Posted: Sep 29, 2021 1PM)
Digital intervention increases influenza vaccination rates for people with diabetes in a decentralized randomized trial
JL Lee et al, NPJ Digital Medicine, September 17, 2021
(Posted: Sep 17, 2021 6AM)
Rare variant MX1 alleles increase human susceptibility to zoonotic H7N9 influenza virus
Y Chen et al, Science, August 20, 2021
(Posted: Aug 20, 2021 8AM)
CDC Diagnostic Tests for COVID-19
CDC, August 7, 2021
(Posted: Aug 09, 2021 0AM)
Can Vaccine Prioritization Reduce Disparities in Covid-19 Burden for Historically Marginalized Populations?
E Rosenstrom et al, MEDRXIV, July 30, 2021
(Posted: Jul 31, 2021 8AM)
A vital sign-based prediction algorithm for differentiating COVID-19 versus seasonal influenza in hospitalized patients
N Yanamala et al, NPJ Digital Medicine, June 4, 2021
(Posted: Jun 05, 2021 9AM)
COV-ID: A LAMP sequencing approach for high-throughput co-detection of SARS-CoV-2 and influenza virus in human saliva
RW Thomson et al, MEDRXIV, April 23, 2021
(Posted: Apr 24, 2021 10AM)
Inflammatory profiles across the spectrum of disease reveal a distinct role for GM-CSF in severe COVID-19.
Thwaites Ryan S et al. Science immunology 2021 3 (57)
(Posted: Mar 25, 2021 6AM)
COVID-19 Vaccines vs Variants—Determining How Much Immunity Is Enough
R Rubin, JAMA, March 17, 2021
(Posted: Mar 18, 2021 9AM)
How COVID unlocked the power of RNA vaccines
The technology could revolutionize efforts to immunize against HIV, malaria, influenza and more.
E Dolgin, Nature News, January 12, 2021
(Posted: Jan 12, 2021 1PM)
The importance of seasonal influenza vaccination for people with disabilities during the COVID-19 pandemic.
Peacock Georgina et al. Disability and health journal 2020 Dec 101058
(Posted: Jan 08, 2021 8AM)
Shots of hope
J Cohen, Science December 17, 2020
(Posted: Dec 18, 2020 8AM)
Comparison of the characteristics, morbidity, and mortality of COVID-19 and seasonal influenza: a nationwide, population-based retrospective cohort study
L Piroth et al, Lancet Respiratory Medicine
(Posted: Dec 18, 2020 7AM)
New Technologies for Influenza Vaccines.
Rockman Steven et al. Microorganisms 2020 Nov (11)
(Posted: Dec 07, 2020 9AM)
Reverse genetics for influenza B viruses and recent advances in vaccine development.
Cardenas-Garcia Stivalis et al. Current opinion in virology 2020 Nov 191-202
(Posted: Dec 07, 2020 9AM)
RNA vaccines: an introduction
PHG Foundation, November 2020
(Posted: Nov 26, 2020 8AM)
High-risk Groups for Influenza Complications.
Uyeki Timothy M et al. JAMA 2020 Nov
(Posted: Nov 03, 2020 8AM)
Inborn errors of type I IFN immunity in patients with life-threatening COVID-19
Q Zhang et al, Science, September 24, 2020
(Posted: Sep 25, 2020 0PM)
Assessing Risk Factors for Severe COVID-19 Illness
CDC, August 2020
(Posted: Aug 14, 2020 10AM)
Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States.
Silverman Justin D et al. Science translational medicine 2020 Jun
(Posted: Jul 30, 2020 8AM)
Detection and Genetic Characterization of Community-Based SARS-CoV-2 Infections — New York City, March 2020
D Bushman et al, CDC MMWR, July 17, 2020
(Posted: Jul 16, 2020 1PM)
Comparing SARS-CoV-2 with SARS-CoV and influenza pandemics
E Petersen et al, LANcet, July 3, 2020
(Posted: Jul 05, 2020 8AM)
Deep phenotyping of 34,128 patients hospitalised with COVID-19 and a comparison with 81,596 influenza patients in America, Europe and Asia: an international network study
E Burn et al, MEDRXIV, June 28, 2020
(Posted: Jun 29, 2020 7AM)
Using influenza surveillance networks to estimate state-specific prevalence of SARS-CoV-2 in the United States
JD Silverman et al, Sci Trans Med, June 2020
(Posted: Jun 26, 2020 9AM)
Human genetics of life-threatening influenza pneumonitis.
Zhang Qian et al. Human genetics 2020 Jun 139(6-7) 941-948
(Posted: Jun 16, 2020 3PM)
Real Time Investigation of a large Nosocomial Influenza A Outbreak Informed by Genomic Epidemiology
W Javaid et al, MEDRXIV, May 2020
(Posted: May 15, 2020 9AM)
Using ILI surveillance to estimate state-specific case detection rates and forecast SARS-CoV-2 spread in the United States
JD Silverman et al, MEDRXIV, April 26, 2020
(Posted: Apr 26, 2020 4PM)
An international characterisation of patients hospitalised with COVID-19 and a comparison with those previously hospitalised with influenza
A Burn et al, MEDRXIV, April 26, 2020
(Posted: Apr 26, 2020 8AM)
Using ILI surveillance to estimate state-specific case detection rates and forecast SARS-CoV-2 spread in the United States
JD Silverman et al, MEDRXIV, April 3, 2020
(Posted: Apr 04, 2020 10AM)
Development of CRISPR as a prophylactic strategy to combat novel coronavirus and influenza
BTR Abbott et al, IORXIV, March 2020
(Posted: Mar 18, 2020 8AM)
Using a machine learning approach to predict mortality in critically ill influenza patients: a cross-sectional retrospective multicentre study in Taiwan.
Hu Chien-An et al. BMJ open 2020 Feb 10(2) e033898
(Posted: Mar 04, 2020 9AM)
Mining coronavirus genomes for clues to the outbreak’s origins
J Cohen, Science, January 2020
(Posted: Feb 09, 2020 4PM)
Beyond the Data Podcast, CDC Public Health Grand Rounds
CDC, January 2020
(Posted: Jan 28, 2020 7AM)
Your Fitbit could help health officials predict flu outbreaks in real-time
A Kim, CNN, January 2020
(Posted: Jan 24, 2020 8AM)
Harnessing wearable device data to improve state-level real-time surveillance of influenza-like illness in the USA: a population-based study
JM Radin et al, Lancet Digital HEalth, January 16, 2020
(Posted: Jan 17, 2020 8AM)
The Emerging Role of Pathogen Genomics in Public Health
CDC Public Health Grand Rounds, January 21, 2020
(Posted: Jan 08, 2020 10AM)
Progress in Pathogen Genomics as a Prototype for Precision Public Health
MJ Khoury, CDC Blog Post, January 2, 2020
(Posted: Jan 04, 2020 2PM)
Accuracy of real-time multi-model ensemble forecasts for seasonal influenza in the U.S.
Reich Nicholas G et al. PLoS computational biology 2019 Nov 15(11) e1007486
(Posted: Nov 26, 2019 8AM)
The Search for a Universal Flu Vaccine Heats Up
J Abbasi, JAMA, November 6, 2019
(Posted: Nov 07, 2019 8AM)
People at High Risk For Flu Complications
CDC, 2019
(Posted: Oct 15, 2019 8AM)
Get Vaccinated to Fight Flu
CDC, September 2019
(Posted: Sep 30, 2019 8AM)
A sticking point for rapid flu tests?
E Svoboda, Nature Outlook, September 2019
(Posted: Sep 24, 2019 9AM)
Real-time flu tracking- By monitoring social media, scientists can monitor outbreaks as they happen.
C Schmidt, Nature Outlook, September 18, 2019
(Posted: Sep 19, 2019 9AM)
Disrupting the gut microbiome may affect some immune responses to flu vaccination
NIH, September 6, 2019
(Posted: Sep 08, 2019 2PM)
The 1918 influenza pandemic: 100 years of questions answered and unanswered.
Taubenberger Jeffery K et al. Science translational medicine 2019 Jul (502)
(Posted: Jul 26, 2019 9AM)
Preventive care services and health behaviors in children with fragile X syndrome.
Gilbertson Kendra E et al. Disability and health journal 2019 May
(Posted: Jul 19, 2019 10AM)
Key Findings: Preventive Care Services and Health Behaviors in Children with Fragile X Syndrome
CDC, July 2019
(Posted: Jul 17, 2019 8AM)
Flu Outbreak Prediction Using Twitter Posts Classification and Linear Regression With Historical Centers for Disease Control and Prevention Reports: Prediction Framework Study.
Alessa Ali et al. JMIR public health and surveillance 2019 Jun 5(2) e12383
(Posted: Jul 02, 2019 9AM)
FluSight: Flu Forecasting
CDC, June 2019
(Posted: Jun 28, 2019 9AM)
Complementing the power of deep learning with statistical model fusion: Probabilistic forecasting of influenza in Dallas County, Texas, USA.
Soliman Marwah et al. Epidemics 2019 Jun 100345
(Posted: Jun 19, 2019 9AM)
Summary of Progress since 2009
CDC, June 2019
(Posted: Jun 12, 2019 9AM)
Current and future influenza vaccines
S Yamayoshi et al, Nature Medicine, January 28, 2019
(Posted: Jan 29, 2019 6PM)
The respiratory microbiome and susceptibility to influenza virus infection.
Lee Kyu Han et al. PloS one 2019 (1) e0207898
(Posted: Jan 20, 2019 8AM)
A collaborative multiyear, multimodel assessment of seasonal influenza forecasting in the United States.
Reich Nicholas G et al. Proceedings of the National Academy of Sciences of the United States of America 2019 Jan
(Posted: Jan 18, 2019 10AM)
Improved state-level influenza nowcasting in the United States leveraging Internet-based data and network approaches
FS Lu et al, Nature Communications, January 11, 2019
(Posted: Jan 12, 2019 3PM)
Host and viral determinants of influenza A virus species specificity.
Long Jason S et al. Nature reviews. Microbiology 2018 Nov
(Posted: Dec 03, 2018 9AM)
Influenza vaccine: Where are we and where do we go?
Keshavarz Mohsen et al. Reviews in medical virology 2018 Nov e2014
(Posted: Dec 03, 2018 9AM)
Flu mutations in a single cell help to predict immune response- Genetic diversity of the virus may explain variability in how well a cell fights back.
C Arnold, Nature News, October 29, 2018
(Posted: Oct 29, 2018 1PM)
CDC Scientists Become First in History to Directly Sequence the Entire RNA Genomes of Influenza A Viruses
CDC, September26, 2018
(Posted: Sep 26, 2018 11AM)
Genomic surveillance of avian-origin influenza A viruses causing human disease.
Lam Tommy T et al. Genome medicine 2018 Jun (1) 50
(Posted: Jul 02, 2018 10AM)
Taking flight with Precision Global Health: a scoping review on avian influenza
NE Bempong et al, JPHE, June 2018
(Posted: Jul 02, 2018 8AM)
Stanford scientists discover biomarker for flu susceptibility
Stanford University, June 2018
(Posted: Jun 17, 2018 1PM)
Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
- Page last reviewed:Feb 1, 2024
- Page last updated:Mar 27, 2024
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