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Last Posted: Nov 08, 2022
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Precision medicine for inflammatory bowel disease
H Carr, PHG Foundation, September 30, 2022

IBD is a relapsing inflammatory disease that is increasing in newly industrialized countries. Treatment decisions for IBD are currently based on trial and error, resulting in patient uncertainty and potential for uncontrolled disease. Precision medicine approaches could inform treatment decisions and ensure the right patient gets the right treatment at the right time, increasing disease control and improving patients’ quality of life. Precision medicine for IBD is not yet ready for the clinic and requires further research and validation

Longitudinal multi-omics analysis identifies early blood-based predictors of anti-TNF therapy response in inflammatory bowel disease
N Mishra et al, Genome Medicine, September 24, 2022

We performed a longitudinal, blood-based multi-omics study in two prospective IBD patient cohorts receiving first-time infliximab therapy (discovery: 14 patients, replication: 23 patients). Samples were collected at up to 7 time points (from baseline to 14 weeks after therapy induction). RNA-sequencing and genome-wide DNA methylation data were analyzed and correlated with clinical remission at week 14 as a primary endpoint.


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