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Last Posted: Apr 17, 2024
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RNA Injection Every 6 Months to Improve Adherence and Lower Blood Pressure in Patients With Hypertension.
Ernesto L Schiffrin et al. JAMA 2024 2

From the article: "A new report from the KARDIA-1 clinical trial demonstrates that reducing angiotensinogen with the silencing RNA zilebesiran, BP may be lowered with injections of the small interfering RNA every 6 months, which could prove useful for improving adherence to treatment. The use of an injection every 6 months, if shown to produce sustained BP lowering, could help achieve goal BP in patients who do not adhere to currently prescribed antihypertensive treatment, a major cause of both uncontrolled and difficult to control hypertension. "

Association Between a First-Degree Family History and Self-Reported Personal History of Obesity, Diabetes, and Heart and Blood Conditions: Results From the All of Us Research Program.
Danielle Rasooly et al. J Am Heart Assoc 2023 11 e030779

From the abstract: "We assessed the association between a self-reported family history of ODHBs and their risk in the adult population (age =20 years) of the AoU (All of Us) Research Program, a longitudinal cohort study of diverse participants across the United States. We conducted a family history-wide association study to systematically assess the association of a first-degree family history of 15 ODHBs in AoU. We use the FamWAS method to estimate 225 familial associations among 15 ODHBs. The results include overlapping associations between family history of different types of cardiometabolic conditions (such as type 2 diabetes and coronary artery disease), and their risk factors (obesity, hypertension), where adults with a family history of 1 ODHB exhibited 1.1 to 5.6 times (1.5, on average) the odds of having a different ODHB. "

Cost effectiveness review of text messaging, smartphone application, and website interventions targeting T2DM or hypertension.
Ruben Willems et al. NPJ Digit Med 2023 8 (1) 150

Digital health interventions have been shown to be clinically-effective for type 2 diabetes mellitus (T2DM) and hypertension prevention and treatment. This study synthesizes and compares the cost-effectiveness of text-messaging, smartphone application, and websites. We found that digital interventions are cost-effective without substantial differences between the different delivery modes. Future health economic studies should increase transparency, conduct sufficient sensitivity analyses, and appraise the ICUR more critically in light of a reasoned willingness-to-pay threshold.

Silencing Angiotensinogen in Hypertension.
Rhian M Touyz et al. N Engl J Med 2023 7 (3) 278-281

Addressing the challenges to improve antihypertensive therapy together with the urgency for better blood-pressure control has led to renewed interest in the development of targeted, simplified approaches to treatment. For the first time in almost 20 years, numerous new drug classes have been tested in clinical trials. These drugs are typically targeted with greater precision than previous drugs, have fewer side effects, and are user-friendly and of durable effect.

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Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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