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Last Posted: Jan 30, 2024
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What to Know About PREVENT, the AHA's New Cardiovascular Disease Risk Calculator.
Howard Larkin et al. JAMA 2023 12

From the article: "After 10 years, the American Heart Association (AHA) has updated its cardiovascular disease risk calculator for all adults aged 30 to 79 years without known cardiovascular disease. The Predicting Risk of Cardiovascular Disease Events (PREVENT) calculator is based on newer data from a larger, more diverse sample than the existing tool, the commonly used Pooled Cohort Equations (PCEs), released in 2013 for non-Black Hispanic and White adults aged 40 to 79 years. The PREVENT equations also take into account other health conditions, such as kidney and metabolic diseases, for determining the 10- and 30-year chances of both atherosclerotic cardiovascular disease and heart failure. "

A deep learning-based electrocardiogram risk score for long term cardiovascular death and disease
JW Hughes et al, NPJ Digital Medicine, September 12, 2023

From the abstract: "The electrocardiogram (ECG) is the most frequently performed cardiovascular diagnostic test, but it is unclear how much information resting ECGs contain about long term cardiovascular risk. Here we report that a deep convolutional neural network can accurately predict the long-term risk of cardiovascular mortality and disease based on a resting ECG alone."

The role of aldehyde dehydrogenase 2 in cardiovascular disease.
Jian Zhang et al. Nature reviews. Cardiology 2023 2

Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating ALDH2 rs671 polymorphism, present in up to 8% of the global population and in up to 50% of the East Asian population, is associated with increased risk of cardiovascular conditions such as coronary artery disease, alcohol-induced cardiac dysfunction, pulmonary arterial hypertension, heart failure and drug-induced cardiotoxicity.


Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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