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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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209 hot topic(s) found with the query "Genomic medicine"

Genomic Medicine Year in Review: 2019
T Manolio et al, AJHG, December 4, 2019 (Posted: Dec-06-2019 9AM)

A NHGRI Working Group attempted to identify in its view the ten most significant advances among 48 recognized “accomplishments” published during the past 12 months. These papers clustered into 11 broad categories; 12 papers spanned two categories. We selected ten papers for this review. Brief summaries are provided below.

Are providers prepared for genomic medicine: interpretation of Direct-to-Consumer genetic testing (DTC-GT) results and genetic self-efficacy by medical professionals
BMC Health Services Research, November 25, 2019 (Posted: Nov-27-2019 5AM)

In this national survey, specialists remain the best group to assist patients with DTC-GT, however, primary care providers may still provide accurate interpretation of test results when specialists are unavailable.

Artificial intelligence in clinical and genomic diagnostics.
Dias Raquel et al. Genome medicine 2019 Nov (1) 70 (Posted: Nov-24-2019 7AM)

We focus on emerging methods for specific tasks in clinical genomics, including variant calling, genome annotation and variant classification, and phenotype-to-genotype correspondence. Finally, we end with a discussion on the future potential of AI in individualized medicine applications.

Is ‘likely pathogenic’ really 90% likely? Reclassification data in ClinVar
SM Harrison et al, Genome Medicine, November 21, 2019 (Posted: Nov-23-2019 8AM)

In 2015, professional guidelines defined the term ‘likely pathogenic’ to mean with a 90% chance of pathogenicity. To determine whether current practice reflects this definition, ClinVar classifications were tracked from 2016 to 2019. During that period, between 83.8 and 99.1% of likely pathogenic classifications were reclassified as pathogenic.

Current Policy Challenges in Genomic Medicine
RD Klein, Clinical Chemistry, November 2019 (Posted: Nov-12-2019 8AM)

Coverage and reimbursement policies present serious challenges to genetic and genomic testing. The potential for regulation of LDTs looms as a significant threat to diagnostic innovation, patient access, and the viability of molecular genetic testing laboratories. Changes in patent law could cause gene patents to reemerge as barriers to genomic medicine.

Delivering genome sequencing in clinical practice: an interview study with healthcare professionals involved in the 100 000 Genomes Project.
Sanderson Saskia C et al. BMJ open 2019 Nov (11) e029699 (Posted: Nov-10-2019 8AM)

Healthcare professionals responsible for delivering clinical genome sequencing have largely positive views about the potential for genome sequencing to improve diagnostic yield, but also significant concerns about practical aspects of offering these tests.

UVM Health Network to offer DNA testing as part of primary care
K Jickling, Support VTDigger, November 7,y 2019 (Posted: Nov-09-2019 8AM)

The tests are part of a pilot project that will allow primary care doctors and geneticists to identify and treat preventable diseases earlier. Using blood drawn as part of the appointment, the tests will analyze 147 genes for mutations that are linked to certain diseases, such as cancer or heart disease.

Genomic Medicine XII: Genomics and Risk Prediction
NHGRI 2019 meeting and slide presentations (Posted: Nov-05-2019 8AM)

Summary and slides of meeting to Review the state of science of polygenic risk scores and how it can be improved; examine other information sources that should be integrated with genetic variant information in predicting risk; identify research directions in development and implementation of genomic risk prediction.

Tracking human genes along the translational continuum
K Lee et al, NPJ Genomic Medicine, October 16, 2019 (Posted: Oct-17-2019 9AM)

Understanding the drivers of research on human genes is a critical component to success of translation efforts of genomics into medicine and public health. Using publicly available curated online databases we sought to identify specific genes that are featured in translational genetic research in comparison to all genomics research publications.

Was the Human Genome Project a dud?
EF Torrey, Dallas Morning News, October 13, 2019 (Posted: Oct-14-2019 4PM)

Two decades later it has become clear that the Human Genome Project was vastly oversold. It has led to improvement for a few rare genetic conditions, but its major intellectual contribution to date has been a better understanding of human evolution. But for most human diseases the results have been meager.

New competency framework for genomic testing
Genomics Education Programme, October 8, 2019 (Posted: Oct-11-2019 8AM)

With the roll-out of the NHS Genomic Medicine Service, Healthcare professionals will need to be equipped to facilitate patient consent to these tests, and provide information to patients. The Genomics Education Programme has developed a competency framework that identifies eight areas of proficiency to facilitate and consent patients to genomic tests. It is intended as a cross-professional guide for best practice, and has been designed around four categories of healthcare professionals based on their training and experience.

Family Health History: The First Genetic Test in Precision Medicine.
Bennett Robin L et al. The Medical clinics of North America 2019 Nov 103(6) 957-966 (Posted: Oct-09-2019 8AM)

The collection of family history has always been a tool for genetic evaluation, but it remains an essential tool even in the age of genomic medicine. Patients may have a risk for a disease based on family history regardless of the results of genetic and genomic tests.

Can one overcome “unhealthy genes”?
J Lazarte et al, NPJ Genomic Medicine (Posted: Oct-04-2019 9AM)

Like a book, our genome is not isolated from innumerable relationships, including those with the environment and conscious lifestyle choices.1 Furthermore, an axis of complex interactions between individual genes underlies the phenotype at any point in time.

One byte at a time: evidencing the quality of clinical service next-generation sequencing for germline and somatic variants
M Weronika et al, EJHG, September 29, 2-10 (Posted: Oct-01-2019 8AM)

For accredited laboratories as well as those seeking accreditation, both objective measures of quality and external review of laboratory processes are required. External quality assessment (EQA), or Proficiency Testing (PT), can assess a laboratory’s service through an independent external agency.

Translational genomics and precision medicine: Moving from the lab to the clinic
E Zeggini et al, Science, September 27, 2019 (Posted: Sep-28-2019 8AM)

Translational genomics aims to improve human health by building on discoveries made through genetics research and applying them in the clinical setting. This progress has been made possible by technological advances in genomics and analytics and by the digital revolution.

Healthcare System-Funded Preventive Genomic Screening: Challenges for Australia and Other Single-Payer Systems
P Lacaze et al, Public Health Genomics, September 24, 2019 (Posted: Sep-25-2019 9AM)

The prospect of healthcare systems offering preventive genomic testing to all adults is becoming feasible. Some single-payer or state-funded healthcare systems are already considering offering universal testing as part of routine care. The paper outlines challenges ahead in considering screening and discusses research that is helping shape future direction.

Rethinking the ethical principles of genomic medicine services
SB Johnson et al, Eur J Hum Genetics, September 18, 2019 (Posted: Sep-21-2019 1PM)

This paper examines ethical principles that should guide regulatory processes regarding consent and data sharing in this context. We argue that genomic data in a health system carries substantial societal benefits, and that the collective nature of genomics means that patients who benefit from sequencing have an ethical obligation to share health information

Implementation science and genomic medicine in action: A case study
M Clyne et al, CDC Blog, September 18, 2019 Brand (Posted: Sep-19-2019 9AM)

An ideal opportunity to understand how a genomic research activity falls into the implementation science realm is to read through the details of an applicable study. Here, we will guide you through a study on ”Implementing Universal Lynch Syndrome Screening: Identifying Strategies to Facilitate and Maintain Programs in Different Organizational Contexts."

Genetic Counseling and Public Health in the Era of Precision Medicine
MJ Khoury, CDC Blog, September 18, 2019 Brand (Posted: Sep-19-2019 9AM)

As more genetic counselors make a leap from individual patient care to population health concerns including implementation and disparities, genetic counselors will help enhance the public’s genetic awareness and literacy about genomics and family health history, contribute to policy, evaluation and implementation, and drive the overall success of genomic medicine.

Genome sequencing in healthcare: understanding the UK general public’s views and implications for clinical practice
LM Ballard et al, Eur J Humn Genetics, September 16, 2019 (Posted: Sep-17-2019 7AM)

The study garnered public views regarding genome sequencing, incidental findings (IFs), and sharing genetic information with relatives. Participants (n?=?1954) from the British general public completed a survey, distributed via email. Overall, the public had a positive view of genomic sequencing, choosing ‘informative’ as the most popular word.

Predictive value of genomic screening: cross-sectional study of cystic fibrosis in 50,788 electronic health records
JP Sugunarajav et al, NPJ Genomic Medicine, September 5, 2019 (Posted: Sep-06-2019 7AM)

Despite EHR-based phenotyping limitations, the presence or absence of pathogenic CFTR variants has strong predictive value for CF diagnosis when EHR data is used as the sole phenotyping source.

The Genomics Research and Innovation Network: creating an interoperable, federated, genomics learning system.
Mandl Kenneth D et al. Genetics in medicine : official journal of the American College of Medical Genetics 2019 Sep (Posted: Sep-05-2019 8AM)

Has Genomic Medicine Delivered in Cancer?
DJ Kerr, Medscape, August 2019 (Posted: Sep-05-2019 8AM)

Recognition of Board-Certified Clinical Laboratory Professionals as Qualified Healthcare Professionals
ACMG, August 29, 2019 (Posted: Aug-29-2019 9AM)

The American College of Medical Genetics and Genomics (ACMG) strongly recommends that appropriately trained and board-certified doctoral level clinical laboratory professionals be recognized as Qualified Healthcare Professionals (QHPs).

NIH announces six inaugural Genomic Innovator Awards
NIH, August 27, 2019 Brand (Posted: Aug-28-2019 7AM)

If You Build It Will They Come? The Urgent Need for Implementation Science in Genomic Medicine
M Clyne et al, CDC Blog, 2017 Brand (Posted: Aug-26-2019 11AM)

Exome sequencing of 457 autism families recruited online provides evidence for autism risk genes
P Feliciano et al, NPJ Genomic Medicine, August23, 2019 (Posted: Aug-23-2019 11AM)

Is Genetic Medicine Making the World Less Fair?
L Hercher, the Nation, August 23, 2019 (Posted: Aug-23-2019 9AM)

Harmonizing Clinical Sequencing and Interpretation for the eMERGE III Network
eMERGE consortium, AJHG, August 22, 2019 (Posted: Aug-23-2019 8AM)

This study integrated structured genomic results into multiple electronic health record systems, setting the stage for clinical decision support to enable genomic medicine. The established processes enable different sequencing sites to harmonize interpretation of sequencing tests, a critical achievement toward global standardization of genomic testing.

Genomic medicine: time for health-care transformation
RH Scott et al, The Lancet, August 6, 2019 (Posted: Aug-06-2019 11AM)

Genomic Medicine Series
The Lancet, August 5, 2019 (Posted: Aug-06-2019 9AM)

The maturing area of genomic medicine, encompassing the use of individuals’ genetic information to guide clinical treatment, is featured in this Series. In these five, timely reviews, authors present an overview of efforts to implement genomic medicine, including contemporary tools and resources.

The Human Genomic Revolution: Past, Present, and Future
E. Lander presentation, Broad Institute, July 2019 (Posted: Aug-05-2019 8AM)

Over 15 years ago, the scientific community celebrated the sequencing of the first human genome. It’s time to ask how this monumental effort has transformed biomedical science, from basic research to the understanding and treatment of disease. Eric Lander surveys the impact — what we’ve learned, and what lies ahead.

Family still matters: Counseling patients with complex family histories of colon and endometrial cancers.
Gemmell Amber P et al. Molecular genetics & genomic medicine 2019 Jul e886 (Posted: Jul-31-2019 8AM)

There are no national guidelines for the management of patients with a family history consistent with Lynch syndrome (LS) but a negative genetic test. To determine current management practices, genetic counselors' (GCs) recommendations were assessed.

Can Equity in Genomic Medicine Become a Quality Goal?
NHGRI 1-hour webinar by Katrina Armstrong, July 2019 Brand (Posted: Jul-29-2019 1PM)

Implementation of a genomic medicine multi-disciplinary team approach for rare disease in the clinical setting: a prospective exome sequencing case series.
Taylor John et al. Genome medicine 2019 Jul (1) 46 (Posted: Jul-29-2019 1PM)

The study reports a consecutive case series of 132 patients (involving 10 medical specialties with 43.2% cases having a neurological disorder) undergoing exome sequencing over a 10-month period.The costs of running the MDT are also reported.

What will it take to implement genomics in practice? Lessons from the IGNITE Network.
Ginsburg Geoffrey S et al. Personalized medicine 2019 Jul (Posted: Jul-28-2019 4PM)

While many aspects of implementation science are generic, the unique features of genomic medicine call for adapting current implementation science models to meet the needs of patients, providers and health systems adopting these complex interventions. Since 2013, the IGNITE network has faced numerous challenges. To enable future research, those challenges and our insights for solutions are highlighted.

Genomic knowledge in the contextstic exome sequencing: changes over time, persistent subgroup differences, and associations with psychological sequencing outcomes.
Rini Christine et al. Genetics in medicine : official journal of the American College of Medical Genetics 2019 Jul (Posted: Jul-20-2019 4PM)

People undergoing diagnostic genome-scale sequencing are expected to have better psychological outcomes when they can incorporate and act on accurate, relevant knowledge that supports informed decision making. The NCGENES study of diagnostic exome sequencing to evaluate associations between factual genomic knowledge and sequencing outcomes.

Genomics: the power, potential and pitfalls of the new technologies and how they are transforming healthcare.
Josephs Katherine S et al. Clinical medicine (London, England) 2019 Jul (4) 269-272 (Posted: Jul-19-2019 8AM)

New genomic technologies are transforming healthcare. Within the next decade, healthcare professionals will be using genomic data to diagnose and manage their patients. Despite these advances, few clinicians are prepared for this genomics-based future. Through five patient-focused scenarios, this article showcases new genomic technologies while highlighting the inherent challenges associated with complex genomic data.

New journal article and films highlight progress in genomics
Genomics Education Program, July 18, 2019 (Posted: Jul-18-2019 0PM)

The changing face of clinical genetics service delivery in the era of genomics: a framework for monitoring service delivery and data from a comprehensive metropolitan general genetics service.
Fennell Andrew Paul et al. Genetics in medicine : official journal of the American College of Medical Genetics 2019 Jul (Posted: Jul-15-2019 9AM)

Clinical genetics is an evolving specialty. Methods for monitoring implementation and workflow changes are needed. This literature review shows inconsistent metrics and lays out a framework for further use.

Secondary findings from next generation sequencing: Psychological and ethical issues. Family and patient perspectives.
Houdayer F et al. European journal of medical genetics 2019 Jun 103711 (Posted: Jul-10-2019 8AM)

Access to active search for actionable secondary findings (SF) in diagnostic practice is a major psychological and ethical issue for genomic medicine. In this study, the authors analyzed the preferences of patients and their families regarding SF and identified the reporting procedures necessary for informed consent

Genetic Variation, Comparative Genomics, and the Diagnosis of Disease.
Eichler Evan E et al. The New England journal of medicine 2019 Jul (1) 64-74 (Posted: Jul-05-2019 8AM)

Australian Genomics: A Federated Model for Integrating Genomics into Healthcare.
Stark Zornitza et al. American journal of human genetics 2019 Jul (1) 7-14 (Posted: Jul-05-2019 8AM)

Australian Genomics is a national collaborative research partnership of more than 80 organizations piloting a whole-of-system approach to integrating genomics into healthcare that is based on federation principles. The aim of Australian Genomics is to assess the application of genomic testing in healthcare at the translational interface between research and clinical delivery.

Analyzing and Reanalyzing the Genome: Findings from the MedSeq Project
K Machini et al, AJHG, June 27, 2019 (Posted: Jun-28-2019 8AM)

Although genome sequencing is increasingly available in clinical and research settings, many questions remain about the interpretation of sequencing data. The Medseq project finds substantial numbers of new and reclassified variants in genome sequencing results over time. The study highlights the need for periodic reinterpretation and reanalysis of genome data, a major challenge for genomic medicine.

Educating healthcare providers in the delivery of genomic medicine
J McCarthy et al, Pers Medicine, June 2019 (Posted: Jun-27-2019 8AM)

Foreword to a special focus issue on genomics education of health care providers. including articles on implementing personalized medicine cancer program in a community cancer system, provider engagement in precision oncology and pharmacogenomic education for health care professionals through electronic educational courses.

Veterans Genomic Cohort Nearing 1 Million
R Rubin, JAMA, June 25, 2019 (Posted: Jun-27-2019 8AM)

The Million Veteran Program, a voluntary research initiative studying how genes affect veterans? health, recently enrolled its 750 000th participant. The program, which began enrolling veterans in 2011, has grown into one of the largest research cohorts of its kind in the world, and it has the greatest representation of minorities of any US genomic cohort.

Incidence, demographic characteristics, and geographic distribution of sickle cell trait and sickle cell anemia births in Michigan, 1997-2014.
Reeves Sarah L et al. Molecular genetics & genomic medicine 2019 Jun e795 (Posted: Jun-26-2019 9AM)

Intermountain, Amgen subsidiary to launch DNA study of 500,000 patients
A Joseph, Stat News, June 12, 2019 (Posted: Jun-12-2019 7AM)

Genomic malpractice: what healthcare providers need to know to reduce the risk
J McCarthy, Precision Medicine Advisor, June 10, 2019 (Posted: Jun-11-2019 8AM)

Long-Read Sequencing Emerging in Medical Genetics.
Mantere Tuomo et al. Frontiers in genetics 2019 10426 (Posted: May-29-2019 9AM)

Continuous pharmacogenomics and genomic medicine education for healthcare professionals through electronic educational courses.
Tsermpini Evangelia-Eirini et al. Personalized medicine 2019 May (Posted: May-29-2019 9AM)

Introduction to Genomics
NHGRI, 2019 Brand (Posted: May-23-2019 8AM)

The Genomic Medicine Integrative Research Framework: A Conceptual Framework for Conducting Genomic Medicine Research
CR Horowtiz et al, Cell, May 16, 2019 (Posted: May-17-2019 7AM)

Genomics’ “Green” Future
J Lemieux, GEN News, May 1, 2019 (Posted: May-03-2019 7AM)

The Convergence of Research and Clinical Genomics
E Birney, AJHG, May 2, 2019 (Posted: May-02-2019 4PM)

Gene discovery informatics toolkit defines candidate genes for unexplained infertility and prenatal or infantile mortality
R Dawes et al, NPJ Genomic Medicine, April 15, 2019 (Posted: Apr-29-2019 11AM)

Genomic Medicine Meets Public Health in the Prevention of Cardiovascular Disease: Familial Hypercholesterolemia as a Paradigm
CDC Webinar, May 30, 2019 Brand (Posted: Apr-28-2019 7AM)

The Responsibility to Recontact Research Participants after Reinterpretation of Genetic and Genomic Research Results.
Bombard Yvonne et al. American journal of human genetics 2019 Apr (4) 578-595 (Posted: Apr-08-2019 9AM)

Application whole exome sequencing for the clinical molecular diagnosis of patients with Duchenne muscular dystrophy; identification of four novel nonsense mutations in four unrelated Chinese DMD patients.
Zhang Yan et al. Molecular genetics & genomic medicine 2019 Apr e622 (Posted: Apr-03-2019 9AM)

A duty to recontact in genetics: context matters
NAA. Giesbertz et al, Nature Reviews Genetics, April 2019 (Posted: Apr-01-2019 9AM)

Regarding the rights and duties of Clinical Laboratory Geneticists in genetic healthcare systems; results of a survey in over 50 countries
T Liehr et al, Eur J Human Genetics, March 28, 2019 (Posted: Mar-29-2019 10AM)

Implementing genomic medicine towards universal health coverage 2030
Global Alliance on Genomics and Health, 2019 (Posted: Mar-28-2019 8AM)

Medical Genetics Awareness Week, April 2019
ACMG, March 2019 (Posted: Mar-27-2019 10AM)

Defining and Achieving Health Equity in Genomic Medicine.
Jooma Sonya et al. Ethnicity & disease 2019 29(Suppl 1) 173-178 (Posted: Mar-27-2019 9AM)

Leveraging Implementation Science to Address Health Disparities in Genomic Medicine: Examples from the Field.
Roberts Megan C et al. Ethnicity & disease 2019 29(Suppl 1) 187-192 (Posted: Mar-27-2019 9AM)

IGNITE network: Response of patients to genomic medicine interventions.
Orlando Lori A et al. Molecular genetics & genomic medicine 2019 Mar e636 (Posted: Mar-27-2019 8AM)

Genomic Medicine-Progress, Pitfalls, and Promise.
Shendure Jay et al. Cell 2019 Mar 177(1) 45-57 (Posted: Mar-27-2019 8AM)

Largescale population genomics versus deep phenotyping: Brute force or elegant pragmatism towards precision medicine
L Yehia et al, NPJ Genomic Medicine, March 26, 2019 (Posted: Mar-26-2019 9AM)

Assessing optimism and pessimism about genomic medicine: Development of a Genomic Orientation (GO) scale.
Horrow Caroline et al. Clinical genetics 2019 Mar (Posted: Mar-20-2019 9AM)

Genomic Health Care Today and Tomorrow: Expert Perspectives.
Jenkins Jean F et al. Seminars in oncology nursing 2019 Feb (1) 131-143 (Posted: Mar-07-2019 10AM)

Early Lessons from the Implementation of Genomic Medicine Programs.
Williams Marc S et al. Annual review of genomics and human genetics 2019 Feb (Posted: Mar-06-2019 10AM)

The secret to a new drug could be hiding in your genes- Companies are searching gene databases for people whose DNA says they should be very sick, but who aren’t.
A Regalado, MIT Tech Review, February 2019 (Posted: Mar-04-2019 8AM)

Translating genomic medicine to the clinic: challenges and opportunities.
Zhang Huan et al. Genome medicine 2019 Feb (1) 9 (Posted: Mar-01-2019 11AM)

A decade of Genome Medicine: toward precision medicine
Rabia Begum Genome Medicine 2019 11:13 (Posted: Mar-01-2019 11AM)

Defining and Achieving Health Equity in Genomic Medicine
S Jooma et al, Ethn Dis. 2019;29(Suppl 1): 173-178 (Posted: Feb-21-2019 11AM)

Leveraging Implementation Science to Address Health Disparities in Genomic Medicine:Examples from the Field
MC Roberts et al, Ethncity and Disease, 2019(suppl 1): 187-192. (Posted: Feb-21-2019 11AM)

Health research: Applying genome technologies to the study of disease
Open Access News, February 18, 2019 (Posted: Feb-18-2019 0PM)

Ten years of Genome Medicine
C Auffray et al, Genome Medicine, February 15, 2019 (Posted: Feb-15-2019 11AM)

Using deep learning to identify translational research in genomic medicine beyond bench to bedside
YY Hsu et al, Database, February 2019 (Posted: Feb-08-2019 1PM)

Current conditions in medical genetics practice
DR Maisese et al, Genetics in Medicine, January 28, 2019 (Posted: Jan-28-2019 11AM)

Turn your head, cough, submit your DNA: Your next physical may include genetic testing
Chicago Tribune, January 25, 2019 (Posted: Jan-28-2019 7AM)

Spinning the Genome: Why Science Hype Matters.
Caulfield Timothy et al. Perspectives in biology and medicine 2018 61(4) 560-571 (Posted: Jan-23-2019 2PM)

The contribution of genomics in the medicine of tomorrow, clinical applications and issues.
Laviolle Bruno et al. Therapie 2018 Dec (Posted: Jan-23-2019 2PM)

Where is genomics going next?
B Cheifet, Genome Biology, January 22, 2019 (Posted: Jan-22-2019 10AM)

Color Partnering With Health Systems Exploring Impact of Genomic Testing on Outcomes, Cost
T Ray, Genomeweb, January 11, 2019 (Posted: Jan-12-2019 3PM)

Research Focus: beyond the 100 000 genomes
G Watts, The Lancet, January 2019 (Posted: Jan-06-2019 8AM)

Integrating Genomics into Healthcare: A Global Responsibility
Z Stark et al, AJHG, January 3, 2019 (Posted: Jan-04-2019 9AM)

All the reasons 2018 was a breakout year for DNA data
A Regalado, MIT Tech Review, December 29, 2018 (Posted: Dec-30-2018 4PM)

Pathogenic copy number variants that affect gene expression contribute to genomic burden in cerebral palsy
MA Corbett et al,. NPJ Genomic Medicine, Decemeber 2018 (Posted: Dec-20-2018 8AM)

New algorithm could accelerate diagnosis of genetic diseases using clinical records
H Santoro, Stanford Blog, December 2018 (Posted: Dec-18-2018 8AM)

Your invaluable genome-Genomic data is the currency of a new era of medicine that promises incredible advances
Genomics Education UK, October 2018 (Posted: Nov-21-2018 0PM)

Understanding Disparities in Access to Genomic Medicine: Proceedings of a Workshop
NASEM workshop, November 2018 (Posted: Nov-14-2018 9AM)

Implementing universal Lynch syndrome screening (IMPULSS): protocol for a multi-site study to identify strategies to implement, adapt, and sustain genomic medicine programs in different organizational contexts
AK Rahm et al, BMC Health Services Res, October 30, 2018 (Posted: Nov-01-2018 11AM)

Stakeholders’ views on the value of outcomes from clinical genetic and genomic interventions
M Scheuner et al, Genetics in Medicine, October 31, 2018 (Posted: Oct-31-2018 8AM)

UK Biobank — a new era in genomic medicine
OG Bahcall, Nat Rev Genetics, October 23, 2018 (Posted: Oct-24-2018 8AM)

Clinical whole-exome sequencing results impact medical management.
Niguidula Nancy et al. Molecular genetics & genomic medicine 2018 Oct (Posted: Oct-17-2018 8AM)

NIH-supported projects remove major obstacles standing in the way of genomic medicine
NIH News, October 12, 2018 Brand (Posted: Oct-15-2018 10AM)

The NHS genomic service could transform medicine
The Economist, September 2018 (Posted: Sep-28-2018 11AM)

Heterogeneity in clinical sequencing tests marketed for autism spectrum disorders
Ny Hoang et al, npj Genomic Medicine, Sepetmber 19, 2018 (Posted: Sep-19-2018 1PM)

Enhancing diversity to reduce health information disparities and build an evidence base for genomic medicine.
Hindorff Lucia A et al. Personalized medicine 2018 Sep (Posted: Sep-19-2018 9AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.