Resource allocation in genetic and genomic medicine
J Buchanan et al, J Community Genetics, September 24, 2022
Integrating genomic medicine within national health services has so far not been straightforward . Amongst other considerations, effective translation requires that careful attention is paid to issues surrounding priority setting and resource allocation. Commissioning genomic medicine services in a fair, equitable, and appropriate manner necessitates rigorous exploration of the ethical, policy, and practical implications, including factors such as cost, opportunity cost, clinical effectiveness, cost-effectiveness, need, ability to benefit, and procedural fairness.
Trends in Tier 1 Genomic Applications 2013-2022
M Clyne et al, CDC Blog Post, September 20, 2022
The CDC Tier 1 genomic applications database can help consumers, providers, health care organizations and public health programs accelerate the translation of genomic discoveries into improved population health. Advances in genomics and precision medicine are proceeding at a rapid pace. Many genomic tests have reached clinical practice without clear indication as to whether their use will actually improve health. In order to provide general information to healthcare providers and the general public, in 2014 our office introduced a simple approach for classifying genomic applications based upon 1) type of evidence and 2) recommendation for use of genomic applications. This systematic classification approach assigns genomic applications into one of three tiers.
Understanding the Patient Experience of Receiving Clinically Actionable Genetic Results from the MyCode Community Health Initiative, a Population-Based Genomic Screening Initiative
A Baker et al, J Per Medicine, September 15, 2022
Coding of 63 interviews among 60 participants revealed that participants were satisfied with the results disclosure process, initially experienced a range of positive, neutral, and negative psychological reactions to results, adjusted positively to results over time, undertook clinically indicated actions in response to results, and communicated results with relatives to whom they felt emotionally close.
Human genomics vs Clinical genomics
E Topol, Ground Truths, September 11, 2022
For decades, the genomics research community has been in high gear productivity, extensively publishing data about medical conditions. But so little has reached clinical practice outside of a few exceptions like rapid neonatal sequencing or adults with serious, undiagnosed conditions, or in specific use cases in cancer. Even those are only performed by a limited number of health systems.