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Last Posted: May 30, 2024
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Helicobacter pylori Treatment and Gastric Cancer Risk Among Individuals With High Genetic Risk for Gastric Cancer

From the abstract: "Question: Is genetic susceptibility for gastric cancer associated with the outcomes of its primary prevention strategies? Findings: In this cohort study of more than 100?000 Chinese adults, a polygenic risk score associated with the risk of gastric cancer was derived. Helicobacter pylori treatment was associated with reduced gastric cancer risk for individuals with a high genetic risk during long-term follow-up but not for those with low genetic risk. Meaning: The findings of this study support the benefits of H pylori treatment for individuals with a high genetic risk of gastric cancer and suggest the utilization of genetic susceptibility for implementing effective gastric cancer primary prevention. "


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