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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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68 hot topic(s) found with the query "Exposome"

Prioritizing the Exposome to Reduce Cardiovascular Disease Burden.
Erica S Spatz et al. JAMA Cardiol 2023 11 (Posted: Nov 14, 2023 1PM)

From the paper: "There is an imperative to address the exposome in efforts to advance health equity, requiring a combination of research and action. In focusing on environmental exposures that are not only measurable but modifiable (eg, reducing street temperatures by increasing green spaces and planting trees that give shade), there is an opportunity to derive the direct benefits (eg, fewer cardiac arrests and strokes, higher well-being) while addressing societal disparities and racism (eg, prioritizing minoritized communities that have been failed by discriminatory investments in landscape and housing) "

The contribution of the exposome to the burden of cardiovascular disease.
Thomas Münzel et al. Nat Rev Cardiol 2023 5 (Posted: May 21, 2023 9AM)

The exposome describes the harmful biochemical and metabolic changes that occur in our body owing to the totality of different environmental exposures throughout the life course, which ultimately lead to adverse health effects and premature deaths. In this Review, we describe the exposome concept with a focus on environmental physical and chemical exposures and their effects on the burden of cardiovascular disease. We discuss selected exposome studies and highlight the relevance of the exposome concept for future health research as well as preventive medicine.

Interplay Between the Exposome and the Genome in Health and Disease
E Drzymalla et al, CDC Blog Post. February 16, 2023 Brand (Posted: Feb 18, 2023 8AM)

Neither the exposome or the genome contributes to disease risk or pathology in isolation. The interaction between these two fields provides more information on risk for disease development for individuals and populations. As a result, understanding the exposome, the genome, and the interplay between them is an important step for understanding disease development and improving disease prevention.

Molecular mechanisms of environmental exposures and human disease
H Wu et al, Nature Rev Genetics, January 30, 2023 (Posted: Jan 31, 2023 8AM)

We review evidence showing the environmental impact on gene expression through epigenetic modifications, including DNA methylation, histone modification and non-coding RNAs. We also highlight recent studies that evaluate recently discovered molecular processes through which the environment can exert its effects, including extracellular vesicles, the epitranscriptome and the mitochondrial genome. Finally, we discuss current challenges when studying the exposome — the cumulative measure of environmental influences over the lifespan — and its integration into future environmental health research.

Multi-omics signatures of the human early life exposome
L Maitre et al, Nature Comm, November 21, 2022 (Posted: Nov 21, 2022 8AM)

In the Human Early Life Exposome (HELIX) project, a multi-centre cohort of 1301 mother-child pairs, we associate individual exposomes consisting of >100 chemical, outdoor, social and lifestyle exposures assessed in pregnancy and childhood, with multi-omics profiles (methylome, transcriptome, proteins and metabolites) in childhood. We identify 1170 associations, 249 in pregnancy and 921 in childhood, which reveal potential biological responses and sources of exposure. Pregnancy exposures, including maternal smoking, cadmium and molybdenum, are predominantly associated with child DNA methylation changes.

From the Genome to the Exposome: Mapping Causal Associations Between Environmental Factors and Population Health
D Rasooly et al, CDC Blog Post, September 6, 2022 Brand (Posted: Sep 06, 2022 0PM)

Complementary to the “genome,” which is the complete set of an individual’s genetic information, the “exposome” represents an individual’s complete set of environmental exposures throughout their lifetime. Coined in 2005, the “exposome” captures the variable and dynamic environmental exposures from the prenatal period onwards. Factors studied in the exposome extend from social differences and inequalities to behavioral factors such as tobacco smoking and physical activity. Our genome and exposome interact throughout our lives in causing various diseases.

Integrative analysis of genomic and exposomic influences on youth mental health.
Choi Karmel W et al. Journal of child psychology and psychiatry, and allied disciplines 2022 8 (Posted: Aug 11, 2022 7AM)

Understanding complex influences on mental health problems in young people is needed to inform early prevention strategies. Both genetic and environmental factors are known to influence youth mental health, but a more comprehensive picture of their interplay, including wide-ranging environmental exposures – that is, the exposome – is needed. We perform an integrative analysis of genomic and exposomic data in relation to internalizing and externalizing symptoms in a cohort of 4,314 unrelated youth from the Adolescent Brain and Cognitive Development (ABCD) Study.

Nongenetic Factors Associated With Psychotic Experiences Among UK Biobank Participants Exposome-Wide Analysis and Mendelian Randomization Analysis
BD Lin et al, JAMA Psychiatry, July 20, 2022 (Posted: Jul 20, 2022 0PM)

What are the factors associated with psychotic experiences? In this cohort study of 155?247 UK Biobank participants, exposome-wide association analysis yielded 148 correlates of psychotic experiences, with 36 independent associations further identified in the fully adjusted multivariable model. Mendelian randomization analyses of these 36 variables indicated a forward association with ever having experienced sexual assault and pleiotropy of risk-taking behavior and a reverse association with ever having experienced a physically violent crime, cannabis use, and worrying too long after embarrassment.

Special focus issue on epigenomics and health disparities: foreword.
Argentieri M Austin et al. Epigenomics 2021 10 (Posted: Oct 15, 2021 10AM)

Although epigenomic researchers have been investigating the influences of physical environmental exposures (e.g., air pollution, contaminants and heavy metal exposures and lifestyle factors such as smoking, alcohol and nutrition) on epigenetic mechanisms for years under the banner of ‘environmental epigenomics’, the field is at a crossroads where a fundamental rethinking of what constitutes a human environment is necessary, especially in the pursuit of understanding disparities in health and disease. It will be crucial for the field of environmental epigenomics to expand its inquiry to the entire exposome (i.e., all nongenetic influences on health, including social, economic, cultural, built environment and housing and psychosocial dimensions of life) in order to truly come to terms with the determinants of health inequality from an epigenomic perspective.

From the Exposome to the Socioexposome in COVID-19 Research—A Call for More Multidisciplinary Research
S Koch et al, JAMA Network Open, December 29, 2020 (Posted: Dec 31, 2020 9AM)

A socioexposome approach combines expertise in the fields of genomics, environmental exposures, and health behavior sciences with the expertise pooled in social sciences.7 With this multidisciplinary framework, researchers can situate and contextualize natural science data and findings across the individual, local, and global scales, rendering a full picture of the interplay among biological disease pathways and social and environmental forces.

Exposome changes in primary school children following the wide population non-pharmacological interventions implemented due to COVID-19 in Cyprus: a national survey
C Constantino et al, MEDRXIV, October 23, 2020 (Posted: Oct 25, 2020 10AM)

Precision Health Analytics With Predictive Analytics and Implementation Research- JACC State-of-the-Art Review
TA Pearson et al, JACC, July 2020 (Posted: Jul 15, 2020 0PM)

Predictive analytics expands the quality and quantity of data needed to inform patient care. Complex genome and exposome data will inform new cardiovascular decision tools. New decision tools require implementation research to define use, benefits, and sustainability. Precision health requires training for new teams of data scientists and clinicians.

The metabolome: A key measure for exposome research in epidemiology.
Walker Douglas I et al. Current epidemiology reports 2019 693-103 (Posted: Dec 18, 2019 8AM)

The study of interactions between genome and exposome in the development of systemic lupus erythematosus.
Leffers Henrik Christian Bidstrup et al. Autoimmunity reviews 2019 Apr (4) 382-392 (Posted: Apr 22, 2019 9AM)

Take a Deep Breath and Say Hi to Your Exposome Researchers begin to explore the unique cloud of airborne microbes and chemicals that surrounds each of us
Scientific American, September 27, 2018 (Posted: Sep 29, 2018 0PM)

Dynamic Human Environmental Exposome Revealed by Longitudinal Personal Monitoring
C Jiang et al, Cell, September 2018 (Posted: Sep 22, 2018 0PM)

The Exposome: Molecules to Populations.
Niedzwiecki Megan M et al. Annual review of pharmacology and toxicology 2018 Aug (Posted: Sep 17, 2018 7AM)

Link the exposome to the genome to improve human health and well-being
A Macherone, Stat News, September 13, 2018 (Posted: Sep 16, 2018 2PM)

Air pollution and the fetal origin of disease: A systematic review of the molecular signatures of air pollution exposure in human placenta.
Luyten Leen J et al. Environmental research 2018 Jun 310-323 (Posted: Jul 06, 2018 0PM)

Toward Capturing the Exposome: Exposure Biomarker Variability and Co-Exposure Patterns in the Shared Environment.
Chung Ming Kei et al. Environmental science & technology 2018 Jul (Posted: Jul 06, 2018 8AM)

Integration of the human exposome with the human genome to advance medicine.
R Barouki et al. Biochimie 2018 Jun (Posted: Jul 03, 2018 11AM)

The Exposome Paradigm and the Complexities of Environmental Research in Psychiatry.
Guloksuz Sinan et al. JAMA psychiatry 2018 Jun (Posted: Jun 09, 2018 7AM)

An exposome perspective: Early-life events and immune development in a changing world.
Renz Harald et al. The Journal of allergy and clinical immunology 2017 Jul (1) 24-40 (Posted: Dec 11, 2017 9AM)

Yale school of public health symposium on lifetime exposures and human health: the exposome; summary and future reflections.
Johnson Caroline H et al. Human genomics 2017 Dec (1) 32 (Posted: Dec 11, 2017 9AM)

Opportunities and Challenges for Environmental Exposure Assessment in Population-Based Studies.
Patel Chirag J et al. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2017 Sep (9) 1370-1380 (Posted: Dec 11, 2017 9AM)

Use of the “Exposome” in the Practice of Epidemiology: A Primer on -Omic Technologies
DG Debord et al, AJE, 2016 (Posted: Oct 08, 2017 2PM)

Informatics and Data Analytics to Support Exposome-Based Discovery for Public Health.
Manrai Arjun K et al. Annual review of public health 2017 Mar 279-294 (Posted: Aug 18, 2017 0PM)

The Exposome Research Paradigm: an Opportunity to Understand the Environmental Basis for Human Health and Disease.
Buck Louis Germaine M et al. Current environmental health reports 2017 Mar (1) 89-98 (Posted: Aug 18, 2017 0PM)

Analytic Complexity and Challenges in Identifying Mixtures of Exposures Associated with Phenotypes in the Exposome Era.
Patel Chirag J et al. Current epidemiology reports 2017 (1) 22-30 (Posted: Aug 18, 2017 0PM)

How Sensors Might Help Define the External Exposome.
Loh Miranda et al. International journal of environmental research and public health 2017 Apr (4) (Posted: Aug 18, 2017 0PM)

'Omics' and endocrine-disrupting chemicals - new paths forward.
Messerlian Carmen et al. Nature reviews. Endocrinology 2017 Jul (Posted: Aug 18, 2017 0PM)

Toward Capturing the Exposome: Exposure Biomarker Variability and Co-Exposure Patterns in the Shared Environment
MK Chung et al, BioxRiv, August 2017 (Posted: Aug 18, 2017 0PM)

Toward the integration of Omics data in epidemiological studies: still a "long and winding road".
López de Maturana Evangelina et al. Genetic epidemiology 2016 Nov (7) 558-569 (Posted: Jan 10, 2017 10AM)

The skin aging exposome.
Krutmann Jean et al. Journal of dermatological science 2016 Sep (Posted: Oct 25, 2016 3PM)

The exposome concept: a challenge and a potential driver for environmental health research.
Siroux Valérie et al. European respiratory review : an official journal of the European Respiratory Society 2016 Jun (140) 124-9 (Posted: Aug 07, 2016 4PM)

Metabolic profiling in human exposome studies.
Athersuch Toby J et al. Mutagenesis 2015 Nov (6) 755-62 (Posted: Dec 06, 2015 8AM)

Using exposomics to assess cumulative risks and promote health.
Smith Martyn T et al. Environmental and molecular mutagenesis 2015 Dec (9) 715-23 (Posted: Dec 06, 2015 8AM)

The Naturome Awaits the Nurturome
RA Stein GEN News, December 1, 2015 (Posted: Dec 06, 2015 8AM)

Commentary: Mapping the Human Exposome: Without It, How Can We Find Environmental Risk Factors for ALS?
A AlChalabi, Epidemiology, Nove,ber 2015 (Posted: Nov 08, 2015 7AM)

The Exposome Turns 10
CH Arnaud, C&EN, September 28, 2015 (Posted: Sep 29, 2015 4PM)

Using personal sensors to assess the exposome and acute health effects.
Nieuwenhuijsen Mark J et al. Int J Environ Res Public Health 2014 Aug (8) 7805-19 (Posted: May 20, 2015 2PM)

A biobehavioral perspective on telomere length and the exposome.
Lyon Debra E et al. Biol Res Nurs 2014 Oct (4) 448-55 (Posted: May 20, 2015 2PM)

Distinguishing between the metabolome and xenobiotic exposome in environmental field samples analysed by direct-infusion mass spectrometry based metabolomics and lipidomics.
Southam Andrew D et al. Metabolomics 2014 (6) 1050-1058 (Posted: May 20, 2015 2PM)

T3DB: the toxic exposome database.
Wishart David et al. Nucleic Acids Res. 2015 Jan (Database issue) D928-34 (Posted: May 20, 2015 2PM)

Exploration of preterm birth rates using the public health exposome database and computational analysis methods.
Kershenbaum Anne D et al. Int J Environ Res Public Health 2014 Dec (12) 12346-66 (Posted: May 20, 2015 2PM)

The public health exposome: a population-based, exposure science approach to health disparities research.
Juarez Paul D et al. Int J Environ Res Public Health 2014 Dec (12) 12866-95 (Posted: May 20, 2015 2PM)

Development of exposome correlation globes to map out environment-wide associations.
Patel Chirag J et al. Pac Symp Biocomput 2015 231-42 (Posted: May 20, 2015 2PM)

Commentary on the contributions and future role of occupational exposure science in a vision and strategy for the discipline of exposure science.
Harper Martin et al. J Expo Sci Environ Epidemiol 2015 Feb 11. (Posted: May 20, 2015 2PM)

From exposome to microbiome to infectome--'pathogens vs. sanogens'.
Limper M et al. Neth J Med 2015 Feb (2) 51-2 (Posted: May 20, 2015 2PM)

Preconception and prenatal environmental factors associated with communication impairments in 9 year old children using an exposome-wide approach.
Steer Colin D et al. PLoS ONE 2015 (3) e0118701 (Posted: May 20, 2015 2PM)

Some challenges of studies aiming to relate the Exposome to human health.
Slama Rémy et al. Occup Environ Med 2015 Jun (6) 383-4 (Posted: May 20, 2015 2PM)

Evaluation of the Potential Use of Toxicogenomics Technology in Hazard Identification
National Toxicology Program, January 2015 Brand (Posted: May 16, 2015 7AM)

Integrating toxicogenomics into human health risk assessment: lessons learned from the benzo[a]pyrene case study.
Chepelev Nikolai L et al. Crit. Rev. Toxicol. 2015 Jan (1) 44-52 (Posted: May 16, 2015 7AM)

High-throughput data integration of RNA-miRNA-circRNA reveals novel insights into mechanisms of benzo[a]pyrene-induced carcinogenicity.
Caiment Florian et al. Nucleic Acids Res. 2015 Mar 11. (5) 2525-34 (Posted: May 16, 2015 7AM)

The exposome concept in a human nutrigenomics study: evaluating the impact of exposure to a complex mixture of phytochemicals using transcriptomics signatures.
van Breda Simone G J et al. Mutagenesis 2015 Feb 22. (Posted: May 16, 2015 7AM)

Integration of metabolic activation with a predictive toxicogenomics signature to classify genotoxic versus nongenotoxic chemicals in human TK6 cells.
Buick Julie K et al. Environ. Mol. Mutagen. 2015 Mar 2. (Posted: May 16, 2015 7AM)

Development of a toxicogenomics signature for genotoxicity using a dose-optimization and informatics strategy in human cells.
Li Heng-Hong et al. Environ. Mol. Mutagen. 2015 Mar 2. (Posted: May 16, 2015 7AM)

Comparison on the molecular response profiles between nano zinc oxide (ZnO) particles and free zinc ion using a genome-wide toxicogenomics approach.
Su Guanyong et al. Environ Sci Pollut Res Int 2015 May 5. (Posted: May 16, 2015 7AM)

Asymmetric author-topic model for knowledge discovering of big data in toxicogenomics.
Chung Ming-Hua et al. Front Pharmacol 2015 81 (Posted: May 16, 2015 7AM)

Toxicity Assessment of 4-Methyl-1-cyclohexanemethanol and Its Metabolites in Response to a Recent Chemical Spill in West Virginia, USA.
Lan Jiaqi et al. Environ. Sci. Technol. 2015 May 11. (Posted: May 16, 2015 7AM)

The DNA damage response: the omics era and its impact.
Derks Kasper W J et al. DNA Repair (Amst.) 2014 Jul 214-20 (Posted: May 16, 2015 7AM)

Toxicogenomics and cancer susceptibility: advances with next-generation sequencing.
Ning Baitang et al. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2014 (2) 121-58 (Posted: May 16, 2015 7AM)

Toxicogenetics: in search of host susceptibility to environmental toxicants.
Alam Gelareh et al. Front Genet 2014 327 (Posted: May 16, 2015 7AM)

How can bioinformatics and toxicogenomics assist the next generation of research on physical exercise and athletic performance.
Kerksick Chad M et al. J Strength Cond Res 2015 Jan (1) 270-8 (Posted: May 16, 2015 7AM)

Toxicogenomics in vitro as an alternative tool for safety evaluation of petroleum substances and PAHs with regard to prenatal developmental toxicity.
Tsitou Polyxeni et al. Toxicol In Vitro 2015 Mar (2) 299-307 (Posted: May 16, 2015 7AM)

Technical guide for applications of gene expression profiling in human health risk assessment of environmental chemicals.
Bourdon-Lacombe Julie A et al. Regul. Toxicol. Pharmacol. 2015 May 2. (Posted: May 16, 2015 7AM)

Characterising the epigenome as a key component of the fetal exposome in evaluating in utero exposures and childhood cancer risk.
Ghantous Akram et al. Mutagenesis 2015 Feb 26. (Posted: Mar 08, 2015 6PM)

Exposome and exposomics
Brand (Posted: Feb 25, 2015 0PM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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