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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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13 hot topic(s) found with the query "Cystic fibrosis "

Cystic Fibrosis
CDC, June 2020 Brand (Posted: Jun-30-2020 8AM)

Cystic fibrosis (CF) is a genetic disorder that causes problems with breathing and digestion. People with cystic fibrosis (CF) are among those who might be more likely to have severe illness from COVID-19. Learn more about steps you can take.


Fulfilling the Promise - Ensuring the Success of Newborn Screening throughout Life
CDC, November 2019 Brand (Posted: Nov-13-2019 8AM)

Each year, more than 13,000 newborn babies are identified with conditions such as cystic fibrosis, sickle cell disease, congenital heart defects, and hearing loss through a public health program called newborn screening. Without specialized care and treatment, these babies would face long-term disability, or even death.


Dare to Dream: The Long Road to Targeted Therapies for Cystic Fibrosis
NIH Director's Blog, October 31, 2019 Brand (Posted: Nov-01-2019 9AM)

Today, I’m overjoyed to say that this dream finally appears to have come true for about 90 percent of people with CF. Two international teams, including researchers report impressive results from phase 3 clinical trials of a triple drug therapy for individuals with CF and at least one copy of Phe508del, the most common CF-causing mutation.


Thirtieth Anniversary of Cystic Fibrosis Gene Discovery
Francis Collins, NIH Director's blog, August 2019 Brand (Posted: Sep-08-2019 2PM)

In 1989, the gene that causes cystic fibrosis, was discovered by a collaborative research effort involving the University of Michigan, Ann Arbor, and colleagues at the Hospital for Sick Children, Toronto. This year marks the 30th anniversary of the discovery, which has yielded life-sustaining targeted therapies for many kids born with this rare disease.


Scientists find new approach that shows promise for treating cystic fibrosis
NIH, March 13, 2019 Brand (Posted: Mar-14-2019 10AM)


Evaluating the Impact of Precision Medicine: How Ivacaftor Reduces Hospitalizations of Patients with Cystic Fibrosis
RF Green al, CDC Blog Post, May 8, 2018 Brand (Posted: May-08-2018 5PM)


Cystic Fibrosis and C. Diff : A Dangerous Combination
CDC Safe Healthcare Blog Post, 2017 Brand (Posted: Feb-07-2018 0PM)


Cystic Fibrosis DNA Mutation Detection Proficiency Testing
CDC Division of Laboratory Systems, 2017 Brand (Posted: Jul-11-2017 11AM)


Cystic Fibrosis: Keeping the Momentum Going
Francis Collins, NIH Director, December 8, 2015 Brand (Posted: Dec-08-2015 9AM)


Pulmonary Rehabilitation
From NHLBI health topic site Brand (Posted: Jan-01-2014 0AM)

What Is Pulmonary Rehabilitation? Pulmonary (PULL-mun-ary) rehabilitation, also called pulmonary rehab or PR, is a broad program that helps improve the well-being of people who have chronic (ongoing) breathing problems. For example, PR may benefit people who have COPD (chronic obstructive pulmonary disease), sarcoidosis (sar-koy-DOE-sis), idiopathic pulmonary fibrosis, or cystic fibrosis. PR also can benefit people who need lung surgery, both before and after the surgery. PR doesn't replace medical therapy. Instead, it's used with medical therapy and may include: ?Exercise training ?Nutritional counseling ?Education on your lung disease or condition and how to manage it ?Energy-conserving techniques ?Breathing strategies ?Psychological counseling and/or group support PR involves a long-term commitment from the patient and a team of health care providers. The PR team may include doctors, nurses, and specialists. Examples of specialists include respiratory therapists, physical and occupational therapists, dietitians or nutritionists, and psychologists or social workers. PR often is an outpatient program based in a hospital or clinic. Some patients also can receive PR in their homes. When you start PR, your rehab team will create a plan that's tailored to your abilities and needs. You'll likely attend your PR program weekly. Your team also will expect you to follow your plan, including exercises and lifestyle changes, at home. PR has many benefits. It can improve your ability to function and your quality of life. The program also may help relieve your breathing problems. Even if you have advanced lung disease, you can still benefit from PR.


Cystic Fibrosis
From NHLBI health topic site Brand (Posted: Jan-01-2014 0AM)

What Is Cystic fibrosis (SIS-tik fi-BRO-sis), or CF, is an inherited disease of the secretory (see-KREH-tor-ee) glands. Secretory glands include glands that make mucus and sweat. "Inherited" means the disease is passed from parents to children through genes. People who have CF inherit two faulty genes for the disease?one from each parent. The parents likely don't have the disease themselves. CF mainly affects the lungs, pancreas, liver, intestines, sinuses, and sex organs. Overview Mucus is a substance made by tissues that line some organs and body cavities, such as the lungs and nose. Normally, mucus is a slippery, watery substance. It keeps the linings of certain organs moist and prevents them from drying out or getting infected. If you have CF, your mucus becomes thick and sticky. It builds up in your lungs and blocks your airways. (Airways are tubes that carry air in and out of your lungs.) The buildup of mucus makes it easy for bacteria to grow. This leads to repeated, serious lung infections. Over time, these infections can severely damage your lungs. The thick, sticky mucus also can block tubes, or ducts, in your pancreas (an organ in your abdomen). As a result, the digestive enzymes that your pancreas makes can't reach your small intestine. These enzymes help break down food. Without them, your intestines can't fully absorb fats and proteins. This can cause vitamin deficiency and malnutrition because nutrients pass through your body without being used. You also may have bulky stools, intestinal gas, a swollen belly from severe constipation, and pain or discomfort. CF also causes your sweat to become very salty. Thus, when you sweat, you lose large amounts of salt. This can upset the balance of minerals in your blood and cause many health problems. Examples of these problems include dehydration (a lack of fluid in your body), increased heart rate, fatigue (tiredness), weakness, decreased blood pressure, heat stroke, and, rarely, death. If you or your child has CF, you're also at higher risk for diabetes or two bone-thinning conditions called osteoporosis (OS-te-o-po-RO-sis) and osteopenia (OS-te-o-PEE-nee-uh). CF also causes infertility in men, and the disease can make it harder for women to get pregnant. (The term "infertility" refers to the inability to have children.) Outlook The symptoms and severity of CF vary. If you or your child has the disease, you may have serious lung and digestive problems. If the disease is mild, symptoms may not show up until the teen or adult years. The symptoms and severity of CF also vary over time. Sometimes you'll have few symptoms. Other times, your symptoms may become more severe. As the disease gets worse, you'll have more severe symptoms more often. Lung function often starts to decline in early childhood in people who have CF. Over time, damage to the lungs can cause severe breathing problems. Respiratory failure is the most common cause of death in people who have CF. As treatments for CF continue to improve, so does life expectancy for those who have the disease. Today, some people who have CF are living into their forties or fifties, or longer. Early treatment for CF can improve your quality of life and increase your lifespan. Treatments may include nutritional and respiratory therapies, medicines, exercise, and other treatments. Your doctor also may recommend pulmonary rehabilitation (PR). PR is a broad program that helps improve the well-being of people who have chronic (ongoing) breathing problems. Other Names ?Cystic fibrosis of the pancreas ?Fibrocystic disease of the pancreas ?Mucoviscidosis (MU-ko-vis-ih-DO-sis) ?Mucoviscidosis of the pancreas ?Pancreas fibrocystic disease ?Pancreatic cystic fibrosis


Bronchiectasis
From NHLBI health topic site Brand (Posted: Jan-01-2014 0AM)

Bronchiectasis (brong-ke-EK-ta-sis) is a condition in which damage to the airways causes them to widen and become flabby and scarred. The airways are tubes that carry air in and out of your lungs. Bronchiectasis usually is the result of an infection or other condition that injures the walls of your airways or prevents the airways from clearing mucus. Mucus is a slimy substance that the airways produce to help remove inhaled dust, bacteria, and other small particles. In bronchiectasis, your airways slowly lose their ability to clear out mucus. When mucus can't be cleared, it builds up and creates an environment in which bacteria can grow. This leads to repeated, serious lung infections. Each infection causes more damage to your airways. Over time, the airways lose their ability to move air in and out. This can prevent enough oxygen from reaching your vital organs. Bronchiectasis can lead to serious health problems, such as respiratory failure, atelectasis (at-eh-LEK-tah-sis), and heart failure. Bronchiectasis Figure A shows a cross-section of the lungs with normal airways and with widened airways. Figure B shows a cross-section of a normal airway. Figure C shows a cross-section of an airway with bronchiectasis. Figure A shows a cross-section of the lungs with normal airways and with widened airways. Figure B shows a cross-section of a normal airway. Figure C shows a cross-section of an airway with bronchiectasis. Overview Bronchiectasis can affect just one section of one of your lungs or many sections of both lungs. The initial lung damage that leads to bronchiectasis often begins in childhood. However, symptoms may not occur until months or even years after you start having repeated lung infections. In the United States, common childhood infections?such as whooping cough and measles?used to cause many cases of bronchiectasis. However, these causes are now less common because of vaccines and antibiotics. Now bronchiectasis usually is due to a medical condition that injures the airway walls or prevents the airways from clearing mucus. Examples of such conditions include cystic fibrosis and primary ciliary (SIL-e-ar-e) dyskinesia (dis-kih-NE-ze-ah), or PCD. Bronchiectasis that affects only one part of the lung may be caused by a blockage rather than a medical condition. Bronchiectasis can be congenital (kon-JEN-ih-tal) or acquired. Congenital bronchiectasis affects infants and children. It's the result of a problem with how the lungs form in a fetus. Acquired bronchiectasis occurs as a result of another condition or factor. This type of bronchiectasis can affect adults and older children. Acquired bronchiectasis is more common than the congenital type. Outlook Currently, bronchiectasis has no cure. However, with proper care, most people who have it can enjoy a good quality of life. Early diagnosis and treatment of bronchiectasis are important. The sooner your doctor starts treating bronchiectasis and any underlying conditions, the better your chances of preventing further lung damage. Other Names ?Acquired bronchiectasis ?Congenital bronchiectasis


Cystic fibrosis
From NCATS Genetic and Rare Diseases Information Center Brand (Posted: Jan-01-2011 0AM)



Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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