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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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429 hot topic(s) found with the query "Colorectal cancer"

A Genomic Test for Colorectal Cancer Risk: Is This Acceptable and Feasible in Primary Care?
S Saya et al, Public Health Genomics, July 2020 (Posted: Jul-21-2020 7AM)

We aimed to assess the feasibility and acceptability of administering a CRC genomic test in primary care. In 150 participants, test uptake was high (126, 84%), with 125 (83%) having good knowledge of the genomic test. Moderate risk participants were impacted more by the test.

ctDNA applications and integration in colorectal cancer: an NCI Colon and Rectal–Anal Task Forces whitepaper
A Dasari et al, Nature Rev Clin Oncol, July 6, 2020 (Posted: Jul-07-2020 10AM)

The panel focused on four key areas in which ctDNA has the potential to change clinical practice, including the detection of minimal residual disease, the management of patients with rectal cancer, monitoring responses to therapy, and tracking clonal dynamics in response to targeted therapies and other systemic treatments.

Clinical, Pathology, Genetic, and Molecular Features of Colorectal Tumors in Adolescents and Adults 25 Years or Younger.
de Voer Richarda M et al. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2020 Jun (Posted: Jun-28-2020 3PM)

We found features of CRCs in adolescents or young adults to differ from those of patients older than 60 years. In 39% of patients a genetic tumor-risk syndrome was identified. This suggests new strategies for clinical management. Performing genetic analyses for every individual diagnosed with CRC at age 25 years or younger would aid in this optimization.

Cancer prevention with aspirin in hereditary colorectal cancer (Lynch syndrome), 10-year follow-up and registry-based 20-year data in the CAPP2 study: a double-blind, randomised, placebo-controlled trial
J Burn et al, The Lancet June 13, 2020 (Posted: Jun-13-2020 7AM)

In the double-blind, randomized CAPP2 trial, 861 patients from 43 international centres worldwide (707 [82%] from Europe, 112 [13%] from Australasia, 38 [4%] from Africa, and four [<1%] from The Americas) with Lynch syndrome were randomly assigned to receive 600 mg aspirin daily or placebo. Cancer outcomes were monitored for at least 10 years from recruitment.

Local cellular cues that influence the immunology of colorectal cancer treatment
GP Donaldson et al, Nature Medicine, May 25, 2020 (Posted: May-26-2020 7AM)

Therapeutic interventions in colorectal cancer are dependent on immune responses to dying epithelial cells that are modulated by specific members of the gut microbiota.

Adequacy evaluation of the annual colonoscopic surveillance and individual difference of disease phenotypes in Lynch syndrome.
Taniguchi Fumitaka et al. Japanese journal of clinical oncology 2020 May (Posted: May-12-2020 4PM)

Efficacy of Immunotherapy in Microsatellite-Stable or Mismatch Repair Proficient Colorectal Cancer—Fact or Fiction?
RB Corcoran et al, JAMA Oncology, May 7, 2020 (Posted: May-08-2020 9AM)

The observation that a subset of patients with MSS colorectal cancer may derive some modest benefit from combined immune checkpoint blockade suggests that novel combinations of immune checkpoint inhibitors with agents that may further enhance the immune response may be a promising approach, and several clinical trials are ongoing.

NCCN Updates Clinical Practice Guideline for Colorectal Cancer
JCCN, May 1, 2020 (Posted: May-02-2020 8AM)

Potential impact of family history–based screening guidelines on the detection of early‚Äźonset colorectal cancer
S Gupta et al, Cancer, April 20, 2020 (Posted: Apr-20-2020 7AM)

Of Colorectal cancer cases aged 40 to 49 years, 1 in 4 met family history–based early screening criteria, and nearly all cases who met these criteria could have had CRC diagnosed earlier (or possibly even prevented) if earlier screening had been implemented as per family history–based guidelines.

New study highlights importance of family history-based screening for colorectal cancer
H Zia, Stat News, April 20, 2020 (Posted: Apr-20-2020 7AM)

Associations Between Mutations in MSH6 and PMS2 and Risk of Surveillance-detected Colorectal Cancer.
Lamba Mehul et al. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2020 Mar (Posted: Apr-08-2020 9AM)

Cost-effectiveness Evaluation of Targeted Surgical and Endoscopic Therapies for Early Colorectal Adenocarcinoma Based on Biomarker Profiles
SR Jang et al. JAMA Network Open, March 9, 2020 (Posted: Mar-10-2020 8AM)

Assessment of Treatment Cost-effectiveness Using a Colorectal Cancer Mutation Profile
TJ Yeatman et al, JAMA Netwotk Open, March 9, 2020 (Posted: Mar-10-2020 8AM)

The addition of genetic testing to clinicopathologic features (ie, the current standard of care) may provide a new means of determining the most cost-effective, highest-quality approach for this early stage of disease. A prospective comparison of genetic vs pathologic staging in predicting surgical pathologic staging will be necessary.

What Is Colorectal Cancer Screening?
CDC, March 2020 Brand (Posted: Mar-09-2020 8AM)

Regular screening, beginning at age 50, is the key to preventing colorectal cancer. If you think you may be at increased risk for colorectal cancer, learn your family health history and ask your doctor if you should begin screening before age 50.

Should polygenic risk scores be used in risk-stratified colorectal cancer screening?
WD Dotson et al, CDC Blog Post, February 24, 2020 Brand (Posted: Feb-25-2020 9AM)

Dcreening based on polygenic risk prediction is not ready for widespread implementation. Stratification based on polygenic and/or multifactorial risk assessment may mature to the point of displacing family history-based approaches, but for the foreseeable future, family history may remain a valuable clinical tool for identifying individuals at increased risk.

Deep learning for prediction of colorectal cancer outcome: a discovery and validation study.
Skrede Ole-Johan et al. Lancet (London, England) 2020 Feb (10221) 350-360 (Posted: Feb-03-2020 9AM)

A clinically useful prognostic marker was developed using deep learning allied to digital scanning of conventional haematoxylin and eosin stained tumor tissue sections. The biomarker stratified stage II and III patients into sufficiently distinct prognostic groups that potentially could be used to guide treatment selection.

Gut Microbiome Link to Increased CRC in Younger Adults?
R Nelson, Medscape, January 27, 2020 (Posted: Feb-02-2020 9AM)

Colorectal cancer (CRC) has increased dramatically in adults younger than 50 years of age in many high-income countries, and there has been speculation as to why. Now, a small study points to differences in the gut microbiome between younger and older CRC patients.

A new comprehensive colorectal cancer risk prediction model incorporating family history, personal characteristics, and environmental factors.
Zheng Yingye et al. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2020 Jan (Posted: Jan-16-2020 8AM)

A familial risk profile (FRP) was calculated to summarize individuals' risk based on detailed cancer family history, family structure, probabilities of mutation in major CRC susceptibility genes, and a polygenic component.Our findings suggested detailed family history may be useful for targeted risk-based screening and clinical management

Associations of Pathogenic Variants in MLH1, MSH2, and MSH6 With Risk of Colorectal Adenomas and Tumors and With Somatic Mutations in Patients With Lynch Syndrome.
Engel Christoph et al. Gastroenterology 2020 Jan (Posted: Jan-15-2020 8AM)

Improving cancer screening programs
M Kalager et al, Science, January 10, 2020 (Posted: Jan-11-2020 11AM)

Future tests such as panels of genetic markers for prostate and breast cancer screening are expected to enter national screening programs soon. In the United States, a fecal DNA marker panel for colorectal cancer is recommended by some organizations on the basis of microsimulation modeling data and not RCTs.

Benefit from extended surveillance interval on colorectal cancer risk in Lynch syndrome.
Lindberg Lars Joachim et al. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2019 Dec (Posted: Jan-02-2020 10AM)

'Polygenic' analyses may sharpen disease risk predictions.
Kaiser Jocelyn et al. Science (New York, N.Y.) 2019 12 (6472) 1431 (Posted: Dec-21-2019 4PM)

Recent studies show a woman could receive a more individualized, accurate cancer risk estimate by factoring in other gene variants. A preprint posted last month finds that a person's “polygenic” background influences not only the disease risk conferred by a BRCA1 defect, but also risks from single gene mutations linked to colorectal cancer and heart disease.

Extent of Pedigree Required to Screen for and Diagnose Hereditary Nonpolyposis Colorectal Cancer: Comparison of Simplified and Extended Pedigrees.
Heo Yoonjung et al. Diseases of the colon and rectum 2019 Dec (Posted: Dec-18-2019 8AM)

Low Rates of Genetic Counseling and Testing in Individuals at Risk for Lynch Syndrome reported in the National Health Interview Survey.
Faust Nolan et al. Gastroenterology 2019 Dec (Posted: Dec-11-2019 9AM)

Head-to-Head Comparison of Family History of Colorectal Cancer and a Genetic Risk Score for Colorectal Cancer Risk Stratification.
Weigl Korbinian et al. Clinical and translational gastroenterology 2019 Nov (Posted: Dec-11-2019 9AM)

New AI-powered imaging technique IDs colorectal cancer with 100% accuracy
M Walter, AI in Health Care, December 10, 2019 (Posted: Dec-10-2019 9AM)

The Current Practice of Lynch Syndrome Diagnosis and Management in Italy: A Qualitative Assessment.
Tognetto Alessia et al. Public health genomics 2019 Dec 1-19 (Posted: Dec-07-2019 7AM)

Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG).
Monahan Kevin J et al. Gut 2019 Nov (Posted: Dec-04-2019 9AM)

This guideline is an update from the 2010 guidelines for colorectal screening and surveillance in moderate and high-risk groups; however, this guideline is concerned specifically with people who have increased lifetime risk of CRC due to hereditary factors, including those with Lynch syndrome, polyposis or a family history of CRC.

Polygenic background modifies penetrance of monogenic variants conferring risk for coronary artery disease, breast cancer, or colorectal cancer
AC Fahed et al, MedRXIV, November 29, 2019 (Posted: Dec-02-2019 8AM)

For three genomic conditions (coronary artery disease, breast cancer, and colorectal cancer) polygenic risk powerfully modifies the risk conferred by monogenic risk variants. Across the lowest to highest percentiles of polygenic risk, disease risk ranged from 17% to 78% for coronary artery disease; 13% to 76% for breast cancer; and 11% to 80% for colon cancer.

People with genetic condition should be given aspirin daily to slash their risk of colorectal cancer
Denton Daily, November 24, 2019 (Posted: Nov-25-2019 8AM)

Thousands of people with a common genetic condition should take aspirin every day to slash their risk of colorectal cancer, health officials rule. In its draft NICE While there are risks associated with long-term aspirin use, the committee agreed that the benefits are likely to outweigh any potential harms.

Colorectal cancer-associated microbiota contributes to oncogenic epigenetic signatures
I Sobhani, et al, PNAS, November 11, 2019 (Posted: Nov-12-2019 8AM)

This study advances our appreciation and understanding of the role of colon dysbiosis in the pathogenesis of colorectal cancer. In a human pilot study of 266 individuals, greater epigenomic (methylation) DNA alterations correlated with CRC and microbiota composition.

Guidelines for the management of hereditary colorectal cancer from the BSG /ACPGBI/UKCGG
British Society Gastroenterology, October 2019 (Posted: Nov-10-2019 8AM)

Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/ Association of Coloproctologists of Great Britain and Ireland (ACPGBI)/ United Kingdom Cancer Genetics Group (UKCGG).

KETOS: Clinical decision support and machine learning as a service - A training and deployment platform based on Docker, OMOP-CDM, and FHIR Web Services.
Gruendner Julian et al. PloS one 2019 (10) e0223010 (Posted: Oct-23-2019 8AM)

The Colorectal Cancer Risk Assessment Tool
NCI, 2019 Brand (Posted: Oct-21-2019 10AM)

The Colorectal Cancer Risk Assessment Tool was designed for doctors and other health care providers to use with their patients. The tool estimates the risk of colorectal cancer over the next 5 years and the lifetime risk for men and women who are: Between the ages of 45 and 85. This tool takes about 5 minutes to complete.

Cost-effectiveness of risk-stratified colorectal cancer screening based on polygenic risk – current status and future potential
SK Naber et al, JNCI SPectrum, October 17, 2019 (Posted: Oct-18-2019 8AM)

This cost-effectiveness analysis shows that currently, colorectal cancer screening based on polygenic risk is unlikely to be cost effective compared to uniform screening. This is expected to change with a?>?0.05 increase in AUC value, a?>?30% reduction in polygenic testing costs, or a?>?5% increase in adherence with screening.

The predicted impact and cost-effectiveness of systematic testing of people with incident colorectal cancer for Lynch syndrome.
Kang Yoon-Jung et al. The Medical journal of Australia 2019 Oct (Posted: Oct-16-2019 9AM)

A Patient’s Guide to Endometrial Cancer-This cancer is on the rise. But early detection saves lives.
MO Shroeder, US News, October 4, 2019 (Posted: Oct-05-2019 9AM)

Risk factors for this cancer include: obesity, diabetes, having close relatives like a parent or sibling who have endometrial cancer or colorectal cancer, and a genetic condition called Lynch syndrome. Having Lynch syndrome greatly increases a woman’s risk of developing endometrial cancer, and other cancers like colon and ovarian cancer

Can an Aspirin a Day Prevent Colorectal Cancer in People with Lynch Syndrome?
S Bowen et al, CDC Blog, October 2, 2019 Brand (Posted: Oct-04-2019 10AM)

The new NICE draft guidance based on a groundbreaking clinical trial, in review, at the time of this blog, NICE is circulating draft language, based on clinical trials, which essentially states that an aspirin taken daily for more than two years reduces the risk of colorectal cancer among people with Lynch syndrome.

Sir John Burn Delivers Seminar on Prediction and Prevention of Colorectal Cancer in Patients with Lynch Syndrome
NCI,September 26, 2019 Brand (Posted: Sep-28-2019 8AM)

He presented new insights into the mechanisms and natural history of colorectal cancer associated with Lynch Syndrome and the longitudinal trials on protective effects of aspirin. He also presented efforts to build robust, international, annotated genetic databases.

Inequities in multi-gene hereditary cancer testing: lower diagnostic yield and higher VUS rate in individuals who identify as Hispanic, African or Asian and Pacific Islander as compared to European.
Ndugga-Kabuye Mesaki K et al. Familial cancer 2019 Sep (Posted: Sep-25-2019 9AM)

White-light Endoscopy is Adequate for Lynch Syndrome Surveillance in a Randomized and Non-inferiority Study.
Rivero-Sánchez Liseth et al. Gastroenterology 2019 Sep (Posted: Sep-18-2019 10AM)

Rates of Actionable Genetic Findings in Individuals with Colorectal Cancer or Polyps Ascertained from a Community Medical Setting
AS Gordon et al, AJHG, AUgust 15, 2019 (Posted: Aug-16-2019 8AM)

Rationale for evaluating breast cancers of Lynch syndrome patients for mismatch repair gene expression.
Sorscher Steven et al. Breast cancer research and treatment 2019 Aug (Posted: Aug-14-2019 8AM)

Offer daily aspirin to those with inherited genetic condition to reduce the risk of colorectal cancer
NICE, August 2, 2019 (Posted: Aug-03-2019 4PM)

Aspirin taken daily for 2 years or more could reduce the risk of colorectal cancer in people with Lynch syndrome (LS), says NICE in new draft updated guidance.

Family still matters: Counseling patients with complex family histories of colon and endometrial cancers.
Gemmell Amber P et al. Molecular genetics & genomic medicine 2019 Jul e886 (Posted: Jul-31-2019 8AM)

There are no national guidelines for the management of patients with a family history consistent with Lynch syndrome (LS) but a negative genetic test. To determine current management practices, genetic counselors' (GCs) recommendations were assessed.

Next Generation Sequencing Reveals Novel Mutations in Mismatch Repair Genes and Other Cancer Predisposition Genes in Asian Patients with Suspected Lynch Syndrome.
Ow Samuel G W et al. Clinical colorectal cancer 2019 Jun (Posted: Jul-31-2019 8AM)

Cancer risks by gene, age, and gender in 6350 carriers of pathogenic mismatch repair variants: findings from the Prospective Lynch Syndrome Database.
Dominguez-Valentin Mev et al. Genetics in medicine : official journal of the American College of Medical Genetics 2019 Jul (Posted: Jul-26-2019 9AM)

Pathogenic variants in several genes cause Lynch syndrome and result in imprecisely known cancer risks. This cohort study aimed to provide age and organ-specific cancer risks according to gene and gender and to determine survival after cancer.

Lynch Syndrome Screening in Gynecological Cancers: Results of an International Survey with Recommendations for Uniform Reporting Terminology for Mismatch Repair Immunohistochemistry Results.
Ryan Neil et al. Histopathology 2019 Jul (Posted: Jul-24-2019 10AM)

Risk prediction models for colorectal cancer incorporating common genetic variants: a systematic review
McGeoch, L. et. al. Cancer Epidemiology, Biomarkers & Prevention (Posted: Jul-15-2019 9AM)

This is an updated systematic review of colorectal cancer risk prediction models that incorporate genetic factors. The addition of genetics may increase predictive ability by 0.01 to 0.05. There are added value beyond using family history alone and potential implications for starting age of colorectal cancer screening.

Suboptimal Adherence in Clinical Practice to Guidelines Recommendation to Screen for Lynch Syndrome.
Jain A et al. Digestive diseases and sciences 2019 Jun (Posted: Jun-19-2019 9AM)

Circulating biomarkers for early detection and clinical management of colorectal cancer.
Marcuello María et al. Molecular aspects of medicine 2019 Jun (Posted: Jun-14-2019 9AM)

Molecular biomarkers and precision medicine in colorectal cancer: a systematic review of health economic analyses.
Henderson Raymond et al. Oncotarget 2019 May 10(36) 3408-3423 (Posted: Jun-12-2019 7AM)

Metagenomic and metabolomic analyses reveal distinct stage-specific phenotypes of the gut microbiota in colorectal cancer.
Yachida Shinichi et al. Nature medicine 2019 Jun (Posted: Jun-10-2019 9AM)

Deficient mismatch repair testing in colorectal cancer: more than just screening for Lynch syndrome.
West N P et al. Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2019 Jun 21(6) 621-622 (Posted: Jun-05-2019 10AM)

Universal tumor screening for Lynch syndrome: Perceptions of Canadian pathologists and genetic counselors of barriers and facilitators.
Dicks Elizabeth et al. Cancer medicine 2019 May (Posted: May-22-2019 8AM)

Can Circulating Tumor DNA in Early-Stage Colorectal Cancer Be More Than a Prognostic Biomarker?
Morris Van et al. JAMA oncology 2019 May (Posted: May-10-2019 9AM)

Analysis of Plasma Cell-Free DNA by Ultradeep Sequencing in Patients With Stages I to III Colorectal Cancer.
Reinert Thomas et al. JAMA oncology 2019 May (Posted: May-10-2019 9AM)

Hereditary cancer syndromes, their testing and prevention.
Foretová Lenka et al. Casopis lekaru ceskych 2019 158(1) 15-21 (Posted: May-08-2019 9AM)

Epigenetic-based therapy for colorectal cancer: Prospect and involved mechanisms.
Rezapour Saleheh et al. Journal of cellular physiology 2019 Apr (Posted: May-07-2019 9AM)

Health and lifestyle behaviors in colorectal cancer survivors with and without Lynch syndrome.
Donato Kirsten M et al. Journal of community genetics 2019 Apr (Posted: May-01-2019 9AM)

Effect of chromoendoscopy in the proximal colon on colorectal neoplasia detection in Lynch syndrome: a multicenter randomized controlled trial.
Haanstra Jasmijn F et al. Gastrointestinal endoscopy 2019 Apr (Posted: May-01-2019 9AM)

Colorectal Cancer Screening
N Gupta et al, JAMA Clinical Guidelines Synopsis, April 25, 2019 (Posted: Apr-25-2019 0PM)

Could a Vaccine Prevent Colorectal Cancer in People with Lynch Syndrome?
NCI, April 19, 2019 Brand (Posted: Apr-22-2019 8AM)

Screening for Lynch Syndrome by Immunohistochemistry of Mismatch Repair Proteins: Significance of Indeterminate Result and Correlation With Mutational Studies.
Sarode Venetia R et al. Archives of pathology & laboratory medicine 2019 Mar (Posted: Apr-03-2019 9AM)

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation
AM Thomas et al, Nature Medicine, April 1, 2019 (Posted: Apr-02-2019 10AM)

Meta-analysis of fecal metagenomes reveals global microbial signatures that are specific for colorectal cancer
J wirbel et al, Nature Medicine, April 1, 2019 (Posted: Apr-02-2019 10AM)

Can polyps detected by early screening help to identify individuals at risk of hereditary colorectal cancer syndromes?
L Steinmark et al, Jackson Lab, March 2019 (Posted: Mar-29-2019 10AM)

The Manchester International Consensus Group recommendations for the management of gynecological cancers in Lynch syndrome.
Crosbie Emma J et al. Genetics in medicine : official journal of the American College of Medical Genetics 2019 Mar (Posted: Mar-29-2019 9AM)

Total abdominal colectomy is cost-effective in treating colorectal cancer in patients with genetically diagnosed Lynch Syndrome.
Jiang Boxiang et al. American journal of surgery 2019 Mar (Posted: Mar-27-2019 9AM)

Familial colorectal cancer risk in half siblings and siblings: nationwide cohort study.
Tian Yu et al. BMJ (Clinical research ed.) 2019 Mar l803 (Posted: Mar-20-2019 8AM)

Women's preferences for cancer risk management strategies in Lynch syndrome.
Sun Charlotte C et al. Gynecologic oncology 2019 Mar (3) 514-521 (Posted: Mar-20-2019 8AM)

Colon Cancer Screening Can Save Your Life- With colorectal cancer being found in an increasing number of younger adults, the pressure is on to screen millions more.
JE Brody, NY Times, March 11, 2019 (Posted: Mar-17-2019 4PM)

Lynch Syndrome: From Screening to Diagnosis to Treatment in the Era of Modern Molecular Oncology.
Cohen Stacey A et al. Annual review of genomics and human genetics 2019 Mar (Posted: Mar-12-2019 10AM)

What Are the Symptoms of Colorectal Cancer?
CDC, 2019 Brand (Posted: Mar-04-2019 9AM)

Development of FamilyTalk: an Intervention to Support Communication and Educate Families About Colorectal Cancer Risk.
Bowen Deborah J et al. Journal of cancer education : the official journal of the American Association for Cancer Education 2019 Feb (Posted: Feb-12-2019 10AM)

Genomic Features and Clinical Management of Patients with Hereditary Pancreatic Cancer Syndromes and Familial Pancreatic Cancer.
Ohmoto Akihiro et al. International journal of molecular sciences 2019 Jan 20(3) (Posted: Feb-06-2019 10AM)

Comprehensive Paired Tumor/Germline Testing for Lynch Syndrome: Bringing Resolution to the Diagnostic Process.
Salvador Monalyn U et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2019 Jan JCO1800696 (Posted: Feb-06-2019 10AM)

Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland: Findings from an International Workshop.
Nikolaidis Christos et al. Public health genomics 2019 Jan 1-12 (Posted: Jan-30-2019 9AM)

A Simplified Genomic Profiling Approach Predicts Outcome in Metastatic Colorectal Cancer.
Capalbo Carlo et al. Cancers 2019 Jan 11(2) (Posted: Jan-30-2019 9AM)

Lynch-like syndrome is as frequent as Lynch syndrome in early-onset non-familial non-polyposis colorectal cancer.
Antelo M et al. International journal of cancer 2019 Jan (Posted: Jan-30-2019 9AM)

A panel of seven-miRNA signature in plasma as potential biomarker for colorectal cancer diagnosis.
Zhang Huo et al. Gene 2019 Mar 687246-254 (Posted: Jan-23-2019 10AM)

Recent advances in Lynch syndrome.
Biller Leah H et al. Familial cancer 2019 Jan (Posted: Jan-15-2019 10AM)

Testing strategies to reduce morbidity and mortality from Lynch syndrome.
Keränen Anne et al. Scandinavian journal of gastroenterology 2018 Dec 1-6 (Posted: Jan-02-2019 4PM)

Researchers Develop Personalized Medicine Tool for Inherited Colorectal Cancer Syndrome Risk
Huntsman Cancer Institute, December 10, 2018 (Posted: Dec-11-2018 11AM)

Personalized medicine tool for inherited colorectal cancer syndrome
Science Daily, December 10, 2018 (Posted: Dec-11-2018 10AM)

Risk and prognostic factors for endometrial carcinoma after diagnosis of breast or Lynch-associated cancers-A population-based analysis.
Johnatty Sharon E et al. Cancer medicine 2018 Nov (Posted: Dec-04-2018 10AM)

Risks of Colorectal Cancer and Cancer-Related Mortality in Familial Colorectal Cancer Type X and Lynch Syndrome Families.
Choi Yun-Hee et al. Journal of the National Cancer Institute 2018 Oct (Posted: Nov-07-2018 11AM)

Mismatch Repair Protein Expression in Endometrioid Intraepithelial Neoplasia/Atypical Hyperplasia: Should We Screen for Lynch Syndrome in Precancerous Lesions?
Lucas Elena et al. International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists 2018 Oct (Posted: Nov-07-2018 11AM)

Microsatellite Instability Is Associated With the Presence of Lynch Syndrome Pan-Cancer.
Latham Alicia et al. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018 Oct JCO1800283 (Posted: Nov-01-2018 9AM)

Early Detection of Colorectal Cancer: a Multi-Center Pre-Clinical Case Cohort Study for Validation of a Combined DNA Stool Test.
Dollinger Matthias M et al. Clinical laboratory 2018 Oct 64(10) 1719-1730 (Posted: Oct-24-2018 10AM)

The added value of genetic information in colorectal cancer risk prediction models: development and evaluation in the UK Biobank prospective cohort study.
Smith Todd et al. British journal of cancer 2018 Oct (Posted: Oct-17-2018 8AM)

Current mismatch repair deficiency tumor testing practices and capabilities: A survey of Australian pathology providers.
Mascarenhas Lyon et al. Asia-Pacific journal of clinical oncology 2018 Oct (Posted: Oct-10-2018 7AM)

Learning by Example: An International Perspective on Reflex-Testing for Lynch Syndrome.
Palter Vanessa N et al. Annals of surgical oncology 2018 Oct (Posted: Oct-03-2018 8AM)

Targeted Next Generation Sequencing of MLH1 , MSH2 , and MSH6 Genes in Patients with Endometrial Carcinoma <50 Years of Age.
Özdemir Taha Resid et al. Balkan medical journal 2018 Sep (Posted: Sep-26-2018 10AM)

Could earlier colorectal cancer screening help identify more people with hereditary cancer?
L Steinmark, Jackson Labs, September 25, 2018 (Posted: Sep-26-2018 8AM)

Barriers to Lynch Syndrome Testing and Preoperative Result Availability in Early-onset Colorectal Cancer: A National Physician Survey Study.
Noll Alan et al. Clinical and translational gastroenterology 2018 Sep (9) 185 (Posted: Sep-25-2018 9AM)

Colon cancer is attacking this family and the answer may lie in genetics
mLive, September 19, 2018 (Posted: Sep-20-2018 8AM)

Molecular Background of Colorectal Tumors From Patients With Lynch Syndrome Associated With Germline Variants in PMS2.
Ten Broeke Sanne W et al. Gastroenterology 2018 155(3) 844-851 (Posted: Sep-19-2018 9AM)

Targeted next-generation sequencing in the detection of mismatch repair deficiency in endometrial cancers.
Dong Fei et al. Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2018 Sep (Posted: Sep-19-2018 9AM)

Diagnostics of Pleiotropy in Mendelian Randomization Studies: Global and Individual Tests for Direct Effects.
Dai James Y et al. American journal of epidemiology 2018 Sep (Posted: Sep-12-2018 9AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.