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Last Posted: Nov 27, 2022
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NIH-funded study finds personalized kidney screening for people with type 1 diabetes could reduce costs, detect disease earlier
NIH, November 2, 2022 Brand

Taking a personalized approach to kidney disease screening for people with type 1 diabetes (T1D) may reduce the time that chronic kidney disease (CKD) goes undetected, according to a new analysis. According to the model’s findings: People with AER of 21-30 mg per 24 hours and a HbA1c of at least 9% are at high risk for developing CKD and could be screened for urine albumin every six months. This screening frequency could reduce time with undetected kidney disease so that appropriate interventions can be instituted as early as possible. Those with AER = 10 mg per 24 hours and a HbA1c = 8% are at lower risk for developing CKD and could be screened every two years. This change reduces patient burden and potentially saves millions of dollars compared to annual screening. All others with T1D = 5 years could continue to be screened annually.

Preeclampsia, Genomics and Public Health
E Dawson et al, CDC Blog Post, October 25, 2022

Preeclampsia is estimated to occur in 5 to 7 percent of all pregnancies and is one of the leading causes of maternal morbidity. Risk factors for preeclampsia include first pregnancy; history of preeclampsia; history of hypertension, chronic kidney disease, or both; history of thrombophilia (a condition that increases risk of blood clots); pregnancy from in vitro fertilization; family history of preeclampsia. A recent study identified a cell free RNA (cfRNA) signature that was promising in predicting pre-eclampsia several weeks before the onset of symptoms.

Genome-wide polygenic score to predict chronic kidney disease across ancestries
A Khan et al, Nature Medicine, June 16, 2022

Chronic kidney disease (CKD) is a common complex condition associated with high morbidity and mortality. Polygenic prediction could enhance CKD screening and prevention; however, this approach has not been optimized for ancestrally diverse populations. By combining APOL1 risk genotypes with genome-wide association studies (GWAS) of kidney function, we designed, optimized and validated a genome-wide polygenic score (GPS) for CKD. The new GPS was tested in 15 independent cohorts, including 3 cohorts of European ancestry (n?=?97,050), 6 cohorts of African ancestry (n?=?14,544), 4 cohorts of Asian ancestry (n?=?8,625) and 2 admixed Latinx cohorts (n?=?3,625).

Chronic Kidney Disease Basics
CDC, March 2022 Brand

Kidney diseases are a leading cause of death in the United States. About 37 million US adults are estimated to have CKD, and most are undiagnosed. 40% of people with severely reduced kidney function (not on dialysis) are not aware of having CKD. Talk to your doctor about getting tested if you have any of these risk factors: Diabetes, High blood pressure, Heart disease, Family history of CKD, Obesity.

Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.