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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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356 hot topic(s) found with the query "Cancer"

What Are the Risk Factors for Lung Cancer?
CDC, November 2020 Brand (Posted: Nov-18-2020 10AM)

Your risk of lung cancer may be higher if your parents, brothers or sisters, or children have had lung cancer. This could be true because they also smoke, or they live or work in the same place where they are exposed to radon and other substances that can cause lung cancer.

Breast Cancer Among Men
T Ellington, CDC Blog, October 2020 Brand (Posted: Oct-26-2020 9AM)

Although rare, men can get breast cancer. Although having risk factors does not mean a man will get breast cancer, there are some things that may increase the risk like genetic mutations and a family history of breast cancer.

FDA Approves Blood Tests That Can Help Guide Cancer Treatment
NCI, October 16, 2020 Brand (Posted: Oct-16-2020 1PM)

The Food and Drug Administration (FDA) has approved two blood tests, known as liquid biopsies, that can help guide treatment decisions for people with cancer. The tests were approved for people with any solid cancer (e.g., lung, prostate), but not for those with blood cancers,.

Polygenic risk scores: What are they and what can public health do with them?
CDC Webinar with DR Cecile Janssens, August 13, 2020 Brand (Posted: Jul-27-2020 8AM)

This mini-course will provide an introduction to polygenic risk score models, including examples for cancer and cardiovascular disease. Discussions will include how to develop and validate these models.

Lung Adenocarcinoma (LUAD) Discoveries from two NCI Proteomics Consortia
NCI, July 9, 2020 Brand (Posted: Jul-10-2020 6AM)

Advances in genomics have revealed new insights in the biology of LUAD, but comprehensive information about how various gene mutations lead to this disease is still lacking. Investigators addressed this challenge by adding comprehensive proteomics to genomics, or proteogenomics, to reveal an additional dimension of lung cancer biology.

A New FDA Approval Furthers the Role of Genomics in Cancer Care
NCI Director blog, July 8, 2020 Brand (Posted: Jul-09-2020 9AM)

A recent drug approval by the Food and Drug Administration (FDA) marks another milestone in the treatment of cancer. The action by FDA expands the growing list of approved uses for the immune checkpoint inhibitor pembrolizumab

Strategies to Identify and Care for Individuals with Inherited Cancer Syndromes
NCI Webinar, July 30, 2020 Brand (Posted: Jul-07-2020 10AM)

Focused on health care delivery and identifying best practices for case ascertainment and follow-up care in inherited cancer syndromes, NCI seeks to improve sustainable implementation of care delivery models. This webinar discusses the hereditary cancers Cancer Moonshot effort, research and perspective from a current grantee, and directions for future work.

AI dual-stain approach improved accuracy, efficiency of cervical cancer screening in NCI study
NCI, June 2020 Brand (Posted: Jun-30-2020 8AM)

In recent years, clinicians have hoped to take advantage of advances in digital imaging and machine learning to improve cervical cancer screening. The challenge is to identify which women with positive HPV test results are most likely to have precancerous changes in their cervical cells.

NCI COVID-19 in Cancer Patients Study (NCCAPS)
NCI, May 2020 Brand (Posted: May-23-2020 10AM)

Researchers Search the Genome for Clues to Early Age Onset Cancers in Racial/Ethnic Minorities
NCI, March 2020 Brand (Posted: May-11-2020 10AM)

While researchers have identified some of the genetic changes that lead to cancer development, a key knowledge gap remains: finding the genetic changes that drive the development of cancers that arise at an earlier age than average (early onset) in racially and ethnically diverse populations.

What Is Colorectal Cancer Screening?
CDC, March 2020 Brand (Posted: Mar-09-2020 8AM)

Regular screening, beginning at age 50, is the key to preventing colorectal cancer. If you think you may be at increased risk for colorectal cancer, learn your family health history and ask your doctor if you should begin screening before age 50.

Should polygenic risk scores be used in risk-stratified colorectal cancer screening?
WD Dotson et al, CDC Blog Post, February 24, 2020 Brand (Posted: Feb-25-2020 9AM)

Dcreening based on polygenic risk prediction is not ready for widespread implementation. Stratification based on polygenic and/or multifactorial risk assessment may mature to the point of displacing family history-based approaches, but for the foreseeable future, family history may remain a valuable clinical tool for identifying individuals at increased risk.

A 2020 Reality Check on the Public Health Impact of Cancer Genomics and Precision Medicine
Khoury MJ et al, CDC BLog, February 10, 2020 Brand (Posted: Feb-11-2020 9AM)

Precision oncology has had some major successes… And yet, the overall effect of precision medicine on care for patients with cancer has been modest. Nonetheless, it is important for public health to explore using novel and more precise approaches to monitor cancer burden, and implement proven cancer control goals especially in hard to reach populations

Insurance Status Helps Explain Racial Disparities in Cancer Diagnosis
NIH Director's blog, January 2020 Brand (Posted: Jan-27-2020 7AM)

As Use of Genomic Data Expands in Cancer Care, Patients Share Their Stories
NCI, December 3, 2019 Brand (Posted: Dec-06-2019 8AM)

The expanding use of personal genomic data has raised questions, including: Which patients should undergo genomic testing? Who controls a person’s genomic data? What are the potential benefits and risks of sharing one’s genomic data with researchers or family members?

Communication and Decision Making for Individuals with Inherited Cancer Syndromes
NCI, November 2019 Brand (Posted: Nov-22-2019 8AM)

NCI support for projects that will be conducted to develop, test, and evaluate interventions and implementation approaches, or adapt existing approaches, to improve cancer risk communication between patients with an inherited susceptibility to cancer (and their families) and providers so that affected individuals can make informed clinical risk management decisions.

Study Suggests Repurposed Drugs Might Treat Aggressive Lung Cancer
NIH Director's Blog, November 19, 2019 Brand (Posted: Nov-21-2019 7AM)

Using gene-editing technology to conduct a systematic, large-scale search for druggable vulnerabilities in certain types of cancer cells grown in lab dishes, researchers recently identified a metabolic pathway that appears to play a key role in small cell lung cancer. What makes this news even more encouraging is drugs that block this pathway already exist.

PARP Inhibitors Show Promise as Initial Treatment for Ovarian Cancer
NCI, October 29, 2019 Brand (Posted: Oct-31-2019 0PM)

Drugs known as PARP inhibitors are used to treat some women with advanced ovarian cancer that has returned after earlier treatment. Now, results from three new clinical trials show that the drugs might also benefit women who are newly diagnosed with advanced ovarian cancer.

Analysis Shows Women with High Breast Cancer Recurrence Scores Benefit from Chemo
NCI, October 25, 2019 Brand (Posted: Oct-26-2019 10AM)

For women with the most common type of early-stage breast cancer and high scores on the Oncotype DX test, receiving chemotherapy with hormone therapy after surgery can lead to excellent long-term outcomes. That’s the conclusion of a new data analysis from the NCI-funded TAILORx clinical trial.

Enhancing Observational Data Collection to Inform Precision Cancer Research and Care
DCCPS, NCI, October 2019 Brand (Posted: Oct-22-2019 11AM)

DCCPS supports research in surveillance, epidemiology, health care delivery, behavioral science, and cancer survivorship. It is a source of expertise and evidence on issues such as the quality of cancer care, the economic burden of cancer, geographic information systems, statistical methods, communication, behavioral research and health care delivery.

The Colorectal Cancer Risk Assessment Tool
NCI, 2019 Brand (Posted: Oct-21-2019 10AM)

The Colorectal Cancer Risk Assessment Tool was designed for doctors and other health care providers to use with their patients. The tool estimates the risk of colorectal cancer over the next 5 years and the lifetime risk for men and women who are: Between the ages of 45 and 85. This tool takes about 5 minutes to complete.

General “Take Action” Infographic
CDC Cancer, 2019 Brand (Posted: Oct-08-2019 8AM)

Lower your risk of hereditary breast and ovarian cancer. Asking relatives about their cancer histories can be hard. Follow these tips: Share that you have learned that cancers can run in families. Explain that you are creating a record of your family’s history of cancer. •Encourage family members to respond in a way that is most comfortable to them.

Easing the Burden of Children and Families Dealing with Cancer
JE Bloyd, CDC Cancer Blog, October 2019 Brand (Posted: Oct-08-2019 8AM)

Implementation Science Centers in Cancer Control (ISC3)
NCI, October 2019 Brand (Posted: Oct-05-2019 8AM)

The Implementation Science Centers in Cancer Control (ISC3) Program supports the rapid development, testing, and refinement of innovative approaches to implement a range of evidence-based cancer control interventions. Centers all feature "implementation laboratories" involving clinical and community sites.

Can an Aspirin a Day Prevent Colorectal Cancer in People with Lynch Syndrome?
S Bowen et al, CDC Blog, October 2, 2019 Brand (Posted: Oct-04-2019 10AM)

The new NICE draft guidance based on a groundbreaking clinical trial, in review, at the time of this blog, NICE is circulating draft language, based on clinical trials, which essentially states that an aspirin taken daily for more than two years reduces the risk of colorectal cancer among people with Lynch syndrome.

After a Breast Cancer Diagnosis, Men May Be More Likely to Die than Women
NCI, October 2, 2019 Brand (Posted: Oct-04-2019 9AM)

Men may be more likely than women to die after being diagnosed with breast cancer, particularly during the first 5 years after diagnosis. Fewer than 1% of breast cancers diagnosed each year occur in men and many of them aree associated with BRCA mutations.

Sir John Burn Delivers Seminar on Prediction and Prevention of Colorectal Cancer in Patients with Lynch Syndrome
NCI,September 26, 2019 Brand (Posted: Sep-28-2019 8AM)

He presented new insights into the mechanisms and natural history of colorectal cancer associated with Lynch Syndrome and the longitudinal trials on protective effects of aspirin. He also presented efforts to build robust, international, annotated genetic databases.

Learn Your Family History of Breast and Ovarian Cancer
CDC, 2019 Brand (Posted: Sep-16-2019 8AM)

Learning your family history of cancer, from both your mother’s and father’s sides, can help you know if you have a higher risk for getting breast or ovarian cancer at a young age.Asking your relatives about their cancer histories can be hard. Here are some tips for talking with your family about this topic.

Men, It’s Time for Real Talk about Prostate Health
DM Parker, CDC Blog, August 2019 Brand (Posted: Sep-11-2019 0PM)

Research by the United States Preventive Services Task Force (USPSTF), a group of health care experts, shows that men aged 55 to 69 benefit most from screening. Specifically, the USPSTF lists African American men and men with a family history of prostate cancer as higher risk groups.

Opportunities in Cancer Research: The Immune System and Microbiome
NCI 2021 annual plan, 2019 Brand (Posted: Sep-10-2019 9AM)

Cancer immunotherapy has emerged as a powerful tool in cancer treatment. The key insight was that a patient’s own immune system could be harnessed to recognize and destroy cancer cells. Thanks to decades of basic research, this insight has led to new treatments that have saved or extended the lives of many patients.

What you need to know about ovarian cancer
CDC, 2019 Brand (Posted: Sep-05-2019 8AM)

There is no way to know for sure if you will get ovarian cancer. Most women get it without being at high risk. However, several factors may increase a woman’s risk for ovarian cancer, including if you are middle-aged or older; have close family members who have had ovarian cancer; have a genetic mutation called BRCA1 or BRCA2, or Lynch syndrome.

More Treatment Options Emerging for Some Men with Metastatic Prostate Cancer
NCI, 2019 Brand (Posted: Sep-03-2019 10AM)

Study Tests Immunotherapy in People with Cancer and Autoimmune Diseases
NCI, August 26, 2019 Brand (Posted: Aug-27-2019 7AM)

Implementing Universal Lynch Syndrome Screening across Multiple Healthcare Systems: Identifying Strategies to Facilitate and Maintain Programs in Different Organizational Contexts
NCI, August 2019 Brand (Posted: Aug-23-2019 11AM)

The National Cancer Institute frequently receives requests for examples of funded grant applications. Several investigators and their organizations agreed to let Implementation Science (IS) post excerpts of their dissemination and implementation (D&I) grant applications online.

The Childhood Cancer Data Initiative: Transforming the Pediatric Cancer Landscape through Sharing Data
DR Lowy, NCI, August 15, 2019 Brand (Posted: Aug-19-2019 8AM)

The Childhood Cancer Data Initiative presents a tremendous opportunity—and responsibility—to leverage new technologies for gathering and integrating data and building a framework for easily sharing data among researchers who study pediatric cancer and clinicians who treat our youngest patients with cancer.

Validation of New High Throughput, Low Cost HPV Test for Cervical Cancer Prevention
NCI, August 6, 2019 Brand (Posted: Aug-08-2019 8AM)

A next-generation sequencing assay for detection of 51 types of human papillomavirus (HPV)provides a high-throughput, low cost, and reliable method of detecting cervical precancer and estimating HPV vaccination efficacy.

Emily and Caroline’s Story
CDC Bring Your Brave, 2019 Brand (Posted: Aug-05-2019 8AM)

Every woman reacts differently to finding out she has a high chance of developing breast cancer, based on family history and genetic testing. Managing your breast cancer risk is not a one-size-fits-all thing. Caroline and Emily chose different paths, but their support for each other and their decisions remained unwavering

Childhood Cancer Data Initiative (CCDI) Symposium
NCI, July 29-31, 2019 Brand (Posted: Jul-30-2019 8AM)

The NCI Childhood Cancer Data Initiative (CCDI) Symposium: a scientific meeting to gain a common understanding of the current issues and opportunities in childhood cancer research that can be addressed through enhanced data collection and maximum utilization of that data.

Infographic: “What Every Young Woman Needs to Know About Hereditary Breast and Ovarian Cancer”
CDC, 2019 Brand (Posted: Jul-17-2019 9AM)

Development of Cancer Immunotherapy
NCI, June 2019 Brand (Posted: Jun-28-2019 8AM)

More than 30 years ago the idea was heretical: a patient?s immune system could be harnessed to fight cancer. NCI scientists? pursuit of this idea chartered the development of immunotherapy. Read the story of the developments and applications of immunotherapy in modern day cancer treatment

Big Data Scientist Training Enhancement Program (BD-STEP)
NCI, 2019 Brand (Posted: Jun-24-2019 8AM)

A two-year fellowship opportunity that uses data science to advance cancer research and care.

Advances in breast cancer research
NCI, May 2019 Brand (Posted: Jun-17-2019 7AM)

The Childhood Cancer Data Initiative: Why Data Sharing Is Essential to Progress
D Lowy, NCI Director Blog, June 12, 2019 Brand (Posted: Jun-12-2019 10AM)

New Drugs, New Side Effects: Complications of Cancer Immunotherapy
NCI, May 2019 Brand (Posted: May-31-2019 0PM)

Cancer and Women: Learn your family history of cancer and what you can do to lower your cancer risk
CDC Cancer, May 2019 Brand (Posted: May-13-2019 11AM)

Cancer Genetics and Epidemiology Video Library
NCI, 2019 Brand (Posted: May-12-2019 2PM)

Women’s Stories
CDC Bring Your Brave Campaign, 2019 Brand (Posted: May-10-2019 0PM)

Personalized Combination Therapies Yield Better Cancer Outcomes
F Collins, NIH Director Blog, April 30, 2019 Brand (Posted: May-02-2019 8AM)

Fewer Women with Ovarian, Breast Cancer Undergo Genetic Testing than Expected
NCI, April 2019 Brand (Posted: Apr-23-2019 1PM)

Could a Vaccine Prevent Colorectal Cancer in People with Lynch Syndrome?
NCI, April 19, 2019 Brand (Posted: Apr-22-2019 8AM)

Low-Coverage Whole Genome Sequencing: Learning From Less Data
PI Wang, NCI, April 16, 2019 Brand (Posted: Apr-17-2019 9AM)

Bioinformatics, Big Data, and Cancer
NCI, March 2019 Brand (Posted: Mar-31-2019 5PM)

Notice of Availability of Administrative Supplements for Geospatial, Multilevel, and Contextual Approaches in Cancer Control and Population Sciences
NCI, March 2019 Brand (Posted: Mar-29-2019 10AM)

Pediatric Genomic Data Inventory
NCI, 2019 Brand (Posted: Mar-29-2019 10AM)

Small Area Estimates for Cancer-Related Measures
NCI, 2019 Brand (Posted: Mar-12-2019 9AM)

What Are the Symptoms of Colorectal Cancer?
CDC, 2019 Brand (Posted: Mar-04-2019 9AM)

CDC-RFA-DP19-1905 The CDC Cancer Genomics Program: Translating Research into Public Health Practice Department of Health and Human Services
CDC Funding announcement, closing date, April 15, 2019 Brand (Posted: Feb-19-2019 0PM)

What Is Breast Cancer Screening?
CDC, 2019 Brand (Posted: Feb-18-2019 0PM)

World Cancer Day 2019
CDC, 2019 Brand (Posted: Feb-04-2019 1PM)

United States Cancer Statistics: Data Visualizations
CDC_NCI, 2019 Brand (Posted: Feb-01-2019 8AM)

Atezolizumab Approved for Initial Treatment of Metastatic Lung Cancer
NCI, January 2019 Brand (Posted: Jan-29-2019 7AM)

Cancer Surveillance and GIS Tools and Resources
NCI, 2019 Brand (Posted: Jan-28-2019 5PM)

Using Artificial Intelligence to Detect Cervical Cancer
NIH Director's Blog, January 17, 2019 Brand (Posted: Jan-19-2019 7AM)

Epigenetics may hold key to arsenic’s role in cancer
E Hood, The Environmental Factors, NIEHS, January 2019 Brand (Posted: Jan-15-2019 9AM)

Preventing Cervical Cancer in the 21st Century
CDC Public Health Grand Rounds, January 15, 2018 Brand (Posted: Jan-15-2019 9AM)

BRCA Exchange aggregates data on thousands of BRCA variants to inform understanding of cancer risk
NCI, January 9, 2019 Brand (Posted: Jan-09-2019 4PM)

For Early-Stage Lung Cancer, Study Identifies Potential New Biomarker, Treatment Target
NCI, January 3, 2019 Brand (Posted: Jan-07-2019 0AM)

Solicitation for NCI Genomic Characterization Centers
NCI, December 2018 Brand (Posted: Dec-09-2018 9AM)

Fecal microbiota transplantation helps restore beneficial bacteria in cancer patients
NIH, September 26, 2018 Brand (Posted: Sep-27-2018 7AM)

Most tumors in body share important mutations
NIH Research Matters, September 25, 2018 Brand (Posted: Sep-25-2018 1PM)

Finding Pediatric Cancer Genomic Data through PGDI
NCI, September 2018 Brand (Posted: Sep-09-2018 10AM)

Family History and Cancer
CDC Division of Cancer Control and Prevention, 2018 Brand (Posted: Sep-03-2018 9AM)

When Should You Be Screened for Colorectal Cancer?
S Bowen et al, CDC Blog Post, August 30, 2018 Brand (Posted: Aug-31-2018 8AM)

Approaches to Identify and Care for Individuals with Inherited Cancer Syndromes (U01 Clinical Trial Required)
NCI Moonshot Funding Announcement, August 10, 2018 Brand (Posted: Aug-13-2018 2PM)

NIH and Prostate Cancer Foundation launch large study on aggressive prostate cancer in African-American men
NCI, July 2018 Brand (Posted: Jul-30-2018 8AM)

Skin Cancer Prevention Progress Report
CDC, 2018 Brand (Posted: Jul-06-2018 10AM)

Using Genetic Risk Scores in Cancer Screening: Are We There Yet?
Roberts M et al, CDC Blog Post, July 5, 2018 Brand (Posted: Jul-06-2018 8AM)

Test predicts whether chemotherapy will help early-stage breast cancer patients
NIH Research Matters, June 12, 2018 Brand (Posted: Jun-12-2018 11AM)

Cancer and Men
Brand (Posted: Jun-11-2018 1PM)

New approach to immunotherapy leads to complete response in breast cancer patient unresponsive to other treatments
NCI, June 4, 2018 Brand (Posted: Jun-04-2018 1PM)

NCI-MATCH precision medicine clinical trial releases new findings, strengthens path forward for targeted cancer therapies
Brand (Posted: Jun-04-2018 11AM)

The Genomic Data Commons Turns 2: Progress in Clinical Tool Development
LM Staudt, NCI, Blog Post, May 31, 2018 Brand (Posted: May-31-2018 2PM)

Systematic Functional Annotation of Somatic Mutations in Cancer
NCI, May 2018 Brand (Posted: May-28-2018 10AM)

Are Some Tumors Just ‘Born to Be Bad’?
NIH Director's blog, May 22, 2018 Brand (Posted: May-22-2018 10AM)

Annual Report to the Nation: overall cancer mortality continues to decline, prostate cancer mortality has stabilized
NCI, Press Release, May 22, 2018 Brand (Posted: May-22-2018 10AM)

FDA grants orphan drug status to selumetinib for neurofibromatosis type 1 (NF1) treatment
NCI Cancer Research, May 2018 Brand (Posted: May-20-2018 10AM)

After TCGA: Building Clinical Genomic Resources
PI Wang, NCI blog, May 16, 2018 Brand (Posted: May-16-2018 10AM)

Study Shows Experimental Screening Test Can Detect Endometrial and Ovarian Cancers
NCI, May 2018 Brand (Posted: May-08-2018 8AM)

Liquid Biopsy: Using DNA in Blood to Detect, Track, and Treat Cancer
Brand (Posted: May-04-2018 9AM)

Breast Cancer Prevention (PDQ®)–Patient Version
Brand (Posted: May-03-2018 8AM)

Sun Safe Selfie
Nearly 5 million people are treated for skin cancer each year in the United States. Skin cancer can be serious, expensive, and sometimes even deadly Brand (Posted: May-01-2018 0PM)

Cryo-EM Images Capture Key Enzyme Tied to Cancer, Aging
NIH Director Blog, May 1, 2018 Brand (Posted: May-01-2018 0PM)

Cancer Genomics- Transforming how we study, diagnose, and treat cancer
NHGRI, Apr 9, 2018 Brand (Posted: Apr-09-2018 10AM)

NIH completes in-depth genomic analysis of 33 cancer types
NIH News, Apr 5, 2018 Brand (Posted: Apr-05-2018 1PM)

Cancer disparities
Brand (Posted: Apr-03-2018 1PM)

Marleah’s Story
For Marleah, breast cancer at a young age runs in the family. Brand (Posted: Mar-20-2018 2PM)

Working Toward Greater Precision in Childhood Cancers
NIH Director Blog, Mar 6, 2018 Brand (Posted: Mar-11-2018 0PM)

Prevent Colorectal Cancer: We Can Do It!
CA Gelb, CDC blog post, Mar 1, 2018 Brand (Posted: Mar-05-2018 11AM)

Planning a Genomic Characterization Study? Tips for Collecting and Processing Biospecimens
NCI, Jan 2018 Brand (Posted: Feb-11-2018 8AM)

NCI Recognizes World Cancer Day 2018
Brand (Posted: Feb-01-2018 9AM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.