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Last Posted: Sep 13, 2023
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How to fight antibiotic resistance.
Mike May et al. Nat Med 2023 7 (7) 1583-1586

Researchers use artificial intelligence and bioinformatics to discover new antimicrobials, while governments pilot financial incentives for pharma. Antimicrobial resistance (AMR) to existing medicines creates one of the biggest dangers for global health. According to the Antimicrobial Resistance Collaborators, AMR had a role in 4.95 million deaths in 2019, with the highest death rate — 27.3 deaths per 100,000 people — found in sub-Saharan Africa. This is a problem that only promises to get worse.

The evolution and international spread of extensively drug resistant Shigella sonnei.
Lewis C E Mason et al. Nature communications 2023 4 (1) 1983

Our genomic epidemiological analyses of 3,304 isolates from the United Kingdom, Australia, Belgium, France, and the United States of America revealed an internationally connected outbreak with a most recent common ancestor in 2018 carrying a low-fitness cost resistance plasmid, previously observed in travel associated sublineages of S. flexneri. Our results highlight the persistent threat of horizontally transmitted antimicrobial resistance and the value of continuing to work towards early and open international sharing of genomic surveillance data.

An ISO-certified genomics workflow for identification and surveillance of antimicrobial resistance
NL Sherry et al, Nature Comm, January 4, 2023

Here, we report the creation and validation of abritAMR, an ISO-certified bioinformatics platform for genomics-based bacterial AMR gene detection. The abritAMR platform utilises NCBI’s AMRFinderPlus, as well as additional features that classify AMR determinants into antibiotic classes and provide customised reports. We validate abritAMR by comparing with PCR or reference genomes, representing 1500 different bacteria and 415 resistance alleles.

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Disclaimer: Articles listed in the Public Health Genomics and Precision Health Knowledge Base are selected by the CDC Office of Public Health Genomics to provide current awareness of the literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the update, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.

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