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Last Posted: Apr 23, 2024
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AI-assisted prediction of differential response to antidepressant classes using electronic health records.
Yi-Han Sheu et al. NPJ Digit Med 2023 4 (1) 73

Antidepressant selection is largely a trial-and-error process. We used electronic health record (EHR) data and artificial intelligence (AI) to predict response to four antidepressants classes (SSRI, SNRI, bupropion, and mirtazapine) 4 to 12 weeks after antidepressant initiation. The final data set comprised 17,556 patients. We show that antidepressant response can be accurately predicted from real-world EHR data with AI modeling, and our approach could inform further development of clinical decision support systems for more effective treatment selection.

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