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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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112 hot topic(s) found with the query "Alcohol"

Assessment of the Association of D2 Dopamine Receptor Gene and Reported Allele Frequencies With Alcohol Use Disorders A Systematic Review and Meta-analysis
Y Jung et al, JAMA Network Open, November 9, 2019 (Posted: Nov-10-2019 8AM)

In this meta-analysis, the significant association of DRD2 with AUD was reassessed. The DRD2 association was attributable to anomalously low control allele frequencies, not function, in positive studies.

Alzheimer's Disease-Genes Do Not Equal Destiny
CDC Podcast, October 22, 2019 Brand (Posted: Oct-23-2019 8AM)

A healthy lifestyle may help reduce your risk of developing Alzheimer's disease. Two large, long term studies indicate that adequate physical activity, a nutritious diet, limited alcohol consumption, and not smoking may help-even for people at average and intermediate risk because of their genes.

Want To Reduce Suicides? Follow The Data — To Medical Offices, Motels And Even Animal Shelters
M O'Hagan, KHN News, September 23, 2019 (Posted: Sep-24-2019 9AM)

A data collection tool through which investigators could easily record a checklist. It included not only age and cause of death, but also yes/no questions on things like evidence of alcohol abuse, history of interpersonal violence, health crises, job losses and so on. In addition, the county created a procedure, called a suicide fatality review

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality
H Zou et al, BioRXIV, August 2019 (Posted: Aug-22-2019 7AM)

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although genome-wide association studies (GWASs) have identified PAU risk genes, the genetic architecture of this trait is not fully understood.

New study offers "good news" for those with genetic risk for Alzheimer's
CBS News, July 15, 2019 (Posted: Jul-17-2019 8AM)

A healthy lifestyle can cut your risk of developing Alzheimer's or other forms of dementia even if you have genes that raise your risk for these mind-destroying diseases, a large study has found. Regardless of how much genetic risk someone had, a good diet, adequate exercise, limiting alcohol and not smoking made dementia less likely.

A healthy lifestyle may offset genetic risk for Alzheimer’s
Associated Press, July 14, 2019 (via StatNews) (Posted: Jul-16-2019 8AM)

A healthy lifestyle can cut your risk of developing Alzheimer?s or other forms of dementia even if you have genes that raise your risk for these mind-destroying diseases, a large study has found. People with high genetic risk and poor health habits were about three times more likely to develop dementia versus those with low genetic risk and good habits. Regardless of how much genetic risk someone had, a good diet, adequate exercise, limiting alcohol and not smoking made dementia less likely.

Lentiviral Gene Therapy Combined with Low-Dose Busulfan in Infants with SCID-X1.
Mamcarz Ewelina et al. The New England journal of medicine 2019 Apr (16) 1525-1534 (Posted: Apr-18-2019 8AM)

Alcohol and DNA Methylation: An Epigenome-Wide Association Study in Blood and Normal Breast Tissue
LE Wilson et al, AM J Epidemiology, February 15, 2019 (Posted: Feb-25-2019 9AM)

How genes affect tobacco and alcohol use Data from 1.2 million people reveal how tobacco and alcohol use may be linked to your genes and to various
Eureka Alert, February 21, 2019 (Posted: Feb-21-2019 9AM)

Excessive Alcohol Consumption
Recommendations from the Community Preventive Services Task Force Brand (Posted: Jan-23-2019 2PM)

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
M Liu et al, Nature Genetics, January 14, 2019 (Posted: Jan-14-2019 11AM)

Phenylalanine ammonia lyase (PAL): From discovery to enzyme substitution therapy for phenylketonuria.
Levy Harvey L et al. Molecular genetics and metabolism 2018 Aug (4) 223-229 (Posted: Dec-03-2018 9AM)

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders
E Evangelou et al, BIORXIV, October 30, 2018 (Posted: Oct-31-2018 8AM)

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)
S Sanchez-Roige et al, BIORxIV, AUgust 2, 2018 (Posted: Aug-03-2018 0PM)

Review and gap analysis: molecular pathways leading to fetal alcohol spectrum disorders.
Ehrhart Friederike et al. Molecular psychiatry 2018 Jun (Posted: Jul-16-2018 1PM)

Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?
Prytkova Iya et al. Alcoholism, clinical and experimental research 2018 Jun (Posted: Jul-16-2018 1PM)

A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.
Kim Jueun et al. The American journal on addictions 2018 Jul (Posted: Jul-16-2018 1PM)

Predicting smoking abstinence with biological and self-report measures of adherence to varenicline: Impact on pharmacogenetic trial outcomes.
Peng Annie R et al. Drug and alcohol dependence 2018 Jun 19072-81 (Posted: Jul-11-2018 9AM)

Pharmacogenomics and Patient Treatment Parameters to Opioid Treatment in Chronic Pain: A Focus on Morphine, Oxycodone, Tramadol, and Fentanyl.
Lloyd Renae A et al. Pain medicine (Malden, Mass.) 2017 Dec (12) 2369-2387 (Posted: Apr-02-2018 1PM)

Utility of Genetic Testing in Fetal Alcohol Spectrum Disorder.
Jamuar Saumya S et al. The Journal of pediatrics 2018 Feb (Posted: Feb-06-2018 11AM)

Study of first-graders shows fetal alcohol spectrum disorders prevalent in U.S. communities
NIH Research Matters, Feb 6, 2018 (Posted: Feb-06-2018 11AM)

Fetal Alcohol Spectrum Disorders: One Woman’s Story
Brand (Posted: Sep-06-2017 10AM)

Overview of the Genetic Basis and Epigenetic Mechanisms that Contribute to FASD Pathobiology.
Liyanage Vichithra R B et al. Current topics in medicinal chemistry 2017 (7) 808-828 (Posted: Sep-05-2017 11AM)

Nature, Nurture, and Cancer Risks: Genetic and Nutritional Contributions to Cancer.
Theodoratou Evropi et al. Annual review of nutrition 2017 Aug 293-320 (Posted: Sep-01-2017 8AM)

Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.
Andersen Allan M et al. JAMA psychiatry 2017 Aug (Posted: Aug-21-2017 11AM)

Genetic Counseling for Alcohol Addiction: Assessing Perceptions and Potential Utility in Individuals with Lived Experience and Their Family Members.
Kalb Fayth M et al. Journal of genetic counseling 2017 Feb (Posted: Apr-12-2017 8AM)

Personalized Medicine of Alcohol Addiction: Pharmacogenomics and beyond.
Manolopoulos Vangelis George et al. Current pharmaceutical biotechnology 2017 Feb (Posted: Apr-07-2017 10AM)

ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective.
Chang Jeffrey S et al. Journal of biomedical science 2017 Mar (1) 19 (Posted: Apr-07-2017 10AM)

Clinical importance of pharmacogenetics in the treatment of hepatitis C virus infection.
Kamal Adina Maria et al. Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologie 2016 57(2 Suppl) 675-680 (Posted: Apr-05-2017 11AM)

Epigenetics studies of fetal alcohol spectrum disorder: where are we now?
Lussier Alexandre A et al. Epigenomics 2017 Mar (3) 291-311 (Posted: Feb-27-2017 1PM)

Overview of the Genetics of Alcohol Use Disorder.
Tawa Elisabeth A et al. Alcohol and alcoholism (Oxford, Oxfordshire) 2016 Sep (5) 507-14 (Posted: Jan-24-2017 11AM)

DNA methylation and alcohol use disorders: Progress and challenges.
Zhang Huiping et al. The American journal on addictions 2016 Oct (Posted: Jan-24-2017 11AM)

The genetics of alcohol dependence and alcohol-related liver disease.
Stickel Felix et al. Journal of hepatology 2017 Jan (1) 195-211 (Posted: Jan-24-2017 11AM)

The Surgeon General Report on Alcohol, Drugs and Health
Surgeon General, HHS, November 2016 (Posted: Nov-20-2016 7AM)

Surgeon General’s Report on Alcohol, Drugs, and Health
VH Murthy, JAMA, November 17, 2016 (Posted: Nov-20-2016 7AM)

Genetic feedback to reduce alcohol consumption in hospital outpatients with risky drinking: feasibility and acceptability.
Johnson Natalie A et al. Public health research & practice 2016 Sep 26(4) (Posted: Oct-12-2016 11AM)

Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer
J Gong et al, PLOS Genetics, October 2016 (Posted: Oct-12-2016 9AM)

FASD Awareness
Brand (Posted: Sep-09-2016 9AM)

The Genetics of Fetal Alcohol Spectrum Disorders.
Eberhart Johann K et al. Alcoholism, clinical and experimental research 2016 Jun (6) 1154-65 (Posted: Sep-09-2016 9AM)

DNA methylation signature of human fetal alcohol spectrum disorder.
Portales-Casamar Elodie et al. Epigenetics & chromatin 2016 25 (Posted: Sep-09-2016 9AM)

An Update on Fetal Alcohol Syndrome-Pathogenesis, Risks, and Treatment.
Gupta Keshav K et al. Alcoholism, clinical and experimental research 2016 Aug (8) 1594-602 (Posted: Sep-09-2016 9AM)

Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism.
Wall Tamara L et al. Alcohol research : current reviews 2016 (1) 59-68 (Posted: Aug-06-2016 10AM)

Genetic imaging consortium for addiction medicine: From neuroimaging to genes.
Mackey Scott et al. Progress in brain research 2016 203-23 (Posted: Apr-06-2016 11AM)

Pharmacogenetics of alcohol use disorders and comorbid psychiatric disorders.
Helton Sarah G et al. Psychiatry research 2015 Dec (2) 121-9 (Posted: Apr-06-2016 11AM)

Study supports single-question alcohol screen for adolescents
NIAAA, April 6, 2016 Brand (Posted: Apr-06-2016 11AM)

Alcohol misuse, genetics, and major bleeding among warfarin therapy patients in a community setting.
Roth Joshua A et al. Pharmacoepidemiology and drug safety 2015 Jun 24(6) 619-27 (Posted: Feb-24-2016 10AM)

Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine.
Yohn Nicole L et al. Progress in biophysics and molecular biology 2015 Jul (1-2) 21-33 (Posted: Feb-16-2016 7PM)

Editorial: Genetics and epigenetics of fetal alcohol spectrum disorders.
S Mason et al. Frontline Genetics, 2015 Brand (Posted: Feb-02-2016 4PM)

Associative DNA methylation changes in children with prenatal alcohol exposure.
Laufer Benjamin I et al. Epigenomics 2015 Dec (8) 1259-74 (Posted: Feb-02-2016 4PM)

Fetal Alcohol Exposure Reduces Dopamine Receptor D2 and Increases Pituitary Weight and Prolactin Production via Epigenetic Mechanisms.
Gangisetty Omkaram et al. PloS one 2015 (10) e0140699 (Posted: Feb-02-2016 4PM)

DNA methylation changes in fetal alcohol spectrum disorder.
Portales-Casamar Elodie et al. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2015 Dec (Pt A) 126 (Posted: Feb-02-2016 4PM)

Worldwide Prevalence of Fetal Alcohol Spectrum Disorders: A Systematic Literature Review Including Meta-Analysis.
Roozen Sylvia et al. Alcoholism, clinical and experimental research 2016 Jan (1) 18-32 (Posted: Feb-02-2016 4PM)

Alcohol and Pregnancy: Why take the risk?
Brand (Posted: Feb-02-2016 4PM)

Genetic variation (CHRNA5), medication (combination nicotine replacement therapy vs. varenicline), and smoking cessation.
Chen Li-Shiun et al. Drug and alcohol dependence 2015 Sep 278-82 (Posted: Jan-25-2016 10AM)

Genetic and environmental contributions to initiation of cigarette smoking in young African-American and European-American women.
Sartor Carolyn E et al. Drug and alcohol dependence 2015 Dec 54-9 (Posted: Jan-06-2016 8PM)

Childhood attention-deficit/hyperactivity disorder symptoms and the development of adolescent alcohol problems: A prospective, population-based study of Swedish twins.
Quinn Patrick D et al. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2015 Dec (Posted: Jan-05-2016 0PM)

Genetics of Alcoholic Liver Disease.
Anstee Quentin M et al. Seminars in liver disease 2015 Nov (4) 361-74 (Posted: Dec-21-2015 3PM)

Alcohol’s Effect on Health: What the Science Says
AE Carroll, New York Times, December 21, 2015 (Posted: Dec-21-2015 3PM)

Commonalities and Distinctions Among Mechanisms of Addiction to Alcohol and Other Drugs.
Ozburn Angela R et al. Alcoholism, clinical and experimental research 2015 Oct (10) 1863-77 (Posted: Oct-30-2015 1PM)

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
S Buch et al, Nature Genetics, October 19, 2015 (Posted: Oct-19-2015 3PM)

Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.
Hart Amy B et al. Alcoholism, clinical and experimental research 2015 Aug (8) 1312-27 (Posted: Oct-16-2015 2PM)

Advances in Medications and Tailoring Treatment for Alcohol Use Disorder.
Seneviratne Chamindi et al. Alcohol research : current reviews 2015 (1) 15-28 (Posted: Oct-16-2015 2PM)

Excessive alcohol use continues to be drain on American economy
Brand (Posted: Oct-16-2015 2PM)

Importance of genetics in fetal alcohol effects: null mutation of the nNOS gene worsens alcohol-induced cerebellar neuronal losses and behavioral deficits.
Bonthius Daniel J et al. Neurotoxicology 2015 Jan 60-72 (Posted: Sep-03-2015 3PM)

Reduced DNA methylation at the PEG3 DMR and KvDMR1 loci in children exposed to alcohol in utero: a South African Fetal Alcohol Syndrome cohort study.
Masemola Matshane L et al. Front Genet 2015 85 (Posted: Sep-03-2015 3PM)

Editorial: Genetics and epigenetics of fetal alcohol spectrum disorders.
Mason Stephen et al. Front Genet 2015 146 (Posted: Sep-03-2015 3PM)

International Fetal Alcohol Spectrum Disorders Awareness Day
CDC MMWR Weekly, September 4, 2015 Brand (Posted: Sep-03-2015 3PM)

Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose mother drank alcohol during pregnancy.
FASDs are completely preventable if a woman does not drink alcohol during pregnancy. Brand (Posted: Sep-03-2015 3PM)

Evaluation of Moderate Alcohol Use With QT Interval and Heart Rate Using Mendelian Randomization Analysis Among Older Southern Chinese Men in the Guangzhou Biobank Cohort Study.
Au Yeung Shiu Lun et al. Am. J. Epidemiol. 2015 Aug 15. (4) 320-7 (Posted: Aug-21-2015 10AM)

Metabolomics - the complementary field in systems biology: a review on obesity and type 2 diabetes.
Abu Bakar Mohamad Hafizi et al. Mol Biosyst 2015 Jul (7) 1742-74 (Posted: Aug-17-2015 7PM)

Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines for IFNL3 (IL28B) genotype and PEG interferon-a-based regimens.
Muir A J et al. Clin. Pharmacol. Ther. 2014 Feb (2) 141-6 (Posted: Jul-14-2015 2PM)

PEG-Interferon-a ribavirin-induced HCV viral clearance: a pharmacogenetic multicenter Spanish study.
Milara Javier et al. Farm Hosp 2015 Jan-Feb (1) 29-43 (Posted: Jul-14-2015 2PM)

Serum Interferon-Related MicroRNAs as Biomarkers to Predict the Response to Interferon Therapy in Chronic Hepatitis C Genotype 4.
Motawi Tarek Kamal et al. PLoS ONE 2015 (3) e0120794 (Posted: Jul-14-2015 2PM)

Interleukin 28B polymorphisms as predictors of sustained virological response in chronic hepatitis C: systematic review and meta-analysis.
Cariani E et al. Pharmacogenomics J. 2015 Apr 28. (Posted: Jul-14-2015 2PM)

Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.
Reyes-Gibby Cielito C et al. BMC Syst Biol 2015 25 (Posted: Jul-08-2015 9AM)

Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.
Hart Amy B et al. Alcohol. Clin. Exp. Res. 2015 Jun 25. (Posted: Jun-29-2015 2PM)

PNPLA3 Gene Polymorphism Is Associated With Predisposition to and Severity of Alcoholic Liver Disease.
Salameh Habeeb et al. Am. J. Gastroenterol. 2015 Jun (6) 846-56 (Posted: Jun-10-2015 11AM)

Epigenetics-A New Frontier for Alcohol Research
NIAAA Alcohol Alert May 2015 Brand (Posted: May-28-2015 0PM)

Are genetic variants for tobacco smoking associated with cannabis involvement?
Agrawal Arpana et al. Drug Alcohol Depend 2015 May 1. 183-7 (Posted: May-28-2015 7AM)

The association of rs1051730 genotype on adherence to and consumption of prescribed nicotine replacement therapy dose during a smoking cessation attempt.
Ware Jennifer J et al. Drug Alcohol Depend 2015 Jun 1. 236-40 (Posted: May-28-2015 7AM)

Effect of ADRB2 (adrenergic receptor ß2) gene polymorphisms on the occurrence of asthma and on the response to nebulized salbutamol in South Indian patients with bronchial asthma.
Shah Neel Jayesh et al. J Asthma 2015 May 19. 1-8 (Posted: May-23-2015 9AM)

An extended Swedish national adoption study of alcohol use disorder.
Kendler Kenneth S et al. JAMA Psychiatry 2015 Mar (3) 211-8 (Posted: Apr-25-2015 11AM)

Implantable cardioverter-defibrillator therapy in brugada syndrome: a 20-year single-center experience.
Conte Giulio et al. J. Am. Coll. Cardiol. 2015 Mar 10. (9) 879-88 (Posted: Apr-24-2015 3PM)

Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence.
Forero Diego A et al. Drug Alcohol Depend 2015 Apr 1. 259-63 (Posted: Apr-05-2015 9AM)

Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: Results from the German Investigation on Neurobiology in Alcoholism (GINA).
Semmler Alexander et al. Alcohol 2015 Mar (2) 97-101 (Posted: Apr-05-2015 9AM)

Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults.
Salvatore Jessica E et al. Clin Psychol Sci 2015 Mar (2) 189-201 (Posted: Apr-05-2015 9AM)

ACN9 and alcohol dependence: Family-based association analysis in multiplex alcohol dependence families.
Hill Shirley Y et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2015 Apr (3) 179-87 (Posted: Apr-05-2015 9AM)

Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence?
Hart Amy B et al. Addict Biol 2015 Apr 1. (Posted: Apr-05-2015 9AM)

Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.
Eriksson C J Peter et al. Adv. Exp. Med. Biol. 2015 41-58 (Posted: Apr-05-2015 9AM)

The 5-HT7 receptor as a potential target for treating drug and alcohol abuse.
Hauser Sheketha R et al. Front Neurosci 2014 448 (Posted: Apr-05-2015 9AM)

Common single nucleotide variants underlying drug addiction: more than a decade of research.
Bühler Kora-Mareen et al. Addict Biol 2015 Jan 21. (Posted: Apr-05-2015 9AM)

NIH Recognizes Alcohol Awareness Month 2015
Brand (Posted: Apr-05-2015 9AM)

Gout: a comprehensive review.
Rymal Eric et al. JAAPA 2014 Sep (9) 26-31 (Posted: Mar-21-2015 3PM)

Genetic polymorphisms in alcohol dehydrogenase, aldehyde dehydrogenase and alcoholic chronic pancreatitis susceptibility: A meta-analysis.
Zhong Yanjun et al. Gastroenterol Hepatol 2014 Dec 22. (Posted: Mar-17-2015 5PM)

Genetic polymorphisms of ADH1B, ADH1C and ALDH2, alcohol consumption, and the risk of gastric cancer: the Japan Public Health Center-based prospective study.
Hidaka Akihisa et al. Carcinogenesis 2015 Feb (2) 223-31 (Posted: Mar-04-2015 10AM)

Association study of GABRG2 polymorphisms with suicidal behaviour in schizophrenia patients with alcohol use disorder.
Zai Clement C et al. Neuropsychobiology 2014 (3) 154-8 (Posted: Feb-28-2015 8PM)

CDC Information: April is Alcohol Awareness Month
Brand (Posted: Feb-25-2015 0PM)

CDC Vital Signs: Alcohol poisoning deaths. A deadly consequence of binge drinking,
January 2015 Brand (Posted: Feb-25-2015 0PM)

Frequently asked questions about alcohol and public health
Brand (Posted: Feb-25-2015 0PM)

Alcohol and public health
Brand (Posted: Feb-25-2015 0PM)


Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.