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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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118 hot topic(s) found with the query "Alcohol"

A phenome-wide association and Mendelian randomisation study of alcohol use variants in a diverse cohort comprising over 3 million individuals.
Mariela V Jennings et al. EBioMedicine 2024 4 105086 (Posted: Apr 08, 2024 9AM)

From the abstract: " We performed exploratory phenome-wide association studies (PheWAS) of three of the best studied protective single nucleotide polymorphisms (SNPs) in genes encoding ethanol metabolising enzymes (ADH1B: rs1229984-T, rs2066702-A; ADH1C: rs698-T) using up to 1109 health outcomes across 28 phenotypic categories (e.g., substance-use, mental health, sleep, immune, cardiovascular, metabolic) from a diverse 23andMe cohort, including European (N = 2,619,939), Latin American (N = 446,646) and African American (N = 146,776) populations to uncover new and perhaps unexpected associations. We found that that polymorphisms in genes encoding alcohol metabolising enzymes affect multiple domains of health beyond alcohol-related behaviours. Understanding the underlying mechanisms of these effects could have implications for treatments and preventative medicine."

How Family History Influences Your Drinking
DG Smith, NY Times, December 13, 2023 (Posted: Dec 17, 2023 3PM)

From the article: " Alcohol use disorder — the inability to stop or control one’s drinking despite negative consequences — is a highly heritable condition. Research suggests that having an immediate family member, like a parent or sibling, with the disorder increases an individual’s chances of developing it roughly three- to fourfold. Approximately 50 percent of a person’s risk comes from their genes, but their home and social environments are also important factors."

Multi-ancestry study of the genetics of problematic alcohol use in over 1 million individuals
H Zhou et al, Nature, December 6, 2023 (Posted: Dec 07, 2023 8AM)

From the abstract: "Problematic alcohol use (PAU), a trait that combines alcohol use disorder and alcohol-related problems assessed with a questionnaire, is a leading cause of death and morbidity worldwide. Here we conducted a large cross-ancestry meta-analysis of PAU in 1,079,947 individuals (European, N?=?903,147; African, N?=?122,571; Latin American, N?=?38,962; East Asian, N?=?13,551; and South Asian, N?=?1,716 ancestries). We observed a high degree of cross-ancestral similarity in the genetic architecture of PAU and identified 110 independent risk variants. "

Diagnostic Criteria for Identifying Individuals at High Risk of Progression From Mild or Moderate to Severe Alcohol Use Disorder
AP Miller et al, JAMA Network Open, October 10, 2023 (Posted: Oct 10, 2023 0PM)

From the abstract: "Does emphasis on specific criteria for alcohol use disorder (AUD) improve the identification of individuals at risk for developing more severe AUD? In this cohort study, cross-sectional and longitudinal multimodal secondary analyses involving a combined 15?928 individuals indicated that endorsement of criteria empirically designated as representing greater severity of AUD was significantly associated with 2-fold increased likelihood of progression from mild-to-moderate AUD to severe AUD, even after accounting for total criterion count. Emphasis on more severe criteria as indicators of vulnerability for severe AUD in current diagnostic approaches may increase detection of individuals with greater likelihood for disorder progression. "

FASDetect as a machine learning-based screening app for FASD in youth with ADHD
L Ehrig et al, NPJ Digital Medicine, July 19, 2023 (Posted: Jul 20, 2023 7AM)

Fetal alcohol-spectrum disorder (FASD) is underdiagnosed and often misdiagnosed as attention-deficit/hyperactivity disorder (ADHD). Here, we develop a screening tool for FASD in youth with ADHD symptoms. To develop the prediction model, medical record data from a University outpatient unit are assessed including 275 patients aged 0–19 years old with FASD with or without ADHD and 170 patients with ADHD without FASD aged 0–19 years old. We train 6 machine learning models based on 13 selected variables and evaluate their performance.

Early Pregnancy Loss
K Walter, JAMA, April 2023 (Posted: Apr 16, 2023 6AM)

Early pregnancy loss is caused most commonly by fetal chromosomal abnormalities, which account for more than two-thirds of all early pregnancy loss between 6 and 10 weeks of gestation. Risk factors for early pregnancy loss include older age at onset of pregnancy, prior pregnancy loss, some medical conditions (such as diabetes, hyperthyroidism, and lupus), and exposures during pregnancy that may harm a developing fetus (such as alcohol; some viral or bacterial infections; environmental exposure to lead, mercury, or radiation; and certain medications).

Children must co-design digital health research
The Lancet Digital Health editorial, April 2023 (Posted: Apr 09, 2023 7AM)

A recent umbrella review has shown promise in the use of digital health interventions to reduce risk behaviours in adolescents, including improving physical activity and diet. Digital health interventions have also been proven to reduce alcohol use in adolescents in long-term studies. However, the 2021 WHO framework on developing youth-centred digital health interventions highlights that digital health is not a silver bullet. So, can technology really improve health behaviour in children?

The role of aldehyde dehydrogenase 2 in cardiovascular disease.
Jian Zhang et al. Nature reviews. Cardiology 2023 2 (Posted: Feb 26, 2023 8AM)

Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme involved in the detoxification of alcohol-derived acetaldehyde and endogenous aldehydes. The inactivating ALDH2 rs671 polymorphism, present in up to 8% of the global population and in up to 50% of the East Asian population, is associated with increased risk of cardiovascular conditions such as coronary artery disease, alcohol-induced cardiac dysfunction, pulmonary arterial hypertension, heart failure and drug-induced cardiotoxicity.

Use of incorrect and correct methods to account for age in studies on epigenetic accelerated aging: implications and recommendations for best practices.
Nancy Krieger et al. American journal of epidemiology 2023 2 (Posted: Feb 05, 2023 11AM)

Motivated by our conduct of a literature review on social exposures and accelerated aging as measured by a growing number of epigenetic “clocks” (which estimate age via DNA methylation patterns (DNAm)), we report on three different approaches – 1 incorrect and 2 correct – in the epidemiologic literature on treatment of age in these and other studies using other common exposures (i.e., body mass index and alcohol consumption).

Clinical Impact of the CYP2C19 Gene on Diazepam for the Management of Alcohol Withdrawal Syndrome
TT Ho et al, J Per Med, February 3, 2023 (Posted: Feb 04, 2023 7AM)

Gene-environment interactions in Alzheimer disease: the emerging role of epigenetics.
Migliore Lucia et al. Nature reviews. Neurology 2022 9 (11) 643-660 (Posted: Nov 06, 2022 1PM)

With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex aetiology that is likely to involve multiple susceptibility genes and environmental factors. The role of environmental factors is difficult to determine and, until a few years ago, the molecular mechanisms underlying gene–environment (G?×?E) interactions in AD were largely unknown. Here, we review evidence that has emerged over the past two decades to explain how environmental factors, such as diet, lifestyle, alcohol, smoking and pollutants, might interact with the human genome. In particular, we discuss how various environmental AD risk factors can induce epigenetic modifications of key AD-related genes and pathways.

Genome-Wide Investigation of Maximum Habitual Alcohol Intake in US Veterans in Relation to Alcohol Consumption Traits and Alcohol Use Disorder.
Deak Joseph D et al. JAMA network open 2022 10 (10) e2238880 (Posted: Oct 28, 2022 9AM)

What is the genetic architecture of maximum habitual alcohol intake (MaxAlc), and how does it compare with other alcohol consumption measures? This genetic association study of MaxAlc in 247?455 European- and African-ancestry individuals identified 15 genome-wide significant loci, including multiple novel associations. MaxAlc was genetically correlated with measures of alcohol-related problems, demonstrated significantly different correlations with psychiatric traits compared with other alcohol consumption traits, and loaded on a factor with alcohol problem traits, while alcohol consumption measures loaded on a separate factor.

Does Moderate Drinking Protect Your Heart? A Genetic Study Offers a New Answer.
G Kolata, NY Times, March 29, 2022 (Posted: Mar 30, 2022 6AM)

By studying the relationship between gene variants and alcohol consumption, scientists found no real cardiac benefit to drinking, even modestly. Researchers have found genetic variants that predispose a person to heavier or lighter drinking. Because the variants are distributed randomly in a population, they can serve in a study as the equivalent of randomly assigning people to abstain or to drink at varying levels. Researchers can ask if those with variants that are linked to greater alcohol consumption have more heart disease and high blood pressure than those with variants linked to lower consumption.

Culturally adapting internet- and mobile-based health promotion interventions might not be worth the effort: a systematic review and meta-analysis
S Balci et al, NPJ Digital Medicine, March 23, 2022 (Posted: Mar 24, 2022 8AM)

Out of 9438 records, 13 randomized controlled trials (RCT) investigating culturally adapted health promotion IMI addressing healthy eating, physical activity, alcohol consumption, sexual health behavior, and smoking cessation included. From the included studies 10,747 participants were eligible. Culturally adapted IMI proved to be non-superior over active control conditions in short- (g?=?0.10, [95% CI -0.19 to 0.40]) and long-term (g?=?0.20, [95% CI -0.11 to 0.51]) in promoting health behavior. However, culturally adapted IMI for physical activity (k?=?3, N?=?296) compared to active controls yielded a beneficial effect in long-term (g?=?0.48, [95%CI 0.25 to 0.71]).

Special focus issue on epigenomics and health disparities: foreword.
Argentieri M Austin et al. Epigenomics 2021 10 (Posted: Oct 15, 2021 10AM)

Although epigenomic researchers have been investigating the influences of physical environmental exposures (e.g., air pollution, contaminants and heavy metal exposures and lifestyle factors such as smoking, alcohol and nutrition) on epigenetic mechanisms for years under the banner of ‘environmental epigenomics’, the field is at a crossroads where a fundamental rethinking of what constitutes a human environment is necessary, especially in the pursuit of understanding disparities in health and disease. It will be crucial for the field of environmental epigenomics to expand its inquiry to the entire exposome (i.e., all nongenetic influences on health, including social, economic, cultural, built environment and housing and psychosocial dimensions of life) in order to truly come to terms with the determinants of health inequality from an epigenomic perspective.

Machine learning prediction of blood alcohol concentration: a digital signature of smart-breathalyzer behavior
K Aschbacher et al, NPJ Digital Medicine, April 20, 2021 (Posted: Apr 21, 2021 7AM)

We developed a digital phenotype of long-term smart-breathalyzer behavior to predict individuals’ breath alcohol concentration (BrAC) levels trained on data from a smart breathalyzer. We analyzed roughly one million datapoints from 33,452 users of a commercial smart-breathalyzer device, collected between 2013 and 2017. For validation, we analyzed the associations between state-level observed smart-breathalyzer BrAC levels and impaired-driving motor vehicle death rates.

Smoking, alcohol consumption, and cancer: A mendelian randomisation study in UK Biobank and international genetic consortia participants.
Larsson Susanna C et al. PLoS medicine 2020 Jul (7) e1003178 (Posted: Jul 29, 2020 8AM)

Our findings support the well-established relationship between smoking and lung cancer and suggest that smoking may also be a risk factor for cancer of the head and neck, oesophagus, stomach, cervix, and bladder. We found no evidence supporting a relationship between alcohol consumption and overall or site-specific cancer risk.

The association of alcohol polygenic risk scores with mental health outcomes: A multi-generational analysis in the Avon Longitudinal Study of Parents and Children
KE Easey et al, MEDRXIV, July 7, 2020 (Posted: Jul 08, 2020 6AM)

An alcohol PRS derived from GWAS of alcohol use in the general population was shown to be associated with frequency and amount of alcohol consumed during pregnancy, and maternal depression at 32 weeks gestation.

Genome-wide meta-analysis of problematic alcohol use in 435,563 individuals yields insights into biology and relationships with other traits
H Zhou et al, Nature Neuroscience, May 25, 2020 (Posted: May 27, 2020 7AM)

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although genome-wide association studies have identified PAU risk genes, the genetic architecture of this trait is not understood. We conducted a proxy-phenotype meta-analysis of PAU in 435,563? European-ancestry individuals.

Association of Nongenetic Factors With Breast Cancer Risk in Genetically Predisposed Groups of Women in the UK Biobank Cohort
K Alajmi et al, JAMA Network Open, April 24, 2020 (Posted: Apr 24, 2020 11AM)

This cohort study evaluated 2728 women with breast cancer and 88?489 controls and noted lower risks of breast cancer among women who practice a healthy lifestyle (exercise, healthy weight, low alcohol intake, and no oral contraceptive use, as well as avoiding or limiting use of hormonal replacement therapy) among low, intermediate, and high genetic risk groups.

Genetic evidence for protective effects of smoking and drinking behavior on Parkinson's disease: A Mendelian Randomization study
CD Baleon et al, MEDRXIV, April 24, 2020 (Posted: Apr 24, 2020 8AM)

We use a two-sample Mendelian randomization (MR) experimental design to infer causal relationships between smoking (initiation, age of initiation, heaviness, and cessation) and alcohol (drinks per week) consumption as exposure variables and PD as the health outcome.

Whole‐Genome Approach Discovers Novel Genetic and Nongenetic Variance Components Modulated by Lifestyle for Cardiovascular Health
X Zhou et al, JAHA, April 2020 (Posted: Apr 23, 2020 8AM)

We used a novel whole-genome approach to estimate the genetic and nongenetic effects on—and hence their predispositions to—cardiovascular risk and determined whether they vary with respect to lifestyle factors such as physical activity, smoking, alcohol consumption, and dietary intake.

Assessment of the Association of D2 Dopamine Receptor Gene and Reported Allele Frequencies With Alcohol Use Disorders A Systematic Review and Meta-analysis
Y Jung et al, JAMA Network Open, November 9, 2019 (Posted: Nov 10, 2019 8AM)

In this meta-analysis, the significant association of DRD2 with AUD was reassessed. The DRD2 association was attributable to anomalously low control allele frequencies, not function, in positive studies.

Alzheimer's Disease-Genes Do Not Equal Destiny
CDC Podcast, October 22, 2019 Brand (Posted: Oct 23, 2019 8AM)

A healthy lifestyle may help reduce your risk of developing Alzheimer's disease. Two large, long term studies indicate that adequate physical activity, a nutritious diet, limited alcohol consumption, and not smoking may help-even for people at average and intermediate risk because of their genes.

Want To Reduce Suicides? Follow The Data — To Medical Offices, Motels And Even Animal Shelters
M O'Hagan, KHN News, September 23, 2019 (Posted: Sep 24, 2019 9AM)

A data collection tool through which investigators could easily record a checklist. It included not only age and cause of death, but also yes/no questions on things like evidence of alcohol abuse, history of interpersonal violence, health crises, job losses and so on. In addition, the county created a procedure, called a suicide fatality review

Meta-analysis of problematic alcohol use in 435,563 individuals identifies 29 risk variants and yields insights into biology, pleiotropy and causality
H Zou et al, BioRXIV, August 2019 (Posted: Aug 22, 2019 7AM)

Problematic alcohol use (PAU) is a leading cause of death and disability worldwide. Although genome-wide association studies (GWASs) have identified PAU risk genes, the genetic architecture of this trait is not fully understood.

New study offers "good news" for those with genetic risk for Alzheimer's
CBS News, July 15, 2019 (Posted: Jul 17, 2019 8AM)

A healthy lifestyle can cut your risk of developing Alzheimer's or other forms of dementia even if you have genes that raise your risk for these mind-destroying diseases, a large study has found. Regardless of how much genetic risk someone had, a good diet, adequate exercise, limiting alcohol and not smoking made dementia less likely.

A healthy lifestyle may offset genetic risk for Alzheimer’s
Associated Press, July 14, 2019 (via StatNews) (Posted: Jul 16, 2019 8AM)

A healthy lifestyle can cut your risk of developing Alzheimer?s or other forms of dementia even if you have genes that raise your risk for these mind-destroying diseases, a large study has found. People with high genetic risk and poor health habits were about three times more likely to develop dementia versus those with low genetic risk and good habits. Regardless of how much genetic risk someone had, a good diet, adequate exercise, limiting alcohol and not smoking made dementia less likely.

Alcohol and DNA Methylation: An Epigenome-Wide Association Study in Blood and Normal Breast Tissue
LE Wilson et al, AM J Epidemiology, February 15, 2019 (Posted: Feb 25, 2019 9AM)

How genes affect tobacco and alcohol use Data from 1.2 million people reveal how tobacco and alcohol use may be linked to your genes and to various
Eureka Alert, February 21, 2019 (Posted: Feb 21, 2019 9AM)

Excessive Alcohol Consumption
Recommendations from the Community Preventive Services Task Force Brand (Posted: Jan 23, 2019 2PM)

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use
M Liu et al, Nature Genetics, January 14, 2019 (Posted: Jan 14, 2019 11AM)

Genome-wide association and functional studies identify 46 novel loci for alcohol consumption and suggest common genetic mechanisms with neuropsychiatric disorders
E Evangelou et al, BIORXIV, October 30, 2018 (Posted: Oct 31, 2018 8AM)

Genome-wide association study meta-analysis of the Alcohol Use Disorder Identification Test (AUDIT) in two population-based cohorts (N=141,932)
S Sanchez-Roige et al, BIORxIV, AUgust 2, 2018 (Posted: Aug 03, 2018 0PM)

Review and gap analysis: molecular pathways leading to fetal alcohol spectrum disorders.
Ehrhart Friederike et al. Molecular psychiatry 2018 Jun (Posted: Jul 16, 2018 1PM)

Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells?
Prytkova Iya et al. Alcoholism, clinical and experimental research 2018 Jun (Posted: Jul 16, 2018 1PM)

A systematic review: Candidate gene and environment interaction on alcohol use and misuse among adolescents and young adults.
Kim Jueun et al. The American journal on addictions 2018 Jul (Posted: Jul 16, 2018 1PM)

Predicting smoking abstinence with biological and self-report measures of adherence to varenicline: Impact on pharmacogenetic trial outcomes.
Peng Annie R et al. Drug and alcohol dependence 2018 Jun 19072-81 (Posted: Jul 11, 2018 9AM)

Utility of Genetic Testing in Fetal Alcohol Spectrum Disorder.
Jamuar Saumya S et al. The Journal of pediatrics 2018 Feb (Posted: Feb 06, 2018 11AM)

Study of first-graders shows fetal alcohol spectrum disorders prevalent in U.S. communities
NIH Research Matters, Feb 6, 2018 (Posted: Feb 06, 2018 11AM)

Fetal Alcohol Spectrum Disorders: One Woman’s Story
Brand (Posted: Sep 06, 2017 10AM)

Overview of the Genetic Basis and Epigenetic Mechanisms that Contribute to FASD Pathobiology.
Liyanage Vichithra R B et al. Current topics in medicinal chemistry 2017 (7) 808-828 (Posted: Sep 05, 2017 11AM)

Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence.
Andersen Allan M et al. JAMA psychiatry 2017 Aug (Posted: Aug 21, 2017 11AM)

Genetic Counseling for Alcohol Addiction: Assessing Perceptions and Potential Utility in Individuals with Lived Experience and Their Family Members.
Kalb Fayth M et al. Journal of genetic counseling 2017 Feb (Posted: Apr 12, 2017 8AM)

Personalized Medicine of Alcohol Addiction: Pharmacogenomics and beyond.
Manolopoulos Vangelis George et al. Current pharmaceutical biotechnology 2017 Feb (Posted: Apr 07, 2017 10AM)

ALDH2 polymorphism and alcohol-related cancers in Asians: a public health perspective.
Chang Jeffrey S et al. Journal of biomedical science 2017 Mar (1) 19 (Posted: Apr 07, 2017 10AM)

Epigenetics studies of fetal alcohol spectrum disorder: where are we now?
Lussier Alexandre A et al. Epigenomics 2017 Mar (3) 291-311 (Posted: Feb 27, 2017 1PM)

Overview of the Genetics of Alcohol Use Disorder.
Tawa Elisabeth A et al. Alcohol and alcoholism (Oxford, Oxfordshire) 2016 Sep (5) 507-14 (Posted: Jan 24, 2017 11AM)

DNA methylation and alcohol use disorders: Progress and challenges.
Zhang Huiping et al. The American journal on addictions 2016 Oct (Posted: Jan 24, 2017 11AM)

The genetics of alcohol dependence and alcohol-related liver disease.
Stickel Felix et al. Journal of hepatology 2017 Jan (1) 195-211 (Posted: Jan 24, 2017 11AM)

The Surgeon General Report on Alcohol, Drugs and Health
Surgeon General, HHS, November 2016 (Posted: Nov 20, 2016 7AM)

Surgeon General’s Report on Alcohol, Drugs, and Health
VH Murthy, JAMA, November 17, 2016 (Posted: Nov 20, 2016 7AM)

Genetic feedback to reduce alcohol consumption in hospital outpatients with risky drinking: feasibility and acceptability.
Johnson Natalie A et al. Public health research & practice 2016 Sep 26(4) (Posted: Oct 12, 2016 11AM)

Genome-Wide Interaction Analyses between Genetic Variants and Alcohol Consumption and Smoking for Risk of Colorectal Cancer
J Gong et al, PLOS Genetics, October 2016 (Posted: Oct 12, 2016 9AM)

FASD Awareness
Brand (Posted: Sep 09, 2016 9AM)

The Genetics of Fetal Alcohol Spectrum Disorders.
Eberhart Johann K et al. Alcoholism, clinical and experimental research 2016 Jun (6) 1154-65 (Posted: Sep 09, 2016 9AM)

DNA methylation signature of human fetal alcohol spectrum disorder.
Portales-Casamar Elodie et al. Epigenetics & chromatin 2016 25 (Posted: Sep 09, 2016 9AM)

An Update on Fetal Alcohol Syndrome-Pathogenesis, Risks, and Treatment.
Gupta Keshav K et al. Alcoholism, clinical and experimental research 2016 Aug (8) 1594-602 (Posted: Sep 09, 2016 9AM)

Biology, Genetics, and Environment: Underlying Factors Influencing Alcohol Metabolism.
Wall Tamara L et al. Alcohol research : current reviews 2016 (1) 59-68 (Posted: Aug 06, 2016 10AM)

Genetic imaging consortium for addiction medicine: From neuroimaging to genes.
Mackey Scott et al. Progress in brain research 2016 203-23 (Posted: Apr 06, 2016 11AM)

Pharmacogenetics of alcohol use disorders and comorbid psychiatric disorders.
Helton Sarah G et al. Psychiatry research 2015 Dec (2) 121-9 (Posted: Apr 06, 2016 11AM)

Study supports single-question alcohol screen for adolescents
NIAAA, April 6, 2016 Brand (Posted: Apr 06, 2016 11AM)

Alcohol misuse, genetics, and major bleeding among warfarin therapy patients in a community setting.
Roth Joshua A et al. Pharmacoepidemiology and drug safety 2015 Jun 24(6) 619-27 (Posted: Feb 24, 2016 10AM)

Multigenerational and transgenerational inheritance of drug exposure: The effects of alcohol, opiates, cocaine, marijuana, and nicotine.
Yohn Nicole L et al. Progress in biophysics and molecular biology 2015 Jul (1-2) 21-33 (Posted: Feb 16, 2016 7PM)

Editorial: Genetics and epigenetics of fetal alcohol spectrum disorders.
S Mason et al. Frontline Genetics, 2015 Brand (Posted: Feb 02, 2016 4PM)

Associative DNA methylation changes in children with prenatal alcohol exposure.
Laufer Benjamin I et al. Epigenomics 2015 Dec (8) 1259-74 (Posted: Feb 02, 2016 4PM)

Fetal Alcohol Exposure Reduces Dopamine Receptor D2 and Increases Pituitary Weight and Prolactin Production via Epigenetic Mechanisms.
Gangisetty Omkaram et al. PloS one 2015 (10) e0140699 (Posted: Feb 02, 2016 4PM)

DNA methylation changes in fetal alcohol spectrum disorder.
Portales-Casamar Elodie et al. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2015 Dec (Pt A) 126 (Posted: Feb 02, 2016 4PM)

Worldwide Prevalence of Fetal Alcohol Spectrum Disorders: A Systematic Literature Review Including Meta-Analysis.
Roozen Sylvia et al. Alcoholism, clinical and experimental research 2016 Jan (1) 18-32 (Posted: Feb 02, 2016 4PM)

Alcohol and Pregnancy: Why take the risk?
Brand (Posted: Feb 02, 2016 4PM)

Genetic variation (CHRNA5), medication (combination nicotine replacement therapy vs. varenicline), and smoking cessation.
Chen Li-Shiun et al. Drug and alcohol dependence 2015 Sep 278-82 (Posted: Jan 25, 2016 10AM)

Genetic and environmental contributions to initiation of cigarette smoking in young African-American and European-American women.
Sartor Carolyn E et al. Drug and alcohol dependence 2015 Dec 54-9 (Posted: Jan 06, 2016 8PM)

Childhood attention-deficit/hyperactivity disorder symptoms and the development of adolescent alcohol problems: A prospective, population-based study of Swedish twins.
Quinn Patrick D et al. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2015 Dec (Posted: Jan 05, 2016 0PM)

Genetics of Alcoholic Liver Disease.
Anstee Quentin M et al. Seminars in liver disease 2015 Nov (4) 361-74 (Posted: Dec 21, 2015 3PM)

Alcohol’s Effect on Health: What the Science Says
AE Carroll, New York Times, December 21, 2015 (Posted: Dec 21, 2015 3PM)

Commonalities and Distinctions Among Mechanisms of Addiction to Alcohol and Other Drugs.
Ozburn Angela R et al. Alcoholism, clinical and experimental research 2015 Oct (10) 1863-77 (Posted: Oct 30, 2015 1PM)

A genome-wide association study confirms PNPLA3 and identifies TM6SF2 and MBOAT7 as risk loci for alcohol-related cirrhosis
S Buch et al, Nature Genetics, October 19, 2015 (Posted: Oct 19, 2015 3PM)

Advances in Medications and Tailoring Treatment for Alcohol Use Disorder.
Seneviratne Chamindi et al. Alcohol research : current reviews 2015 (1) 15-28 (Posted: Oct 16, 2015 2PM)

Excessive alcohol use continues to be drain on American economy
Brand (Posted: Oct 16, 2015 2PM)

Importance of genetics in fetal alcohol effects: null mutation of the nNOS gene worsens alcohol-induced cerebellar neuronal losses and behavioral deficits.
Bonthius Daniel J et al. Neurotoxicology 2015 Jan 60-72 (Posted: Sep 03, 2015 3PM)

Reduced DNA methylation at the PEG3 DMR and KvDMR1 loci in children exposed to alcohol in utero: a South African Fetal Alcohol Syndrome cohort study.
Masemola Matshane L et al. Front Genet 2015 85 (Posted: Sep 03, 2015 3PM)

Editorial: Genetics and epigenetics of fetal alcohol spectrum disorders.
Mason Stephen et al. Front Genet 2015 146 (Posted: Sep 03, 2015 3PM)

International Fetal Alcohol Spectrum Disorders Awareness Day
CDC MMWR Weekly, September 4, 2015 Brand (Posted: Sep 03, 2015 3PM)

Fetal alcohol spectrum disorders (FASDs) are a group of conditions that can occur in a person whose mother drank alcohol during pregnancy.
FASDs are completely preventable if a woman does not drink alcohol during pregnancy. Brand (Posted: Sep 03, 2015 3PM)

Evaluation of Moderate Alcohol Use With QT Interval and Heart Rate Using Mendelian Randomization Analysis Among Older Southern Chinese Men in the Guangzhou Biobank Cohort Study.
Au Yeung Shiu Lun et al. Am. J. Epidemiol. 2015 Aug 15. (4) 320-7 (Posted: Aug 21, 2015 10AM)

Gene network analysis shows immune-signaling and ERK1/2 as novel genetic markers for multiple addiction phenotypes: alcohol, smoking and opioid addiction.
Reyes-Gibby Cielito C et al. BMC Syst Biol 2015 25 (Posted: Jul 08, 2015 9AM)

Alcohol Dependence Genetics: Lessons Learned From Genome-Wide Association Studies (GWAS) and Post-GWAS Analyses.
Hart Amy B et al. Alcohol. Clin. Exp. Res. 2015 Jun 25. (Posted: Jun 29, 2015 2PM)

Epigenetics-A New Frontier for Alcohol Research
NIAAA Alcohol Alert May 2015 Brand (Posted: May 28, 2015 0PM)

Are genetic variants for tobacco smoking associated with cannabis involvement?
Agrawal Arpana et al. Drug Alcohol Depend 2015 May 1. 183-7 (Posted: May 28, 2015 7AM)

The association of rs1051730 genotype on adherence to and consumption of prescribed nicotine replacement therapy dose during a smoking cessation attempt.
Ware Jennifer J et al. Drug Alcohol Depend 2015 Jun 1. 236-40 (Posted: May 28, 2015 7AM)

An extended Swedish national adoption study of alcohol use disorder.
Kendler Kenneth S et al. JAMA Psychiatry 2015 Mar (3) 211-8 (Posted: Apr 25, 2015 11AM)

Meta-analysis of six genes (BDNF, DRD1, DRD3, DRD4, GRIN2B and MAOA) involved in neuroplasticity and the risk for alcohol dependence.
Forero Diego A et al. Drug Alcohol Depend 2015 Apr 1. 259-63 (Posted: Apr 05, 2015 9AM)

Alcohol abuse and cigarette smoking are associated with global DNA hypermethylation: Results from the German Investigation on Neurobiology in Alcoholism (GINA).
Semmler Alexander et al. Alcohol 2015 Mar (2) 97-101 (Posted: Apr 05, 2015 9AM)

Polygenic risk for externalizing disorders: Gene-by-development and gene-by-environment effects in adolescents and young adults.
Salvatore Jessica E et al. Clin Psychol Sci 2015 Mar (2) 189-201 (Posted: Apr 05, 2015 9AM)

ACN9 and alcohol dependence: Family-based association analysis in multiplex alcohol dependence families.
Hill Shirley Y et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2015 Apr (3) 179-87 (Posted: Apr 05, 2015 9AM)

Which alcohol use disorder criteria contribute to the association of ADH1B with alcohol dependence?
Hart Amy B et al. Addict Biol 2015 Apr 1. (Posted: Apr 05, 2015 9AM)

Genetic-epidemiological evidence for the role of acetaldehyde in cancers related to alcohol drinking.
Eriksson C J Peter et al. Adv. Exp. Med. Biol. 2015 41-58 (Posted: Apr 05, 2015 9AM)

The 5-HT7 receptor as a potential target for treating drug and alcohol abuse.
Hauser Sheketha R et al. Front Neurosci 2014 448 (Posted: Apr 05, 2015 9AM)

Common single nucleotide variants underlying drug addiction: more than a decade of research.
Bühler Kora-Mareen et al. Addict Biol 2015 Jan 21. (Posted: Apr 05, 2015 9AM)

NIH Recognizes Alcohol Awareness Month 2015
Brand (Posted: Apr 05, 2015 9AM)

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Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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