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Hot Topics of the Day|PHGKB
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12/01/2021

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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The omicron variant has been found in 24 countries
S Neuman, NPR, December 1, 2021

First Confirmed Case of Omicron Variant Detected in the United States
CDC, December 1, 2021 Brand

The California and San Francisco Departments of Public Health have confirmed that a recent case of COVID-19 among an individual in California was caused by the Omicron variant (B.1.1.529). The individual was a traveler who returned from South Africa on November 22, 2021. The individual, who was fully vaccinated and had mild symptoms that are improving, is self-quarantining and has been since testing positive. All close contacts have been contacted and have tested negative.

What You Need to Know about Variants: Omicron
CDC, November 30, 2021 Brand

On Tuesday, November 30, 2021, the U.S. government SARS-CoV-2 Interagency Group made the decision to classify the Omicron variant as a Variant of Concern (VOC). This decision is based on multiple factors, including the detection of Omicron cases in multiple countries, transmission and displacement of Delta in South Africa, and mutations in the virus that could indicate a reduction in the effectiveness of COVID-19 vaccines and certain monoclonal antibody treatments. No cases of this variant have been identified in the U.S. to date. CDC is following the details of this new variant.

Omicron: What Is Known — and Still Unknown- Intense research into the new coronavirus variant first identified in southern Africa has just begun. World leaders have urged people not to panic — and to get vaccinated, if they can.
A Jacobs, NY Times, November 30, 2021

How 2 Flights to Europe May Have Spurred Spread of New Variant- A confounding array of Covid rules and lax enforcement of mask wearing may have sent infected passengers on two KLM flights from South Africa on to “who knows where.”
J Horowitz, NY Times, November 30, 2021

Effectiveness of a third dose of BNT162b2 or mRNA-1273 vaccine for preventing post-vaccination COVID-19 infection: an observational study
A Sharma et al, MEDRXIV, November 30, 2021

SARS-CoV-2 Delta variant saliva viral load is 15-fold higher than wild-type strains
K Imai et al, MEDRXIV, November 30, 2021

Identification of susceptibility loci for adverse events following COVID-19 vaccination in the Japanese population: A web-based genome-wide association study.
S Nogawa et al, MEDRXIV, November 30, 2021

COVID-19 Variant Detection with a High-Fidelity CRISPR-Cas12 Enzyme
CL Fasching et al, MEDRXIV, November 30, 2021

The Clinical Genome Resource (ClinGen) Familial Hypercholesterolemia Variant Curation Expert Panel consensus guidelines for LDLR variant classification
JR Chora et al, Genetics in Medicine, NOvember 30, 2021

The Clinical Genome Resource Familial Hypercholesterolemia (FH) Variant Curation Expert Panel was tasked with optimizing the existing ACMG/AMP framework for disease-specific classification in FH. In this study, we provide consensus recommendations for the most common FH-associated gene, LDLR, where >2300 unique FH-associated variants have been identified.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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