Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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Archived Hot Topics of the Day By Date
Implications of the Emerging SARS-CoV-2 Variant VOC 202012/01
CDC, December 22, 2020
There is no evidence that this variant causes more severe illness or increased risk of death. Information regarding the virologic, epidemiologic, and clinical characteristics of the variant are rapidly emerging. CDC, in collaboration with other agencies, is monitoring the situation closely. CDC will communicate new information as it becomes available.
New Variant of Virus that Causes COVID-19 Detected
CDC, December 22, 2020
It is still early in the identification of this variant, so we have a great deal to learn. More studies on the new variant are needed to understand how widely the new variant has spread in the UK and potentially around the world; how the new variant differs from earlier variants; how the disease caused by this variant differs from the disease caused by other variants that are currently circulating.
The Role of Testing in Reducing SARS-CoV-2 Transmission on College Campuses.
Barrios Lisa C et al. The Journal of adolescent health : official publication of the Society for Adolescent Medicine 2021 Jan (1) 1-2
Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning
B Patterson et al, BIORXIV, December 22, 2020
Mutation Landscape of SARS COV2 in Africa
AA Nassir et al, BIORXIV, December 21, 2020
Assessing Progress in Health Care Quality Through the Lens of COVID-19.
Corrigan Janet M et al. JAMA 2020 Dec (24) 2483-2484
Viewing the health care system through the lens of the COVID-19 pandemic indicates that major shortcomings and challenges must still be addressed before the health care sector will have crossed the quality chasm. Of the 6 aims, COVID-19 raises particular concerns about safety, timeliness and equity.
Phylogenetic supertree reveals detailed evolution of SARS-CoV-2
T Li et al, Scientific Reports, December 22, 2020
we applied the matrix representation with parsimony (MRP) pseudo-sequence supertree analysis to study the origin and evolution of SARS-CoV-2. The MRP pseudo-sequence supertree analysis firmly disputes bat coronavirus RaTG13 be the last common ancestor of SARS-CoV-2, which was implied by other phylogenetic tree analysis based on viral genome sequences.
Clinical utility of genomic sequencing: a measurement toolkit
RZ Hayeems et al, NPJ Genomic Medicine, December 2020
Following a consensus-based process, we align with a broad definition of clinical utility and propose a conceptually-grounded and empirically-guided measurement toolkit focused on four domains of utility: diagnostic thinking efficacy, therapeutic efficacy, patient outcome efficacy, and societal efficacy. For each domain of utility, we offer specific indicators and measurement strategies.