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Hot Topics of the Day|PHGKB
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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

The molecular landscape of Asian breast cancers reveals clinically relevant population-specific differences
JW Pan et al, Nat Comms, December 22, 2020

Compared to breast tumors in Caucasian women, we show an increased prevalence of HER2-enriched molecular subtypes and higher prevalence of TP53 somatic mutations in ER+ Asian breast tumors. We also observe elevated immune scores in Asian breast tumors, suggesting potential clinical response to immune checkpoint inhibitors.

Implications of the Emerging SARS-CoV-2 Variant VOC 202012/01
CDC, December 22, 2020 Brand

There is no evidence that this variant causes more severe illness or increased risk of death. Information regarding the virologic, epidemiologic, and clinical characteristics of the variant are rapidly emerging. CDC, in collaboration with other agencies, is monitoring the situation closely. CDC will communicate new information as it becomes available.

New Variant of Virus that Causes COVID-19 Detected
CDC, December 22, 2020 Brand

It is still early in the identification of this variant, so we have a great deal to learn. More studies on the new variant are needed to understand how widely the new variant has spread in the UK and potentially around the world; how the new variant differs from earlier variants; how the disease caused by this variant differs from the disease caused by other variants that are currently circulating.

The Role of Testing in Reducing SARS-CoV-2 Transmission on College Campuses.
Barrios Lisa C et al. The Journal of adolescent health : official publication of the Society for Adolescent Medicine 2021 Jan (1) 1-2

Immune-Based Prediction of COVID-19 Severity and Chronicity Decoded Using Machine Learning
B Patterson et al, BIORXIV, December 22, 2020

Mutation Landscape of SARS COV2 in Africa
AA Nassir et al, BIORXIV, December 21, 2020

Assessing Progress in Health Care Quality Through the Lens of COVID-19.
Corrigan Janet M et al. JAMA 2020 Dec (24) 2483-2484

Viewing the health care system through the lens of the COVID-19 pandemic indicates that major shortcomings and challenges must still be addressed before the health care sector will have crossed the quality chasm. Of the 6 aims, COVID-19 raises particular concerns about safety, timeliness and equity.

Phylogenetic supertree reveals detailed evolution of SARS-CoV-2
T Li et al, Scientific Reports, December 22, 2020

we applied the matrix representation with parsimony (MRP) pseudo-sequence supertree analysis to study the origin and evolution of SARS-CoV-2. The MRP pseudo-sequence supertree analysis firmly disputes bat coronavirus RaTG13 be the last common ancestor of SARS-CoV-2, which was implied by other phylogenetic tree analysis based on viral genome sequences.

Clinical utility of genomic sequencing: a measurement toolkit
RZ Hayeems et al, NPJ Genomic Medicine, December 2020

Following a consensus-based process, we align with a broad definition of clinical utility and propose a conceptually-grounded and empirically-guided measurement toolkit focused on four domains of utility: diagnostic thinking efficacy, therapeutic efficacy, patient outcome efficacy, and societal efficacy. For each domain of utility, we offer specific indicators and measurement strategies.

Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.