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Hot Topics of the Day|PHGKB
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12/22/2019

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

The Gene: An Intimate Story
NHGRI, 2019 Brand

Science, social history and personal stories weave together a historical biography of the human genome while also exploring the stunning breakthroughs in understanding the impact genes play on heredity, disease and behavior.

ClinVar Celebrates 1 Million Submissions
NCBI, December 2019 Brand

Recommendations for the collection and use of multiplexed functional data for clinical variant interpretation.
Gelman Hannah et al. Genome medicine 2019 Dec (1) 85

Our recommendations to clinicians and diagnostic labs on how to evaluate the quality of multiplexed functional datasets, and how different datasets could be incorporated into the ACMG/AMP variant-interpretation framework, will hopefully clarify whether and how such data should be used.

Manufacturing: the next breakthrough in gene therapy
D Blumenthal, Stat News, December 18, 2019

What You’re Unwrapping When You Get a DNA Test for Christmas
H Murphy, NY Times, December 22, 2019

So what do these developments mean for that DNA kit sitting under your Christmas tree? Men’s Journal calls them “one of the hottest gifting ideas,” and US Weekly promises that “they’re going to love it, no matter how tough of a critic they are.” But is using one of these kits also opening the door to letting the police use your DNA to arrest your cousin?

Proxy gene-by-environment Mendelian randomization study confirms a causal effect of maternal smoking on offspring birthweight, but little evidence of long-term influences on offspring health.
Yang Qian et al. International journal of epidemiology 2019 Dec

Our study demonstrated how offspring genotype can be used to proxy for the mother’s genotype in gene-by-environment MR. We confirmed the causal effect of maternal (G0) smoking on offspring (G1) birthweight, but found little evidence of an effect on G1 longer-term health outcomes.


Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Public Health Genomics to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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