Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content


Hot Topics of the Day|PHGKB
Search PHGKB:

11/12/2021

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

Sign up MyPHGKB to receive the daily hot topic email alert.

Search Archive:
Archived Hot Topics of the Day By Date

From Public Health Genomics to Precision Public Health: On to the Next Generation!
Muin J. Khoury Video Presentation, at the Transdisciplinary Conference for Future Leaders in Precision Public Health. Posted on November 11, 2021

In this presentation Dr Khoury discusses the evolution of the field of public health genomics over the past 25 years into precision medicine and precision public health, which involves applications of genomics , big data and predictive analytics to population health. He also describes ongoing applications of precision public health to the COVID-19 response.

Transdisciplinary Conference for Future Leaders in Precision Public Health
Speakers Slide Presentations, November 2021

This virtual event held in October 2021 connected future research leaders around the world interested in the role of genetics and precision health in the promotion of public health. The speakers provided opportunities for early career investigators to discuss new developments in precision public health with leading experts in the field. Attendees heard from expert epidemiologists, behavioral scientists, statisticians, and global public health leaders about topics such as health equity in genetic epidemiology, genetic risk communication in cancer care, and biostatistics and modeling.

New tool points to mutation behind Delta’s infectiousness
M Wadman, Science, November 11, 2021

Booster shots are most popular in poorly vaccinated states where coronavirus rages
D Keating et al, Washington Post, November 11, 2021

Rapid, Reliable and Robust approach for extraction-free RT-PCR based detection of SARS-CoV-2 in clinical setting to expedite large scale screening
Dubey et al, AMEDRXIV, November 11, 2021

An Open Repository of Real-Time COVID-19 Indicators
A Reinhart et al, MEDRXIV, November 11, 2021

The COVID-19 pandemic presented enormous data challenges in the United States. Policy makers, epidemiological modelers, and health researchers all require up-to-date data on the pandemic and relevant public behavior, ideally at fine spatial and temporal resolution. The COVIDcast API is our attempt to fill this need: operational since April 2020, it provides open access to both traditional public health surveillance signals (cases, deaths, and hospitalizations) and many auxiliary indicators of COVID- 19 activity, such as signals extracted from de-identified medical claims data, massive online surveys, cell phone mobility data, and internet search trends. These are available at a fine geographic resolution (mostly at the county level) and are updated daily.

Mapping the human genetic architecture of COVID-19: an update
The COVID-19 Host Genetics Initiative, MEDRXIV, November 11, 2021

The Coronavirus Disease 2019 (COVID-19) pandemic continues to pose a major public health threat especially in countries with low vaccination rates. To better understand the biological underpinnings of SARS-CoV-2 infection and COVID-19 severity we formed the COVID19 Host Genetics Initiative. Here we present GWAS meta-analysis of up to 125,584 cases and over 2.5 million controls across 60 studies from 25 countries, adding 10 new genome-wide significant loci to the 13 we previously identified1. Genes in novel loci include SFTPD, MUC5B and ACE2, reveal compelling insights regarding disease susceptibility and severity.

Using mobile phone data to estimate dynamic population changes and improve the understanding of a pandemic: A case study in Andorra
AA Berke et al, MEDRXIV, November 11, 2021

A prototype vaccination model for endemic Covid-19 under waning immunity and imperfect vaccine take-up
JS Dagpunar et al, MEDRXIV, November 11, 2021

COVID-19 convalescents exhibit deficient humoral and T cell responses to variant of concern Spike antigens at 12 month post-infection
PG Valtanen etal, MEDRXIV, November 11, 2021

SARS-CoV-2 Delta vaccine breakthrough transmissibility in Alachua, Florida
BR Magalis et al, MEDRXIV, November 12, 2021

Reports of myocarditis and pericarditis following mRNA COVID-19 vaccines: A systematic review of spontaneously reported data from the UK, Europe, and the US and of the literature
S Lane et al, MEDRXIV, November 12, 2021

Overall, there were 435 reports of myocarditis and 327 reports of pericarditis reported to the UK's Yellow Card scheme up to 20 October 2021. To 21 October 2021, in the US, 1936 reports of myocarditis and 1271 reports of pericarditis had been submitted to VAERS; there had been 2924 reports of myocarditis and 1855 reports of pericarditis submitted to EudraVigilance to the same date. Most reports (73.3%) had been submitted following Comirnaty (Pfizer/BioNTech). Males represented 74.9% of reports of myocarditis and 56.9% of pericarditis overall (for US and EU/EEA populations only), and the majority of reports concerned vaccinees ages under 40 years. Reports were more frequent following the second dose of mRNA COVID-19 vaccine.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
TOP