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Hot Topics of the Day|PHGKB
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11/05/2019

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

The genetics of human ageing
D Melzer et al, November 5, 2019

Large-scale genome-wide association studies have identified many loci that influence key human ageing traits, including lifespan. Multi-trait loci have been linked with several age-related diseases, suggesting shared ageing influences. Mutations that drive accelerated ageing in progeria point to an important role for genome maintenance and stability.

Introduction to Genomics (Spanish version)
NHGRI, 2019 Brand

Increasing genomic literacy is a major goal of @DNADay. To achieve this goal, @genome_gov now offers its “Introduction to Genomics” resource in Spanish. Learn more.

CMS Aims to Broaden Coverage for NGS Testing in Breast, Ovarian Cancer -Expansion would include patients with risk factors for inherited susceptibility mutations
I Ingram, MedPage Today, October 31, 2019

In a proposed decision memo on Tuesday, the agency stated that sufficient evidence exists to support testing when treating physicians determine that patients with breast and ovarian cancer have clinical indications for germline testing, risk factors for an inherited cancer, and have yet to receive such testing.

VIDEO: FH can be vehicle for precision public health
K Wilemon and D Rader, Healio, NOvember 3, 2019

In this video exclusive, Daniel J. Rader, MD, chair of the department of genetics, chief of the division of translational medicine and human genetics, spoke with Katherine Wilemon, CEO of the FH Foundation, about major takeaways from the FH Foundation’s FH Global Summit, which focused on familial hypercholesterolemia as a driver for precision public health.

Cystic fibrosis: triple therapy shows promising results
E Mahase, BMJ, November 4, 2019

The triple therapy Trikafta (elexacaftor, tezacaftor, and ivacaftor) has the potential to lead to “transformative improvements in the lives of people with cystic fibrosis,” two phase III trials indicate. The studies looked at the efficacy and safety of Trikafta in patients with one copy of Phe508del—the most common gene mutation for cystic fibrosis.

Is Crispr the Next Antibiotic?
K Sheikh, NY Times, October 2019

In nature, the gene-editing tool Crispr protects bacteria against viruses. Now it’s being harnessed in the fight against superbugs and the flu.

Genomic Medicine XII: Genomics and Risk Prediction
NHGRI 2019 meeting and slide presentations

Summary and slides of meeting to Review the state of science of polygenic risk scores and how it can be improved; examine other information sources that should be integrated with genetic variant information in predicting risk; identify research directions in development and implementation of genomic risk prediction.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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