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Hot Topics of the Day|PHGKB
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10/05/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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The Family Health History Group
NHGRI, October 2020 Brand

The group connects stakeholders, researchers, and thought leaders to share learning, understand barriers, and discuss issues and potential solutions related to collection of family health history information. Multidisciplinary members come from government, industry, health care, research, advocacy, and policy backgrounds, and represent many countries.

Whole genome, transcriptome and methylome profiling enhances actionable target discovery in high-risk pediatric cancer
M Wong et al, Nature Medicine, October 5, 2020

The Zero Childhood Cancer Program is a precision medicine program to benefit children with poor-outcome, rare, relapsed or refractory cancer. Using tumor and germline whole genome sequencing (WGS) and RNA sequencing (RNAseq) across 252 tumors from high-risk pediatric patients with cancer, we identified 968 reportable molecular aberrations.

Crowding and the shape of COVID-19 epidemics
B Rader et al, Nature Medicine, October 5, 2020

We analyzed highly resolved spatial variables in cities, together with case count data, to investigate the role of climate, urbanization and variation in interventions. We show that the degree to which cases of COVID-19 are compressed into a short period of time is strongly shaped by population aggregation and heterogeneity, such that epidemics in crowded cities are more spread over time, and crowded cities have larger total attack rates than less populated cities.

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection
AA Minervina et al, BIORXIV, October 1, 2020

Multiple early introductions of SARS-CoV-2 into a global travel hub in the Middle East
A Abou Tayoun et al, BIORXIV, October 1, 2020

Synonymous mutations and the molecular evolution of SARS-Cov-2 origins
H Wang et al, BIORXIV, October 2, 2020

Early Evidence of Effectiveness of Digital Contact Tracing for SARS-CoV-2 in Switzerland
M Salathe et al, MEDRXIV, October 4, 2020

Predicting public take-up of digital contact tracing during the COVID-19 crisis: Results of a national survey
YE Saw et al, MEDRXIV, October 5, 2020

The Pandemic of Health Care Inequity
LR Thronson et al, JAMA Network Open, October 2, 2020

Access to digital services is important not just for health care but also for education, housing, other social services, job applications, and food delivery in communities with COVID-19 outbreaks. Cross-sector collaboration among health care systems, local governments, telecommunication companies, schools, community-based organizations, and philanthropic organizations is needed to address inequitable access and provide assistance for communities with the most risk.

Prediction of Overall Survival Among Female Patients With Breast Cancer Using a Prognostic Signature Based on 8 DNA Repair–Related Genes
D Zhang et al, JAMA Network Open, October 5, 2020

A prognostic signature based on 8 DNA repair–related genes predicted overall survival among female patients with breast cancer, thereby providing a new modality for the accurate diagnosis and targeted treatment of breast cancer.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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