Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content


Hot Topics of the Day|PHGKB
Search PHGKB:

09/29/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

Sign up MyPHGKB to receive the daily hot topic email alert.

Search Archive:
Archived Hot Topics of the Day By Date

COVID-19 Trends Among School-Aged Children — United States, March 1–September 19, 2020
RT Leeb et al, CDC MMWR, September 28, 2020

Since March, 277,285 COVID-19 cases in children have been reported. COVID-19 incidence among adolescents aged 12–17 years was approximately twice that in children aged 5–11 years. Underlying conditions were more common among school-aged children with severe outcomes related to COVID-19. Data varied over time and by region of the United States.

Genetic variants mimicking therapeutic inhibition of IL-6 receptor signaling and risk of COVID-19
J Bovijn et al, Lancet Rheumatology, September 25, 2020

Our findings show that IL6R variants mimicking therapeutic inhibition of IL-6 receptor are associated with a lower risk of hospitalization for COVID-19, a phenotype that is associated with disease severity (eg, requiring supplemental oxygen is a typical reason for hospitalization).

Clinical Course And Risk Factors For In-hospital Death In Critical COVID-19 In Wuhan, China
F Li et al, MEDRXIV, September 28, 2020

A novel haemocytometric COVID-19 prognostic score developed and validated in an observational multicentre European hospital-based study
J Linssen et al, EDRXIV, September 28, 2020

A Systematic Review and Meta-analysis of Pregnancy and COVID-19: Signs and Symptoms, Laboratory Tests and Perinatal Outcomes
H Hassanipour et al, MEDRXIV, September 28, 2020

Different innate and adaptive immune response to SARS-CoV-2 infection of asymptomatic, mild and severe cases
R Carsetti, et al, MEDRXIV, September 28, 2020

Diagnosis value of SARS-CoV-2 antigen/antibody combined testing using rapid diagnostic tests at hospital admission
N Veyrenche et al, MEDRXIV, September 28, 2020

SalivaDirect: A simplified and flexible platform to enhance SARS-CoV-2 testing capacity
CBF Vogels et al, MEDRXIV, September 28, 2020

The role of genomics in global cancer prevention
O Ginsburg et al, Nature Rev Clin Oncology, September 2020

In this Review, we present the relevant history and emerging frontiers of cancer genetics and genomics from the perspective of global cancer prevention. We highlight the importance of local context in the adoption of new technologies and emergent evidence, with illustrative examples from worldwide.

Impact of newborn screening and quality of therapy on the neurological outcome in glutaric aciduria type 1: a meta-analysis
N Boy et al, Genetics in Medicine, September 28, 2020

This meta-analysis demonstrates that NBS programs for Glutaric Aciduria Type 1 (GA1) have an overall positive effect on the neurological outcome of affected individuals but their success critically depends on the quality of therapy.

Development and Validation of a Serum Metabolomic Signature for Endometrial Cancer Screening in Postmenopausal Women
J Troisi et al, JAMA Network Open, September 28, 2020

Is combining the blood metabolomic signature of endometrial carcinoma with an ensemble machine learning algorithm a useful system for screening test for endometrial cancer? In this study of 1550 postmenopausal women, the proposed screening test correctly identified all 16 women with endometrial cancer, with 2 false-positive results and 0 false-negative results.

Global maps of travel time to healthcare facilities
DJ Weiss et al, Nature Medicine, September 28, 2020

Leveraging the geographically variable strengths of our facility datasets, we characterize travel time to healthcare facilities in unprecedented detail. We produce maps of travel time with and without access to motorized transport, thus characterizing travel time to healthcare for populations distributed across the wealth spectrum.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
TOP