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Hot Topics of the Day|PHGKB
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Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

The Need for Electronic Health Records to Support Delivery of Behavioral Health Preventive Services.
Huffstetler Alison N et al. JAMA 2022 8

To accomplish digital health goals, it is essential to adhere to 3 key principles. First, digital health systems need to make it easy for clinicians to deliver national guidelines and quality recommendations. Second, digital health systems need to make information actionable for clinicians and patients. Third, digital health systems need to be easy to use; they should be intuitive for users, easily accessible, and not require complex workflows to enter and retrieve data.

Tools for assessing quality and risk of bias in Mendelian randomization studies: a systematic review.
Spiga Francesca et al. International journal of epidemiology 2022 7

We present an overview of tools and methods to assess risk of bias/quality of evidence in MR analysis. Issues commonly addressed relate to the three standard assumptions of instrumental variables analyses, the choice of genetic instrument(s) and features of the population(s) from which the data are collected (particularly in two-sample MR), in addition to more traditional non-MR-specific epidemiological biases. The identified tools should be tested and validated for general use before recommendations can be made on their widespread use.

The oral microbiome and lung cancer risk: An analysis of 3 prospective cohort studies
E Vogtman et al, JNCI, August 5, 2022

Previous studies suggested associations between the oral microbiome and lung cancer, but studies were predominantly cross-sectional and underpowered. Multiple oral microbial measures were prospectively associated with lung cancer risk in three US cohort studies with associations varying by smoking history and histologic subtype. The oral microbiome may offer new opportunities for lung cancer prevention.

Association of Newborn Telomere Length With Blood Pressure in Childhood.
Martens Dries S et al. JAMA network open 2022 8 (8) e2225521

In this birth cohort study including 485 newborns, participants with a longer birth TL had a significantly lower diastolic and mean arterial pressure at the age of 4 to 6 years. Furthermore, longer newborn TL was significantly associated with lower odds of having high childhood blood pressure. These results suggest that TL at birth associates with early life vascular health and that newborn TL may be a programmed molecular mediator containing genetic and prenatal environmental exposure information contributing to vascular health later in life.

Monkeypox DNA correlates with virus infectivity in clinical samples
N Paran et al, BIORXIV, August 3, 2022

We show strong correlation between viral DNA content and virus infectivity in clinical specimens. Moreover, we define a PCR threshold value which correspond to non-infectious virus, and suggest that our data can be translated into informed decision-making regarding risk assessment, protective measures and guidelines for Monkeypox patients.

Disclaimer: Articles listed in Hot Topics of the Day are selected by the CDC Office of Genomics and Precision Public Health to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.