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Hot Topics of the Day|PHGKB
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08/06/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Combined Utility of 25 Disease and Risk Factor Polygenic Risk Scores for Stratifying Risk of All-Cause Mortality
A Meisner et al, AJHG, August 5, 2020

PRS were moderately associated with all-cause mortality in independent data within the UK Biobank: the estimated hazard ratios per standard deviation were 1.10 and 1.15 for women and men, respectively. Differences in life expectancy between the top and bottom 5% of the PRS were estimated to be 4.79 years and 6.75 years for women and men, respectively.

Assessment of multiplex digital droplet RT-PCR as an accurate diagnosis tool for SARS-CoV-2 detection in nasopharyngeal swabs and saliva samples
K Cassinari et al, MEDRXIV, August 4, 2020

SARS-CoV-2 genome analysis of strains in Pakistan reveals GH, S and L clade strains at the start of the pandemic
NK Ghanchi et al, BIORXIV, August 4, 2020

Analytical validity of nanopore sequencing for rapid SARS-CoV-2 genome analysis
RA Bull et al, BIORXIV, August 4, 2020

Machine Learning-Based Protein Microarray Digital Assay Analysis
Y Song et al, BIORXIV, August 4, 2020

Exposure Density and Neighborhood Disparities in COVID-19 Infection Risk: Using Large-scale Geolocation Data to Understand Burdens on Vulnerable Communities
B Hong, et al, ARXIV, August 4, 2020

We develop a generalizable method for assessing neighborhood activity levels by land use type using smartphone geolocation data over a three-month period covering more than 12 million unique users within the Greater New York area. We measure and analyze disparities in community social distancing by identifying patterns in neighborhood activity levels.

Immunology Is Where Intuition Goes to Die Which is too bad because we really need to understand how the immune system reacts to the coronavirus.
E Yong, the Atlantic, August 5, 2020

Association Between ABCB1 Genetic Variants and Persistent Chemotherapy-Induced Alopecia in Women With Breast Cancer
RN Torres et al, JAMA Derm, August 5, 2020

This is the first study, to our knowledge, that identifies an association between a regulatory variant in the ABCB1 gene and the occurrence of pCIA in patients with breast cancer who were treated with docetaxel-based therapies.

Overview of the current status of gene therapy for primary immune deficiencies
CY Ku, J Allergy Clin Immunol, August 2020

Although common platforms of cells, vectors, or editing reagents are used for these disorders, each individual genetic cause of an immune deficiency requires its own vector or editing tools and a package of preclinical data on efficacy and safety to initiate clinical trials.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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