Skip directly to search Skip directly to A to Z list Skip directly to navigation Skip directly to page options Skip directly to site content


Hot Topics of the Day|PHGKB
Search PHGKB:

08/05/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

Sign up MyPHGKB to receive the daily hot topic email alert.

Search Archive:
Archived Hot Topics of the Day By Date

Coronavirus RNA proofreading: molecular basis and therapeutic targeting
F Robson et al, Molecular Cell, August 5, 2020

We review the molecular basis of the CoV proofreading complex and evaluate its potential as a drug target. We also consider existing nucleoside analogues and novel genomic techniques as potential anti-CoV therapeutics that could be used individually or in combination to target the proofreading mechanism.

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness
KS Corbett et al, Nature, August 5, 2020

Application of Social Vulnerability Index to Identify High- risk Population of Contracting COVID-19 Infection: a state-level study.
O Estefania et al, MEDRXIV, August 4, 2020

By applying the social vulnerability index and analyzing data from a total of 102 counties across the state of Illinois, we investigated which factors enhanced the risk of contracting the infection and which were related to a lower risk of infection.

Potent neutralizing antibodies target new regions of coronavirus spike
NIH Research Matters, August 4, 2020 Brand

Covid-19 apps and wearables are everywhere. Can they actually benefit patients?
C Ross, StatNews, August 4, 2020

Application of exome sequencing for prenatal diagnosis: a rapid scoping review.
Pratt Misty et al. Genetics in medicine : official journal of the American College of Medical Genetics 2020 Aug

Few studies reported clinical outcomes related to impact, decision-making, and clinical utility. Qualitative studies (n?=?6) provided useful insights into patient and health-care provider experiences with exome sequencing.

Health systems as venture capital investors in digital health: 2011–2019
KC Safavi et al, NPJ Digital Medicine, August 4, 2020

From 2011 to 2019, we found that health systems made 184 investments in 105 companies. Compared with other investors, they were more likely to invest in companies focused on workflow, on-demand health services, and data infrastructure/interoperability.

Association of Cerebrospinal Fluid Tumor DNA Genotyping With Survival Among Patients With Lung Adenocarcinoma and Central Nervous System Metastases
YS Li et al, JAMA Network Open, August 4, 2020

Patients with a diagnosis of lung adenocarcinoma and CNS metastases experienced heterogeneous survival outcomes based on genetic profiling in cerebrospinal fluid. These data suggest that CSF might facilitate risk stratifying CNS metastases into appropriate outcomes and provide reference for further clinical study.

From genetics to bariatric surgery and soda taxes: Using all the tools to curb the rising tide of obesity
A Misra et al, PLOS Medicine, July 31, 2020

While environmental and policy interventions to tackle obesity are often discussed separately from metabolic and genetic risk factors, researchers have increasingly linked environmental and biological components of risk to help personalize and direct interventions. The influence of genetic risk for obesity on food choice behaviors is not well understood.

What is Epigenetics?
CDC, August 2020 Brand

While genetic changes can alter which protein is made, epigenetic changes affect gene expression to turn genes “on” and “off.” Since your environment and behaviors, such as diet and exercise, can result in epigenetic changes, it is easy to see the connection between your genes and your behaviors and environment.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
TOP