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Hot Topics of the Day|PHGKB
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08/04/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Virus Surveillance and Diagnosis With a CRISPR-Based Platform
T Hampton, JAMA, August 4, 2020

How to Think Like an Epidemiologist- Don’t worry, a little Bayesian analysis won’t hurt you.
S Roberts, NY Times, August 4, 2020

SARS-CoV-2 genome sequences from late April in Stockholm, Sweden reveal a novel mutation in the spike protein
T Aparecida et al, BIORXIV, August 3, 2020

A machine learning explanation of the pathogen-immune relationship of SARS-CoV-2 (COVID-19) and models of prognostic biomarkers to predict asymptomatic infections
E Luellen, MEDRXIV, August 3, 2020

Genomic heterogeneity and clinical characterization of SARS-CoV-2 in Oregon
AK Dowdell et al, MEDRXIV, August 4, 2o020

We report viral sequences from 188 patients across the hospitals and associated clinics in Oregon dating back to the early days of the outbreak. We show a rapid emergence and dominance of Spike D614G-positive variants. We also highlight significant diversity in sequences indicative that these genomes could be utilized for outbreak tracing.

An Exploration of Impact of COVID 19 on mental health -Analysis of tweets using Natural Language Processing techniques
S Sengupta et al, MEDRXIV, August 4, 2020

A longitudinal survey for genome-based identification of SARS-CoV-2 in sewage water in selected lockdown areas of Lahore city, Pakistan; a potential approach for future smart lockdown strategy
T Yacoub et al, MEDRXIV, August 4, 2020

R3T (Rapid Research Response Team) One-step RT-qPCR kit for COVID-19 diagnostic using in-house enzymes
M Takahashi et al, MEDRXIV, August 4, 2020

Digitizing clinical trials
OT Inan et al, NPJ Digital Medicine, July 31, 2020

The concept of a “digital clinical trial” involves leveraging digital technology to improve participant access, engagement, trial-related measurements, and/or interventions, enable concealed randomized intervention allocation, and has the potential to transform clinical trials and to lower their cost.

Assessment of Real-World Use of Behavioral Health Mobile Applications by a Novel Stickiness Metric
AD Carlo et al, JAMA Network Open, August 3, 2020

In this cross-sectional study, we describe usage patterns of popular mobile behavioral health apps and identify characteristics of those that are most continually accessed (also known as the stickiest), with the aim of informing future research on behavioral health app engagement.

Assessment of Disparities in Digital Access Among Medicare Beneficiaries and Implications for Telemedicine
ET Roberts et al, JAMA Internal Medicine, August 3, 2020

Using data from 2018, we found that 26.3% of Medicare beneficiaries lacked digital access at home, making it unlikely that they could have telemedicine video visits with clinicians. The proportion of beneficiaries who lacked digital access was higher among those with low socioeconomic status, those 85 years or older, and in communities of color.

An optimal posttreatment surveillance strategy for cancer survivors based on an individualized risk-based approach
GQ Zhou et al, Nature Comms, August 3, 2020

A total of 7,043 newly-diagnosed patients are grouped according to a clinic-molecular risk grouping system. We use a random survival forest model to simulate the monthly probability of disease recurrence, and thereby establish risk-based surveillance.

Personalized circulating tumor DNA analysis as a predictive biomarker in solid tumor patients treated with pembrolizumab
SV Bratman et al, Nature Cancer, August 2020

Immune checkpoint blockade (ICB) provides clinical benefit to a subset of patients with cancer. However, existing biomarkers do not reliably predict treatment response across diverse cancer types. Limited data exist to show how serial circulating tumor DNA (ctDNA) testing may perform as a predictive biomarker in patients receiving ICB

Personalized Treatments in Pancreatic Cancer: The Progress Continues
H Virgil, Oncology Nursing News, August 3, 2020

Although pancreatic cancer has been a historically difficult disease to treat, the emergence of novel combinations have allowed for more patients to receive later lines of therapy, and recent advances have inspired a shift to more personalized treatment approaches to improve outcomes.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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