Association of Receiving a Fourth Dose of the BNT162b Vaccine With SARS-CoV-2 Infection Among Health Care Workers in Israel.
Cohen Matan J et al. JAMA network open 2022 8 (8) e2224657
Was there a benefit of vaccinating health care workers with a fourth dose of BNT162b2 vaccine during the Omicron variant outbreak of the COVID-19 pandemic?
In this multicenter cohort study of 29?611 health care workers in Israel, the breakthrough infection rate among those who received 4 doses was 6.9% compared with 19.8% in those who received 3 doses.
Covid-19: is omicron less lethal than delta?
Lorenzo-Redondo Ramon et al. BMJ (Clinical research ed.) 2022 8 o1806
Neutralization of SARS-CoV-2 Omicron sublineages by 4 doses of mRNA vaccine
X Xie et al, BIORXIV, July 29, 2022
In sera from 2- 3- and 4-dose vaccinees in the US with and without BA.1 breakthrough, vaccine plus prior BA.1 better neutralized Omicron VOCs than 4-doses with no infection. Neutralization titers were similar for 2- and 3-doses post breakthrough and were 1.4, 4.8, 3.1, 4.1, 4.9, and 3.9x higher for WA1/2020, BA.1-, BA.2-, BA.212.1-, BA.3-, and BA.4/5, respectively, for 2-dose and breakthroughs vs 4 doses only.
Coronaviruses exploit a host cysteine-aspartic protease for replication
H Chu et al, Nature, August 3, 2022
We show that a cysteine-aspartic protease of the apoptosis cascade, caspase-6, serves as an important host factor for efficient coronavirus replication. We demonstrate that caspase-6 cleaves coronavirus nucleocapsid (N) proteins, generating N fragments that serve as interferon (IFN) antagonists, thus facilitating virus replication.
Heart disease after COVID: what the data say
SM Sidik, Nature, August 2, 2022
Some studies suggest that the risk of cardiovascular problems, such as a heart attack or stroke, remains high even many months after a SARS-CoV-2 infection clears up. Researchers are starting to pin down the frequency of these issues and what is causing the damage.
Cardiovascular safety of COVID-19 vaccines in real-world studies: a systematic review and meta-analysis
Y Chang et al, MEDRXIV, August 2, 2022
Association of SARS-CoV-2 BA.4/BA.5 Omicron lineages with immune escape and clinical outcome
JA Lewnard et al, MEDRXIV, August 2, 2022
Development, testing and validation of a SARS-CoV-2 multiplex panel for detection of the five major variants of concern on a portable PCR platform
BJ Stanhope et al, MEDRXIV, August 2, 2022
We have created a panel of four triplex RT-qPCR assays targeting 12 mutations to detect and differentiate all five variants of concern: Alpha, Beta, Gamma, Delta and Omicron. We also developed an expanded pentaplex assay that can reliably distinguish among the major sublineages (BA.1-BA.5) of Omicron. In silico, analytical and clinical testing of the variant panel indicate the assays have a sensitivity and specificity of >95%. This variant panel can be used as a Research Use Only screening tool for triaging SARS-CoV-2 positive samples prior to whole genome sequencing.
Limited induction of lung-resident memory T cell responses against SARS-CoV-2 by mRNA vaccination
DKJ Pieren et al, MEDRXIV, August 2, 2022