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Hot Topics of the Day|PHGKB
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07/28/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Could You Have Covid-19? Soon Your Smartwatch or Smart Ring Might Tell You- Wearable devices with sensors that continuously gather your temperature, heart rate and blood oxygen could become personal warning systems for the coronavirus
WSJ, July 28, 2020

Seek COVER: Development and validation of a personalized risk calculator for COVID-19 outcomes in an international network
RD Williams et al, MERXIV, July 27, 2020

We developed and validated COVID-19 Estimated Risk (COVER) scores that quantify a patient's risk of hospital admission (COVER-H), requiring intensive services (COVER-I), or fatality (COVER-F) in the 30-days following COVID-19 diagnosis. We analyzed a federated network of electronic medical records and claims data from 14 data sources and 6 countries.

Phase 3 clinical trial of investigational vaccine for COVID-19 begins
NIH News, July 27, 2020 Brand

A Phase 3 clinical trial designed to evaluate if an investigational vaccine can prevent symptomatic coronavirus disease 2019 (COVID-19) in adults has begun. The vaccine, known as mRNA-1273, was co-developed by the Cambridge, Massachusetts-based biotechnology company Moderna, Inc., and the National Institute of Allergy and Infectious Diseases (NIAID).

Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individuals
HV Doddapanenni et al, BIORXIV, July 27, 2020

Evolution And Genetic Diversity Of SARSCoV-2 In Africa Using Whole Genome Sequences
BO Motayo et al, BIORXIV, July 27, 2020

Predicting the Emergence of SARS-CoV-2 Clades
S Jain et al, BIORXIV, July 27, 2020

As Covid-19 surges, researchers amass lung scans to build AI systems for patient care
C Ross, Stat News, July 27, 2020

Why (and how) COVID-19 could move us closer to the "health information for all" goal
M Capocasa et al, MEDRXIV, July 27, 2020

A genomics approach to male infertility
N Alhathal et al, Genetics in Medicine, July 28, 2020

Patients with severe oligospermia and nonobstructive azoospermia were investigated using exome sequencing (ES) in parallel with the standard practice of chromosomal analysis. In 285 patients, 10.5% (n?=?30) had evidence of chromosomal aberrations while nearly a quarter (n?=?69; 24.2%) had a potential monogenic form of male infertility.

Genome-wide detection of tandem DNA repeats that are expanded in autism
B Trost et al, Nature, July 27, 2020

Rare tandem repeat expansions had a prevalence of 23.3% in autism-affected children versus 20.7% in unaffected children, suggesting a collective contribution to autism risk of 2.6%. They included novel autism-linked tandem repeat expansions in DMPK and FXN, known for neuromuscular conditions, and in novel loci such as FGF14 and CACNB1.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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