Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.
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Archived Hot Topics of the Day By Date
Bidirectional genome-wide CRISPR screens reveal host factors regulating SARS-CoV-2, MERS-CoV and seasonal HCoVs
A Rebendenne et al, Nature Genetics, July 25, 2022
CRISPR knockout (KO) screens have identified host factors regulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) replication. Here, we conducted a meta-analysis of these screens, which showed a high level of cell-type specificity of the identified hits, highlighting the necessity of additional models to uncover the full landscape of host factors.
Genome-wide bidirectional CRISPR screens identify mucins as host factors modulating SARS-CoV-2 infection
SB BIering et al, Nature Genetics, July 25, 2022
We conducted genome-wide CRISPR knockout and activation screens in human lung epithelial cells with endogenous expression of the SARS-CoV-2 entry factors ACE2 and TMPRSS2. We uncovered proviral and antiviral factors across highly interconnected host pathways, including clathrin transport, inflammatory signaling, cell-cycle regulation, and transcriptional and epigenetic regulation. We further identified mucins, a family of high molecular weight glycoproteins, as a prominent viral restriction network that inhibits SARS-CoV-2 infection in vitro and in murine models.
It's the virus, stupid.
E Topol, Ground Truths, July 24, 2022
New Cardiovascular Risk Assessment Techniques for Primary Prevention: JACC Review Topic of the Week.
Verma Kunal P et al. Journal of the American College of Cardiology 2022 7 (4) 373-387
Risk factor-based models fail to accurately estimate risk in select populations, in particular younger individuals. A sizable number of people are also classified as being at intermediate risk, for whom the optimal preventive strategy could be more precise. Several personalized risk prediction tools, including coronary artery calcium scoring, polygenic risk scores, and metabolic risk scores may be able to improve risk assessment, pending supportive outcome data from clinical trials.
UK explores whole-genome sequencing for newborn babies
T Burki, The Lancet, July 23, 2022
A pilot program will assess the risks and benefits of screening babies for a huge number of conditions. The UK Newborn Genomes Program is still in its infancy. It was created last year by Genomics England to oversee plans to undertake whole-genome sequencing of up to 200?000 newborn babies. The sequencing will be run as part of a research project within the National Health Service (NHS). The aim is to examine whether screening healthy babies for a broad range of rare genetic conditions could improve outcomes.