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Hot Topics of the Day|PHGKB
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07/22/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Serosurveillance and the COVID-19 Epidemic in the US: Undetected, Uncertain, and Out of Control.
Brown Tyler S et al. JAMA 2020 Jul

Responding to the urgent need for data tracking the extent of the COVID-19 epidemic, epidemiologists, medical researchers, and public health officials have in recent months advanced an array of research efforts seeking to measure the cumulative incidence of COVID-19 via serologic evidence of prior infection.

White Neighborhoods Have More Access To COVID-19 Testing Sites- But the disease is hitting Black and Hispanic communities hardest.
SR Kim et al, FiveThirtyEight, July 22, 2020

Big data analysis is one of the first to look at testing site locations in all 50 states using data provided by the health care navigation company Castlight Health. An assessment of city and state health department websites also revealed fewer testing sites in areas primarily inhabited by racial minorities.

How Long Does COVID-19 Immunity Last?
D Thompson, the Atlantic, uly 21, 2020

Testing the association between blood type and COVID-19 infection, intubation, and death
M Zietz et al, MEDRXIV< July 21, 2020

Explainable-Machine-Learning to discover drivers and to predict mental illness during COVID-19
IP Jha et al, MEDRXIV, July 21, 2020

Recurrent SARS-CoV-2 RNA positivity after COVID-19: A systematic review and meta analysis
M Azam et al, MEDRXIV, July 21, 2020

Population genetic analysis of Indian SARS-CoV-2 isolates reveals a unique phylogenetic cluster
D Das et al, BIORXIV, July 20, 2020

Structural analysis of SARS-CoV-2 genome and predictions of the human interactome
A Vandelli et al, BIORXIV, July 20, 2020

Implementing Stepped Pooled Testing for Rapid COVID-19 Detection
A Srivastava et al, ARXIV, July 19, 2020

Responsible, practical genomic data sharing that accelerates research
JB Byrd et al, Nat Rev Genetics, July 21, 2020

To illuminate the rationales for sharing data, the technical challenges and the social and cultural challenges, we consider the stakeholders in the scientific enterprise. We discuss current best practices for various types of genomic data, as well as opportunities to promote ethical data sharing that accelerates science by aligning incentives.

Blood DNA methylation signatures to detect dementia prior to overt clinical symptoms
PD Fransquet et al, Blood Based Biomarkers, July 2020

DNAm was measured in 73 individuals prior to dementia diagnosis and 87 cognitively healthy controls matched for age, sex, smoking, education, and baseline cognition. Discernible blood DNAm signatures are in dementia cases before the appearance of overt clinical symptoms. Further investigation is needed to determine clinical utility.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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