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Hot Topics of the Day|PHGKB
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07/10/2020

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Rigorous wildlife disease surveillance
M Watsa et al, Science July 10, 2020

Pathophysiology, Transmission, Diagnosis, and Treatment of Coronavirus Disease 2019 (COVID-19) A Review
MJ Wiersinga et al, JAMA, July 10, 2020

Revealing COVID-19 transmission in Australia by SARS-CoV-2 genome sequencing and agent-based modeling
RJ Rocket et al, Nature Medicine, July 9, 2020

Here we examine the added value of near real-time genome sequencing of SARS-CoV-2 in a subpopulation of infected patients during the first 10 weeks of COVID-19 containment in Australia and compare findings from genomic surveillance with predictions of a computational agent-based model (ABM).

The mathematical strategy that could transform coronavirus testing- Four charts show how pooling samples from many people can save time or resources.
Nature News, July 10, 2020

There are many ways to conduct group testing, and scientists in several countries are experimenting with the best method for doing this during a pandemic. Their ideas largely come from a field of mathematics known as group testing, which has been widely used — from detecting faulty Christmas-tree lights to estimating the prevalence of HIV in a population.

COVID-19 Mortality Risk Assessment: An International Multi-Center Study
D Berstimas et al, MEDRXIV, July 9, 2020

Post-lockdown detection of SARS-CoV-2 RNA in the wastewater of Montpellier, France
J Trottier et al, MEDRXIV, July 9, 2020

COVID_19 Prevention Network
NIH, July 2020 Brand

Interested in volunteering for a COVID-19 Prevention Clinical Study? The mission of this network is to conduct Phase 3 vaccine and monoclonal antibody efficacy studies for the prevention of COVID-19.

New genomic data studies launch to combat Covid-19
Genetics Education Program, July 9, 2020

Association of Circulating Tumor DNA and Circulating Tumor Cells After Neoadjuvant Chemotherapy With Disease Recurrence in Patients With Triple-Negative Breast Cancer- Preplanned Secondary Analysis of the BRE12-158 Randomized Clinical Trial
JAMA Oncology, July 9, 2020

Detection of circulating tumor DNA and circulating tumor cells after neoadjuvant chemotherapy in patients with early-stage triple-negative breast cancer is independently associated with disease recurrence, above and beyond standard clinical parameters, and represents an important novel stratification factor for future postneoadjuvant trials.

Association of Independent Prognostic Factors and Treatment Modality With Survival and Recurrence Outcomes in Breast Cancer
D Nguyen et al, JAMA Network Open, July 9, 2020

Lung Adenocarcinoma (LUAD) Discoveries from two NCI Proteomics Consortia
NCI, July 9, 2020 Brand

Advances in genomics have revealed new insights in the biology of LUAD, but comprehensive information about how various gene mutations lead to this disease is still lacking. Investigators addressed this challenge by adding comprehensive proteomics to genomics, or proteogenomics, to reveal an additional dimension of lung cancer biology.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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