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Hot Topics of the Day|PHGKB
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06/12/2021

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Archived Hot Topics of the Day By Date

Progress With the All of Us Research Program: Opening Access for Researchers.
Ramirez Andrea H et al. JAMA 2021 6

As of April 2021, there were 278?365 adults who completed the initial steps of program participation (including consent for health-related research use of data, donation of biospecimens [urine and blood or saliva], sharing of electronic health record [EHR] data by their health care organization, in-person provision of physical measurements, and surveys about demographics, lifestyle, and overall health) that qualified them as core participants and 380?881 adults who completed at least the primary consent to participate.

Urinary exosome microRNA signatures as a noninvasive prognostic biomarker for prostate cancer
S Shin et al, NPJ Digital Medicine, June 11, 2021

we developed a “Prostate Cancer Metastasis Risk Scoring (PCa-MRS)” model. The PCa-MRS showed superior stratification power (AUC?=?0.925) to preoperative PSA or clinical Gleason score. Patients with high scores showed significantly poorer biochemical recurrence-free survival than those with low scores (P?=?6.53?×?10-10). Our results showed the potential of urinary exosomal miRNAs as noninvasive markers for predicting metastasis and prognosis in PCa patients.

The Bloodline Newsletter
CDC, June 2021 Brand

The Bloodline is a quarterly newsletter that provides updates about the SCDC program. Subscribe to the newsletter to stay updated on the SCDC program’s health communications activities, data, presentations, and more.

A safer way to share health data.
O'Leary Karen et al. Nature medicine 2021 6

Artificial intelligence (AI)-based tools are becoming ever more proficient at clinical decision-making. However, the requirement for large datasets means that data must be either stored centrally or controlled by central custodians, which raises concerns about data ownership, confidentiality and security.

Continuous health monitoring: An opportunity for precision health.
Gambhir Sanjiv S et al. Science translational medicine 2021 6 (597)

Continuous health monitoring and integrated diagnostic devices, worn on the body and used in the home, will help to identify and prevent early manifestations of disease. However, challenges lie ahead in validating new health monitoring technologies and in optimizing data analytics to extract actionable conclusions from continuously obtained health data.

Using large-scale experiments and machine learning to discover theories of human decision-making.
Peterson Joshua C et al. Science (New York, N.Y.) 2021 6 (6547) 1209-1214

Predicting and understanding how people make decisions has been a long-standing goal in many fields, with quantitative models of human decision-making informing research in both the social sciences and engineering. We show how progress toward this goal can be accelerated by using large datasets to power machine-learning algorithms that are constrained to produce interpretable psychological theories.

Machine-generated theories of human decision-making
S Bhatia et al, Science, June 11, 2021


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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