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Hot Topics of the Day|PHGKB
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05/18/2021

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Disparities in COVID-19 Vaccination Coverage Between Urban and Rural Counties — United States, December 14, 2020–April 10, 2021
BP Murthy et al, MMWR< May 18, 2021

COVID-19 vaccination coverage was lower in rural counties (38.9%) than in urban counties (45.7%); disparities persisted among age groups and by sex. Disparities in COVID-19 vaccination access and coverage between urban and rural communities can hinder progress toward ending the pandemic.

Health systems resilience in managing the COVID-19 pandemic: lessons from 28 countries
V Haldane et al, Nature Medicine May 18, 2021

Assessing health systems resilience is vital in helping policymakers plan for sustainable recovery and strengthen systems to better prepare and respond to current and future crises. Using an adapted and improved resilience framework, our review highlights many parallels in the measures implemented by countries in response to COVID-19. The similarities across countries with divergent health outcomes makes clear that there is no one silver bullet toward a resilient health system

Equitable allocation of COVID-19 vaccines in the United States
H Schmidt et al, Nature Medicine, May 18, 2021

We analyzed vaccine allocation plans published by 8 November 2020, tracking updates through to 30 March 2021. We evaluated whether jurisdictions adopted proposals to reduce inequity using disadvantage indices and related place-based measures. By 30 March 2021, 14 jurisdictions had prioritized specific zip codes in combination with metrics such as COVID-19 incidence, and 37 jurisdictions (including 34 states) had adopted disadvantage indices, compared to 19 jurisdictions in November 2020.

Sociodemographic inequality in COVID-19 vaccination coverage amongst elderly adults in England: a national linked data study
V Nafilyan et al, MEDRXIV, May 17, 2021

HLA-B*15:01 is associated with asymptomatic SARS-CoV-2 infection
DG Augusto et al, MEDRXIV, May 17, 2021

Global genomic pathogen surveillance to inform vaccine strategies: a decade-long expedition in pneumococcal genomics
SD Bentley et al, Genome Medicine, May 17, 2021

In this review, we consider the strengths and challenges for pathogen genomic surveillance using the experience of the Global Pneumococcal Sequencing (GPS) project as an early example. We highlight the multifaceted nature of genome data and recent advances in genome-based tools to extract useful information to inform vaccine strategies and treatment options.

Higher Rates of Bleeding and Use of Treatment Products Found Among Young Boys Compared to Girls with von Willebrand Disease
CDC, May 17, 2021 Brand

Researchers analyzed information from 2,712 children with VWD. The children were 2–12 years old and enrolled in the Universal Data Collection (UDC) system during 1998 to 2011. On average, among all VWD types, boys were younger at their first bleed and at diagnosis of VWD than girls. There were no differences in life quality or well-being status in boys versus girls. Some minority children with VWD (Hispanic or Asian/Pacific Islander/American Indian/American Native) were at higher risk of bleeding, compared to children who are non-Hispanic white.

Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
N Mullins et al, Nature Genetics, May 17, 2021

We performed a genome-wide association study of 41,917 bipolar disorder cases and 371,549 controls of European ancestry, which identified 64 associated genomic loci. Bipolar disorder risk alleles were enriched in genes in synaptic signaling pathways and brain-expressed genes, particularly those with high specificity of expression in neurons of the prefrontal cortex and hippocampus. Significant signal enrichment was found in genes encoding targets of antipsychotics, calcium channel blockers, antiepileptics and anesthetics.


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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