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Hot Topics of the Day|PHGKB
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05/17/2021

Hot Topics of the Day are picked by experts to capture the latest information and publications on public health genomics and precision health for various diseases and health topics. Sources include published scientific literature, reviews, blogs and popular press articles.

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Why CDC Measures Vaccine Effectiveness
CDC, May 17, 2021 Brand

Many factors can affect how a vaccine works in real-world conditions. These factors include: Host factors such as people not included in clinical trials who may respond differently to the vaccine; Virus factors such as variants, Programmatic factors such as following dosing schedules or storing and handling vaccines properly. Understanding how COVID-19 vaccines work in real-world conditions will allow CDC, FDA, and other partners to ensure vaccines offer real-world protection against COVID-19.

Neutralizing antibody levels are highly predictive of immune protection from symptomatic SARS-CoV-2 infection
DS Khoury et al, Nature Medicine, May 17, 2021

Predictive models of immune protection from COVID-19 are urgently needed to identify correlates of protection to assist in the future deployment of vaccines. To address this, we analyzed the relationship between in vitro neutralization levels and the observed protection from SARS-CoV-2 infection using data from seven current vaccines and from convalescent cohorts. we show that neutralization level is highly predictive of immune protection, and provide an evidence-based model of SARS-CoV-2 immune protection that will assist in developing vaccine strategies to control the future trajectory of the pandemic.

A Predictive Modelling Framework for COVID-19 Transmission to Inform the Management of Mass Events
C Donnat et al, MEDRXIV, May 16, 2021

CovidExpress: an interactive portal for intuitive investigation on SARS-CoV-2 related transcriptomes
MN Djekidel et al, BIORXIV< May 16, 2021

Potent neutralization of SARS-CoV-2 variants of concern by an antibody with a unique genetic signature and structural mode of spike recognition
KJ Kramer et al, BIORXIV, May 16, 2021

Durability of mRNA-1273-induced antibodies against SARS-CoV-2 variants
A Pegu et al, BIORXIV< May 16, 2021


Disclaimer: Articles listed in Hot Topics of the Day are selected by Public Health Genomics Branch to provide current awareness of the scientific literature and news. Inclusion in the update does not necessarily represent the views of the Centers for Disease Control and Prevention nor does it imply endorsement of the article's methods or findings. CDC and DHHS assume no responsibility for the factual accuracy of the items presented. The selection, omission, or content of items does not imply any endorsement or other position taken by CDC or DHHS. Opinion, findings and conclusions expressed by the original authors of items included in the Clips, or persons quoted therein, are strictly their own and are in no way meant to represent the opinion or views of CDC or DHHS. References to publications, news sources, and non-CDC Websites are provided solely for informational purposes and do not imply endorsement by CDC or DHHS.
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